Systemic factors and renal hemodynamic effects of high-protein meal versus low-protein meal in conscious dogs.

Abstract:

:The effects of a high-protein (HP) and low-protein (LP) meal on glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and renal vascular resistance (RVR) were examined in conscious dogs. Ingestion of the HP and LP meal produced a temporary increase in systemic hemodynamic parameters due in part to a 'cephalic phase' of sympathetic excitement. However only the HP significantly altered renal hemodynamics, i.e. GFR, ERPF and RVR. Plasma renin activity (PRA), serum aldosterone and plasma atrial natriuretic peptide (ANP) concentrations were not significantly altered by either a HP or LP meal. Of all the serum electrolytes measured, serum Ca2+ concentrations were significantly lower after a HP meal. It would appear that protein-meal-induced changes in renal hemodynamics are independent of changes in systemic hemodynamics. The exact mechanism of action of a HP meal on renal hemodynamics is not clear, but it appears that one mechanism by which a HP meal may alter renal hemodynamics is by altered calcium homeostasis.

journal_name

Nephron

journal_title

Nephron

authors

Zawada ET,Saelens DA,Alavi FK,Lembke JM

doi

10.1159/000188228

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

112-7

issue

1

eissn

1660-8151

issn

2235-3186

journal_volume

68

pub_type

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