Abstract:
:The present study was aimed to determine the effect of caffeine on the development of renal hypertension. Two-kidney, 1-clip (2K1C) hypertension and deoxycorticosterone acetate (DOCA, 200 mg/kg, subcutaneous implantation)-salt (0.9% NaCl drinking) hypertension were instituted in Sprague-Dawley rats. They were then grouped into two groups each: one was supplemented with caffeine (0.1%) in their drinking solution and the other was not. Systolic blood pressure was measured up to 24 days. Caffeine exacerbated the development of 2K1C hypertension in association with a higher plasma renin concentration (PRC). Caffeine ingestion, however, did not exacerbate but ameliorated DOCA-salt hypertension in which PRC was comparable between the caffeine-ingested and control groups. Concentrations of plasma atrial natriuretic peptide (pANP) were significantly different between the caffeine-ingested and control groups neither in 2K1C nor in DOCA-salt rats, suggesting that ANP was not responsible for the modified blood pressure. Acute caffeine infusion (350 micrograms/min, 30 min) in anesthetized normotensive rats caused increases in urinary excretion (volume and sodium) and in PRC without significantly affecting the blood pressure and pANP. These results suggest that caffeine specifically exacerbates 2K1C hypertension through increasing renin release whereas it ameliorates DOCA-salt hypertension possibly through increasing renal excretion.
journal_name
Nephronjournal_title
Nephronauthors
Choi KC,Lee J,Moon KH,Park KK,Kim SW,Kim NHdoi
10.1159/000187574subject
Has Abstractpub_date
1993-01-01 00:00:00pages
619-22issue
4eissn
1660-8151issn
2235-3186journal_volume
65pub_type
杂志文章相关文献
NEPHRON文献大全abstract::Six cases of perimembranous-type renal amyloidosis were reported. This type of renal amyloidosis was characterized by amyloid deposition predominantly involving the epithelial aspect of the glomerular capillary wall. Florid spicular arrangement was another representative feature. This type of amyloid deposition was fo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185697
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Renal dyslipoproteinemia is characterized by the accumulation of intact and partially metabolized triglyceride-rich lipoproteins. Reduced lipolytic enzyme activities may be one of the major pathophysiological mechanisms contributing to a retarded catabolism of these lipoproteins in patients with renal insuff...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000189551
更新日期:1997-01-01 00:00:00
abstract::Norepinephrine (NE) content, release and uptake by brain synaptosomes are reduced in chronic renal failure (CRF), and this has been attributed to the state of secondary hyperparathyroidism. The decrease in NE content in CRF could not be explained by changes in NE uptake or release since in normal circumstances, NE con...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186831
更新日期:1992-01-01 00:00:00
abstract::25 patients undergoing regular haemodialysis for chronic renal failure underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the intermediate period of everyday activity at home. A low dialysate potassium concentration (1.7 mEq/l) was used. Clinically significant arrhythmias (greater th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183273
更新日期:1984-01-01 00:00:00
abstract::Plasma renin reactivity (PRR) is the in vitro rate of angiotensin generation after addition of exogenous renin to plasma. The purpose of the present study is to compare measurements of PRR in venous effluent from the involved and uninvolved kidneys in both experimental and clinical renovascular hypertension. A two-kid...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180893
更新日期:1977-01-01 00:00:00
abstract::The sera of 64 patients with extracapillary glomerulonephritis were investigated by enzyme-linked immunosorbent assay for the presence of antibody to human neutrophil myeloperoxidase (MPO). In all, circulating anti-MPO were found in 30% and antineutrophil cytoplasm antibodies (ANCA) detected by indirect immunofluoresc...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186124
更新日期:1990-01-01 00:00:00
abstract::The effects of free radicals on the development of crystals attached to the living epithelium have been studied using an experimental model that enables close simulation of the conditions prevailing in the kidney. The results obtained clearly demonstrate that free radical-damaged cells produce a favorable environment ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044939
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Sepsis and septic shock are life-threatening causes of acute kidney injury (AKI) frequently seen and managed in intensive care units (ICUs). Sepsis-associated AKI (SA-AKI) independently contributes to the mortality of sepsis. Understanding the potential factors involved in kidney function recovery may furthe...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000507999
更新日期:2020-01-01 00:00:00
abstract::The effects of a high-protein (HP) and low-protein (LP) meal on glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and renal vascular resistance (RVR) were examined in conscious dogs. Ingestion of the HP and LP meal produced a temporary increase in systemic hemodynamic parameters due in part to a 'c...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188228
更新日期:1994-01-01 00:00:00
abstract::Micropuncture studies were performed in intact and thyroparathyroidectomized (TPTX) dogs to evaluate the relationship between the absolute level of serum ultrafilterable phosphate concentration (SUFP) and proximal bicarbonate reabsorption. In both groups of animals, a reverse linear relationship was noted between the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180864
更新日期:1977-01-01 00:00:00
abstract::We investigated the incidence of painless (silent) myocardial ischemia, manifested as S-T segment deviation, by Holter ECG monitoring in patients with chronic renal failure undergoing regular hemodialysis. Forty-five patients underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the int...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186733
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION/AIMS:The Acute Kidney Injury Network classification is based on small increases in serum creatinine (sCr) for stage 1. This study investigated whether changes in the urinary concentration of neutrophil gelatinase-associated lipocalin (uNGAL) could predict small increases in sCr in patients undergoing coron...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000368413
更新日期:2015-01-01 00:00:00
abstract::The cytokines tumor necrosis factor-alpha (TNF-alpha) and its soluble TNF receptors 55 and 75 (sTNFR55, sTNFR75), interleukin-1 beta (IL-1BETA) and interleukin-6 (IL-6) were measured in plasma from 13 patients with the hemolytic uremic syndrome (HUS) on admission. No significant changes in the plasma levels of TNF-alp...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188737
更新日期:1995-01-01 00:00:00
abstract::We describe a pair of 17-year-old identical twin brothers with asymptomatic proteinuria, one of whom showed focal segmental glomerulosclerosis (FSGS) while the other showed immunoglobulin M (IgM) nephropathy. For each twin, audiological examination was normal. There was no family history of renal failure, deafness, or...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045394
更新日期:1999-06-01 00:00:00
abstract::The efficacy of simvastatin, a competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, was investigated in 12 patients treated with continuous ambulatory peritoneal dialysis (CAPD), displaying hypercholesterolemia and moderate hypertriglyceridemia. After a 4-week placebo period, simvastatin was admi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186993
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several stu...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000493469
更新日期:2019-01-01 00:00:00
abstract::29 patients receiving haemodialysis treatment for chronic renal failure were divided into two groups on the basis of the presence or absence of bone disease as defined by radiology and bone alkaline phosphatase. The group of patient with bone disease showed a significantly greater increase in protein-bound calcium dur...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181632
更新日期:1979-01-01 00:00:00
abstract::Differences have been postulated for the mechanism of natriuresis due to atrial natriuretic peptide (ANP), salt loading with high salt diet (HS) and acute volume expansion (AcVE), in particular between AcVE and ANP based on the observed synergism between the two. Therefore the effects of and the interaction between th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045024
更新日期:1998-01-01 00:00:00
abstract::The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the inc...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183150
更新日期:1984-01-01 00:00:00
abstract::In 42 untreated patients at various stages of chronic renal failure, plasma level of parathyroid hormone was directly proportional to the degree of renal failure and inversely proportional to the serum calcium level. Plasma parathyroid hormone levels were frequently elevated in 21 patients undergoing regular dialysis ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180720
更新日期:1976-01-01 00:00:00
abstract::Patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency very often show progressive glomerulosclerosis with evolution to end-stage disease. High levels of an abnormal lipoprotein (lipoprotein X) cause glomerular capillary endothelial damage. The ultrastructural study of renal biopsy specimens sho...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046001
更新日期:2001-07-01 00:00:00
abstract::We have evaluated the effect of the antihyperlipidemic agent probucol on hyperlipidemia in patients with nephrotic syndrome. Twelve patients with long-standing nephrotic syndrome received 500 mg of probucol daily for 12 weeks. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol were significantl...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184524
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Alterations to the procurement biopsy are one of the main reasons that kidneys are not suitable for transplant and are discarded. The literature on procurement and reperfusion biopsy is inconsistent and heterogeneous. The objective of this study is to describe the correlation of the different histological ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000513120
更新日期:2021-01-28 00:00:00
abstract::Eighteen hemodialysis, 12 chronic ambulatory peritoneal dialysis (CAPD), and 20 renal transplant patients performed maximal treadmill exercise tests. Heart rates and blood pressures were determined every minute and maximal oxygen consumption was measured directly. Exercise capacity as measured by VO2 max is low in dia...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183632
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIM:The impact of dialysis membrane permeability on neutrophil transmigration properties in vitro was examined in the present study. This issue has not been fully scrutinized before. METHODS:We studied the capacity of neutrophils collected from a group of dialysis patients randomly treated with cuprophan, l...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000065028
更新日期:2002-08-01 00:00:00
abstract::Nephrotoxic agents such as puromycin aminonucleoside (PAN) and sodium maleate (MAL) have been used to induce experimental glomerular proteinuria and tubular disease, respectively. Current studies show that PAN caused a massive loss of albumin in the urine while not affecting the excretion of the smaller, sex-dependent...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182134
更新日期:1981-01-01 00:00:00
abstract::To probe renal hemodynamic measurements in relation to simultaneous systemic hemodynamic measurements in normal, adult, conscious dogs on a magnesium-deficient diet, 6 experimental animals were given 4 weeks of a magnesium-deficient diet compared to 9 animals whose dietary magnesium was normal. Systemic hemodynamics w...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185169
更新日期:1988-01-01 00:00:00
abstract::Efficacy and safety of a low-molecular-weight heparin (LMWH) were studied in 33 stable maintenance hemodialysis patients who had a bleeding tendency on unfractionated heparin. The optimal dose of LMWH for each patient was titrated before the study; the mean total LMWH dosage was 1,152 +/- 574 IU. No major bleeding or ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045840
更新日期:2000-12-01 00:00:00
abstract::Lipoproteins might be involved in the pathogenesis of glomerular damage. Uptake of low-density lipoprotein (LDL) by cultured human glomerular cells has been studied using LDL, labelled with the fluorescent probe 1,1'-dioctadecyl-3,3,3'3'-tetramethyl-indocarbocyanine perchlorate (diI). Cells have been characterised usi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185978
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Urolithiasis and free radicals have long been associated. In this study, we have isolated calcium oxalate monohydrate (COM) binding proteins from rat kidney before and after lipid peroxidation (LPO) and studied its properties on calcium oxalate crystal growth. MATERIALS AND METHODS:LPO was carried out using ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045978
更新日期:2001-06-01 00:00:00