Decreased renal clearance of xanthine and hypoxanthine in a patient with renal hypouricemia: a new defect in renal handling of purines.

abstract：BACKGROUND/AIMS:In our earlier studies, we reported high concentrations of intra- and extracellular calcium ions (Ca2+) in the deeper epidermis of patients with chronic kidney disease (CKD) and associated pruritus. To determine the cause of this phenomenon, we measured total calcium (TCa) concentrations in the deeper e...

journal_title：Nephron

authors： Momose A,Shiraiwa Y,Narita S,Kusumi T,Goto S,Sera K

更新日期：2017-01-01 00:00:00

abstract：:In 2014 57.5% of HD patients and 62.7% of PD patients achieved the audit measure for phosphate. 29.0% of HD and 30.3% of PD patients had a serum phosphate above the audit standard range. 79.1% of HD and 79.7% of PD patients had adjusted calcium between 2.2–2.5 mmol/L. 57.4% of HD and 65.0% of PD patients had a serum P...

journal_title：Nephron

authors： Nicholas J,Evans R,Shaw C,Dawnay A

更新日期：2016-01-01 00:00:00

abstract：:Methylguanidine (MG), guanidinosuccinic acid (GSA) and creatinine (Cr), which accumulate in the body in parallel with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine was given to rats for 24 days to induce renal fai...

journal_title：Nephron

authors： Yokozawa T,Mo ZL,Oura H

更新日期：1989-01-01 00:00:00

abstract：:ExHC rats were bred from the Sprague-Dawley strain and are highly susceptible to dietary hypercholesterolemic stimuli. Although chemical and histological examination of the aorta from ExHC rats fed a diet containing 3% cholesterol, 0.6% sodium cholate and 15% olive oil (high-cholesterol diet, HCD) has been reported, r...

journal_title：Nephron

authors： Hattori M,Yamaguchi Y,Kawaguchi H,Ito K

更新日期：1993-01-01 00:00:00

abstract：:We reviewed the recommendations and outcomes for all patients with diabetes mellitus and end-stage renal disease referred to the Medical Center Hospital of Vermont from 1971 through December 1983. During this period, we recommended transplantation in 53 of 73 patients evaluated. Thirty-two transplants were performed i...

journal_title：Nephron

authors： Rimmer JM,Sussman M,Foster R,Gennari FJ

更新日期：1986-01-01 00:00:00

abstract：:A modified sieving technique has been developed to isolate pure glomeruli from monkey, sheep, dog, rabbit and rat kidney. Glomeruli from all these species have been grown in tissue culture and the glomerular cell outgrowth studied by light microscopy and time-lapse cinemicroscopy. The pattern of growth was the same fo...

journal_title：Nephron

authors： Holdsworth SR,Glasgow EF,Atkins RC,Thomson NM

更新日期：1978-01-01 00:00:00

abstract：:To verify the action of heparin on peritoneal transport, we selected 20 patients on acute peritoneal dialysis and performed two 2-hour cycles with 2,000 cm3 of a 1.5% solution, adding 2,000 units of heparin to the second cycle. The patients were also randomized into 2 groups: group A, adding 1.5 mg gentamycin/kg to th...

journal_title：Nephron

authors： Ponce SP,Barata JD,Santos JR

更新日期：1985-01-01 00:00:00

abstract：:Gentamicin doses of 40 mg/kg body weight/day were administered intravenously to 62 Wistar rats. Nineteen animals were also treated orally with an NaHCO3 solution in place of water. The gentamicin-treated animals showed increased albuminuria immediately after the 3rd day of treatment. The fact that this increase was ma...

journal_title：Nephron

authors： Coimbra TM,Lachat JJ

更新日期：1988-01-01 00:00:00

abstract：:An unusual case of progressive systemic sclerosis with rapidly progressing renal failure after a successful delivery is described. The presenting syndrome was malignant hypertension. The blood pressure was refractory to the various therapeutic measures which were instituted, including hemodialysis. The patient, theref...

journal_title：Nephron

authors： Ehrenfeld M,Licht A,Stessman J,Yanko L,Rosenmann E

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND/AIMS:Cardiac surgery-associated severe acute kidney injury (SAKI) is associated with high mortality and poor quality of life. A prognostic score for SAKI may enable prevention of complications. METHODS:This observational study of 2,552 patients undergoing cardiac surgery from January 2006 to December 2011 i...

journal_title：Nephron

authors： Che M,Wang X,Liu S,Xie B,Xue S,Yan Y,Zhu M,Lu R,Qian J,Ni Z,Zhang W,Wang B

更新日期：2019-01-01 00:00:00

abstract：:A simple three-pump-based system for the performance of continuous venovenous haemodialysis is described. The method employs access to the circulation via a double-lumen catheter, and by means of a standard extracorporeal peristaltic pump the blood is circulated through a haemofiltration filter. Standard solutions for...

journal_title：Nephron

authors： Møller Jensen D,Bistrup C,Pedersen RS

更新日期：1996-01-01 00:00:00

abstract：:We determined the clinical and immunopathological effects of dilazep hydrochloride (dilazep) on IgA nephropathy of ddY mice. Group I (early-treatment group, n = 10) was orally treated with 300 mg/kg body weight of this drug from 12 weeks of age until 60 weeks of age, and group II (late-treatment group, n = 10) was als...

journal_title：Nephron

authors： Hayashi T,Kaneko S,Thang NT,Shou I,Shirato I,Tomino Y

更新日期：2000-11-01 00:00:00

abstract：:The role of T cell-mediated immunity in the early phase of nephrotoxic serum nephritis (NTN) was examined by transfer of pan T, CD8-positive, and CD4-positive cells. The disease was induced by transferring rabbit gamma-globulin (RGG)-sensitized T cells to nude (rnu/rnu) rats pretreated with a subnephritogenic dose (a ...

journal_title：Nephron

authors： Kuroda T,Kawasaki K,Oite T,Arakawa M,Shimizu F

更新日期：1994-01-01 00:00:00

abstract：:As with many other amino acids the transport of cystine across the tubular epithelium is coupled to a parallel transport of sodium. We have studied the effect of a sodium-restricted diet on the urinary excretion of cystine in 13 patients with cystinuria, 7 of whom were treated with the SH compound tiopronin (2-mercapt...

journal_title：Nephron

authors： Lindell A,Denneberg T,Edholm E,Jeppsson JO

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Sclerostin is an osteocyte hormone that decreases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chronic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high. AIM:To assess the correlation of serum sclerostin levels ...

journal_title：Nephron

authors： Jean G,Chazot C,Bresson E,Zaoui E,Cavalier E

更新日期：2016-01-01 00:00:00

abstract：:To probe renal hemodynamic measurements in relation to simultaneous systemic hemodynamic measurements in normal, adult, conscious dogs on a magnesium-deficient diet, 6 experimental animals were given 4 weeks of a magnesium-deficient diet compared to 9 animals whose dietary magnesium was normal. Systemic hemodynamics w...

journal_title：Nephron

authors： Zawada ET Jr,TerWee JA,McClung DE

更新日期：1988-01-01 00:00:00

abstract：:Diabetic nephropathy is the leading cause of kidney failure. Treatments with drugs that block the renin-angiotensin system have proven beneficial in slowing kidney disease progression among those with diabetes; their benefit is limited and they do not stop disease progression. Despite multiple clinical trials of vario...

journal_title：Nephron

authors： Toto RD

更新日期：2017-01-01 00:00:00

abstract：:Since 1987, we have experienced 11 children with acute renal failure (ARF) associated with Yersinia pseudotuberculosis (YP) infection. The illness began with the sudden onset of high fever, skin rash and gastrointestinal symptoms. Later in the course, periungual desquamation developed, mimicking Kawasaki disease. Elev...

journal_title：Nephron

authors： Cheong HI,Choi EH,Ha IS,Lee HJ,Choi Y

更新日期：1995-01-01 00:00:00

abstract：:Recent studies have shown that the mass transfer coefficients (MTC) for low- and middle-molecular-weight substances are maintained at medium terms in patients under continuous ambulatory peritoneal dialysis (CAPD) therapy. We have studied the MTC for parathormone (MW 5,500-6,000) in 29 patients under CAPD. 11 patients...

journal_title：Nephron

authors： Rodríguez-Carmona A,Selgas R,Martínez ME,Ortí F,Miguel JL,Salinas M,Riñón C,Sánchez-Sicilia L

更新日期：1984-01-01 00:00:00

abstract：:The main regulatory hormone for the control of erythropoiesis is erythropoietin (EPO). This glycoprotein has a molecular weight of 34,000 daltons, about 40% of which is represented by carbohydrates. EPO leads to an enhanced mitosis and differentiation of erythroid precursors (colony-forming unit erythroid) in the bone...

journal_title：Nephron

authors： Bauer C,Kurtz A,Eckardt KU,Tannahill L

更新日期：1989-01-01 00:00:00

abstract：:It has been reported that calcium deposition and calcium content in cultured human aortic smooth muscle cells (SMC) increased when the cells are incubated in a medium with a high phosphate concentration (2 mM). To determine the cellular components or soluble factors contributing to the deposition, we cultured commerci...

journal_title：Nephron

authors： Watanabe Y,Suzuki M,Oyama Y,Kusano E,Tamba K,Iimura O,Ito C,Imai M,Asano Y

更新日期：2002-12-01 00:00:00

abstract：:Medullary sponge kidney was found in association with congenital absence of teeth (anodontia) in 3 siblings of a single family. Anodontia occurs in the rare familial syndrome of ectodermal dysplasia, but its association with a renal (mesodermal) anomaly is not known. The present report lends further support to a possi...

journal_title：Nephron

authors： Khoury Z,Brezis M,Mogle P

更新日期：1988-01-01 00:00:00

abstract：:Ischemic acute kidney injury (AKI) is predominantly mediated by the innate inflammatory response to damage-associated molecular patterns released during the reperfusion phase of the ischemic event. In this study, we show that pre-emptive IgM infusions to increase binding of natural IgM (nIgM) anti-leucocyte autoantibo...

journal_title：Nephron

authors： Lobo PI,Okusa MD

更新日期：2019-01-01 00:00:00

abstract：:CBA/CaH-kdkd mice develop hereditary tubulointerstitial disease with mononuclear cell infiltration and cyst formation, possibly representing a model of human nephronophthisis. The purpose of the present investigation was to examine the components of the fibrotic changes which typically develop in the kidneys of these ...

journal_title：Nephron

authors： Sibalic V,Sun L,Sibalic A,Oertli B,Ritthaler T,Wüthrich RP

更新日期：1998-11-01 00:00:00

abstract：:Preeclampsia (PE) represents an important cause of acute kidney injury during pregnancy with a high rate of both maternal and fetal morbidity and mortality. The presence of endothelial dysfunction is the main cause of PE development; however, the pathogenic mechanisms are not still fully elucidated. A plethora of harm...

journal_title：Nephron

authors： Pagani F,Cantaluppi V

更新日期：2019-01-01 00:00:00

abstract：:The renal cortex of anesthetized dogs was found to contain per gram lyophilized dry weight 9.5+/-0.6 micronmol ATP, 3.2+/-0.5 MICRONMOL ADP, 0.68+/-0.3 MICRONMOL AMP, and 22.5+/-4.4 micronmol Pi. These amounts were unchanged by the administration of moderate amounts of saline or hypertonic mannitol in load doses of ab...

journal_title：Nephron

authors： Urbaitis BK,Blake WD

更新日期：1977-01-01 00:00:00

abstract：:Cytomegalovirus is the most important viral infection in kidney transplants, but rarely affects the allograft after the sixth month posttransplantation. We present a patient who developed renal failure eighteen months posttransplant; a kidney biopsy showed cytomegalovirus inclusions, acute tubular necrosis and mild in...

journal_title：Nephron

authors： Trimarchi H,Jordan R,Iotti A,Forrester M,Iotti R,Freixas E,Martínez J,Schropp J,Pereyra H,Efrón E

更新日期：2002-10-01 00:00:00

abstract：:By April 26, 2020, infections related to coronavirus disease 2019 (COVID-19) affected people from 210 countries and caused 203,818 reported deaths worldwide. A few studies discussed the outcome of COVID-19 in kidney transplant recipients. This short series demonstrates our experience in managing COVID-19 disease in re...

journal_title：Nephron

authors： Elhadedy MA,Marie Y,Halawa A

更新日期：2020-12-08 00:00:00

abstract：:Renal biopsy specimens from 8 patients with IgA nephropathy (Berger's disease) were examined immunocytochemically at the light and electron microscopic levels with peroxidase-labeled antibodies to IgA, IgM, J chain and secretory component. In 2 of the 8 specimens heavy deposits of IgA, but no IgM, were found in the me...

journal_title：Nephron

authors： Komatsu N,Nagura H,Watanabe K,Nomoto Y,Kobayashi K

更新日期：1983-01-01 00:00:00

abstract：:In 42 untreated patients at various stages of chronic renal failure, plasma level of parathyroid hormone was directly proportional to the degree of renal failure and inversely proportional to the serum calcium level. Plasma parathyroid hormone levels were frequently elevated in 21 patients undergoing regular dialysis ...

journal_title：Nephron

authors： Fuss M,De Backer M,Brauman J,Nijs-Dewolf N,Manderlier T,Brauman H,Corvilain J

更新日期：1976-01-01 00:00:00