Abstract:
:A four-year-old male with steroid refractory nephrotic syndrome was found to have diffuse deposition of alpha 2-macroglobulin (alpha 2M) in the glomeruli which showed diffuse mesangial proliferation and partial hyalinization by light microscopy. Camostat mesylate, a commercially available synthetic proteinase inhibitor, led to biochemical and clinical improvement. Twenty-two patients with 7 biopsy-proven renal diseases did not have any deposition of alpha 2M in their kidney tissue. Though the pathogenetic mechanism is unknown, this is probably the first report of the deposition of alpha 2M in renal tissue.
journal_name
Nephronjournal_title
Nephronauthors
Asami T,Ohsawa S,Tomisawa S,Hashimoto K,Toyabe S,Sakai Kdoi
10.1159/000186874subject
Has Abstractpub_date
1992-01-01 00:00:00pages
211-3issue
2eissn
1660-8151issn
2235-3186journal_volume
61pub_type
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