Abstract:
:Urate deposits within microtophi were found in 8% of unselected autopsies in Brisbane, Australia. Significant association were demonstrated with (a) a history of gouty arthritis and (b) the existence of nitrogen retention and renal disease of apparently primary, but not gouty, origin. However, in 26% of the patients, a retrospective survey of their medical records did not reveal any causative factor. The possible aetiological importance of the urine flow rate is stressed. The presence of medullary urate deposits at autopsy was most frequently associated with a history of gout or the presence of pre-existing and non-gouty renal disease, although no aetiological factor could be determined in a quarter of the cases.
journal_name
Nephronjournal_title
Nephronauthors
Linnane JW,Burry AF,Emmerson BTdoi
10.1159/000182373subject
Has Abstractpub_date
1981-01-01 00:00:00pages
216-22issue
5-6eissn
1660-8151issn
2235-3186journal_volume
29pub_type
杂志文章相关文献
NEPHRON文献大全abstract::As the nephron population diminishes and azotemia develops, each remaining nephron adapts and increases its function by as much as 80%. To determine whether this adaption is permanent or transient, a rat model utilizing one remnant kidney and one normal control kidney was used. In stage one, immediately after ligation...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182879
更新日期:1982-01-01 00:00:00
abstract::A very simple analytical procedure with dimethylmethylene blue as photometric reagent was applied for the evaluation of glycosaminoglycan (GAG) urinary excretions and concentrations in both sexes, calcium oxalate stone formers, and a control group. The GAG concentrations varied significantly in stone formers (males an...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188306
更新日期:1994-01-01 00:00:00
abstract::In a 21-year-old Caucasian women with von Hippel-Lindau disease, norepinephrine-producing adrenal pheochromocytoma was identified as the underlying cause of severe hypertension. She was found to have extremely elevated levels of circulating renin and aldosterone, and she was markedly hypokalemic. Administration of cap...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187071
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:A high prevalence of cardiovascular diseases (CVDs) and infections in patients with chronic kidney disease (CKD) arises partly due to a high inflammatory state and aberrations in immune cells function. Following in vitro stimulation of leukocytes with different T-cell mitogens, we observed a lower level of i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000471814
更新日期:2017-01-01 00:00:00
abstract::A study was conducted to determine whether intraperitoneal and oral administration of formalin-fixed gram-negative bacteria induced immunohistologically and ultrastructurally evident glomerular deposition of IgA and C3 in C3H/HeN mice. Separate treatments with strains of Pseudomonas aeruginosa, Escherichia coli, Haemo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187474
更新日期:1993-01-01 00:00:00
abstract::Bradykinin (BK) elicits extracellular-dependent [Ca2+](i) elevations in mouse mesangial cells (MMC) that are not blocked by verapamil, nifedipine, L-nicardipine, NiCl(2), or LaCl(3). The aim of the present study was to evaluate the mechanisms involved in calcium influx induced by BK in MMC. [Ca2+](i) was analyzed thro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000058409
更新日期:2002-06-01 00:00:00
abstract::The mechanisms by which intercurrent bacterial infections are associated with increased tissue injury in some forms of glomerulonephritis may include complement activation by bacteria and subsequent increased glomerular neutrophil (PMN) infiltration. We have studied the effect of complement activation after cobra veno...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185578
更新日期:1989-01-01 00:00:00
abstract:AIM:Most transplant centres use SV40 large T antigen (TAg) staining for the diagnosis and assessment of BK polyomavirus-associated nephropathy (BKPyVAN). This study was performed to evaluate the significance of capsid protein VP1 expression in BKPyVAN. METHODS:We performed immunohistochemical staining using anti-SV40 ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000510967
更新日期:2020-01-01 00:00:00
abstract::Losses in thyroxine-binding globulin (TBG) in peritoneal dialysate and thyroid function were evaluated in patients undergoing continuous ambulatory peritoneal dialysis (CAPD), in comparison to patients on hemodialysis (HD) without TBG loss in the dialysate. The TBG concentration in the peritoneal dialysate was 0.26 +/...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183634
更新日期:1986-01-01 00:00:00
abstract::Oral phosphatidylcholine at 900 mg/day was given to 4 patients with high lymph absorption for 8 weeks. Fluid and solute transfer before and after treatment were compared to 4 similar controls given placebo. None of the patients had overt ultrafiltration problems. After treatment, overnight peritoneal effluent phosphol...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000186527
更新日期:1991-01-01 00:00:00
abstract::An 11-year-old boy developed Kaposi's sarcoma and progressive T lymphocyte deficiency 5 years after cadaveric kidney transplantation for end-stage renal disease. He had received 17 individual red blood cell transfusions prior to and during transplantation in 1980. Human immunodeficiency virus (HIV) was cultured from b...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184458
更新日期:1987-01-01 00:00:00
abstract::We report a patient with compensated congestive heart failure who developed acute anuric renal failure immediately after indomethacin and triamterene had been added to the treatment regimen. Renal function failed to improve promptly with discontinuation of these medications, anuria persisting for 11 days. While it is ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183461
更新日期:1985-01-01 00:00:00
abstract::The authors utilized two groups of adult male rats to study the effect of chronic-uremic toxemia on the synthesis of thyroid hormones. The control group was sham operated, while the other group had about 70--80% of the left kidney tissue surgically excised and a total right nephrectomy performed 10 days later. At the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181516
更新日期:1978-01-01 00:00:00
abstract::Diffuse crescentic glomerulonephritis was observed in a 40-year-old male patient who had a ventriculoatrial shunt implanted after a traffic accident 10 years previously. Immediately after treatment with immunosuppressants and plasma pheresis, signs of meningitis and septicemia developed. The responsible organism isola...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183441
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND/AIM:Acute renal failure (ARF) is one of the common problems associated with sepsis or multiple organ dysfunction syndrome (MODS). We have investigated the effects of inhibiting selectin-mediated cell adhesion on lipopolysaccharide-induced ARF in rabbits, using sialyl Lewis X oligosaccharide and PB1.3, an ant...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045942
更新日期:2001-04-01 00:00:00
abstract::Epidermal nevus syndrome is an unusual neurocutaneous disorder in which epidermal nevi are associated with abnormalities of the skeleton and central nervous system, including the eyes and somtimes the cardiovascular system. We treated a patient in whom the latter included renal artery stenosis. An 18-year-old man with...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045540
更新日期:2000-01-01 00:00:00
abstract::To clarify the in vivo involvement of cellular adhesion molecules and cytokines in human glomerulonephritis, we have investigated the glomerular and interstitial expression of intercellular adhesion molecule 1 (ICAM-1) in 69 kidney biopsy specimens by immunohistochemical methods and its correlation with serum bioactiv...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000190225
更新日期:1997-01-01 00:00:00
abstract::Exaggerated natriuresis in response to hypertonic saline infusion occurs with great regularity in patients with documented previous attacks of poststreptococcal glomerulonephritis. Five patients were studied before and after 1 week of dietary sodium restriction in order to examine the possibility that increased extrac...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180852
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND/AIMS:Increased susceptibility of the kidney to acute renal failure (ARF) in the setting of sepsis even in the absence of systemic hypotension is well known. In the hypothesis that the proinflammatory cytokines and lipopolysaccharide (LPS) in gram-negative sepsis can directly cause renal tubular cell apoptosi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064280
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND/AIMS:The renal prognosis of post-renal acute kidney injury (PoR-AKI) has not been verified so far. The objective of this study was to assess the association of baseline anemia with long-term renal prognosis in patients with PoR-AKI. METHODS:We performed a multicenter retrospective cohort study. Consecutive ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000452810
更新日期:2017-01-01 00:00:00
abstract::Previously, we have shown that insulin binding (IB) to erythrocytes was decreased in uremic patients and that hemodialysis corrected the receptor defect. In the present study cross-incubation experiments were performed using uremic and control erythrocytes and plasma. Incubation of control erythrocytes with uremic pla...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182990
更新日期:1983-01-01 00:00:00
abstract::Computerized tomography (CT) has the advantage of allowing the isolation of trabecular bone of the axial skeleton, which is the more sensitive to metabolic changes. By means of single-energy X-ray CT we have devised a method for assessing trabecular bone mass (TBM) at L-4 vertebral body, which has an acceptable reprod...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184007
更新日期:1986-01-01 00:00:00
abstract::Calcitonin, whatever its origin, produces a decrease in the renal tubular reabsorption of sodium, phosphate and calcium in man and in the rat. Renal receptors for calcitonin have been demonstrated in the membranes of rat tubular cells using 125I salmon calcitonin as a tracer. Hormone-receptor interaction initiates the...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180515
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000371448
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Pruritus is one of the most common and disturbing symptoms in hemodialysis (HD) patients. The pathogenesis of pruritus in HD patients is multifactorial; however, a little progress in understanding this pathogenesis has been achieved. OBJECTIVES:To evaluate the frequency and risk factors of pruritus among HD...
journal_title:Nephron
pub_type: 杂志文章,多中心研究
doi:10.1159/000501409
更新日期:2019-01-01 00:00:00
abstract::The effect of treatment with 1 alpha-hydroxycholecalciferol (1 alpha-OH-D3) and different diets on uremic arterial disease was studied. Three groups of rabbits with chronic renal failure (CRF) were kept on three diets with a low, medium or high content of calcium and phosphate. Half the rabbits in each group were trea...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183007
更新日期:1983-01-01 00:00:00
abstract::5 patients, including 4 with partial lipodystrophy and 1 with dense deposit disease (type II mesangiocapillary glomerulonephritis; MCGN), had positive C3 nephritic factor assays by both a crossed-gel immunoelectrophoretic and a magnesium-dependent hemolytic assay. One or more early classic complement component was sig...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181754
更新日期:1980-01-01 00:00:00
abstract::Previous reports on the nephritogenic and immunological enhancing capacity of posttransplant circulating immune complexes (CICs) are conflicting and have been confined to the study of acute rejection episode (AR). This study was undertaken to assess the nephritogenicity of CICs in patients undergoing accelerated acute...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182633
更新日期:1982-01-01 00:00:00
abstract::Previous studies of IgA nephropathy have demonstrated a number of prognostically significant clinical and pathological factors in groups of patients with the full histological spectrum of the disease. Whether these factors can be applied to a group of IgA nephropathy patients with disease of moderate degree is unknown...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184518
更新日期:1987-01-01 00:00:00
abstract::The urinary transforming growth factor beta (TGF-beta) excretion was measured in 33 patients including 10 with systemic lupus erythematosus (SLE), 8 with focal glomerular sclerosis (FGS), 9 with IgA nephropathy (IgAN), and 6 with membranous nephropathy (MN), and in 7 healthy subjects by enzyme-linked immunosorbent ass...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187852
更新日期:1994-01-01 00:00:00