Abstract:
:Inflammation is broadly recognized as an important factor in the pathogenesis of acute kidney injury (AKI), but pharmacological approaches to alleviate inflammation in AKI have been without success in clinical trials. Neuromodulation by nonpharmacological methods is emerging as a novel therapeutic strategy to treat inflammatory diseases. Recently, our group and others have demonstrated that vagus nerve stimulation and pulsed ultrasound ameliorated inflammation via the cholinergic anti-inflammatory pathway (CAP) in various animal models, including renal ischemia-reperfusion injury. Delineating the precise mechanisms by which these methods activate the CAP and ameliorate inflammation is mandatory for the broad clinical application in the future. Novel techniques, such as optogenetics, are expected to elucidate these complex mechanisms.
journal_name
Nephronjournal_title
Nephronauthors
Tanaka S,Inoue T,Hossack JA,Okusa MDdoi
10.1159/000477218subject
Has Abstractpub_date
2017-01-01 00:00:00pages
277-281issue
4eissn
1660-8151issn
2235-3186pii
000477218journal_volume
137pub_type
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