Abstract:
:A 57-year-old man with renal cell carcinoma associated with membranous glomerulonephropathy (MGN) developed a transient amelioration of the nephrotic syndrome after excision of the tumor. We tried to identify a nephritogenic tumor antigen using the immunoblotting technique in this patient with MGN, since previous studies examined the interaction between tumor antigens and IgG eluted from the kidney tissue using immunofluorescence or immunodiffusion techniques, and no studies have identified the specific tumor antigen with the immunoblotting method. In the present study, no significant immunoreactivity was noted between the IgG eluted from renal cortical tissues of the patient and renal cell carcinoma proteins. Further studies are necessary to establish the pathogenic mechanism of MGN associated with malignancy.
journal_name
Nephronjournal_title
Nephronauthors
Togawa A,Yamamoto T,Suzuki H,Watanabe K,Matsui K,Nagase M,Hishida Adoi
10.1159/000049047subject
Has Abstractpub_date
2002-02-01 00:00:00pages
219-21issue
2eissn
1660-8151issn
2235-3186pii
nef90219journal_volume
90pub_type
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