Abstract:
:To explain the occurrence of tubular and glomerular proteinuria in patients with primarily tubular or glomerular dysfunction, it is usually assumed that the mechanisms responsible for the renal tubular transport of small and large proteins are different. The present in vivo study does not support this hypothesis since it clearly shows that small and large proteins (e.g., beta 2-microglobulin and albumin) can compete for renal uptake. Our results lead us to postulate the existence of common tubular reabsorption sites for which proteins exhibit different affinities depending on their charge, size and conformation.
journal_name
Nephronjournal_title
Nephronauthors
Bernard A,Viau C,Ouled A,Lauwerys Rdoi
10.1159/000184090subject
Has Abstractpub_date
1987-01-01 00:00:00pages
115-8issue
2eissn
1660-8151issn
2235-3186journal_volume
45pub_type
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