Abstract:
BACKGROUND/AIMS:Anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is a cause of biopsy-proven acute kidney injury, more common in the elderly. Treatment requires immunosuppression, which can have significant toxic effects. The aim of this study was to assess whether morbidity and mortality that are associated with immunosuppression for AAV varied with age. METHODS:A retrospective review of 232 patients given induction therapy with prednisolone and cyclophosphamide was conducted. Information was collected on baseline characteristics (including requirement for dialysis at presentation) and the occurrence of leukopenia, infection, end-stage renal disease and death during follow-up. RESULTS:Median follow-up was 51 months. Older patients (aged ≥70 years) were treated with lower total cyclophosphamide doses than those aged <70 years (mean 7.3 g (SD 4.4) vs. 10.7 g (SD 7.4), respectively). Increasing age was associated with an increased risk of leukopenia (odds ratio (OR) 1.50; 95% confidence interval (CI) 1.20-1.86; p < 0.001), and older patients were more likely to develop infections in the first year (OR 1.87; 95% CI 1.1-3.2). Older patients were also significantly more likely to require dialysis at presentation (OR 1.66; 95% CI 1.13-2.5) and longer term. After multivariable adjustment, age and requirement for dialysis at presentation were significant predictors of death (hazard ratio (HR) per year of age 1.07; 95% CI 1.03-1.11; p < 0.001 and HR 2.2; 95% CI 1.10-4.38; p = 0.03, respectively). CONCLUSIONS:Among patients treated with prednisolone and cyclophosphamide, increasing age and dialysis dependency were associated with worse survival. Older patients were more likely to develop treatment-related complications despite lower cumulative doses of immunosuppression. Morbidity and mortality associated with treatment must therefore be carefully balanced against that associated with the disease process itself.
journal_name
Nephronjournal_title
Nephronauthors
Judge PK,Reschen ME,Haynes R,Sharples EJdoi
10.1159/000447018subject
Has Abstractpub_date
2016-01-01 00:00:00pages
223-31issue
4eissn
1660-8151issn
2235-3186pii
000447018journal_volume
133pub_type
杂志文章相关文献
NEPHRON文献大全abstract::The protective efficacy of three schedules of a recombinant hepatitis B vaccine was evaluated in 42 patients undergoing dialysis at a teaching hospital. The rate of seroconversion after vaccination was highest (82.3%) among the recipients of three 20-micrograms doses (i.e. double the conventional dose for healthy adul...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000189103
更新日期:1996-01-01 00:00:00
abstract::It is unknown whether continuous renal replacement techniques result in diminished morbidity and mortality when compared to conventional dialytic techniques. To investigate this issue a previously described, retrospectively studied group of critically ill patients with severe acute renal failure treated by conventiona...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188675
更新日期:1995-01-01 00:00:00
abstract::Human peritoneal mesothelial cells lie on a basement membrane-like material consisting of fibronectin (FN), type I collagen (CI), type III collagen (CIII) and laminin (LA). To understand how these extracellular matrix (ECM) proteins affect mesothelial cell behavior, we investigated their effect on the adhesion and pro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189530
更新日期:1997-01-01 00:00:00
abstract::The aim of this study was to assess the psychosocial effects of exercise training on hemodialysis (HD) patients. Thirty-one uremic patients, aged 50.6+/-11.6 years, on maintenance HD were studied. Twenty patients were selected at random for a 6-month exercise renal rehabilitation program (ERRP) consisting of 3 weekly ...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000190266
更新日期:1997-01-01 00:00:00
abstract::We followed renal function through the natriuretic phase of 6 occasions of drug-induced recovery from minimal lesions nephrotic syndrome (MLNS). Protein excretion started to fall 1-3 days prior to the start of the natriuresis. The natriuresis was accompanied by a rise in glomerular filtration rate (GFR, inulin clearan...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184486
更新日期:1987-01-01 00:00:00
abstract::We encountered 11 patients with aluminum-associated bone disease (AABD), and treated them with deferoxamine (DFO). In 3 patients, a second bone biopsy was done during DFO treatment. Clinical features of AABD were compared with surgically proven secondary hyperparathyroidism (2 degrees HPT) with osteitis fibrosa on X-r...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183668
更新日期:1986-01-01 00:00:00
abstract::To explain the occurrence of tubular and glomerular proteinuria in patients with primarily tubular or glomerular dysfunction, it is usually assumed that the mechanisms responsible for the renal tubular transport of small and large proteins are different. The present in vivo study does not support this hypothesis since...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184090
更新日期:1987-01-01 00:00:00
abstract::Animal models are essential tools to understand the mechanisms underlying the development and progression of renal disease and to study potential therapeutic approaches. Recently, interventional models suitable to induce acute and chronic kidney disease in the mouse have become a focus of interest due to the wide avai...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000445171
更新日期:2016-01-01 00:00:00
abstract::In normal subjects, the gastric ionisation of calcium and phosphate seems to be a prerequisite for their intestinal absorption. We investigated the behavior of the plasma calcium and phosphate profile in 30 patients on regular dialysis treatment in the 6 h following a meal containing 1 g of calcium and 2 g of phosphat...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064290
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:A constant finding in beta (2)-microglobulin (beta 2m) amyloidosis is an increase in tissue heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans (PGs) at sites of amyloid deposits. However, the binding characteristics of PGs with beta 2m have not been elucidated yet. METHODS:Using affinity retard...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000049037
更新日期:2002-02-01 00:00:00
abstract::We studied the effects of mid-term enalapril administration on protein-load-induced renal responses in 10 patients with early chronic renal failure (serum creatinine 2.70 +/- 1.0 mg/dl). The oral protein load was performed twice, before and after a 10-day therapy with enalapril. Glomerular filtration rate (125I-iothal...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185624
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Idiopathic membranous nephropathy remains the leading cause of nephrotic syndrome in Caucasian adults. Immunosuppressive therapy with cyclosporine (CSA) is often successful in reducing proteinuria, but its use is associated with a high relapse rate. Rituximab, a monoclonal antibody that specifically targets ...
journal_title:Nephron
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000430849
更新日期:2015-01-01 00:00:00
abstract::The morphologic basis of proteinuria in experimental chronic serum sickness glomerulonephritis in rabbits was studied by light and electron microscopy using horseradish peroxidase (effective radius 30 A; mol. wt. 40,000) and ferritin (effective radius 60 A; mol. wt. 480,000) as protein tracers. It was found that more ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181260
更新日期:1978-01-01 00:00:00
abstract::We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046114
更新日期:2001-12-01 00:00:00
abstract::The effects of chronic ethanol ingestion on the rat kidney were studied. Rats were fed a liquid diet containing ethanol for 5 weeks to induce chronic alcoholism. Renal ischemia was introduced by clamping the renal artery and vein either for 10 or 20 min. The glomerular filtration rate (GFR) and the renal blood flow (R...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185729
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND/AIMS:Children with a solitary functioning kidney have a risk of renal injury caused by hyperfiltration. Timely intervention with renin-angiotensin inhibitors may be beneficial. We examined whether trajectory of estimated glomerular filtration rate (eGFR) would predict renal injury, defined as microalbuminuri...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000490200
更新日期:2018-01-01 00:00:00
abstract::The purpose of this study was to identify and characterize humic compounds in Anticolana Valley (Fiuggi) water. The capacity of this class of compounds to mobilize metals from solid phases could have an important role in calculi solubilization. Humic compounds were isolated, purified and characterised by FTIR, 1H-NMR ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046304
更新日期:1999-01-01 00:00:00
abstract::Plasma immunoreactive atrial natriuretic factor (ANF) levels, their chromatographic profiles (high-performance liquid chromatography; HPLC) and changes during sequential ultrafiltration (UF; 1 litre/h) and biochemical correction without fluid removal (BC; 3 h) were studied in 8 end-stage chronic renal failure patients...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000185919
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Experimental evidence suggests that hyperosmolality may be a causative factor in the development of both salt-sensitive hypertension and chronic kidney disease (CKD). There are no population-wide studies in young persons to assess the relationships among these factors. OBJECTIVE:To determine the association...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000497780
更新日期:2019-01-01 00:00:00
abstract::A retrospective analysis of renal vein renin results has been done in 96 patients with renal artery stenosis and hypertension studied in two Italian centers (Sassari and Pisa) with respect to the outcome of either surgery or percutaneous transluminal angioplasty (PTA). In all patients the renal vein renin ratio and th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184039
更新日期:1986-01-01 00:00:00
abstract::We describe two preparations for chronic peritoneal dialysis in the dog. In one group uremia was induced by nephrectomy and in the other by ureteral ligation. Peritoneal access was obtained using the Ash disc column catheter. Survival of the animals ranged from 27 to 83 days. Using a dialysis schedule similar in conce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183093
更新日期:1983-01-01 00:00:00
abstract::Hyperparathyroidism is a common problem for patients on renal replacement therapy programs. Many long-term dialysis patients require parathyroidectomy while on dialysis. Some patients, however, despite severe renal osteodystrophy, are transplanted, and in these a large proportion show a slow resolution of bony problem...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046051
更新日期:2001-09-01 00:00:00
abstract::Sickle cell nephropathy characterized by proteinuria and predominantly glomerular lesions has not been studied as extensively as renal tubular alterations in sickle cell disease. We reviewed our experience with this entity over a 14-year period. Of 13 children with either proteinuria or the nephrotic syndrome, 8 showe...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183404
更新日期:1985-01-01 00:00:00
abstract::A previously described method for recovering a proximal renal tubular epitheal antigen (HRTE-1) from normal human kidney was modified by using ion-exchange and immunoaffinity chromatography in order to create easily reproducible conditions for antigen isolation. Radioiodinated HRTE-1 was then used to establish a 3-hou...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181942
更新日期:1980-01-01 00:00:00
abstract::A 55-year-old white male, with silicosis diagnosed 10 years earlier, presented massive proteinuria with microscopic hematuria, moderate renal failure and distal polyneuropathy. Bilateral renal angiography showed multiple intraparenchymal saccular aneurysms. Renal biopsy disclosed a focal segmental necrotizing glomerul...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185391
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Post-transplant diabetes mellitus (PTDM) is a frequent and severe complication after renal transplantation. In fact, PTDM is a risk factor for both infection and cardiovascular diseases. The prevalence and incidence of PTDM have a bimodal evolution: early (up to 3 months) and late PTDM (beyond 12 months). Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000511320
更新日期:2021-01-01 00:00:00
abstract::We reviewed the recommendations and outcomes for all patients with diabetes mellitus and end-stage renal disease referred to the Medical Center Hospital of Vermont from 1971 through December 1983. During this period, we recommended transplantation in 53 of 73 patients evaluated. Thirty-two transplants were performed i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183693
更新日期:1986-01-01 00:00:00
abstract::Bradykinin (BK) elicits extracellular-dependent [Ca2+](i) elevations in mouse mesangial cells (MMC) that are not blocked by verapamil, nifedipine, L-nicardipine, NiCl(2), or LaCl(3). The aim of the present study was to evaluate the mechanisms involved in calcium influx induced by BK in MMC. [Ca2+](i) was analyzed thro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000058409
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND/AIMS:Glomerular basement membrane (GBM) thickening and mesangial matrix expansion are characteristic features of diabetic nephropathy. The present study investigates the role of endothelins (ETs) in the pathogenesis of such changes in diabetic nephropathy. METHODS:Diabetic (streptozotocin-induced, 65 mg/kg)...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046319
更新日期:2002-01-01 00:00:00
abstract::Serum prolactin levels were elevated in male Sprague-Dawley rats with acute renal failure induced by glycerol administration. Specific prolactin binding to kidney membrane preparations was reduced in glycerol and antirat glomerular basement membrane serum-treated rats, after morphological and biochemical acute renal f...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182078
更新日期:1981-01-01 00:00:00