[Regulation of erythropoietin synthesis].

abstract：BACKGROUND/AIM:Interleukin-6 (IL-6) promotes the growth of renal mesangial cells. IL-6 may play a major role in such mesangial proliferation, but there has been little research on IL-6 in relation to diabetic nephropathy because of the difficulty in measuring urinary and serum IL-6 levels. Using a newly developed, high...

journal_title：Nephron

authors： Shikano M,Sobajima H,Yoshikawa H,Toba T,Kushimoto H,Katsumata H,Tomita M,Kawashima S

更新日期：2000-05-01 00:00:00

abstract：:Calcitonin, whatever its origin, produces a decrease in the renal tubular reabsorption of sodium, phosphate and calcium in man and in the rat. Renal receptors for calcitonin have been demonstrated in the membranes of rat tubular cells using 125I salmon calcitonin as a tracer. Hormone-receptor interaction initiates the...

journal_title：Nephron

authors： Ardaillou R

更新日期：1975-01-01 00:00:00

abstract：:Complement factor D, a complement system serine protease, circulating in vivo as its active form, accumulates in patients with chronic renal failure. The pathophysiological role of this active protease in these patients was examined by studies on activities of excess factor D on 10 synthetic peptide substrates for som...

journal_title：Nephron

authors： Inagi R,Miyata T,Oda O,Maeda K,Inoue K

更新日期：1994-01-01 00:00:00

abstract：:Fibrinogen fragments (X, Y, D and E) and fibrin fragments (D-dimer and E) were examined in the urine of 52 patients with various types of renal diseases. One or more of the fibrinogen fragments were detectable in all the urine specimens. D-Dimer together with fibrinogen fragments was found in 38 of the 52 patients. Th...

journal_title：Nephron

authors： Yoshioka K,Iseki T,Akano N,Uraoka Y,Miyata H,Maki S

更新日期：1982-01-01 00:00:00

abstract：:Amyloid P component (AP) is a matrix glycoprotein of adult renal glomeruli. To establish whether the deposition of AP in glomeruli is an age-related phenomenon, this study used indirect immunofluorescence (IF) to investigate 34 renal biopsy specimens and 11 renal autopsy specimens. The biopsy specimens were taken from...

journal_title：Nephron

authors： Rantala IS,Helin HJ,Mustonen JT,Reunala T

更新日期：1997-01-01 00:00:00

abstract：:It is unknown whether continuous renal replacement techniques result in diminished morbidity and mortality when compared to conventional dialytic techniques. To investigate this issue a previously described, retrospectively studied group of critically ill patients with severe acute renal failure treated by conventiona...

journal_title：Nephron

authors： Bellomo R,Farmer M,Parkin G,Wright C,Boyce N

更新日期：1995-01-01 00:00:00

abstract：:In order to assess the effects of sodium depletion on tubular Na and H2O transport in man, renal clearance studies were performed under control conditions and after sodium depletion in 7 normal subjects. The control diet contained 250 mEq of Na daily. Sodium depletion was induced by placing subjects on a 20-mEq/day na...

journal_title：Nephron

authors： DiScala VA,Stein RM

更新日期：1982-01-01 00:00:00

abstract：:Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, ...

journal_title：Nephron

authors： Perico L,Benigni A,Remuzzi G

更新日期：2020-01-01 00:00:00

abstract：:A 62-year-old woman gave clinical manifestation of liver cirrhosis. Urinary protein was false positive, no uremia was found and renal changes were entirely overlooked. Deposition of abundant lipids (globoside and ceramide trihexoside) was found in the kidneys; essentially degenerative changes of the tubular epithelia ...

journal_title：Nephron

authors： Miyasaki K

更新日期：1975-01-01 00:00:00

abstract：:Recurrent intradialytic hypotension is probably the most severely disabling feature in dialysis patients and the etiology is multifactorial. We assessed the efficacy and safety of midodrine, a selective alpha1-adrenergic pressor agent in 12 patients with recurrent intradialytic hypotension. Symptomatic intradialytic h...

journal_title：Nephron

authors： Lim PS,Yang CC,Li HP,Lim YT,Yeh CH

更新日期：1997-01-01 00:00:00

abstract：:Norepinephrine (NE) content, release and uptake by brain synaptosomes are reduced in chronic renal failure (CRF), and this has been attributed to the state of secondary hyperparathyroidism. The decrease in NE content in CRF could not be explained by changes in NE uptake or release since in normal circumstances, NE con...

journal_title：Nephron

authors： Islam A,Smorgorzewski M,Zayed MA,Massry SG

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:De novo expression of CD44 is considered as a marker of parietal epithelial cell (PEC) activation. The aim of our study was to explore CD74 expression, which can form a complex with CD44, in PECs during the progression of focal segmental glomerulosclerosis (FSGS). To clarify the role of CD74 expression ...

journal_title：Nephron

authors： Yamazaki T,Sasaki S,Okamoto T,Sato Y,Hayashi A,Ariga T

更新日期：2016-01-01 00:00:00

abstract：:In 1991, to assess the risk of occupational exposure to blood or other body fluids in health-care workers (HCWs) working in the dialysis setting, properly trained interviewers used standardized questionnaires asking the 583 HCWs employed in 19 Italian dialysis units to recall exposures sustained in the previous year. ...

journal_title：Nephron

authors： Ippolito G,Petrosillo N,Puro V,Arici C,Jagger J

更新日期：1995-01-01 00:00:00

abstract：:The urinary transforming growth factor beta (TGF-beta) excretion was measured in 33 patients including 10 with systemic lupus erythematosus (SLE), 8 with focal glomerular sclerosis (FGS), 9 with IgA nephropathy (IgAN), and 6 with membranous nephropathy (MN), and in 7 healthy subjects by enzyme-linked immunosorbent ass...

journal_title：Nephron

authors： Kanai H,Mitsuhashi H,Ono K,Yano S,Naruse T

更新日期：1994-01-01 00:00:00

abstract：:In 88 patients with the nephrotic syndrome (NS) we estimated plasma volume (PV) with 131I-albumin (RISA) and calculated blood volume (BV) from PV and whole body hematocrit (Ht). To assess whether this method gives erroneously high values in the NS, the transcapillary escape rate of albumin (TER) and large vessel Ht/wh...

journal_title：Nephron

authors： Geers AB,Koomans HA,Boer P,Dorhout Mees EJ

更新日期：1984-01-01 00:00:00

abstract：:The physiologic action of prazosin in man was studied in 23 patients including 10 treated with prazosin plus polythiazide. Responders to prazosin alone (blood pressure fell greater than 10 mm Hg) had a decrease in peripheral resistance (p less than 0.02) and no significant change in plasma volume, while nonresponders'...

journal_title：Nephron

authors： Blaufox MD,Ross L,Koshy K,Lee HB

更新日期：1981-01-01 00:00:00

abstract：:We have previously documented the importance of tumor necrosis factor (TNF) alpha in the pathogenesis of nephrotoxic-serum nephritis in rats. In this study, we evaluated the possible relevance of the well-established cytocidal TNF activity to the mechanism of glomerular injury by assessing sensitivity of rat mesangial...

journal_title：Nephron

authors： Hruby ZW,Cybulsky AV,Lowry RP

更新日期：1990-01-01 00:00:00

abstract：:351 sera from 27 human recipients of renal allografts and 21 healthy blood donors were assayed for circulating immune complexes by the Clq solid-phase radioimmune assay. Increased Clq-binding activity (Clq-BA) was detected in pretransplant sera from 5 patients with chronic pyelonephritis (PN) and 3 patients with chron...

journal_title：Nephron

authors： Kaden J,Falck P,Groth J,Mebel M

更新日期：1981-01-01 00:00:00

abstract：:Tissue fluid and plasma oncotic pressure levels were measured in an unselected group of 13 patients presenting with congestive heart failure. Patients had a mean serum albumin of 3.6 g/dl +/- (SD) 0.35; serum oncotic pressure was 22.23 +/- 1.8 mm Hg; tissue fluid (lower leg) oncotic pressure was 0.985 +/- 0.34 mm Hg. ...

journal_title：Nephron

authors： Kwan T,Pintea M,Garcia Morino F,Preston RR,Li J,Caruso C,Berlyne SD,Berlyne GM

更新日期：1990-01-01 00:00:00

abstract：:The present prospective study was conducted in order to establish the relationship between complement activation and stimulation of phagocyte oxidative metabolism observed in long-term hemodialysis (HD) patients during the early phase of dialysis with cellulosic membranes. Two groups of 10 randomized (HD) patients tre...

journal_title：Nephron

authors： Descamps-Latscha B,Goldfarb B,Nguyen AT,Landais P,London G,Haeffner-Cavaillon N,Jacquot C,Herbelin A,Kazatchkine M

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Scientists use preclinical models of acute kidney injury (AKI) to decipher mechanisms and develop therapy, but translation of therapies to patients remains poor. Models that better resemble patients, including those within clinical care, should be considered. SUMMARY:Mice provide many advantages to the stud...

journal_title：Nephron

authors： Billings FT 4th

更新日期：2019-01-01 00:00:00

abstract：:Blood eosinophils were counted by the counting-chamber method in 21 regular hemodialysis patients. Before dialysis, eosinophil counts were within the normal range in all patients (mean 98 cells/mm3, range 6-350). After the first 15 min of hemodialysis, with not reused coils or hollow-fiber dialysers, a significant dro...

journal_title：Nephron

authors： Bodner G,Peer G,Zakuth V,Spirer ZH,Aviram A

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND/AIMS:Renal function deteriorates with age, but a few studies have addressed this longitudinally in elderly women. Our objective was, using 5 estimated glomerular filtration rates (eGFR)-equations, to evaluate changes in renal function and association with adverse outcomes for a decade in 75-year-old women. ...

journal_title：Nephron

authors： Malmgren L,McGuigan FE,Berglundh S,Westman K,Christensson A,Åkesson K

更新日期：2015-01-01 00:00:00

abstract：:Mizoribine has been shown to possess an immunosuppressive action that inhibits the proliferation of lymphocytes selectively by interfering with inosine monophosphate dehydrogenase. Recent studies have demonstrated that mizoribine improves renal tubulointerstitial fibrosis in the rat model of unilateral ureteral obstru...

journal_title：Nephron

authors： Sato N,Shiraiwa K,Kai K,Watanabe A,Ogawa S,Kobayashi Y,Yamagishi-Imai H,Utsunomiya Y,Mitarai T

更新日期：2001-10-01 00:00:00

abstract：:We investigated the best time of administration of desferrioxamine (DFO) with respect to the dialysis session, using the approach of the stochastic dynamic system, integrated with the classical pharmacokinetic models. In the 6 patients studied, the mean arrival times of DFO, aluminoxamine (AlO) and ferrioxamine (FO) w...

journal_title：Nephron

authors： Andriani M,Nordio M,Saporiti E

更新日期：1996-01-01 00:00:00

abstract：:A 65-year-old man with sclerosing mesenteritis developed the nephrotic syndrome. Percutaneous renal biopsy revealed classical histologic findings of minimal change nephropathy with a mild interstitial nephritis. Immunomodulation with prednisone led to a rapid and complete remission of the proteinuria but did not alter...

journal_title：Nephron

authors： Vernace MA,Bellucci AG,Mossey RT,Susin M,Mailloux LU,Wilkes BM,Katz S,Eskreis D

更新日期：1996-01-01 00:00:00

abstract：:Decreased serum levels of high-density lipoprotein cholesterol (HDL-C) are a well-known risk factor for coronary heart disease (CHD) in the general population and have been suggested as one of the best predictor of CHD after renal transplantation. However, very heterogeneous HDL-C levels have been reported in renal tr...

journal_title：Nephron

authors： Radeau T,Vohl MC,Houde I,Lachance JG,Noël R,Després JP,Douville P,Bergeron J

更新日期：2000-04-01 00:00:00

abstract：:It has been assumed, but not documented, that hypercalcemia induces an appreciable reduction in the serum anion gap (AG) because it represents an increase in the level of unmeasured cations. To test this question, we retrospectively compared the data of 59 hypercalcemic patients with malignancy [group 1, serum Ca 13.3...

journal_title：Nephron

authors： Oster JR,Gutierrez R,Schlessinger FB,Taylor A,Federman DG,Vaamonde CA

更新日期：1990-01-01 00:00:00

abstract：:A low-protein, low-phosphorus diet supplemented with essential amino acids and keto analogues was given to 12 rats, starting from the 90th day after subtotal nephrectomy. The purpose was to assess its effect on the residual renal function and on the nutritional status in rats with already established severe renal fail...

journal_title：Nephron

authors： Barsotti G,Moriconi L,Cupisti A,Dani L,Ciardella F,Lupetti S,Giovannetti S

更新日期：1988-01-01 00:00:00

abstract：:We followed renal function through the natriuretic phase of 6 occasions of drug-induced recovery from minimal lesions nephrotic syndrome (MLNS). Protein excretion started to fall 1-3 days prior to the start of the natriuresis. The natriuresis was accompanied by a rise in glomerular filtration rate (GFR, inulin clearan...

journal_title：Nephron

authors： Koomans HA,Boer WH,Dorhout Mees EJ

更新日期：1987-01-01 00:00:00