Evaluation of the proteolytic activity of factor D accumulated as an active serine protease in patients with chronic renal failure.

abstract：:Focal segmental glomerulosclerosis (FSGS) is a histological pattern of podocyte and glomerulus injury. FSGS can be primary and secondary to other diseases or due to a genetic cause. Strikingly, genetic causes for adult-onset FSGS are often overlooked, likely because identifying patients with genetic forms of FSGS base...

journal_title：Nephron

authors： Snoek R,Nguyen TQ,van der Zwaag B,van Zuilen AD,Kruis HME,van Gils-Verrij LA,Goldschmeding R,Knoers NVAM,Rookmaaker MB,van Eerde AM

更新日期：2019-01-01 00:00:00

abstract：:The investigation of a sample of 99 women on maintenance hemodialysis has shown the presence of sexual disturbances to a great extent: the rate of sexual intercourse and the ability to reach orgasm were significantly lower than in age-matched control women. 80% declared a reduction in their sexual desire and the frequ...

journal_title：Nephron

authors： Mastrogiacomo I,De Besi L,Serafini E,Zussa S,Zucchetta P,Romagnoli GF,Saporiti E,Dean P,Ronco C,Adami A

更新日期：1984-01-01 00:00:00

abstract：:We have evaluated the effect of the antihyperlipidemic agent probucol on hyperlipidemia in patients with nephrotic syndrome. Twelve patients with long-standing nephrotic syndrome received 500 mg of probucol daily for 12 weeks. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol were significantl...

journal_title：Nephron

authors： Iida H,Izumino K,Asaka M,Fujita M,Nishino A,Sasayama S

更新日期：1987-01-01 00:00:00

abstract：:A 65-year-old man with sclerosing mesenteritis developed the nephrotic syndrome. Percutaneous renal biopsy revealed classical histologic findings of minimal change nephropathy with a mild interstitial nephritis. Immunomodulation with prednisone led to a rapid and complete remission of the proteinuria but did not alter...

journal_title：Nephron

authors： Vernace MA,Bellucci AG,Mossey RT,Susin M,Mailloux LU,Wilkes BM,Katz S,Eskreis D

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this study was to characterize renal cell carcinoma tissue by the measurement of microacoustic properties. A scanning acoustic microscope system operating in the frequency range of 100-200 MHz was employed and the attenuation constant and sound speed were measured on the two-dimensional distribution. Th...

journal_title：Nephron

authors： Sasaki H,Tanaka M,Saijo Y,Okawai H,Terasawa Y,Nitta S,Suzuki K

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:In the last decade, great advances have been made in the field of membranous nephropathy (MN). The autoimmune nature of the disease has been confirmed with the description of diverse antigens, and few but very important prospective trials regarding treatment alternatives have been published, changing profoun...

journal_title：Nephron

authors： Trujillo H,Alonso M,Praga M

更新日期：2020-01-01 00:00:00

abstract：:Two observers, unaware of each other's findings and of the diagnosis, examined red cells in the urine of 109 patients by phase-contrast microscopy. All specimens were examined uncentrifuged by inverted microscopy, and 48 of the 109 were also examined under a light microscope after centrifugation. We were unable to con...

journal_title：Nephron

authors： Venkat Raman G,Pead L,Lee HA,Maskell R

更新日期：1986-01-01 00:00:00

abstract：:A case of isolated ACTH deficiency with hyporeninemic hypoaldosteronism, presenting severe hyponatremia, is described. A 57-year-old man complaining of nausea, vomiting and fatigability was admitted to our hospital because of hyponatremia (114 mEq/I). The low levels of serum cortisol and urinary 17-OHCS suggested gluc...

journal_title：Nephron

authors： Okada K,Takahashi S

更新日期：1996-01-01 00:00:00

abstract：:This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...

journal_title：Nephron

authors： Muto S,Asano Y,Hosoda S,Shionoya S,Miura Y,Urabe A,Takaku F

更新日期：1987-01-01 00:00:00

abstract：:The main regulatory hormone for the control of erythropoiesis is erythropoietin (EPO). This glycoprotein has a molecular weight of 34,000 daltons, about 40% of which is represented by carbohydrates. EPO leads to an enhanced mitosis and differentiation of erythroid precursors (colony-forming unit erythroid) in the bone...

journal_title：Nephron

authors： Bauer C,Kurtz A,Eckardt KU,Tannahill L

更新日期：1989-01-01 00:00:00

abstract：:Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending ...

journal_title：Nephron

authors： Di Paolo N,Guarnieri A,Loi F,Sacchi G,Mangiarotti AM,Di Paolo M

更新日期：1993-01-01 00:00:00

abstract：:Lipoproteins might be involved in the pathogenesis of glomerular damage. Uptake of low-density lipoprotein (LDL) by cultured human glomerular cells has been studied using LDL, labelled with the fluorescent probe 1,1'-dioctadecyl-3,3,3'3'-tetramethyl-indocarbocyanine perchlorate (diI). Cells have been characterised usi...

journal_title：Nephron

authors： Rayner HC,Horsburgh T,Brown SL,Lavender FL,Winder AF,Walls J

更新日期：1990-01-01 00:00:00

abstract：:To understand the regulation of vasopressin receptors in an animal model of hypertension, localization and age-related changes in renal arginine vasopressin (AVP) receptors in spontaneously hypertensive rats (SHR) were investigated using in vitro (macro) autoradiography and a radiolabeled receptor assay. Autoradiograp...

journal_title：Nephron

authors： Hosoya M,Ogura T,Watanabe H,Ota Z,Kageyama Z

更新日期：1996-01-01 00:00:00

abstract：:The effects of intravenous iron, with and without androgens, was studied in a group of 39 patients treated by regular haemodialysis, almost all of whom had normal serum iron concentrations. Intravenous iron 1-2 g every 4 months produced a significant rise in haemoglobin from 6.3 to 7.9 g/dl in 17 female patients with ...

journal_title：Nephron

authors： von Hartitzsch B,Kerr DN

更新日期：1976-01-01 00:00:00

abstract：:136 patients on hemodialysis, 89 males and 47 females, were studied; we evaluated the index of hepatic function (SGOT and SGPT) and antibodies against HCV. We observed 42 cases of increased transaminases classified as non-A, non-B (NANB) hepatitis. Antibodies against HCV were present in 40 patients. Among 42 patients ...

journal_title：Nephron

authors： La Russa A,Bufano G,Cauzzi L,Pecchini P

更新日期：1992-01-01 00:00:00

abstract：:A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...

journal_title：Nephron

authors： Lin CH,Huang JJ,Liu HL,Lee SY,Hsieh RY,Tseng CC

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Icodextrin, an effective osmotic substance that has been proposed as an alternative agent for peritoneal dialysis induces ultrafiltration over long dwells. This study examines the peritoneal transport after exposure to Icodextrin in rats. METHODS:Animals were divided in 4 groups and injected daily for 30 da...

journal_title：Nephron

authors： Frajewicki V,Kushnir D,Wajsbrot V,Kohan R,Shostak A,Gotloib L

更新日期：2002-09-01 00:00:00

abstract：:Cardiovascular disease is the major complication and cause of mortality in the dialysis population, accounting for about 40% of deaths. Oxidative stress has been strongly implicated in the pathogenesis of these events. As patients in end-stage renal disease (ESRD) are in a state of elevated free radical activity, the ...

journal_title：Nephron

authors： Wang NP,Lim PS,Chen TT,Thien LM,Wang TH,Hsu WM

更新日期：2002-12-01 00:00:00

abstract：:We found a strain of nonobese, nondiabetic (NON) mice which has spontaneous lipid deposition in glomerular capillary lumina. This strain was developed together with a diabetic strain of nonobese diabetic (NOD) mice for the generation of mouse models of diabetes mellitus. In the NON strain, contrary to the name, impair...

journal_title：Nephron

authors： Watanabe Y,Itoh Y,Yoshida F,Koh N,Tamai H,Fukatsu A,Matsuo S,Hotta N,Sakamoto N

更新日期：1991-01-01 00:00:00

abstract：:Abnormalities in plasma composition of essential fatty acids (EFAs) may be associated with the etiology of pruritus and other skin problems in patients undergoing hemodialysis. To study whether an oral supplementation with omega-6 (n-6) EFAs would restore deranged plasma EFAs and ameliorate skin symptoms, 9 and 7 dial...

journal_title：Nephron

authors： Yoshimoto-Furuie K,Yoshimoto K,Tanaka T,Saima S,Kikuchi Y,Shay J,Horrobin DF,Echizen H

更新日期：1999-02-01 00:00:00

abstract：:Clearance techniques were used to evaluate renal tubular sodium and water excretion in 4 patients with antibiotic-induced acute renal failure (ARF). Creatinine clearances and maximal urine flow rates of patients with ARF (22.6 and 5.23 ml/min, respectively) were significantly lower than control values during hypotonic...

journal_title：Nephron

authors： Hsu CH,Maletz RM,Rozas VV,Kurtz TW

更新日期：1978-01-01 00:00:00

abstract：:We investigated the incidence of painless (silent) myocardial ischemia, manifested as S-T segment deviation, by Holter ECG monitoring in patients with chronic renal failure undergoing regular hemodialysis. Forty-five patients underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the int...

journal_title：Nephron

authors： Kremastinos D,Paraskevaidis I,Voudiklari S,Apostolou T,Kyriakides Z,Zirogiannis P,Toutouzas P

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Complete remission (CR) and partial remission (PR) are beneficial to the long-term outcome of patients with idiopathic membranous nephropathy (iMN). However, we are lacking in studies that evaluate the clinical predictors of response to treatment with prednisone plus cyclophosphamide (CP). The objectives of ...

journal_title：Nephron

authors： Li S,Wang L,Zhang M,Zhou W,Fang W,Wang Q,Qi C,Mou S,Shao X,Ni Z

更新日期：2017-01-01 00:00:00

abstract：:It has been assumed, but not documented, that hypercalcemia induces an appreciable reduction in the serum anion gap (AG) because it represents an increase in the level of unmeasured cations. To test this question, we retrospectively compared the data of 59 hypercalcemic patients with malignancy [group 1, serum Ca 13.3...

journal_title：Nephron

authors： Oster JR,Gutierrez R,Schlessinger FB,Taylor A,Federman DG,Vaamonde CA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Home hemodialysis is usually considered a superior therapy, whose decline is related to demographic, social, psychological and financial factors as well as to competition with renal transplantation and PD. METHODS:A home hemodialysis program was started in November 1998 in the University of Torino, Italy (2...

journal_title：Nephron

authors： Piccoli GB,Bermond F,Mezza E,Quaglia M,Pacitti A,Jeantet A,Segoloni GP

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Peritoneal dialysis (PD) is an ideal model for testing remote monitoring (RM). In this study, we evaluated the RM application longitudinally in stable patients undergoing automated PD (APD). METHODS:This was an observational study, comparing outcomes in patients with (current patients) and without (historic...

journal_title：Nephron

authors： Milan Manani S,Rosner MH,Virzì GM,Giuliani A,Berti S,Crepaldi C,Ronco C

更新日期：2019-01-01 00:00:00

abstract：:Three unusual cases are described which demonstrated hypomagnesemia and symptoms resembling magnesium deficiency syndrome. The hypomagnesemia was most likely secondary to urinary losses from diuresis following release of post-renal obstruction and renal homotransplantation. Heretofore, this association has not been de...

journal_title：Nephron

authors： Davis BB,Preuss HG,Murdaugh HV Jr

更新日期：1975-01-01 00:00:00

abstract：:Hemodynamic and hormonal actions of acute (50 mg) and chronic (150 mg/day) captopril were tested in 10 patients with essential hypertension. Under short-term conditions blood pressure was reduced, heart rate and plasma adrenaline did not change, plasma angiotensin II and plasma aldosterone decreased. Plasma renin acti...

journal_title：Nephron

authors： Stanek B,Silberbauer K

更新日期：1986-01-01 00:00:00

abstract：:Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not exclusively filtered by the kidney and rises relatively late after the onset of acute kidney injury (AKI). This leads to delays in recog...

journal_title：Nephron

authors： Khorashadi M,Beunders R,Pickkers P,Legrand M

更新日期：2020-01-01 00:00:00

abstract：:The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the inc...

journal_title：Nephron

authors： Pru CE,Fryd DS,Kjellstrand CM

更新日期：1984-01-01 00:00:00