Abstract:
:8 patients with thrombotic microangiopathy were treated with a new antithrombotic agent, defibrotide. This drug displays considerable fibrinolytic and antithrombotic activity, and induces generation and release of a prostacyclin-like substance from vascular tissue. At admission all patients presented severe renal involvement and coagulation abnormalities. Neurological manifestations were present in 6. Defibrotide administration was followed by recovery of renal function in 6, disappearance of neurological symptoms and coagulation abnormalities in all patients. The use of defibrotide was not associated with side effects. On the basis of the results obtained in these patients, we suggest that defibrotide might be considered as a valuable drug in the management of patients with thrombotic microangiopathy.
journal_name
Nephronjournal_title
Nephronauthors
Bonomini V,Frascà GM,Raimondi C,Liviano D'arcangelo G,Vangelista Adoi
10.1159/000190340subject
Has Abstractpub_date
1985-01-01 00:00:00pages
195-200issue
2eissn
1660-8151issn
2235-3186journal_volume
40pub_type
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