Comparison between mannitol and saline infusion in HgCl2-induced acute renal failure.

Abstract:

:The effect of isotonic mannitol and saline in the early phase of mercuric chloride-(HgCl2-)induced acute renal failure (ARF) in the dog was evaluated. During the first 3 h after HgCl2 alone, glomerular filtration rate (GFR) fell from 1.94 +/- 0.14 to 1.04 +/- 0.11 and renal blood flow (RBF) from 13.99 +/- 1.18 to 7.28 +/- 0.77 ml/min X kg BW. Isotonic mannitol alone resulted in a fall of GFR by 22% (p less than 0.05 vs. control), but the subsequent administration of HgCl2 could not induce a further fall in GFR and RBF. A similar, if somewhat less pronounced, protective effect was observed when mannitol was started simultaneously with or 2 h after the HgCl2 injection. Infusion of isotonic saline at the same rate as mannitol did not prevent a fall of GFR and RBF from a premercury value of 2.33 +/- 0.31 to 1.36 +/- 0.26 and 16.83 +/- 3.06 to 9.30 +/- 2.65 ml/min X kg BW, respectively. In contrast, massive doses of isotonic saline, provoking urinary volume and solute losses comparable to those observed with mannitol, stabilized GFR after HgCl2 at the normal level (delta GFR = -3%). No relationship between delta GFR and urinary Hg excretion or renal tissue Hg content could be established. In summary, isotonic mannitol prevented the fall of GFR normally observed in the early phase of HgCl2-induced ARF. This effect was not volume mediated and not due to a higher Hg excretion. The protection was correlated with its osmotic diuretic effect.

journal_name

Nephron

journal_title

Nephron

authors

Vanholder R,Leusen I,Lameire N

doi

10.1159/000183307

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

193-201

issue

3

eissn

1660-8151

issn

2235-3186

journal_volume

38

pub_type

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