Effects of oral supplementation with evening primrose oil for six weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients.

Abstract:

:Abnormalities in plasma composition of essential fatty acids (EFAs) may be associated with the etiology of pruritus and other skin problems in patients undergoing hemodialysis. To study whether an oral supplementation with omega-6 (n-6) EFAs would restore deranged plasma EFAs and ameliorate skin symptoms, 9 and 7 dialysis patients were randomly assigned to receive either gamma-linolenic acid (GLA)-rich evening primrose oil (EPO) or linoleic acid (LA) (2 g/day each) for 6 weeks. Plasma concentrations of EFA were analyzed by gas chromatography and uremic skin symptoms were assessed for dryness, pruritus and erythema by questionnaire and visual inspection in a double-blind manner. The patients given EPO exhibited a significant (p < 0.05) increase in plasma dihomo-gamma-linolenic acid (a precursor of anti-inflammatory prostaglandin E1) with no concomitant change in plasma arachidonic acid (a precursor of pro-inflammatory prostaglandin E2 and leukotriene B4). In contrast, those given LA exhibited a significant (p < 0.05) increase in LA but not in any other n-6 EFAs, whereas they exhibited a significant (p < 0.05) decrease in plasma docosahexaenoic acid. The patients given EPO showed a significant (p < 0.05) improvement in the skin scores for the three different uremic skin symptoms over the baseline values and a trend toward a greater improvement (0.05 < p < 0.1) in pruritus scores than those given LA. Results indicate that GLA-rich EPO would be a more favorable supplemental source than LA in terms of shifting eicosanoid metabolism toward a less inflammation status through modifying plasma concentrations of their precursor n-6 EFAs. Further studies are required to confirm the efficacy and safety of EPO therapy for the treatment of uremic pruritus.

journal_name

Nephron

journal_title

Nephron

authors

Yoshimoto-Furuie K,Yoshimoto K,Tanaka T,Saima S,Kikuchi Y,Shay J,Horrobin DF,Echizen H

doi

10.1159/000045271

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

151-9

issue

2

eissn

1660-8151

issn

2235-3186

pii

45271

journal_volume

81

pub_type

临床试验,杂志文章,随机对照试验

相关文献

NEPHRON文献大全
  • A blind controlled trial of phase-contrast microscopy by two observers for evaluating the source of haematuria.

    abstract::Two observers, unaware of each other's findings and of the diagnosis, examined red cells in the urine of 109 patients by phase-contrast microscopy. All specimens were examined uncentrifuged by inverted microscopy, and 48 of the 109 were also examined under a light microscope after centrifugation. We were unable to con...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000184011

    authors: Venkat Raman G,Pead L,Lee HA,Maskell R

    更新日期:1986-01-01 00:00:00

  • Critically ill patients requiring acute renal replacement therapy are at an increased risk of long-term renal dysfunction, but rarely receive specialist nephrology follow-up.

    abstract:BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000371448

    authors: Kirwan CJ,Blunden MJ,Dobbie H,James A,Nedungadi A,Prowle JR

    更新日期:2015-01-01 00:00:00

  • Randomized trial of methylcobalamin and folate effects on homocysteine in hemodialysis patients.

    abstract:BACKGROUND:There are no data available on the effects of intravenous (i.v.) methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fast...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000057605

    authors: Trimarchi H,Schiel A,Freixas E,Díaz M

    更新日期:2002-05-01 00:00:00

  • Technique for the performance of repeatable renal clearances in the conscious male dog.

    abstract::A preparation for performance of renal clearances in the conscious dog is described. The important aspect of the technique is the use of a Pavlov sling and a specially designed restraining apparatus. Of most importance is the use of a 7 French Swan-Ganz balloon-tipped catheter for urinary bladder catheterization. The ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180595

    authors: Garner D,Laks MM

    更新日期:1976-01-01 00:00:00

  • Post partum renal failure due to progressive systemic sclerosis treated with chronic hemodialysis.

    abstract::An unusual case of progressive systemic sclerosis with rapidly progressing renal failure after a successful delivery is described. The presenting syndrome was malignant hypertension. The blood pressure was refractory to the various therapeutic measures which were instituted, including hemodialysis. The patient, theref...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180812

    authors: Ehrenfeld M,Licht A,Stessman J,Yanko L,Rosenmann E

    更新日期:1977-01-01 00:00:00

  • Effects of chronic sodium depletion on renal tubular sodium and water reabsorption in man.

    abstract::In order to assess the effects of sodium depletion on tubular Na and H2O transport in man, renal clearance studies were performed under control conditions and after sodium depletion in 7 normal subjects. The control diet contained 250 mEq of Na daily. Sodium depletion was induced by placing subjects on a 20-mEq/day na...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182635

    authors: DiScala VA,Stein RM

    更新日期:1982-01-01 00:00:00

  • HCV infections in dialysis patients.

    abstract::HCV is seen as an emergent problem in Dialysis Units; in fact, the patients of these centers are at high risk for blood-transmitted infections, through coming microepidemies. For this reason and using the same method, we have studied the prevalence of anti-HCV and virus-derived hepatitis in a dialytic population of 10...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186922

    authors: Scotto G,Savastano AM,Forcella M,Tantimonaco G,Amato G,Salatino G,Pappani A,Stella I

    更新日期:1992-01-01 00:00:00

  • Influence of long-term amelioration of anemia and blood pressure control on left ventricular hypertrophy in hemodialyzed patients.

    abstract::The course of left ventricular hypertrophy was investigated in anemic hemodialysis patients treated with recombinant human erythropoietin (r-huEPO). 12 patients, aged 60.8 +/- 9.9 years (mean +/- SD) were treated for 18.8 +/- 2.7 months. Left ventricular size was estimated by echocardiography performed before treatmen...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186829

    authors: Zehnder C,Zuber M,Sulzer M,Meyer B,Straumann E,Jenzer HR,Blumberg A

    更新日期:1992-01-01 00:00:00

  • Polycythemia of end-stage renal failure: no inhibition of erythropoiesis by uremic serum and markedly increased serum erythropoietin level.

    abstract::This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184292

    authors: Muto S,Asano Y,Hosoda S,Shionoya S,Miura Y,Urabe A,Takaku F

    更新日期:1987-01-01 00:00:00

  • Renal cell carcinoma complicated by emphysematous pyelonephritis in a non-diabetic patient with renal failure.

    abstract::A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064452

    authors: Lin CH,Huang JJ,Liu HL,Lee SY,Hsieh RY,Tseng CC

    更新日期:2002-09-01 00:00:00

  • Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition.

    abstract::End-stage renal disease (ESRD) is common, costly, and it results from progressive chronic kidney disease (CKD). ESRD claims many lives every year. It is increasingly recognized that episodes of acute kidney injury (AKI) predispose to the future development of CKD and ESRD. While our understanding of the pathophysiolog...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000474960

    authors: Ó hAinmhire E,Humphreys BD

    更新日期:2017-01-01 00:00:00

  • Domestic cases of hemorrhagic fever with renal syndrome in the United States.

    abstract::Although serologic studies have identified hantaviral infection in the United States, acute disease has not been recognized. This study describes 3 cases of domestically acquired hemorrhagic fever with renal syndrome (HFRS) in the United States. Infection was due to a local strain of Seoul virus (Baltimore rat virus)....

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188086

    authors: Glass GE,Watson AJ,LeDuc JW,Childs JE

    更新日期:1994-01-01 00:00:00

  • Effects of a polyunsaturated fatty acid-rich diet on serum lipids in patients with chronic renal failure.

    abstract::An abnormal level of serum lipids may be one of the major risk factors for the development of atherosclerosis in patients with chronic renal failure (CRF). In the present study, the effect of polyunsaturated fatty acid-rich and low carbohydrate diet on serum lipids and HDL-cholesterol was studied in 6 nonnephrotic and...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182652

    authors: Tsukamoto Y,Okubo M,Yoneda T,Marumo F,Nakamura H

    更新日期:1982-01-01 00:00:00

  • Hyaluronan and rat renal fibroblasts: in vitro studies.

    abstract::Hyaluronic acid (HA) is a ubiquitous component of extracellular matrix. After tissue injury, HA appears in greater abundance during the inflammatory response and the phase of clearance of cell and matrix debris, before collagen production and matrix degradation. The aim of this study was to examine whether normal rat ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000046019

    authors: Pedagogos E,Hewitson TD,Nicholls KM,Becker GJ

    更新日期:2001-08-01 00:00:00

  • Nephrocalcinosis in Amelogenesis Imperfecta Caused by the FAM20A Mutation.

    abstract:BACKGROUND/AIMS:Enamel-renal syndrome is characterized by nephrocalcinosis, enamel defects, gingival hyperplasia and eruption failures. It has been recently identified that recessive mutations in the FAM20A gene result in amelogenesis imperfecta (AI)-gingival fibromatosis. The aim of this research to determine whether ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000486607

    authors: Koruyucu M,Seymen F,Gencay G,Gencay K,Tuna EB,Shin TJ,Hyun HK,Kim YJ,Kim JW

    更新日期:2018-01-01 00:00:00

  • Circulating anti-tubular basement membrane antibody in a variety of human renal diseases: detection and significance.

    abstract::Serum specimens from 99 selected renal patients were examined over a 3-year period by both a hemagglutination technique (HA) and an indirect immunofluorescent (IIF) method for the presence of circulating antibody against tubular basement membrane (TBM). 11 patients were found with anti-TBM antibodies. 6 of them also h...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181943

    authors: Cattran DC

    更新日期:1980-01-01 00:00:00

  • Effect of the antiplatelet agents ticlopidine and dipyridamole on nephrotoxic serum nephritis in rats.

    abstract::The effect of the antiplatelet agents, ticlopidine and dipyridamole, on nephrotoxic serum nephritis (NTN) was evaluated in rats. An accelerated form of NTN was induced with preimmunization of rabbit IgG 7 days before injection of rabbit antirat nephrotoxic serum. Twelve animals received a peroral dose of 20 mg of ticl...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184169

    authors: Izumino K,Iida H,Asaka M,Sasayama S

    更新日期:1987-01-01 00:00:00

  • Renal venous plasma renin reactivity in clinical and experimental renovascular hypertension: renin reactivity in renovascular hypertension.

    abstract::Plasma renin reactivity (PRR) is the in vitro rate of angiotensin generation after addition of exogenous renin to plasma. The purpose of the present study is to compare measurements of PRR in venous effluent from the involved and uninvolved kidneys in both experimental and clinical renovascular hypertension. A two-kid...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180893

    authors: Kotchen TA,Welch WJ,Daugherty M,Ernst CB

    更新日期:1977-01-01 00:00:00

  • Elevated serum uric acid. A cardiovascular risk factor?

    abstract::A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart d...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181660

    authors: Tweeddale MG,Fodor JG

    更新日期:1979-01-01 00:00:00

  • Combined chemotherapy and radiotherapy for esophageal carcinoma in a hemodialyzed patient. Long-term survival.

    abstract::The use of antimitotic chemotherapy in hemodialysis patients is not yet well codified, and each individual decision remains difficult. We report the case of a 68-year-old hemodialyzed man who developed a squamous cell carcinoma of the upper third of the esophagus. Necessarily disabling surgery was rejected, and three ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189461

    authors: Rebibou JM,Chauffert B,Dumas M,Mousson C,Bone MC,Tanter Y,Rifle G

    更新日期:1996-01-01 00:00:00

  • Serum leptin concentrations in patients on hemodialysis.

    abstract::Serum leptin concentrations in normal humans have been reported to correlate with the body mass index (BMI) as well as with the body fat mass. In this study, we measured serum leptin concentrations in 107 patients on hemodialysis, 30 of whom had diabetes mellitus as the cause, and examined the clinical significance. F...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045122

    authors: Nakazono H,Nagake Y,Ichikawa H,Makino H

    更新日期:1998-09-01 00:00:00

  • Effects on renal function of a low-nitrogen diet supplemented with essential amino acids and ketoanalogues and of hemodialysis and free protein supply in patients with chronic renal failure.

    abstract::Creatinine clearance has been repeatedly measured in three groups of chronic uremics. In the first control group (31 cases), following a conventional low-protein diet, creatinine clearance declined linearly with time. In the second group (12 cases), following very low nitrogen diet supplemented with essential amino ac...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182036

    authors: Barsotti G,Guiducci A,Ciardella F,Giovannetti S

    更新日期:1981-01-01 00:00:00

  • Affinity binding of glycosaminoglycans with beta(2)-microglobulin.

    abstract:BACKGROUND:A constant finding in beta (2)-microglobulin (beta 2m) amyloidosis is an increase in tissue heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans (PGs) at sites of amyloid deposits. However, the binding characteristics of PGs with beta 2m have not been elucidated yet. METHODS:Using affinity retard...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000049037

    authors: Ohashi K,Kisilevsky R,Yanagishita M

    更新日期:2002-02-01 00:00:00

  • Acute renal failure after rifampicin: a case report and survey of the literature.

    abstract::A new case of acute renal failure after rifampicin is presented, together with a review of the 36 similar cases published up to date in the literature. Evidence is provided that irregularities in drug intake, either as true intermittent treatment or as discontinuation of continuous therapy, play an important role in t...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000180596

    authors: Nessi R,Bonoldi GL,Redaelli B,di Filippo G

    更新日期:1976-01-01 00:00:00

  • Estimation of statistical moments for desferrioxamine and its iron and aluminum chelates: contribution to optimisation of therapy in uremic patients.

    abstract::We investigated the best time of administration of desferrioxamine (DFO) with respect to the dialysis session, using the approach of the stochastic dynamic system, integrated with the classical pharmacokinetic models. In the 6 patients studied, the mean arrival times of DFO, aluminoxamine (AlO) and ferrioxamine (FO) w...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188845

    authors: Andriani M,Nordio M,Saporiti E

    更新日期:1996-01-01 00:00:00

  • Chronic nephritis, sensorineural deafness, growth and developmental retardation, hyperkinesis, and cleft soft palate in a 5-year-old boy. A new combination?

    abstract::A 5-year-old Japanese boy showed nephritis similar to, but distinct from, that in Alport syndrome. Nephrotic syndrome without hematuria was noticed at age 2, although renal biopsy at age 4 revealed widespread irregular thickening of the glomerular basement membrane with splitting of the lamina densa on electron micros...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186136

    authors: Kawakami H,Murakami T,Murano I,Ushijima T,Taguchi T,Hattori S,Kajii T

    更新日期:1990-01-01 00:00:00

  • Septicemia due to Yersinia enterocolitica in a long-term hemodialysis patient after a single desferrioxamine administration.

    abstract::A long-term hemodialysis male patient was known to have systemic iron overload due to regular blood transfusions. As he was suspected to have aluminum overload, he received a single intravenous administration of desferrioxamine (that supported the hypothesis). Four days later, he became highly febrile with no focus of...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185208

    authors: Hoen B,Renoult E,Jonon B,Kessler M

    更新日期:1988-01-01 00:00:00

  • Treatment of the nephrotic syndrome with indomethacin.

    abstract::In 25 patients with nephrotic syndromes of different origin, indomethacin caused an immediate decrease in glomerular filtration rate (GFR) and urinary protein excretion. This effect of indomethacin on GFR and proteinuria was more pronounced when the renin-angiotensin system was stimulated by a low-sodium diet and 50 m...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181478

    authors: Donker AJ,Brentjens JR,van der Hem GK,Arisz L

    更新日期:1978-01-01 00:00:00

  • Effect of vitamin C supplementation on renal oxalate deposits in five-sixths nephrectomized rats.

    abstract::We have previously reported that hyperoxalemia can be aggravated by vitamin C supplementation in regular hemodialysis patients. The present study was undertaken to examine the validity of this observation in an experimental setting. Fifty five-sixths nephrectomized rats were divided into two groups: 30 rats were allow...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185389

    authors: Ono K,Ono H,Ono T,Kikawa K,Oh Y

    更新日期:1989-01-01 00:00:00

  • Analysis of urinary albumin excretion in gentamicin-treated rats.

    abstract::Gentamicin doses of 40 mg/kg body weight/day were administered intravenously to 62 Wistar rats. Nineteen animals were also treated orally with an NaHCO3 solution in place of water. The gentamicin-treated animals showed increased albuminuria immediately after the 3rd day of treatment. The fact that this increase was ma...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185043

    authors: Coimbra TM,Lachat JJ

    更新日期:1988-01-01 00:00:00