Abstract：
:Nephrotoxic agents such as puromycin aminonucleoside (PAN) and sodium maleate (MAL) have been used to induce experimental glomerular proteinuria and tubular disease, respectively. Current studies show that PAN caused a massive loss of albumin in the urine while not affecting the excretion of the smaller, sex-dependent alpha 2 mu-globulin. On the other hand, MAL which inhibits the reabsorption of proteins, increased the loss of both alpha 2 mu and albumin. Both nephrotoxic agents increased the excretion of albumin when administered to female rats. MAL-induced proteinuria was used as a direct measure of the renal load for alpha 2 mu and albumin. Renal loads and excretion of alpha 2 mu and albumin were measured in male rats maintained on 0, 20, and 50% casein diets. On the protein-free diet, the excretion of both alpha 2 mu and albumin was reduced (less than 1 mg daily); their renal loads were almost totally reabsorbed. On a 50% casein diet the reabsorption of alpha 2 mu was reduced from a normal of 60% to 10% of the renal load. Thus the high protein diet increased the excretion of alpha 2 mu while having little effect on the excretion of albumin. We suggest that dietary protein exerts two levels of control on the excretion of protein in the urine of the adult male rat. Protein-deficient diets stimulate the general reabsorption of proteins thereby minimizing the excretion of alpha 2 mu and albumin. High protein diets appear to reduce selectively the reabsorption of alpha 2 mu-globulin, thereby increasing its excretion in the urine.
journal_name
Nephronjournal_title
Nephronauthors
Neuhaus OW,Flory W,Biswas N,Hollerman CEdoi
10.1159/000182134subject
Has Abstractpub_date
1981-01-01 00:00:00pages
133-40issue
3eissn
1660-8151issn
2235-3186journal_volume
28pub_type
杂志文章相关文献
NEPHRON文献大全abstract：:Cadmium-induced renal effects were followed (1989) in 16 workers previously exposed to cadmium, who had been shown 5 years earlier to have had tubular damage; all but 1 worker had persistent tubular damage (beta 2-microglobulin > 60 micrograms/mmol creatinine). The mean glomerular filtration rate (GFR) decreased from ...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000187282
更新日期：1993-01-01 00:00:00
abstract：:Collagenolytic activity of rat kidneys with streptozotocin diabetes was estimated by means of a biological collagenase assay and compared to healthy controls. Collagenolytic activity was found significantly decreased in rat kidneys with diabetes correlating with blood glucose levels (r = -0.82, p less than 0.001). Ele...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000182517
更新日期：1982-01-01 00:00:00
abstract：BACKGROUND:Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue might lie with pattern recognition receptors (PRRs), which are triggers of ischemic i...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000456016
更新日期：2017-01-01 00:00:00
abstract：:A retrospective analysis of renal vein renin results has been done in 96 patients with renal artery stenosis and hypertension studied in two Italian centers (Sassari and Pisa) with respect to the outcome of either surgery or percutaneous transluminal angioplasty (PTA). In all patients the renal vein renin ratio and th...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000184039
更新日期：1986-01-01 00:00:00
abstract：:A retrospective study of 100 patients followed for 1-4 years after successful renal transplantation was undertaken to assess the amelioration of previously present metabolic bone disease and to determine the risk factors associated with the development of osteonecrosis. 42% of patients showed some evidence of bony abn...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000181455
更新日期：1978-01-01 00:00:00
abstract：:Most hypertensive subjects are overweight, and as a consequence have an increased prevalence of hypercholesterolaemia, impaired glucose tolerance, and left ventricular hypertrophy. Reduction of the blood pressure by antihypertensive drugs without control of the obesity leaves these additional risk factors for cardiova...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000184543
更新日期：1987-01-01 00:00:00
abstract：:Decreased serum levels of high-density lipoprotein cholesterol (HDL-C) are a well-known risk factor for coronary heart disease (CHD) in the general population and have been suggested as one of the best predictor of CHD after renal transplantation. However, very heterogeneous HDL-C levels have been reported in renal tr...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000045608
更新日期：2000-04-01 00:00:00
abstract：:Urate deposits within microtophi were found in 8% of unselected autopsies in Brisbane, Australia. Significant association were demonstrated with (a) a history of gouty arthritis and (b) the existence of nitrogen retention and renal disease of apparently primary, but not gouty, origin. However, in 26% of the patients, ...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000182373
更新日期：1981-01-01 00:00:00
abstract：:In vitro formation of prostaglandins (PG) E2, F2 alpha, 6-keto-F1 alpha, and thromboxane B2 (TxB2) by glomeruli from rats with reduced renal mass (RRM) were evaluated by radioimmunoassay. Four weeks following ablation of renal mass, PGE2, PGF2 alpha, and TxB2 production by glomeruli from RRM rats was significantly gre...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000183676
更新日期：1986-01-01 00:00:00
abstract：:To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP) in the regulation of blood pressure in uremic patients, and to determine the effect of various types of dialyzer membranes on hemodialysis (HD)-induced changes in pla...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000187399
更新日期：1993-01-01 00:00:00
abstract：:The effects of each of several tannins purified from Rhei Rhizoma on serum constituents were investigated in rats with adenine-induced renal failure. Blood levels of urea nitrogen, methylguanidine (MG), and guanidinosuccinic acid (GSA) were significantly decreased in rats given (-)-epicatechin 3-O-gallate at a dose of...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000186406
更新日期：1991-01-01 00:00:00
abstract：:The recent experience of six large trials of antihypertensive therapy has not clearly demonstrated any beneficial effect on the prevention of coronary heart disease (CHD). The data from the HDFP study have been analyzed by three cholesterol strata at baseline. The higher the baseline cholesterol levels, the greater th...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000184564
更新日期：1987-01-01 00:00:00
abstract：:Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not exclusively filtered by the kidney and rises relatively late after the onset of acute kidney injury (AKI). This leads to delays in recog...
journal_title：Nephron
pub_type： 杂志文章,评审
doi：10.1159/000509352
更新日期：2020-01-01 00:00:00
abstract：:15 patients who had benign, uncomplicated essential hypertension, were treated with chlorthiazide (500 mg twice a day) with or without propranolol (10--20 mg 4 times a day), and the effect of the treatment on plasma renin activity (PRA), urinary aldosterone excretion, total body potassium (TBK) and plasma sodium and p...
journal_title：Nephron
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1159/000181403
更新日期：1978-01-01 00:00:00
abstract：BACKGROUND/AIM:The ultrasonic transit time is currently the best method for measuring the blood flow rate in the extracorporeal hemodialysis circuit. The purpose of this study was to analyze the differences between blood flow as indicated by the hemodialysis blood roller pump (prescribed blood flow) and by an ultrasoni...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000045647
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:At present, the determination of dry weight in patients on hemodialysis is largely made empirically by trial and error. Extracellular volume (ECV) assessment by bioimpedance analysis (BIA) is a preferable technique for determining dry weight, and it also provides useful data on body composition. METHODS:We ...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000064471
更新日期：2002-09-01 00:00:00
abstract：:3-Deoxyglucosone (3-DG) has been identified as an intermediate of the Maillard reaction in vitro. We measured serum 3-DG levels using gas chromatography/mass spectrometry and found a marked elevation in serum 3-DG levels in uremic patients compared with healthy subjects. The uremic patients with diabetes showed signif...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000188516
更新日期：1995-01-01 00:00:00
abstract：:Because of the great problem of viral hepatitis in hemodialysis patients, the Italian Society of Nephrology decided to perform a national epidemiologic survey. We contacted 467 nephrological centers by a questionnaire which let us have information on 25,746 uremic patients: 18,338 on HD, 2,250 on PD and 5,176 with kid...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000186905
更新日期：1992-01-01 00:00:00
abstract：:This study was conducted to test the hypothesis that the margin of safe fluoride exposure is narrowed in rats that are physiologically compromised by renal dysfunction. The study objective was to determine whether increases in fluoride retention and tissue fluoride levels in rats with surgically induced renal insuffic...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000044888
更新日期：1998-01-01 00:00:00
abstract：:The effect of isotonic mannitol and saline in the early phase of mercuric chloride-(HgCl2-)induced acute renal failure (ARF) in the dog was evaluated. During the first 3 h after HgCl2 alone, glomerular filtration rate (GFR) fell from 1.94 +/- 0.14 to 1.04 +/- 0.11 and renal blood flow (RBF) from 13.99 +/- 1.18 to 7.28...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000183307
更新日期：1984-01-01 00:00:00
abstract：:The effect of treatment with 1 alpha-hydroxycholecalciferol (1 alpha-OH-D3) and different diets on uremic arterial disease was studied. Three groups of rabbits with chronic renal failure (CRF) were kept on three diets with a low, medium or high content of calcium and phosphate. Half the rabbits in each group were trea...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000183007
更新日期：1983-01-01 00:00:00
abstract：:The porphyrin status of 38 renal transplant patients was investigated using a sensitive thin-layer chromatographic assay. Abnormalities of porphyrin synthesis observed in patients on hemodialysis were generally reversed on receipt of a transplant with sustained good renal function. Urinary coproporphyrin levels and th...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000182426
更新日期：1982-01-01 00:00:00
abstract：:Acute interstitial nephritis (AIN) has been reported in association with therapy with a number of drugs. We report a patient who developed drug-related AIN while receiving intravenous amoxicillin therapy. The patient developed rash, secondary temperature elevation, and eosinophilia in association with nonoliguric rena...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000182077
更新日期：1981-01-01 00:00:00
abstract：:Focal segmental glomerulosclerosis (FSGS) is a histological pattern of podocyte and glomerulus injury. FSGS can be primary and secondary to other diseases or due to a genetic cause. Strikingly, genetic causes for adult-onset FSGS are often overlooked, likely because identifying patients with genetic forms of FSGS base...
journal_title：Nephron
pub_type：
doi：10.1159/000499937
更新日期：2019-01-01 00:00:00
abstract：:A previously described method for recovering a proximal renal tubular epitheal antigen (HRTE-1) from normal human kidney was modified by using ion-exchange and immunoaffinity chromatography in order to create easily reproducible conditions for antigen isolation. Radioiodinated HRTE-1 was then used to establish a 3-hou...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000181942
更新日期：1980-01-01 00:00:00
abstract：:We examined the ultrastructure of the bovine glomerular basement membrane (GBM) and tubular basement membrane (TBM) using ultra-high-resolution scanning electron microscopy after conductive staining without metal coating. Purified basement membranes (BMs) were obtained by sonication and acellular BMs by detergent trea...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000187800
更新日期：1994-01-01 00:00:00
abstract：:A long-term hemodialysis male patient was known to have systemic iron overload due to regular blood transfusions. As he was suspected to have aluminum overload, he received a single intravenous administration of desferrioxamine (that supported the hypothesis). Four days later, he became highly febrile with no focus of...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000185208
更新日期：1988-01-01 00:00:00
abstract：:The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000046096
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Urinary neutrophil gelatinase associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are markers of acute kidney injury. The albuminuria is a well-known abnormality after physical exercise. The aim of this study was to investigate changes in uNGAL and uKIM-1 after intensive exerc...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000481179
更新日期：2018-01-01 00:00:00
abstract：:The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the inc...
journal_title：Nephron
pub_type： 杂志文章
doi：10.1159/000183150
更新日期：1984-01-01 00:00:00
