Abstract:
:End-stage renal disease (ESRD) is common, costly, and it results from progressive chronic kidney disease (CKD). ESRD claims many lives every year. It is increasingly recognized that episodes of acute kidney injury (AKI) predispose to the future development of CKD and ESRD. While our understanding of the pathophysiology of the AKI to CKD transition is improving, there are no validated therapeutic strategies to prevent this transition. In this review, we summarize the recent progress made in defining the cellular and molecular events underlying the AKI to CKD transition and highlight potential therapeutic targets and strategies to reduce the incidence of CKD following AKI.
journal_name
Nephronjournal_title
Nephronauthors
Ó hAinmhire E,Humphreys BDdoi
10.1159/000474960subject
Has Abstractpub_date
2017-01-01 00:00:00pages
264-267issue
4eissn
1660-8151issn
2235-3186pii
000474960journal_volume
137pub_type
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