Abstract:
:Gastrointestinal infection with verotoxin-producing Escherichia coli (VTEC) has been strongly implicated in the etiology of the hemolytic uremic syndrome (HUS), the leading cause of pediatric acute renal failure. The binding of fluorescein-conjugated VT1 overlaid on to frozen human renal sections has been examined. Sections from biopsies of infants aged < 2 years were compared with those from adult autopsies. VT primarily stained distal convoluted tubules, particularly those adjacent to glomeruli, and collecting ducts. VT-binding was detected within the infant glomerulus but not the adult. Binding of the toxin was removed when the section was pretreated with alpha-galactosidase, confirming the receptor-binding specificity for globotriaosyl ceramide (gal alpha 1-4gal beta 1-4 glucosylceramide), the glycolipid receptor for VT. These studies may suggest that differential localization of this glycolipid in the pediatric renal glomerulus is a risk factor for the development of HUS following infection with VTEC.
journal_name
Nephronjournal_title
Nephronauthors
Lingwood CAdoi
10.1159/000187761subject
Has Abstractpub_date
1994-01-01 00:00:00pages
21-8issue
1eissn
1660-8151issn
2235-3186journal_volume
66pub_type
杂志文章相关文献
NEPHRON文献大全abstract:AIM:To clarify the role of leukocyte subsets in the development of glomerulosclerosis (GS) and interstitial lesions which may contribute to the prognosis of membranous nephropathy (MN), we investigated infiltrating cells in both glomeruli and interstitium in biopsy specimens. METHODS:Forty-one cases of MN were divided...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045213
更新日期:1998-12-01 00:00:00
abstract::We present a rare case of IgA nephropathy in a patient who developed atypical hemolytic uremic syndrome (aHUS) associated with a complement factor H (CFH) gene mutation, and who was successfully treated with eculizmab. A 76-year-old man was admitted as the patients had thrombotic microangiopathies findings. The patien...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000485194
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Complete remission (CR) and partial remission (PR) are beneficial to the long-term outcome of patients with idiopathic membranous nephropathy (iMN). However, we are lacking in studies that evaluate the clinical predictors of response to treatment with prednisone plus cyclophosphamide (CP). The objectives of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000448291
更新日期:2017-01-01 00:00:00
abstract::A four-year-old male with steroid refractory nephrotic syndrome was found to have diffuse deposition of alpha 2-macroglobulin (alpha 2M) in the glomeruli which showed diffuse mesangial proliferation and partial hyalinization by light microscopy. Camostat mesylate, a commercially available synthetic proteinase inhibito...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186874
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIMS:Although the PTH-suppressive effect of intravenous calcitriol has already been demonstrated by various studies, the precise dose-response to calcitriol has not been fully determined for uremic secondary hyperparathyroidism (2HPT). In order to investigate in detail the dose-response of intravenous calcit...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000054729
更新日期:2002-04-01 00:00:00
abstract::Isolated hindquarters of bilaterally nephrectomized and sham-operated rats were perfused in the presence and absence of 14C-labelled serine, respectively. After a perfusion period of 30 min 14C-serine was 4,074 +/- 270 dpm/ml in the perfusion medium of sham-operated animals and decreased to 2,800 +/- 190 dpm/ml in the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183003
更新日期:1983-01-01 00:00:00
abstract::A patient with cadaveric renal transplantation was diagnosed by brain-computed tomography and ELISA as having neurocysticercosis in the CSF. Complete cure was achieved after praziquantel therapy. Function of the allograft was not affected. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184074
更新日期:1987-01-01 00:00:00
abstract::Joseph Andreas Jacobus Plenck was born in 1735 in Vienna where he studied surgery with Johan Christian Retter. At age 35 he was appointed Professor of Surgery and Obstetrics by Maria Theresia. Subsequently he became professor and life long secretary of the Medical Military Academy know as the Josephinum where he worke...
journal_title:Nephron
pub_type: 传,历史文章,杂志文章
doi:10.1159/000064450
更新日期:2002-09-01 00:00:00
abstract::The purpose of this study was to characterize renal cell carcinoma tissue by the measurement of microacoustic properties. A scanning acoustic microscope system operating in the frequency range of 100-200 MHz was employed and the attenuation constant and sound speed were measured on the two-dimensional distribution. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189291
更新日期:1996-01-01 00:00:00
abstract::The course of left ventricular hypertrophy was investigated in anemic hemodialysis patients treated with recombinant human erythropoietin (r-huEPO). 12 patients, aged 60.8 +/- 9.9 years (mean +/- SD) were treated for 18.8 +/- 2.7 months. Left ventricular size was estimated by echocardiography performed before treatmen...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186829
更新日期:1992-01-01 00:00:00
abstract::Pruritus is a common symptom among patients undergoing long-term hemodialysis. However, its etiology remains unclear. In an attempt to clarify its cause we tried to correlate pruritus and its intensity with several serological variables in 94 hemodialysis patients. Our results show that higher serum aluminum concentra...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189499
更新日期:1997-01-01 00:00:00
abstract::A study was undertaken in 24 Chinese patients on maintenance continuous ambulatory peritoneal dialysis, using bezafibrate in its sustained-release form to correct lipid abnormalities. Six patients who received 400 mg/day developed severe muscle weakness with grossly elevated creatine phosphokinase activities within 3 ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186101
更新日期:1990-01-01 00:00:00
abstract::Chyloperitoneum is a rare condition in patients undergoing peritoneal dialysis. We report here a patient who developed chylous ascites during the course of tuberculous peritonitis. The diagnosis was confirmed by cultures of dialysate and peritoneal biopsy, and laparoscopy revealed severe hyperemia and intestine adhesi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188969
更新日期:1996-01-01 00:00:00
abstract::Kidney biopsy remains the gold standard for uncovering the pathogenesis of acute and chronic kidney diseases. However, the ability to perform high resolution, quantitative, molecular and cellular interrogation of this precious tissue is still at a developing stage compared to other fields such as oncology. Here, we di...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000490006
更新日期:2018-01-01 00:00:00
abstract::The pharmacokinetics of procainamide in patients on continuous ambulatory peritoneal dialysis have been studied. A mean peak plasma concentration of 3.2 +/- 0.6 microgram/ml was achieved about 2 h after a single 500-mg oral procainamide hydrochloride dose. The procainamide elimination half-life ranged from 6.1 to 15.3...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183984
更新日期:1986-01-01 00:00:00
abstract::A 55-year-old white male, with silicosis diagnosed 10 years earlier, presented massive proteinuria with microscopic hematuria, moderate renal failure and distal polyneuropathy. Bilateral renal angiography showed multiple intraparenchymal saccular aneurysms. Renal biopsy disclosed a focal segmental necrotizing glomerul...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185391
更新日期:1989-01-01 00:00:00
abstract::A 5-year-old Chinese girl had had absence seizures and received sodium valproate (VPA) treatment which provided good control. Six months later, she developed interstitial nephritis with proteinuria and microhematuria. Renal biopsy revealed interstitial nephritis with granular deposition of immunoglobulin G (IgG) and C...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184867
更新日期:1988-01-01 00:00:00
abstract::The ability of cultured peripheral-blood mononuclear cells (PBMC) to release interleukin-1 alpha and beta (IL-1 alpha, IL-1 beta) in response to concanavalin A (con A) was investigated in patients with chronic renal failure (CRF) and in renal transplant recipients. Mean IL-1 alpha level released by PBMC of healthy sub...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186478
更新日期:1991-01-01 00:00:00
abstract::The variations of ionized and total calcium concentrations were studied during haemodialysis with high flux membrane using dialysate calcium concentrations of 1.63 and 1.76 mmol/l. The changes in ionized and total calcium were related to the predialytic calcium concentration difference between plasma and dialysate. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184951
更新日期:1988-01-01 00:00:00
abstract::The present study was aimed to determine the effect of caffeine on the development of renal hypertension. Two-kidney, 1-clip (2K1C) hypertension and deoxycorticosterone acetate (DOCA, 200 mg/kg, subcutaneous implantation)-salt (0.9% NaCl drinking) hypertension were instituted in Sprague-Dawley rats. They were then gro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187574
更新日期:1993-01-01 00:00:00
abstract::A 58-year-old woman who suffered from a heterozygous Fabry's disease and immune complex crescentic glomerulonephritis (GN) is reviewed. The diagnosis was made on the basis of the pathologic findings and peripheral leukocyte alpha-galactosidase activity. Light microscopy revealed a vacuolization of epithelial cells and...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000063287
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue might lie with pattern recognition receptors (PRRs), which are triggers of ischemic i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000456016
更新日期:2017-01-01 00:00:00
abstract::From a review of the literature regarding kinetic models used for assessing the adequacy of hemodialysis, no definite conclusions can be drawn as to whether the classical urea kinetic model (UKM) or modified direct dialysis quantification (mDDQ) is more reliable. We compared mDDQ with classical UKM and with a modified...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189473
更新日期:1996-01-01 00:00:00
abstract::The physicians in charge of 15 German hemodialysis units furnished data on 713 dialysis patients. Data relating to the vocational status were examined for 612 patients aged 60 years or below. It was found that the current working status varies with psychological and social factors. The data show that the vocational st...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181968
更新日期:1980-01-01 00:00:00
abstract::After successful renal transplantation there is continuing malabsorption of calcium and phosphorus. This is due in part to impaired glomerular filtration rate, and in part to the action of steroid on calcium and phosphorus absorption. The effect of steroids is most marked over the first 18 months after transplantation...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181989
更新日期:1980-01-01 00:00:00
abstract::A simple three-pump-based system for the performance of continuous venovenous haemodialysis is described. The method employs access to the circulation via a double-lumen catheter, and by means of a standard extracorporeal peristaltic pump the blood is circulated through a haemofiltration filter. Standard solutions for...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188835
更新日期:1996-01-01 00:00:00
abstract::The effect of the length of hemodialysis on the outcome of renal transplant was evaluated in 43 recipients of renal allograft. 22 out of 23 patients (95.7%) dialyzed for longer than one year had an excellent renal function at one year, while only 10 out of 20 patients (50%) dialyzed for less than one year had good ren...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180475
更新日期:1975-01-01 00:00:00
abstract::The authors utilized two groups of adult male rats to study the effect of chronic-uremic toxemia on the synthesis of thyroid hormones. The control group was sham operated, while the other group had about 70--80% of the left kidney tissue surgically excised and a total right nephrectomy performed 10 days later. At the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181516
更新日期:1978-01-01 00:00:00
abstract::In an attempt to clarify the renal involvement induced by human parvovirus B19 (HPB19) infection, we investigated 6 adult patients with transient urinary abnormalities followed by erythema infectiosum. All patients had HPB19-specific IgM antibody and showed mild proteinuria of 0.2-1.2 g/day with or without microscopic...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046086
更新日期:2001-11-01 00:00:00
abstract::Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000507305
更新日期:2020-01-01 00:00:00