Effects of chronic sodium depletion on renal tubular sodium and water reabsorption in man.

Abstract:

:In order to assess the effects of sodium depletion on tubular Na and H2O transport in man, renal clearance studies were performed under control conditions and after sodium depletion in 7 normal subjects. The control diet contained 250 mEq of Na daily. Sodium depletion was induced by placing subjects on a 20-mEq/day na diet and administering furosemide (40 mg) dialy for 3 days. Balance studies revealed that the subjects were in Na balance under control conditions, and that after sodium depletion had been established they were in a sodium-retaining state. Subjects were studied under both conditions, after H2O hydration and during a subsequent hypotonic mannitol infusion. After H2O hydration the minimal urinary osmolality averaged 61 and 67 mosm/kg in the sodium depletion and control states, respectively. Sodium depletion was associated with a significant reduction in C inulin, sodium clearance (CNa), urine flow (V), fractional urine flow (V/GFR), free water (CH2O), and fractional free water clearance (CH2O/GFR). During hypotonic mannitol infusion indices of absolute and fractional delivery of Na from the proximal tubule (CH2O + CNa; CH2O/GFR + CNa/GFR) were consistently reduced after sodium depletion and rose more slowly as absolute and fractional distal sodium chloride supply (CH2O + CNa; CH2O/GFR + CNa/GFR) were increased. These data are consistent with the view that modest sodium depletion in man provokes an increase in fractional sodium chloride reabsorption in both the proximal and distal tubules.

journal_name

Nephron

journal_title

Nephron

authors

DiScala VA,Stein RM

doi

10.1159/000182635

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

151-8

issue

2

eissn

1660-8151

issn

2235-3186

journal_volume

31

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Inhibitor of insulin binding to erythrocytes in plasma of uremic patients.

    abstract::Previously, we have shown that insulin binding (IB) to erythrocytes was decreased in uremic patients and that hemodialysis corrected the receptor defect. In the present study cross-incubation experiments were performed using uremic and control erythrocytes and plasma. Incubation of control erythrocytes with uremic pla...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182990

    authors: Milutinović S,Breyer D,Janković N,Molnar V,Stefović A,Rocić B

    更新日期:1983-01-01 00:00:00

  • Effects of a protein load in patients with early chronic renal failure before and after angiotensin II blockade.

    abstract::We studied the effects of mid-term enalapril administration on protein-load-induced renal responses in 10 patients with early chronic renal failure (serum creatinine 2.70 +/- 1.0 mg/dl). The oral protein load was performed twice, before and after a 10-day therapy with enalapril. Glomerular filtration rate (125I-iothal...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185624

    authors: Oldrizzi L,Rugiu C,Maschio G

    更新日期:1989-01-01 00:00:00

  • Acute Kidney Injury and Hemolytic Anemia Secondary to Mycoplasma pneumoniae Infection.

    abstract::Glomerulonephritis as well as kidney injury secondary to fulminant intravascular hemolysis are rare extrapulmonary manifestations of Mycoplasma pneumoniae infection. We describe a 50-year-old female diagnosed with M. pneumoniae infection-associated hemolytic anemia, characterized by negative cold agglutinin tests but ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000478991

    authors: Carrara C,Abbate M,Sabadini E,Remuzzi G

    更新日期:2017-01-01 00:00:00

  • Acute volume expansion and salt-loading studies in rats. The role of atrial natriuretic peptide and catecholamines.

    abstract::Differences have been postulated for the mechanism of natriuresis due to atrial natriuretic peptide (ANP), salt loading with high salt diet (HS) and acute volume expansion (AcVE), in particular between AcVE and ANP based on the observed synergism between the two. Therefore the effects of and the interaction between th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045024

    authors: Reddy S,Salipan-Moore N,Mildenberger S,Willis N,Györy AZ

    更新日期:1998-01-01 00:00:00

  • Hypercalcaemia as a manifestation of malignant urothelial change in analgesic nephropathy.

    abstract::We report two cases of patients with analgesic nephropathy presenting with the symptoms of hypercalcaemia, and who were found to have transitional cell carcinomas of the renal pelvis. On removal of the tumours, calcium levels fell to normal, indicating that a humoral factor produced by the tumour caused the hypercalca...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185586

    authors: Derbyshire ND,Asscher AW,Matthews PN

    更新日期:1989-01-01 00:00:00

  • 5-year follow-up of patients successfully transplanted after immunoadsorption to remove anti-HLA antibodies.

    abstract::The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from ...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000189281

    authors: Higgins RM,Bevan DJ,Vaughan RW,Phillips AO,Snowden S,Bewick M,Scoble JE,Hendry BM

    更新日期:1996-01-01 00:00:00

  • Percutaneous renal biopsy in children: a 27-year experience.

    abstract:BACKGROUND:The introduction of automated biopsy devices and the localization of the kidney by ultrasound were aimed at optimizing efficacy and safety of the percutaneous renal biopsy procedure. We evaluated these technological advances in our renal biopsies performed in children. METHODS:We sequentially used the Silve...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000045090

    authors: Feneberg R,Schaefer F,Zieger B,Waldherr R,Mehls O,Schärer K

    更新日期:1998-08-01 00:00:00

  • Effects of dietary protein on uranyl-nitrate-induced acute renal failure.

    abstract::The effects of dietary protein both before and after uranyl-nitrate-induced acute renal failure were investigated. Male Sprague-Dawley rats were maintained on high-protein (60%), normal-protein (20%), low-protein (5%) and no-protein diets for 8 days prior to intravenous administration of uranyl nitrate (10 mg/kg). Imm...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184167

    authors: Andrews PM,Bates SB

    更新日期:1987-01-01 00:00:00

  • Relationship between serum phosphate concentration and proximal tubular bicarbonate transport.

    abstract::Micropuncture studies were performed in intact and thyroparathyroidectomized (TPTX) dogs to evaluate the relationship between the absolute level of serum ultrafilterable phosphate concentration (SUFP) and proximal bicarbonate reabsorption. In both groups of animals, a reverse linear relationship was noted between the ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180864

    authors: Puschett JB,Fernandez PC

    更新日期:1977-01-01 00:00:00

  • Effect of a low-protein diet on urinary albumin excretion in uremic patients.

    abstract::Fifteen patients with advanced renal failure (creatinine clearance less than 25 ml/mn) and with severe albuminuria (greater than 1.5 g/24 h) were put on a low-protein (0.3 g/kg body weight), low-phosphorus (5-7 mg/kg body weight) diet supplemented with essential amino acids and ketoanalogues. During the 6-month follow...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185189

    authors: Aparicio M,Bouchet JL,Gin H,Potaux L,Morel D,de Precigout V,Lifermann F,Gonzalez R

    更新日期:1988-01-01 00:00:00

  • Effects of chitosan-coated dialdehyde cellulose, a newly developed oral adsorbent, on glomerulonephritis induced by anti-Thy-1 antibody in rats.

    abstract::The effects of chitosan-coated dialdehyde cellulose (chitosan DAC), a newly developed oral adsorbent for urea and ammonia, were examined in a glomerulonephritis model in rats. Mesangial proliferative glomerulonephritis accompanied with proteinuria was induced by an intravenous injection of anti-rat Thy-1.1 monoclonal ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044973

    authors: Yagi M,Kato S,Nishitoba T,Sato H,Kobayashi N,Iinuma N,Nagano N

    更新日期:1998-01-01 00:00:00

  • Critically ill patients requiring acute renal replacement therapy are at an increased risk of long-term renal dysfunction, but rarely receive specialist nephrology follow-up.

    abstract:BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000371448

    authors: Kirwan CJ,Blunden MJ,Dobbie H,James A,Nedungadi A,Prowle JR

    更新日期:2015-01-01 00:00:00

  • Changes in protein-bound calcium during haemodialysis in relation to bone disease.

    abstract::29 patients receiving haemodialysis treatment for chronic renal failure were divided into two groups on the basis of the presence or absence of bone disease as defined by radiology and bone alkaline phosphatase. The group of patient with bone disease showed a significantly greater increase in protein-bound calcium dur...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181632

    authors: Gosling P,Naik RB,Price CP,Sammons HG,Robinson BH

    更新日期:1979-01-01 00:00:00

  • The role of vesico-ureteric (V-U) reflux in the pathogenesis of kidney scars in the rat.

    abstract::In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals. Using Indian ink as a marker, rupture of the forniceal epithelium regularly followed V-U reflux. Intrapelvic pressure rose to 120 mm Hg during the reflu...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180706

    authors: Morgan M,Asscher AW,Moffat DB

    更新日期:1976-01-01 00:00:00

  • Control of aldosterone secretion.

    abstract::This paper reviews the control of aldosterone secretion, including the role played by hepatic metabolic clearance, ACTH, and the renin-angiotensin system, and the interrelationships of aldosterone secretion with sodium and potassium metabolism. The physiological modulations of aldosterone secretion by the upright post...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181613

    authors: Chan JC

    更新日期:1979-01-01 00:00:00

  • Polyarteritis nodosa and necrotizing glomerulonephritis associated with long-standing silicosis.

    abstract::A 55-year-old white male, with silicosis diagnosed 10 years earlier, presented massive proteinuria with microscopic hematuria, moderate renal failure and distal polyneuropathy. Bilateral renal angiography showed multiple intraparenchymal saccular aneurysms. Renal biopsy disclosed a focal segmental necrotizing glomerul...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185391

    authors: Arnalich F,Lahoz C,Picazo ML,Monereo A,Arribas JR,Martínez Ara J,Vázquez JJ

    更新日期:1989-01-01 00:00:00

  • Dopexamine hydrochloride in the human kidney: localization, receptor binding and effect on 3'-5'-cyclic adenosine monophosphate generation.

    abstract::Dopexamine hydrochloride is a synthetic dopamine analogue recently developed to improve myocardial and renal performance in patients suffering from low cardiac output states. The present study was designed to assess the pharmacological profile and the anatomical localization of [3H]-dopexamine binding sites within the...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187518

    authors: Napoleone P,Cavallotti C,Ricci A,Amenta F

    更新日期:1993-01-01 00:00:00

  • Angiography with nonionic X-ray contrast media in severe chronic renal failure: renal function and contrast retention.

    abstract::The effects of contrast media on renal function and the cortical retention of contrast media after abdominal angiography were investigated. Sixteen nondiabetic patients with predialytic chronic renal failure received either the nonionic dimeric contrast medium iodixanol or the monomeric contrast medium iohexol in a do...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000189139

    authors: Jakobsen JA,Berg KJ,Kjaersgaard P,Kolmannskog F,Nordal KP,Nossen JO,Rootwelt K

    更新日期:1996-01-01 00:00:00

  • Polycythemia of end-stage renal failure: no inhibition of erythropoiesis by uremic serum and markedly increased serum erythropoietin level.

    abstract::This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184292

    authors: Muto S,Asano Y,Hosoda S,Shionoya S,Miura Y,Urabe A,Takaku F

    更新日期:1987-01-01 00:00:00

  • Enhanced renal sympathetic tone in liver cirrhosis: evaluation by intrarenal administration of dihydroergocristine.

    abstract::Mean renal blood flow (MRBF), cortical blood flow (CBF), glomerular filtration rate (GFR), heart rate, arterial blood pressure, Na+ and K+ excretion were determined before and 10 min after intrarenal administration of dihydroergocristine (0.017 mg/kg b.w.) in 13 patients suffering from liver cirrhosis. Cardiac output ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182519

    authors: Gatta A,Merkel C,Grassetto M,Milani L,Zuin R,Ruol A

    更新日期:1982-01-01 00:00:00

  • Relative and absolute changes in urinary neutrophil gelatinase-associated lipocalin and correlation with small increases in serum creatinine levels after coronary angiography: an observational study.

    abstract:INTRODUCTION/AIMS:The Acute Kidney Injury Network classification is based on small increases in serum creatinine (sCr) for stage 1. This study investigated whether changes in the urinary concentration of neutrophil gelatinase-associated lipocalin (uNGAL) could predict small increases in sCr in patients undergoing coron...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000368413

    authors: Souza DF,Reis SS,Botelho RV,Ferreira-Filho SR

    更新日期:2015-01-01 00:00:00

  • Soluble P-selectin is released from activated platelets in vivo during hemodialysis.

    abstract::During hemodialysis, platelets are activated across a dialyzer. Soluble P-selectin (sP-selectin) is a form of P-selectin which is a glycoprotein relocated from secretory granules to the surfaces of platelets and endothelial cells after these cells have been physiologically activated. To investigate whether sP-selectin...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044903

    authors: Kawabata K,Nagake Y,Shikata K,Fukuda S,Nakazono H,Takahashi M,Ichikawa H,Makino H

    更新日期:1998-01-01 00:00:00

  • Elevated serum levels of 3-deoxyglucosone, a potent protein-cross-linking intermediate of the Maillard reaction, in uremic patients.

    abstract::3-Deoxyglucosone (3-DG) has been identified as an intermediate of the Maillard reaction in vitro. We measured serum 3-DG levels using gas chromatography/mass spectrometry and found a marked elevation in serum 3-DG levels in uremic patients compared with healthy subjects. The uremic patients with diabetes showed signif...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188516

    authors: Niwa T,Takeda N,Miyazaki T,Yoshizumi H,Tatematsu A,Maeda K,Ohara M,Tomiyama S,Niimura K

    更新日期:1995-01-01 00:00:00

  • Clinical features of aluminum-associated bone disease in long-term hemodialysis patients.

    abstract::We encountered 11 patients with aluminum-associated bone disease (AABD), and treated them with deferoxamine (DFO). In 3 patients, a second bone biopsy was done during DFO treatment. Clinical features of AABD were compared with surgically proven secondary hyperparathyroidism (2 degrees HPT) with osteitis fibrosa on X-r...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183668

    authors: Iwamoto N,Ono T,Yamazaki S,Fukuda T,Kondo M,Yamamoto N,Hiratake Y,Masugi Y,Kubo Y,Hino M

    更新日期:1986-01-01 00:00:00

  • Infection-resistant continuous peritoneal dialysis catheters.

    abstract::The techniques of bonding of anionic antibiotics by treatment with cationic surfactants were applied to continuous ambulatory peritoneal dialysis (CAPD) catheters. The elution of 14C-penicillin from tridodecylmethylammonium chloride (TDMAC) treated silicone elastomer catheters in dialysis solution was biphasic, with 9...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184366

    authors: Trooskin SZ,Donetz AP,Baxter J,Harvey RA,Greco RS

    更新日期:1987-01-01 00:00:00

  • Dialysis-induced eosinophilia.

    abstract::Blood eosinophils were counted by the counting-chamber method in 21 regular hemodialysis patients. Before dialysis, eosinophil counts were within the normal range in all patients (mean 98 cells/mm3, range 6-350). After the first 15 min of hemodialysis, with not reused coils or hollow-fiber dialysers, a significant dro...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182805

    authors: Bodner G,Peer G,Zakuth V,Spirer ZH,Aviram A

    更新日期:1982-01-01 00:00:00

  • Acute renal failure associated with Yersinia pseudotuberculosis infection.

    abstract::Since 1987, we have experienced 11 children with acute renal failure (ARF) associated with Yersinia pseudotuberculosis (YP) infection. The illness began with the sudden onset of high fever, skin rash and gastrointestinal symptoms. Later in the course, periungual desquamation developed, mimicking Kawasaki disease. Elev...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188611

    authors: Cheong HI,Choi EH,Ha IS,Lee HJ,Choi Y

    更新日期:1995-01-01 00:00:00

  • Sustained-release bezafibrate corrects lipid abnormalities in patients on continuous ambulatory peritoneal dialysis.

    abstract::A study was undertaken in 24 Chinese patients on maintenance continuous ambulatory peritoneal dialysis, using bezafibrate in its sustained-release form to correct lipid abnormalities. Six patients who received 400 mg/day developed severe muscle weakness with grossly elevated creatine phosphokinase activities within 3 ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186101

    authors: Chan MK

    更新日期:1990-01-01 00:00:00

  • Association between Ultrafiltration Rate and Clinical Outcome Is Modified by Muscle Mass in Hemodialysis Patients.

    abstract:BACKGROUND:The association between ultrafiltration rate (UFR) and mortality may be affected by the muscle mass or volume status in hemodialysis (HD) patients. However, there is an absence of data regarding this association. METHODS:We performed an observational study on patients (≥18 years old) who had been on HD for ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000509350

    authors: Lim Y,Yang G,Cho S,Kim SR,Lee YJ

    更新日期:2020-01-01 00:00:00

  • Effect of the immunosuppressive agent, ciclosporin, on experimental immune complex glomerulonephritis in rats.

    abstract::Effect of the immunosuppressive agent, ciclosporin (CS), on bovine serum albumin (BSA) nephritis in rats was evaluated. Eight weeks after immunization, 19 male Wistar rats received a daily intravenous dose of BSA (2 mg). Two weeks later, 11 rats received BSA and an oral dose of CS (10 mg/kg), and 8 rats received only ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186251

    authors: Fujita M,Iida H,Asaka M,Izumino K,Takata M,Sasayama S

    更新日期:1991-01-01 00:00:00