The role of vesico-ureteric (V-U) reflux in the pathogenesis of kidney scars in the rat.

abstract：BACKGROUND:Chronic renal failure is commonly associated with disturbances in hypothalamic-pituitary-gonadal function. METHODS:The gonadotrophins, prolactin and estradiol or testosterone levels were measured immediately before renal transplantation, at discharge from the transplantation unit (19 +/- 8 days after Tx) an...

journal_title：Nephron

authors： Saha MT,Saha HH,Niskanen LK,Salmela KT,Pasternack AI

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION/AIMS:The Acute Kidney Injury Network classification is based on small increases in serum creatinine (sCr) for stage 1. This study investigated whether changes in the urinary concentration of neutrophil gelatinase-associated lipocalin (uNGAL) could predict small increases in sCr in patients undergoing coron...

journal_title：Nephron

authors： Souza DF,Reis SS,Botelho RV,Ferreira-Filho SR

更新日期：2015-01-01 00:00:00

abstract：:We describe a case, seemingly sporadic, in which ocular and acral malformations were associated with an interstitial nephropathy; we made a diagnosis of acro-renal-ocular syndrome. There was no stasis, reflux, or urinary tract infection in our patient. We believe that interstitial nephritis in acro-renal-ocular syndro...

journal_title：Nephron

authors： Boscutti G,Pizzolitto S,Montanaro D,Messa P,Messa M,Favazza A,Beltrami CA,Mioni G

更新日期：1994-01-01 00:00:00

abstract：:Hemodynamic and hormonal actions of acute (50 mg) and chronic (150 mg/day) captopril were tested in 10 patients with essential hypertension. Under short-term conditions blood pressure was reduced, heart rate and plasma adrenaline did not change, plasma angiotensin II and plasma aldosterone decreased. Plasma renin acti...

journal_title：Nephron

authors： Stanek B,Silberbauer K

更新日期：1986-01-01 00:00:00

abstract：:X-linked nephrogenic diabetes insipidus (NDI) is a rare disease caused by mutations in the vasopressin V2 receptor (AVPR2) gene. We analyzed the AVPR2 gene in 6 unrelated Korean families with X-linked NDI, and found 6 novel mutations. Two of them were missense point mutations, 2 were short deletions causing frameshift...

journal_title：Nephron

authors： Cheong HI,Park HW,Ha IS,Moon HN,Choi Y,Ko KW,Jun JK

更新日期：1997-01-01 00:00:00

abstract：:Proteoglycans constitute a heterogenous group of complex macromolecules, consisting of a backbone core protein and a variable number of sulfated polysaccharide side chains covalently linked to the core. A dual function for these polyanionic glycosaminoglycans in kidney physiology has been proposed: to maintain a fixed...

journal_title：Nephron

authors： Pyke C,Kristensen P,Ostergaard PB,Oturai PS,Rømer J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) is an ideal model for testing remote monitoring (RM). In this study, we evaluated the RM application longitudinally in stable patients undergoing automated PD (APD). METHODS:This was an observational study, comparing outcomes in patients with (current patients) and without (historic...

journal_title：Nephron

authors： Milan Manani S,Rosner MH,Virzì GM,Giuliani A,Berti S,Crepaldi C,Ronco C

更新日期：2019-01-01 00:00:00

abstract：:An 'epidemic' of aseptic peritonitis occurred in our peritoneal dialysis unit, affecting 5 of 20 patients. Acute and convalescent viral titers were normal in all 5. The peritoneal fluid of the affected patients was not tested for endotoxin, but endotoxin was found in subsequent dialysis fluids from two machines in the...

journal_title：Nephron

authors： Gandhi VC,Kamadana MR,Ing TS,Daugirdas JT,Viol GW,Robinson JA,Geis WP,Hano JE

更新日期：1979-01-01 00:00:00

abstract：:Fifty-eight previously untreated adults with minimal-change nephrotic syndrome (MCNS), who had a mean follow-up period of 35.8 months, were studied with regard to their response to alternate-day steroid therapy. The nephrotic syndrome in 54 patients (93%) remitted by 12 weeks and patients continued to be in remission ...

journal_title：Nephron

authors： Nair RB,Date A,Kirubakaran MG,Shastry JC

更新日期：1987-01-01 00:00:00

abstract：AIM:To clarify the role of leukocyte subsets in the development of glomerulosclerosis (GS) and interstitial lesions which may contribute to the prognosis of membranous nephropathy (MN), we investigated infiltrating cells in both glomeruli and interstitium in biopsy specimens. METHODS:Forty-one cases of MN were divided...

journal_title：Nephron

authors： Saito T,Yusa A,Soma J,Ootaka T,Sato H,Ito S

更新日期：1998-12-01 00:00:00

abstract：:Copper (Cu) and zinc (Zn) were measured in urine, serum and tissues from rats with nephrotic syndrome (NS) induced with a single subcutaneous dose of puromycin aminonucleoside (PAN; 15 mg/100 g BW). Control animals were pair-fed. Urine was collected daily, and the rats were sacrificed on day 10. PAN-nephrotic rats had...

journal_title：Nephron

authors： Pedraza-Chaverrí J,Torres-Rodríguez GA,Cruz C,Mainero A,Tapia E,Ibarra-Rubio ME,Silencio JL

更新日期：1994-01-01 00:00:00

abstract：:To determine whether the chelation of aluminium enhances the haemopoietic response to recombinant human erythropoietin (r-HuEPO), desferrioxamine (DFO) at a dose of 20-30 mg/kg was given to 7 of 17 transfusion-dependent haemodialysis patients treated with r-HuEPO (40 units/kg/dialysis i.v.). The two randomly allocated...

journal_title：Nephron

authors： Roger SD,Stewart JH,Harris DC

更新日期：1991-01-01 00:00:00

abstract：:The role of T cell-mediated immunity in the early phase of nephrotoxic serum nephritis (NTN) was examined by transfer of pan T, CD8-positive, and CD4-positive cells. The disease was induced by transferring rabbit gamma-globulin (RGG)-sensitized T cells to nude (rnu/rnu) rats pretreated with a subnephritogenic dose (a ...

journal_title：Nephron

authors： Kuroda T,Kawasaki K,Oite T,Arakawa M,Shimizu F

更新日期：1994-01-01 00:00:00

abstract：:In the present study the influence of a mixture of keto analogues/amino acids (KA) on PTH levels in 18 RDT patients was examined. Ten of them were treated with KA over a period of 3 months, while the other 8 patients served as control group. The KA-treated patients showed a significant fall in PTH and plasma phosphate...

journal_title：Nephron

authors： Lindenau K,Kokot F,Fröhling PT

更新日期：1986-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a worldwide public health problem associated with a high prevalence of cardiovascular disease (CVD) and impaired quality of life. Previous research for preventing loss of glomerular filtration rate (GFR) has focused on reducing blood pressure (BP) and proteinuria. Angiotensin converting...

journal_title：Nephron

authors： Ahmed A,Jorna T,Bhandari S

更新日期：2016-01-01 00:00:00

abstract：:The morphologic basis of proteinuria in experimental chronic serum sickness glomerulonephritis in rabbits was studied by light and electron microscopy using horseradish peroxidase (effective radius 30 A; mol. wt. 40,000) and ferritin (effective radius 60 A; mol. wt. 480,000) as protein tracers. It was found that more ...

journal_title：Nephron

authors： O'Connell DW,Brentjens JR,Andres GA

更新日期：1978-01-01 00:00:00

abstract：:We found a strain of nonobese, nondiabetic (NON) mice which has spontaneous lipid deposition in glomerular capillary lumina. This strain was developed together with a diabetic strain of nonobese diabetic (NOD) mice for the generation of mouse models of diabetes mellitus. In the NON strain, contrary to the name, impair...

journal_title：Nephron

authors： Watanabe Y,Itoh Y,Yoshida F,Koh N,Tamai H,Fukatsu A,Matsuo S,Hotta N,Sakamoto N

更新日期：1991-01-01 00:00:00

abstract：:The investigation of a sample of 99 women on maintenance hemodialysis has shown the presence of sexual disturbances to a great extent: the rate of sexual intercourse and the ability to reach orgasm were significantly lower than in age-matched control women. 80% declared a reduction in their sexual desire and the frequ...

journal_title：Nephron

authors： Mastrogiacomo I,De Besi L,Serafini E,Zussa S,Zucchetta P,Romagnoli GF,Saporiti E,Dean P,Ronco C,Adami A

更新日期：1984-01-01 00:00:00

abstract：:Complement factor D, a complement system serine protease, circulating in vivo as its active form, accumulates in patients with chronic renal failure. The pathophysiological role of this active protease in these patients was examined by studies on activities of excess factor D on 10 synthetic peptide substrates for som...

journal_title：Nephron

authors： Inagi R,Miyata T,Oda O,Maeda K,Inoue K

更新日期：1994-01-01 00:00:00

abstract：:This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...

journal_title：Nephron

authors： Muto S,Asano Y,Hosoda S,Shionoya S,Miura Y,Urabe A,Takaku F

更新日期：1987-01-01 00:00:00

abstract：:Circumstantial evidence that pIgA has a key role in glomerular injury of IgAN is now strong. Although the answers to the questions posed in this review are necessarily incomplete, they do indicate that (1) pIgA is a major component of mesangial IgA. (2) circulating pIgA is increased and this pIgA is particularly enhan...

journal_title：Nephron

authors： Harper SJ,Feehally J

更新日期：1993-01-01 00:00:00

abstract：:This study was conducted to test the hypothesis that the margin of safe fluoride exposure is narrowed in rats that are physiologically compromised by renal dysfunction. The study objective was to determine whether increases in fluoride retention and tissue fluoride levels in rats with surgically induced renal insuffic...

journal_title：Nephron

authors： Dunipace A,Brizendine E,Wilson M,Zhang W,Wilson C,Katz B,Kafrawy A,Stookey G

更新日期：1998-01-01 00:00:00

abstract：:Renal biopsy specimens obtained from patients with various chronic nephropathies were studied by immunofluorescence (IF), electron and light microscopy. Of 49 biopsies studied by IF, 22 had granular deposits of IgG and/or C3 along the basement membranes of proximal tubules while 14 had linear and 13 both linear and gr...

journal_title：Nephron

authors： Orfila C,Rakotoarivony J,Durand D,Suc JM

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of treatment for renal anemia in patients with chronic kidney disease (CKD). This meta-analysis was designed to evaluate their efficacy and safety. METHOD:Eight databases were searched for randomized controlled trials (RCTs). ...

journal_title：Nephron

authors： Wen T,Zhang X,Wang Z,Zhou R

更新日期：2020-01-01 00:00:00

abstract：:The concentration changes, during hemodialysis treatment, of 18 characteristic uremia compounds, analyzed by high-pressure liquid chromatography in sera of renal patients were studied. Pre- to postdialysis concentration ratios (dialysis ratio, D) varied from 0.83 to 3.04 for the different solutes. A division into thre...

journal_title：Nephron

authors： Schoots AC,Peeters JA,Gerlag PG

更新日期：1989-01-01 00:00:00

abstract：:The kinetics of bromosulfophthalein clearance from plasma, secretion into bile, and, by difference, storage in hepatic cells, were determined, using normal livers and blood from normal rats in the isolated perfused rat liver system. Two suspected uremic 'toxins', urea and guanidinosuccinic acid, were then administered...

journal_title：Nephron

authors： Liang MY,Toporek M,Schepartz B

更新日期：1978-01-01 00:00:00

abstract：:The possible role of altered renal prostaglandin metabolism in the generation of post-obstruction diuresis (POD) was examined in 16 adult male Sprague-Dawley rats. Inhibition of cyclooxygenase by the administration of a combination of two nonsteroidal anti-inflammatory drugs (NSAID), meclofenamate and indomethacin in ...

journal_title：Nephron

authors： Kauker ML,Zawada ET

更新日期：1992-01-01 00:00:00

abstract：AIM:Most transplant centres use SV40 large T antigen (TAg) staining for the diagnosis and assessment of BK polyomavirus-associated nephropathy (BKPyVAN). This study was performed to evaluate the significance of capsid protein VP1 expression in BKPyVAN. METHODS:We performed immunohistochemical staining using anti-SV40 ...

journal_title：Nephron

authors： Masutani K,Matsukuma Y,Tsuchimoto A,Okabe Y,Doi A,Kaku K,Nakamura M,Nakano T,Tsuruya K,Kitazono T

更新日期：2020-01-01 00:00:00

abstract：:Like other biguanide agents, metformin is an anti-hyperglycemic agent with lower tendency towards hypoglycemia compared to other anti-diabetic drugs. Given its favorable effects on serum lipids, obese body habitus, cardiovascular disease, and mortality, metformin is recommended as the first-line pharmacologic agent fo...

journal_title：Nephron

authors： Rhee CM,Kovesdy CP,Kalantar-Zadeh K

更新日期：2017-01-01 00:00:00

abstract：:The frequency of thrombocytopenia in patients with chronic renal failure (CRF) is controversial. This study was undertaken to investigate the platelet count in 55 patients with end-stage renal disease on maintenance hemodialysis and in 19 patients with CRF before hemodialysis had begun. In both groups platelet counts ...

journal_title：Nephron

authors： Gafter U,Bessler H,Malachi T,Zevin D,Djaldetti M,Levi J

更新日期：1987-01-01 00:00:00