Cytoprotective effect of ulinastatin on LLC-PK1 cells treated with antimycin A, gentamicin, and cisplatin.

abstract：:End-stage renal disease (ESRD) is common, costly, and it results from progressive chronic kidney disease (CKD). ESRD claims many lives every year. It is increasingly recognized that episodes of acute kidney injury (AKI) predispose to the future development of CKD and ESRD. While our understanding of the pathophysiolog...

journal_title：Nephron

authors： Ó hAinmhire E,Humphreys BD

更新日期：2017-01-01 00:00:00

abstract：:Normal and streptozotocin diabetic rats were subjected to ischemic injury by unilateral renal artery occlusion for 60 min. The cortical and the medullary oxygen consumption (QO2) in the postischemic and the control, contralateral nonischemic, kidneys were measured 1 h, 1 day, and 1, 2 and 4 weeks for normal rats and 1...

journal_title：Nephron

authors： Kuramochi G,Homma S

更新日期：1993-01-01 00:00:00

abstract：:A case of inferior vena caval compression by hepatic cysts as a complication of adult polycystic kidney disease is presented and its management is discussed. ...

journal_title：Nephron

authors： Yaqoob M,Saffman C,Finn R,Carty AT

更新日期：1990-01-01 00:00:00

abstract：:The biochemistry and function of vanadate and its possible role in health as well as in disease remains one of the most fascinating stories in biology. This review has surveyed the pertinent literature regarding its effect in the normal kidney and other tissues. While inhibition of the Na(+)-K+ ATPase enzyme was the f...

journal_title：Nephron

authors： Dafnis E,Sabatini S

更新日期：1994-01-01 00:00:00

abstract：:In 2014 57.5% of HD patients and 62.7% of PD patients achieved the audit measure for phosphate. 29.0% of HD and 30.3% of PD patients had a serum phosphate above the audit standard range. 79.1% of HD and 79.7% of PD patients had adjusted calcium between 2.2–2.5 mmol/L. 57.4% of HD and 65.0% of PD patients had a serum P...

journal_title：Nephron

authors： Nicholas J,Evans R,Shaw C,Dawnay A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cyst infection is one of the complications of autosomal dominant polycystic kidney disease and polycystic liver disease. The diagnosis is typically made on a mix of clinical, laboratory and imaging abnormalities but the importance of individual items is uncertain. We aimed to perform a Delphi survey amongst ...

journal_title：Nephron

authors： Lantinga MA,Darding AJ,de Sévaux RG,Alam A,Bleeker-Rovers CP,Bobot M,Cornec-Le Gall E,Gevers TJ,Hassoun Z,Meijer E,Mrug M,Nevens F,Onuchic LF,Pei Y,Piccoli GB,Pirson Y,Rangan GK,Torra R,Visser FW,Jouret F,Kanaan N

更新日期：2016-01-01 00:00:00

abstract：:Inflammation is broadly recognized as an important factor in the pathogenesis of acute kidney injury (AKI), but pharmacological approaches to alleviate inflammation in AKI have been without success in clinical trials. Neuromodulation by nonpharmacological methods is emerging as a novel therapeutic strategy to treat in...

journal_title：Nephron

authors： Tanaka S,Inoue T,Hossack JA,Okusa MD

更新日期：2017-01-01 00:00:00

abstract：:Diseases affecting both the lung and the kidney have grave prognosis and serious diagnostic and therapeutic consequences. Here, 3 cases of pulmonary-renal syndrome caused by antiphospholipid syndrome are reported. The patients presented with dyspnea, renal insufficiency, pulmonary infiltrates on chest X-ray and areas ...

journal_title：Nephron

authors： Henning BF,Gröne HJ,Tepel M,Büchner N,Kirchner J,Zidek W

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue might lie with pattern recognition receptors (PRRs), which are triggers of ischemic i...

journal_title：Nephron

authors： DeWolf SE,Shigeoka AA,Scheinok A,Kasimsetty SG,Welch AK,McKay DB

更新日期：2017-01-01 00:00:00

abstract：:HLA antigens of Japanese patients with primary glomerulopathies were determined, and the frequency of each HLA antigen was compared with that of Japanese normal controls. IgA nephropathy with HLA-DR4, idiopathic membraneous glomerulopathy with DR2, lipoid nephrosis with DRw53 and poststreptococcal glomerulonephritis w...

journal_title：Nephron

authors： Naito S,Kohara M,Arakawa K

更新日期：1987-01-01 00:00:00

abstract：:In this study we investigated the interactions between volume changes (body weight), plasma atrial natriuretic peptide (pANP) and ambulatory blood pressure (BP) in 10 patients with end-stage renal disease undergoing regular hemodialysis (HD) treatment three times weekly. Most patients retained their diurnal BP variati...

journal_title：Nephron

authors： Ojanen S,Pietilä K,Pasternack A

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Acid-base disturbances are frequent in critically ill patients. Arterial blood gas (ABG) is the gold standard in the diagnosis of these disturbances, but it is invasive with potential hazards. For patients with a central venous catheter, venous blood gas (VBG) sampling may be an alternative, less-invasive di...

journal_title：Nephron

authors： Schrauben SJ,Negoianu D,Costa C,Cohen RM,Goldfarb S,Fuchs BD,Berns JS

更新日期：2018-01-01 00:00:00

abstract：:The use of antimitotic chemotherapy in hemodialysis patients is not yet well codified, and each individual decision remains difficult. We report the case of a 68-year-old hemodialyzed man who developed a squamous cell carcinoma of the upper third of the esophagus. Necessarily disabling surgery was rejected, and three ...

journal_title：Nephron

authors： Rebibou JM,Chauffert B,Dumas M,Mousson C,Bone MC,Tanter Y,Rifle G

更新日期：1996-01-01 00:00:00

abstract：:As with many other amino acids the transport of cystine across the tubular epithelium is coupled to a parallel transport of sodium. We have studied the effect of a sodium-restricted diet on the urinary excretion of cystine in 13 patients with cystinuria, 7 of whom were treated with the SH compound tiopronin (2-mercapt...

journal_title：Nephron

authors： Lindell A,Denneberg T,Edholm E,Jeppsson JO

更新日期：1995-01-01 00:00:00

abstract：:Circumstantial evidence that pIgA has a key role in glomerular injury of IgAN is now strong. Although the answers to the questions posed in this review are necessarily incomplete, they do indicate that (1) pIgA is a major component of mesangial IgA. (2) circulating pIgA is increased and this pIgA is particularly enhan...

journal_title：Nephron

authors： Harper SJ,Feehally J

更新日期：1993-01-01 00:00:00

abstract：:Severe erythrocytosis is associated with increased whole blood viscosity and impaired blood flow. Since a reduced blood flow will cause tissue hypoxia and since tissue hypoxia is associated with increased synthesis of erythropoietin, erythrocytosis per se should cause an increase in the rate of red cell production. Th...

journal_title：Nephron

authors： Erslev AJ,Caro J,Besarab A

更新日期：1985-01-01 00:00:00

abstract：:We attempted to treat 5 patients on CAPD with fungal peritonitis without removing the catheter. In 1 case, amphotericin B caused a severe chemical peritonitis. The other 4 patients received amphotericin B intravenously and miconazole or flucytosine intraperitoneally. Recovery was obtained in 3 cases without removing t...

journal_title：Nephron

authors： Benevent D,Peyronnet P,Lagarde C,Leroux-Robert C

更新日期：1985-01-01 00:00:00

abstract：:Joseph Andreas Jacobus Plenck was born in 1735 in Vienna where he studied surgery with Johan Christian Retter. At age 35 he was appointed Professor of Surgery and Obstetrics by Maria Theresia. Subsequently he became professor and life long secretary of the Medical Military Academy know as the Josephinum where he worke...

journal_title：Nephron

authors： De Santo NG,Aliotta A,De Santo RM,Aliotta G

更新日期：2002-09-01 00:00:00

abstract：:A 45-year-old male was admitted to the hospital because of polyuria and polydipsia. After admission, proteinuria and hematuria were found. The kidney function deteriorated and necessitated the initiation of chronic hemodialysis. Examination of the bone marrow revealed multiple myeloma and kappa light chains were found...

journal_title：Nephron

authors： Knobler H,Kopolovic J,Kleinman Y,Rubinger D,Silver J,Friedlaender MM,Popovtzer MM

更新日期：1983-01-01 00:00:00

abstract：:Plasma and urine beta-2-microglobulin (B2m) were measured in 37 renal transplant recipients and 34 healthy subjects. Serum B2m was found to be a more sensitive index of renal function than serum creatinine. Renal transplant recipients had significantly higher urine B2m when compared with normal controls. Normal subjec...

journal_title：Nephron

authors： Woo KT,Lee EJ,Lau YK,Lim CH

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIM:Interleukin-6 (IL-6) promotes the growth of renal mesangial cells. IL-6 may play a major role in such mesangial proliferation, but there has been little research on IL-6 in relation to diabetic nephropathy because of the difficulty in measuring urinary and serum IL-6 levels. Using a newly developed, high...

journal_title：Nephron

authors： Shikano M,Sobajima H,Yoshikawa H,Toba T,Kushimoto H,Katsumata H,Tomita M,Kawashima S

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND/AIMS:Genetic cell ablation using the human diphtheria toxin receptor (hDTR) is a new strategy used for analysing cellular function. Diphtheria toxin (DT) is a cytotoxic protein that leaves mouse cells relatively unaffected, but upon binding to hDTR it ultimately leads to cell death. We used a podocyte-specif...

journal_title：Nephron

authors： Stevens M,Neal CR,Salmon AHJ,Bates DO,Harper SJ,Oltean S

更新日期：2018-01-01 00:00:00

abstract：:Mizoribine has been shown to possess an immunosuppressive action that inhibits the proliferation of lymphocytes selectively by interfering with inosine monophosphate dehydrogenase. Recent studies have demonstrated that mizoribine improves renal tubulointerstitial fibrosis in the rat model of unilateral ureteral obstru...

journal_title：Nephron

authors： Sato N,Shiraiwa K,Kai K,Watanabe A,Ogawa S,Kobayashi Y,Yamagishi-Imai H,Utsunomiya Y,Mitarai T

更新日期：2001-10-01 00:00:00

abstract：:We studied complexes composed of C1q and beta 2-microglobulin (C1q.beta 2M) or serum amyloid P-component (C1q.SAP) in the sera of 38 patients receiving hemodialysis (HD) and 20 healthy control subjects using an enzyme-linked immunoassay. We also compared complex levels in HD patients with and without symptoms of HD-as...

journal_title：Nephron

authors： Hasegawa M,Kawashima S,Shikano M,Kojima K,Yanai T,Hassegawa H,Tomita M,Murakami K,Kawamura N,Katsumata H

更新日期：1995-01-01 00:00:00

abstract：:A case of a renal transplant recipient with colchicine-induced myopathy is presented. He was on colchicine therapy for 10 months. He was hospitalized for investigation of fatigue, severe myalgia in the lower extremities and elevated serum aminotransferase levels. His viral markers and other factors that may cause myal...

journal_title：Nephron

authors： Caglar K,Safali M,Yavuz I,Odabaşi Z,Yenicesu M,Vural A

更新日期：2002-12-01 00:00:00

abstract：:We investigated the incidence of painless (silent) myocardial ischemia, manifested as S-T segment deviation, by Holter ECG monitoring in patients with chronic renal failure undergoing regular hemodialysis. Forty-five patients underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the int...

journal_title：Nephron

authors： Kremastinos D,Paraskevaidis I,Voudiklari S,Apostolou T,Kyriakides Z,Zirogiannis P,Toutouzas P

更新日期：1992-01-01 00:00:00

abstract：:A new case of acute renal failure after rifampicin is presented, together with a review of the 36 similar cases published up to date in the literature. Evidence is provided that irregularities in drug intake, either as true intermittent treatment or as discontinuation of continuous therapy, play an important role in t...

journal_title：Nephron

authors： Nessi R,Bonoldi GL,Redaelli B,di Filippo G

更新日期：1976-01-01 00:00:00

abstract：:The concentration of ionic calcium (Ca2+ in the smooth muscular cells of the resistance vessels is a determining factor of their contraction. It depends on the influx of Ca2+ to the interior of the cells through the calcium channels in the sarcolemma. The effect of a specific Ca2+-channel blocking agent - nifedipine -...

journal_title：Nephron

authors： Moreira J,Barata JD,Olias J

更新日期：1985-01-01 00:00:00

abstract：:Fibrinogen fragments (X, Y, D and E) and fibrin fragments (D-dimer and E) were examined in the urine of 52 patients with various types of renal diseases. One or more of the fibrinogen fragments were detectable in all the urine specimens. D-Dimer together with fibrinogen fragments was found in 38 of the 52 patients. Th...

journal_title：Nephron

authors： Yoshioka K,Iseki T,Akano N,Uraoka Y,Miyata H,Maki S

更新日期：1982-01-01 00:00:00

abstract：:Pericardial drainage via percutaneous catheter placement and local nonabsorbable steroid instillation was employed as definitive therapy for uremic patients who had intractable pericardial effusions. Twelve patients are reported. Prior daily dialysis, and in one case systemic steroids, were not curative. 11 of 12 case...

journal_title：Nephron

authors： Buselmeier TJ,Simmons RL,Najarian JS,Mauer SM,Matas AJ,Kjellstrand CM

更新日期：1976-01-01 00:00:00