Abstract:
:Glomerulonephritis as well as kidney injury secondary to fulminant intravascular hemolysis are rare extrapulmonary manifestations of Mycoplasma pneumoniae infection. We describe a 50-year-old female diagnosed with M. pneumoniae infection-associated hemolytic anemia, characterized by negative cold agglutinin tests but with laboratory evidence of complement alternative pathway activation. The patient presented both with anemia and severe kidney failure and she was treated with steroids and red blood cell transfusions along with plasmapheresis. She also received a short course of antibiotics. Renal biopsy showed combined features of resolving postinfectious glomerulonephritis and hemolysis-associated extensive acute tubular injury characterized by renal hemosiderosis and intratubular hemoglobin casts. Electron microscopy revealed features of glomerular microangiopathic injury. The treatment led to complete disease remission and a favorable renal outcome at the first year follow-up.
journal_name
Nephronjournal_title
Nephronauthors
Carrara C,Abbate M,Sabadini E,Remuzzi Gdoi
10.1159/000478991subject
Has Abstractpub_date
2017-01-01 00:00:00pages
148-154issue
2eissn
1660-8151issn
2235-3186pii
000478991journal_volume
137pub_type
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