Abstract:
:Serum specimens from 99 selected renal patients were examined over a 3-year period by both a hemagglutination technique (HA) and an indirect immunofluorescent (IIF) method for the presence of circulating antibody against tubular basement membrane (TBM). 11 patients were found with anti-TBM antibodies. 6 of them also had antibody against glomerular basement membrane (GBM). The other 5 with anti-TBM antibody alone, had a unique natural history and response to therapy which suggested that the antibody was important in the pathogenesis of their disease. The variation seen in end organ damage may indicate that other factors, possibly genetic, are involved in the pathophysiology.
journal_name
Nephronjournal_title
Nephronauthors
Cattran DCdoi
10.1159/000181943subject
Has Abstractpub_date
1980-01-01 00:00:00pages
13-9issue
1eissn
1660-8151issn
2235-3186journal_volume
26pub_type
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