Abstract:
:The kinetics of bromosulfophthalein clearance from plasma, secretion into bile, and, by difference, storage in hepatic cells, were determined, using normal livers and blood from normal rats in the isolated perfused rat liver system. Two suspected uremic 'toxins', urea and guanidinosuccinic acid, were then administered in order to determine if either of these substances would independently alter the kinetics under study. Results indicated that these two compounds have little or no effect on liver function on an acute basis. However, because of the excellent reproducibility obtained, it is believed that this method can be of significant use in the further screening of substances from uremic patients which may be interfering seriously with liver functions.
journal_name
Nephronjournal_title
Nephronauthors
Liang MY,Toporek M,Schepartz Bdoi
10.1159/000181467subject
Has Abstractpub_date
1978-01-01 00:00:00pages
306-11issue
4-6eissn
1660-8151issn
2235-3186journal_volume
22pub_type
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