Abstract:
:In order to assess the effects of sodium depletion on tubular Na and H2O transport in man, renal clearance studies were performed under control conditions and after sodium depletion in 7 normal subjects. The control diet contained 250 mEq of Na daily. Sodium depletion was induced by placing subjects on a 20-mEq/day na diet and administering furosemide (40 mg) dialy for 3 days. Balance studies revealed that the subjects were in Na balance under control conditions, and that after sodium depletion had been established they were in a sodium-retaining state. Subjects were studied under both conditions, after H2O hydration and during a subsequent hypotonic mannitol infusion. After H2O hydration the minimal urinary osmolality averaged 61 and 67 mosm/kg in the sodium depletion and control states, respectively. Sodium depletion was associated with a significant reduction in C inulin, sodium clearance (CNa), urine flow (V), fractional urine flow (V/GFR), free water (CH2O), and fractional free water clearance (CH2O/GFR). During hypotonic mannitol infusion indices of absolute and fractional delivery of Na from the proximal tubule (CH2O + CNa; CH2O/GFR + CNa/GFR) were consistently reduced after sodium depletion and rose more slowly as absolute and fractional distal sodium chloride supply (CH2O + CNa; CH2O/GFR + CNa/GFR) were increased. These data are consistent with the view that modest sodium depletion in man provokes an increase in fractional sodium chloride reabsorption in both the proximal and distal tubules.
journal_name
Nephronjournal_title
Nephronauthors
DiScala VA,Stein RMdoi
10.1159/000182635subject
Has Abstractpub_date
1982-01-01 00:00:00pages
151-8issue
2eissn
1660-8151issn
2235-3186journal_volume
31pub_type
杂志文章相关文献
NEPHRON文献大全abstract::Previously, we have shown that insulin binding (IB) to erythrocytes was decreased in uremic patients and that hemodialysis corrected the receptor defect. In the present study cross-incubation experiments were performed using uremic and control erythrocytes and plasma. Incubation of control erythrocytes with uremic pla...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182990
更新日期:1983-01-01 00:00:00
abstract::We studied the effects of mid-term enalapril administration on protein-load-induced renal responses in 10 patients with early chronic renal failure (serum creatinine 2.70 +/- 1.0 mg/dl). The oral protein load was performed twice, before and after a 10-day therapy with enalapril. Glomerular filtration rate (125I-iothal...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185624
更新日期:1989-01-01 00:00:00
abstract::Glomerulonephritis as well as kidney injury secondary to fulminant intravascular hemolysis are rare extrapulmonary manifestations of Mycoplasma pneumoniae infection. We describe a 50-year-old female diagnosed with M. pneumoniae infection-associated hemolytic anemia, characterized by negative cold agglutinin tests but ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000478991
更新日期:2017-01-01 00:00:00
abstract::Differences have been postulated for the mechanism of natriuresis due to atrial natriuretic peptide (ANP), salt loading with high salt diet (HS) and acute volume expansion (AcVE), in particular between AcVE and ANP based on the observed synergism between the two. Therefore the effects of and the interaction between th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045024
更新日期:1998-01-01 00:00:00
abstract::We report two cases of patients with analgesic nephropathy presenting with the symptoms of hypercalcaemia, and who were found to have transitional cell carcinomas of the renal pelvis. On removal of the tumours, calcium levels fell to normal, indicating that a humoral factor produced by the tumour caused the hypercalca...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185586
更新日期:1989-01-01 00:00:00
abstract::The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000189281
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The introduction of automated biopsy devices and the localization of the kidney by ultrasound were aimed at optimizing efficacy and safety of the percutaneous renal biopsy procedure. We evaluated these technological advances in our renal biopsies performed in children. METHODS:We sequentially used the Silve...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045090
更新日期:1998-08-01 00:00:00
abstract::The effects of dietary protein both before and after uranyl-nitrate-induced acute renal failure were investigated. Male Sprague-Dawley rats were maintained on high-protein (60%), normal-protein (20%), low-protein (5%) and no-protein diets for 8 days prior to intravenous administration of uranyl nitrate (10 mg/kg). Imm...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184167
更新日期:1987-01-01 00:00:00
abstract::Micropuncture studies were performed in intact and thyroparathyroidectomized (TPTX) dogs to evaluate the relationship between the absolute level of serum ultrafilterable phosphate concentration (SUFP) and proximal bicarbonate reabsorption. In both groups of animals, a reverse linear relationship was noted between the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180864
更新日期:1977-01-01 00:00:00
abstract::Fifteen patients with advanced renal failure (creatinine clearance less than 25 ml/mn) and with severe albuminuria (greater than 1.5 g/24 h) were put on a low-protein (0.3 g/kg body weight), low-phosphorus (5-7 mg/kg body weight) diet supplemented with essential amino acids and ketoanalogues. During the 6-month follow...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185189
更新日期:1988-01-01 00:00:00
abstract::The effects of chitosan-coated dialdehyde cellulose (chitosan DAC), a newly developed oral adsorbent for urea and ammonia, were examined in a glomerulonephritis model in rats. Mesangial proliferative glomerulonephritis accompanied with proteinuria was induced by an intravenous injection of anti-rat Thy-1.1 monoclonal ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044973
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000371448
更新日期:2015-01-01 00:00:00
abstract::29 patients receiving haemodialysis treatment for chronic renal failure were divided into two groups on the basis of the presence or absence of bone disease as defined by radiology and bone alkaline phosphatase. The group of patient with bone disease showed a significantly greater increase in protein-bound calcium dur...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181632
更新日期:1979-01-01 00:00:00
abstract::In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals. Using Indian ink as a marker, rupture of the forniceal epithelium regularly followed V-U reflux. Intrapelvic pressure rose to 120 mm Hg during the reflu...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180706
更新日期:1976-01-01 00:00:00
abstract::This paper reviews the control of aldosterone secretion, including the role played by hepatic metabolic clearance, ACTH, and the renin-angiotensin system, and the interrelationships of aldosterone secretion with sodium and potassium metabolism. The physiological modulations of aldosterone secretion by the upright post...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181613
更新日期:1979-01-01 00:00:00
abstract::A 55-year-old white male, with silicosis diagnosed 10 years earlier, presented massive proteinuria with microscopic hematuria, moderate renal failure and distal polyneuropathy. Bilateral renal angiography showed multiple intraparenchymal saccular aneurysms. Renal biopsy disclosed a focal segmental necrotizing glomerul...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185391
更新日期:1989-01-01 00:00:00
abstract::Dopexamine hydrochloride is a synthetic dopamine analogue recently developed to improve myocardial and renal performance in patients suffering from low cardiac output states. The present study was designed to assess the pharmacological profile and the anatomical localization of [3H]-dopexamine binding sites within the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187518
更新日期:1993-01-01 00:00:00
abstract::The effects of contrast media on renal function and the cortical retention of contrast media after abdominal angiography were investigated. Sixteen nondiabetic patients with predialytic chronic renal failure received either the nonionic dimeric contrast medium iodixanol or the monomeric contrast medium iohexol in a do...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000189139
更新日期:1996-01-01 00:00:00
abstract::This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184292
更新日期:1987-01-01 00:00:00
abstract::Mean renal blood flow (MRBF), cortical blood flow (CBF), glomerular filtration rate (GFR), heart rate, arterial blood pressure, Na+ and K+ excretion were determined before and 10 min after intrarenal administration of dihydroergocristine (0.017 mg/kg b.w.) in 13 patients suffering from liver cirrhosis. Cardiac output ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182519
更新日期:1982-01-01 00:00:00
abstract:INTRODUCTION/AIMS:The Acute Kidney Injury Network classification is based on small increases in serum creatinine (sCr) for stage 1. This study investigated whether changes in the urinary concentration of neutrophil gelatinase-associated lipocalin (uNGAL) could predict small increases in sCr in patients undergoing coron...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000368413
更新日期:2015-01-01 00:00:00
abstract::During hemodialysis, platelets are activated across a dialyzer. Soluble P-selectin (sP-selectin) is a form of P-selectin which is a glycoprotein relocated from secretory granules to the surfaces of platelets and endothelial cells after these cells have been physiologically activated. To investigate whether sP-selectin...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044903
更新日期:1998-01-01 00:00:00
abstract::3-Deoxyglucosone (3-DG) has been identified as an intermediate of the Maillard reaction in vitro. We measured serum 3-DG levels using gas chromatography/mass spectrometry and found a marked elevation in serum 3-DG levels in uremic patients compared with healthy subjects. The uremic patients with diabetes showed signif...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188516
更新日期:1995-01-01 00:00:00
abstract::We encountered 11 patients with aluminum-associated bone disease (AABD), and treated them with deferoxamine (DFO). In 3 patients, a second bone biopsy was done during DFO treatment. Clinical features of AABD were compared with surgically proven secondary hyperparathyroidism (2 degrees HPT) with osteitis fibrosa on X-r...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183668
更新日期:1986-01-01 00:00:00
abstract::The techniques of bonding of anionic antibiotics by treatment with cationic surfactants were applied to continuous ambulatory peritoneal dialysis (CAPD) catheters. The elution of 14C-penicillin from tridodecylmethylammonium chloride (TDMAC) treated silicone elastomer catheters in dialysis solution was biphasic, with 9...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184366
更新日期:1987-01-01 00:00:00
abstract::Blood eosinophils were counted by the counting-chamber method in 21 regular hemodialysis patients. Before dialysis, eosinophil counts were within the normal range in all patients (mean 98 cells/mm3, range 6-350). After the first 15 min of hemodialysis, with not reused coils or hollow-fiber dialysers, a significant dro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182805
更新日期:1982-01-01 00:00:00
abstract::Since 1987, we have experienced 11 children with acute renal failure (ARF) associated with Yersinia pseudotuberculosis (YP) infection. The illness began with the sudden onset of high fever, skin rash and gastrointestinal symptoms. Later in the course, periungual desquamation developed, mimicking Kawasaki disease. Elev...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188611
更新日期:1995-01-01 00:00:00
abstract::A study was undertaken in 24 Chinese patients on maintenance continuous ambulatory peritoneal dialysis, using bezafibrate in its sustained-release form to correct lipid abnormalities. Six patients who received 400 mg/day developed severe muscle weakness with grossly elevated creatine phosphokinase activities within 3 ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186101
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The association between ultrafiltration rate (UFR) and mortality may be affected by the muscle mass or volume status in hemodialysis (HD) patients. However, there is an absence of data regarding this association. METHODS:We performed an observational study on patients (≥18 years old) who had been on HD for ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000509350
更新日期:2020-01-01 00:00:00
abstract::Effect of the immunosuppressive agent, ciclosporin (CS), on bovine serum albumin (BSA) nephritis in rats was evaluated. Eight weeks after immunization, 19 male Wistar rats received a daily intravenous dose of BSA (2 mg). Two weeks later, 11 rats received BSA and an oral dose of CS (10 mg/kg), and 8 rats received only ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186251
更新日期:1991-01-01 00:00:00