Circulating immune complexes after cadaver kidney transplantation.

Abstract:

:351 sera from 27 human recipients of renal allografts and 21 healthy blood donors were assayed for circulating immune complexes by the Clq solid-phase radioimmune assay. Increased Clq-binding activity (Clq-BA) was detected in pretransplant sera from 5 patients with chronic pyelonephritis (PN) and 3 patients with chronic glomerulonephritis (GN). A significant decrease of Clq-BA immediately after transplantation could not be found. 6 weeks after transplantation only 2 patients of the PN group showed increased Clq-BA. Serial studies in 17 patients with rejection crises did not show any correlation between the level of serum Clq-BA and the occurrence of rejections. Furthermore, no correlation could be found between the occurrence of complement-dependent lymphocytotoxic antibodies measured by the 51Cr release technique and the level of serum Clq-BA. In contrast, our results show that the probability of graftectomy or graft failure is significantly higher, at least in the early phase after transplantation, when the serum Clq-BA is lowered for several weeks.

journal_name

Nephron

journal_title

Nephron

authors

Kaden J,Falck P,Groth J,Mebel M

doi

10.1159/000182133

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

127-32

issue

3

eissn

1660-8151

issn

2235-3186

journal_volume

28

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Uremic pericardial effusion. Treatment by catheter drainage and local nonabsorbable steroid administration.

    abstract::Pericardial drainage via percutaneous catheter placement and local nonabsorbable steroid instillation was employed as definitive therapy for uremic patients who had intractable pericardial effusions. Twelve patients are reported. Prior daily dialysis, and in one case systemic steroids, were not curative. 11 of 12 case...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180622

    authors: Buselmeier TJ,Simmons RL,Najarian JS,Mauer SM,Matas AJ,Kjellstrand CM

    更新日期:1976-01-01 00:00:00

  • Ultrasonic tissue characterization of renal cell carcinoma tissue.

    abstract::The purpose of this study was to characterize renal cell carcinoma tissue by the measurement of microacoustic properties. A scanning acoustic microscope system operating in the frequency range of 100-200 MHz was employed and the attenuation constant and sound speed were measured on the two-dimensional distribution. Th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189291

    authors: Sasaki H,Tanaka M,Saijo Y,Okawai H,Terasawa Y,Nitta S,Suzuki K

    更新日期:1996-01-01 00:00:00

  • Case report of amyloidosis-like glomerulopathy with hepatic involvement.

    abstract::A few cases of nephrotic syndrome with the glomerular deposition of an amyloid-like material which did not stain with Congo red have been documented. But extrarenal deposits have not been previously reported in this disease. We describe here a case of nephrotic syndrome associated with the deposition of an amyloid-lik...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186449

    authors: Ozawa K,Yamabe H,Fukushi K,Osawa H,Chiba N,Miyata M,Seino S,Inuma H,Sasaki T,Yoshikawa S

    更新日期:1991-01-01 00:00:00

  • Parathyroid hormone plasma level in untreated chronic renal failure and in hemodialyzed patients.

    abstract::In 42 untreated patients at various stages of chronic renal failure, plasma level of parathyroid hormone was directly proportional to the degree of renal failure and inversely proportional to the serum calcium level. Plasma parathyroid hormone levels were frequently elevated in 21 patients undergoing regular dialysis ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180720

    authors: Fuss M,De Backer M,Brauman J,Nijs-Dewolf N,Manderlier T,Brauman H,Corvilain J

    更新日期:1976-01-01 00:00:00

  • Relationship of sympathetic nervous system tone and blood pressure.

    abstract::Plasma concentrations of norepinephrine (NE) appear to reflect sympathetic nervous system (SNS) tone. Plasma NE increases substantially when the SNS is stressed by acute postural change or physical exercise. Standing up from the recumbent position elevates NE by about 90% in healthy normotensive and hypertensive subje...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181614

    authors: Lake CR

    更新日期:1979-01-01 00:00:00

  • Effect of neutral pH and low-glucose degradation product-containing peritoneal dialysis solution on residual renal function in peritoneal dialysis patients: a meta-analysis.

    abstract:BACKGROUND:Glucose degradation products (GDPs) in peritoneal dialysis (PD) solution (PDS) have been shown to inflict damage to the kidney, which is the major organ for advanced glycosylation end product elimination. Hence, this study investigated whether new PDSs with neutral pH and low-GDPs have a beneficial effect on...

    journal_title:Nephron

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000368235

    authors: Wang J,Zhu N,Yuan W

    更新日期:2015-01-01 00:00:00

  • Effect of the antiplatelet agents ticlopidine and dipyridamole on nephrotoxic serum nephritis in rats.

    abstract::The effect of the antiplatelet agents, ticlopidine and dipyridamole, on nephrotoxic serum nephritis (NTN) was evaluated in rats. An accelerated form of NTN was induced with preimmunization of rabbit IgG 7 days before injection of rabbit antirat nephrotoxic serum. Twelve animals received a peroral dose of 20 mg of ticl...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184169

    authors: Izumino K,Iida H,Asaka M,Sasayama S

    更新日期:1987-01-01 00:00:00

  • Serum leptin concentrations in patients on hemodialysis.

    abstract::Serum leptin concentrations in normal humans have been reported to correlate with the body mass index (BMI) as well as with the body fat mass. In this study, we measured serum leptin concentrations in 107 patients on hemodialysis, 30 of whom had diabetes mellitus as the cause, and examined the clinical significance. F...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045122

    authors: Nakazono H,Nagake Y,Ichikawa H,Makino H

    更新日期:1998-09-01 00:00:00

  • Autoradiographic localization and age-related changes in vasopressin receptors in spontaneously hypertensive rats.

    abstract::To understand the regulation of vasopressin receptors in an animal model of hypertension, localization and age-related changes in renal arginine vasopressin (AVP) receptors in spontaneously hypertensive rats (SHR) were investigated using in vitro (macro) autoradiography and a radiolabeled receptor assay. Autoradiograp...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188855

    authors: Hosoya M,Ogura T,Watanabe H,Ota Z,Kageyama Z

    更新日期:1996-01-01 00:00:00

  • Kidneys of chronic alcoholic rats are more vulnerable to ischemic insult.

    abstract::The effects of chronic ethanol ingestion on the rat kidney were studied. Rats were fed a liquid diet containing ethanol for 5 weeks to induce chronic alcoholism. Renal ischemia was introduced by clamping the renal artery and vein either for 10 or 20 min. The glomerular filtration rate (GFR) and the renal blood flow (R...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185729

    authors: Ishigami M,Ohnishi ST,Chan R,Shimada Y,Yabuki S

    更新日期:1989-01-01 00:00:00

  • Use of immunomodulators (thymopentine) in hepatitis B vaccine in elderly patients undergoing chronic hemodialysis.

    abstract::Thymopentine is a synthetic immunomodulator that positively affects T-lymphocyte maturation, reproduction and differentiation. In elderly uremic patients nonresponders to hepatitis B vaccine, the administration of this drug has been shown to improve the response to the new vaccination. ...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000186942

    authors: Melappioni M,Baldassari M,Baldini S,Radicioni R,Panichi N

    更新日期:1992-01-01 00:00:00

  • Membranous glomerulonephritis associated with enterococcal endocarditis.

    abstract::An autopsy case of membranous glomerulonephritis associated with enterococcal endocarditis was reported. Although enterococcal antigen was not identified in glomerular deposits, the eluate from the patient's renal tissue was shown to specifically recombine with cells of the enterococcus isolated from his own ante mort...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183435

    authors: Iida H,Mizumura Y,Uraoka T,Takata M,Sugimoto T,Miwa A,Yamagishi T

    更新日期:1985-01-01 00:00:00

  • Clinicopathological study of patients with mesangial isolated C3d deposition in various glomerular diseases.

    abstract::The clinicopathological findings of isolated mesangial C3d deposition in the absence of other complement components or immunoglobulins are summarized. 55 out of 242 individual human renal biopsies examined by immunoperoxidase microscopy had isolated C3d deposition. This group consisted of 12 patients with chronic glom...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184339

    authors: Doi T,Kanatsu K,Suehiro F,Nagai H,Yoshida H,Hamashima Y

    更新日期:1987-01-01 00:00:00

  • Impaired renal hemodynamic but conserved natriuretic response to dopamine in patients with renal disease.

    abstract::Renal hemodynamics and sodium excretion were determined before and during infusion of dopamine in doses ranging from 0.25 to 8 micrograms/kg/min in healthy volunteers (n = 15) and in patients with renal disease and moderately impaired renal function (n = 21, baseline glomerular filtration rate 34-85 ml/min). While in ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185674

    authors: Smit AJ,Meijer S,Wesseling H,Reitsma WD,Donker AJ

    更新日期:1989-01-01 00:00:00

  • A new kindred with hereditary hypophosphatemic rickets with hypercalciuria: implications for correct diagnosis and treatment.

    abstract::Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a new autosomal form of hypophosphatemic rickets, recently described. This disease is characterized, and differs from other forms of hereditary hypophosphatemic rickets and/or osteomalacia by increased serum levels of 1,25-dihydroxyvitamin D, hypercalci...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187029

    authors: Tieder M,Arie R,Bab I,Maor J,Liberman UA

    更新日期:1992-01-01 00:00:00

  • A Multicenter Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR).

    abstract:BACKGROUND:Idiopathic membranous nephropathy remains the leading cause of nephrotic syndrome in Caucasian adults. Immunosuppressive therapy with cyclosporine (CSA) is often successful in reducing proteinuria, but its use is associated with a high relapse rate. Rituximab, a monoclonal antibody that specifically targets ...

    journal_title:Nephron

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000430849

    authors: Fervenza FC,Canetta PA,Barbour SJ,Lafayette RA,Rovin BH,Aslam N,Hladunewich MA,Irazabal MV,Sethi S,Gipson DS,Reich HN,Brenchley P,Kretzler M,Radhakrishnan J,Hebert LA,Gipson PE,Thomas LF,McCarthy ET,Appel GB,Jeffers

    更新日期:2015-01-01 00:00:00

  • New Ways of Understanding Membranous Nephropathy.

    abstract:BACKGROUND:In the last decade, great advances have been made in the field of membranous nephropathy (MN). The autoimmune nature of the disease has been confirmed with the description of diverse antigens, and few but very important prospective trials regarding treatment alternatives have been published, changing profoun...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000506948

    authors: Trujillo H,Alonso M,Praga M

    更新日期:2020-01-01 00:00:00

  • Basophil sensitization for food allergens in idiopathic nephrotic syndrome.

    abstract::To estimate food sensitization, the human basophil degranulation test (HBDT), usually used for allergy diagnosis, was performed in 34 idiopathic nephrotic syndrome (INS) patients, classified as minimal change glomerular disease, with or without atopic manifestations, and in 19 blood donors; five food allergens (wheat ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183650

    authors: Lagrue G,Heslan JM,Belghiti D,Sainte-Laudy J,Laurent J

    更新日期:1986-01-01 00:00:00

  • Josephus Andreas Jacobus Plenck - a forerunner of modern diuretic therapy.

    abstract::Joseph Andreas Jacobus Plenck was born in 1735 in Vienna where he studied surgery with Johan Christian Retter. At age 35 he was appointed Professor of Surgery and Obstetrics by Maria Theresia. Subsequently he became professor and life long secretary of the Medical Military Academy know as the Josephinum where he worke...

    journal_title:Nephron

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000064450

    authors: De Santo NG,Aliotta A,De Santo RM,Aliotta G

    更新日期:2002-09-01 00:00:00

  • Insulin and the kidney.

    abstract::Changes in renal function and structure are frequently observed in patients with diabetes mellitus. In the early phases of the disease, alterations in glomerular filtration rate, renal plasma flow, glomerular permeability and tubular capacity for glucose reabsorption occur. In the late stages of juvenile onset diabete...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000180518

    authors: Rubenstein AH,Mako ME,Horwitz DL

    更新日期:1975-01-01 00:00:00

  • Control of aldosterone secretion.

    abstract::This paper reviews the control of aldosterone secretion, including the role played by hepatic metabolic clearance, ACTH, and the renin-angiotensin system, and the interrelationships of aldosterone secretion with sodium and potassium metabolism. The physiological modulations of aldosterone secretion by the upright post...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181613

    authors: Chan JC

    更新日期:1979-01-01 00:00:00

  • Usefulness of a highly sensitive urinary and serum IL-6 assay in patients with diabetic nephropathy.

    abstract:BACKGROUND/AIM:Interleukin-6 (IL-6) promotes the growth of renal mesangial cells. IL-6 may play a major role in such mesangial proliferation, but there has been little research on IL-6 in relation to diabetic nephropathy because of the difficulty in measuring urinary and serum IL-6 levels. Using a newly developed, high...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045634

    authors: Shikano M,Sobajima H,Yoshikawa H,Toba T,Kushimoto H,Katsumata H,Tomita M,Kawashima S

    更新日期:2000-05-01 00:00:00

  • High Serum Sclerostin Levels Are Associated with a Better Outcome in Haemodialysis Patients.

    abstract:BACKGROUND:Sclerostin is an osteocyte hormone that decreases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chronic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high. AIM:To assess the correlation of serum sclerostin levels ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000443845

    authors: Jean G,Chazot C,Bresson E,Zaoui E,Cavalier E

    更新日期:2016-01-01 00:00:00

  • Mesangial deposition of J chain-linked polymeric IgA in IgA nephropathy.

    abstract::Renal biopsy specimens from 8 patients with IgA nephropathy (Berger's disease) were examined immunocytochemically at the light and electron microscopic levels with peroxidase-labeled antibodies to IgA, IgM, J chain and secretory component. In 2 of the 8 specimens heavy deposits of IgA, but no IgM, were found in the me...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182907

    authors: Komatsu N,Nagura H,Watanabe K,Nomoto Y,Kobayashi K

    更新日期:1983-01-01 00:00:00

  • Atrial natriuretic peptide and arginine vasopressin in pregnancy and pregnancy-induced hypertension.

    abstract::Atrial natriuretic peptide (ANP) and arginine vasopressin concentrations were measured in 9 patients with pregnancy-induced hypertension. The results were compared to those found in 7 normal pregnant women matched for age, duration of pregnancy, and parity. Plasma ANP levels were significantly higher in the pregnancy-...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185040

    authors: Elias AN,Vaziri ND,Pandian MR,Powers DR,Domurat E

    更新日期:1988-01-01 00:00:00

  • Urinary excretion of alpha 2 mu-globulin and albumin by adult male rats following treatment with nephrotoxic agents.

    abstract::Nephrotoxic agents such as puromycin aminonucleoside (PAN) and sodium maleate (MAL) have been used to induce experimental glomerular proteinuria and tubular disease, respectively. Current studies show that PAN caused a massive loss of albumin in the urine while not affecting the excretion of the smaller, sex-dependent...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182134

    authors: Neuhaus OW,Flory W,Biswas N,Hollerman CE

    更新日期:1981-01-01 00:00:00

  • Prognosis of chronic renal failure. III. Survival after one peritoneal dialysis.

    abstract::Survival after serum creatinine exceeded 10.0 mg/100 ml was increased if one peritoneal dialysis was performed. After one peritoneal dialysis 'survival' of 62 patients to the present time, death or the next dialysis averaged 119 days; median survival was 28 days. Characteristics of prolonged survivors were persisten...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180488

    authors: Maher JF,Ahearn DJ,Bryan CW,Nolph KD

    更新日期:1975-01-01 00:00:00

  • Severe acute renal failure: a comparison of acute continuous hemodiafiltration and conventional dialytic therapy.

    abstract::It is unknown whether continuous renal replacement techniques result in diminished morbidity and mortality when compared to conventional dialytic techniques. To investigate this issue a previously described, retrospectively studied group of critically ill patients with severe acute renal failure treated by conventiona...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188675

    authors: Bellomo R,Farmer M,Parkin G,Wright C,Boyce N

    更新日期:1995-01-01 00:00:00

  • Interference of heparin with peritoneal solute transport.

    abstract::To verify the action of heparin on peritoneal transport, we selected 20 patients on acute peritoneal dialysis and performed two 2-hour cycles with 2,000 cm3 of a 1.5% solution, adding 2,000 units of heparin to the second cycle. The patients were also randomized into 2 groups: group A, adding 1.5 mg gentamycin/kg to th...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000183336

    authors: Ponce SP,Barata JD,Santos JR

    更新日期:1985-01-01 00:00:00

  • Glycosaminoglycans and oxalocalcic urolithiasis.

    abstract::A very simple analytical procedure with dimethylmethylene blue as photometric reagent was applied for the evaluation of glycosaminoglycan (GAG) urinary excretions and concentrations in both sexes, calcium oxalate stone formers, and a control group. The GAG concentrations varied significantly in stone formers (males an...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188306

    authors: Grases F,Llompart I,Conte A,Coll R,March JG

    更新日期:1994-01-01 00:00:00