Failure of sodium restriction to abolish exaggerated natriuresis in poststreptococcal glomerulonephritis.

Abstract:

:Exaggerated natriuresis in response to hypertonic saline infusion occurs with great regularity in patients with documented previous attacks of poststreptococcal glomerulonephritis. Five patients were studied before and after 1 week of dietary sodium restriction in order to examine the possibility that increased extracellular fluid volume might play a role in the response to acute saline infusion. Plasma renin activity (PRA) and PRA responsiveness to sodium depletion were normal, suggesting that extracellular fluid volume was not increased. In all patients, extracellular fluid volume decreased during sodium restriction, as judged by weight loss, cumulative negative sodium balance, small decreases in measured plasma volume, and appropriate increases of PRA and plasma aldosterone concentration. Hypertonic saline infusion provoked exaggerated natriuresis in all patients equally as well after dietary sodium restriction as before. Exaggerated natriuresis in poststreptococcal glomerulonephritis occurs without evidence of chronic expansion of extracellular fluid volume and is not affected by reduction of extracellular fluid volume.

journal_name

Nephron

journal_title

Nephron

authors

Schacht RG,Steele JM Jr,Lowenstein J,Baldwin DS

doi

10.1159/000180852

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

333-41

issue

6

eissn

1660-8151

issn

2235-3186

journal_volume

18

pub_type

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