Abstract:
:Diabetic nephropathy (DN), a distinct manifestation of diabetic kidney disease, affects approximately 30% of patients with diabetes. While most attention has been focused on glomerular changes related to DN, there is growing evidence that tubulopathy is a key feature in the pathogenesis of this disease. The renal proximal tubule cells (RPTCs) are particularly sensitive to the deleterious effect of chronic hyperglycemia. However, the cellular changes that control the dysfunction of the RPTCs are not fully understood. Controlling glucose reabsorption in the proximal tubules via inhibition of glucose transporters (GLUT) has emerged as a promising therapeutic in ameliorating DN. Overactivation of the renal endocannabinoid (eCB) system via the cannabinoid-1 receptor (CB1R) contributes to the development of DN, and its blockade by globally acting or peripherally restricted CB1R antagonists has been shown to ameliorate renal dysfunction in different murine models for diabetes. Recently, we have utilized various pharmacological and genetic tools to show that the eCB/CB1R system contributes to the development of DN via regulating the expression, translocation, and activity of the facilitative GLUT2 located in the RPTCs. These findings have the potential to be translated into therapy, and support the rationale for the preclinical development of novel renal-specific CB1R and/or GLUT2 inhibitors for the treatment of DN.
journal_name
Nephronjournal_title
Nephronauthors
Hinden L,Tam Jdoi
10.1159/000494512subject
Has Abstractpub_date
2019-01-01 00:00:00pages
24-27issue
1eissn
1660-8151issn
2235-3186pii
000494512journal_volume
143pub_type
杂志文章,评审相关文献
NEPHRON文献大全abstract::Three unusual cases are described which demonstrated hypomagnesemia and symptoms resembling magnesium deficiency syndrome. The hypomagnesemia was most likely secondary to urinary losses from diuresis following release of post-renal obstruction and renal homotransplantation. Heretofore, this association has not been de...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180457
更新日期:1975-01-01 00:00:00
abstract::A 5-year-old Chinese girl had had absence seizures and received sodium valproate (VPA) treatment which provided good control. Six months later, she developed interstitial nephritis with proteinuria and microhematuria. Renal biopsy revealed interstitial nephritis with granular deposition of immunoglobulin G (IgG) and C...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184867
更新日期:1988-01-01 00:00:00
abstract:AIM:To determine the prevalence of kidney disease in a cohort of individuals with silicosis. METHODS:Review of medical records and questionnaires from patients reported to a state surveillance system for silicosis. Reporting of individuals with silicosis is required by state law. All individuals with silicosis reporte...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045624
更新日期:2000-05-01 00:00:00
abstract::Propranolol-induced hypoglycemia in hemodialysis patients has been increasingly recognized. We studied the effects of a nonselective beta-blocker (propranolol) and a beta 1-selective-blocker (metoprolol) on glucose metabolism during pharmacologic hyperglucagonemia in these patients. cAMP and insulin responses to gluca...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183367
更新日期:1985-01-01 00:00:00
abstract::Conglomerates of food and mucus or phytobezoars composed of vegetable matter are sometimes found in the stomach in the general population. Reports of phytobezoars in uremic patients are, however, scarce. Here we describe 2 uremic patients in which esophagogastroduodenoscopy was performed due to dyspepsia associated wi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000049075
更新日期:2002-03-01 00:00:00
abstract::We studied the expression of Mac-1 on granulocytes (flow cytometry) from 9 patients (27 examinations) during hemodialysis with cuprophane membranes (CuM). Samples were drawn before dialysis and from the arterial and venous lines at 5, 15 and 180 min. Granulocytopenia was most pronounced after 15 min of treatment. Mac-...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186865
更新日期:1992-01-01 00:00:00
abstract::Renal biopsy specimens from 8 patients with IgA nephropathy (Berger's disease) were examined immunocytochemically at the light and electron microscopic levels with peroxidase-labeled antibodies to IgA, IgM, J chain and secretory component. In 2 of the 8 specimens heavy deposits of IgA, but no IgM, were found in the me...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182907
更新日期:1983-01-01 00:00:00
abstract::We conducted a retrospective study with 750 peritoneal dialysis (PD) patients in a Spanish multicenter registry between 1993 and 1999 to analyze comorbidity and mortality in type 1 diabetes (T1D), type 2 diabetes (T2D) and nondiabetic (ND) patients. 163 patients (21.7%) were diabetic--96 T1D (58.8%) and 67 T2D (42.2%)...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000049065
更新日期:2002-03-01 00:00:00
abstract::Urinary excretion of oxalate, calcium and urate has been investigated in 88 patients affected by idiopathic calcium oxalate stone disease and in 20 normal subjects. Of these ions, only oxalate was found significantly higher in stone formers. Defining hyperoxaluria as urinary oxalate excretion greater than 2 SD above n...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183037
更新日期:1983-01-01 00:00:00
abstract:AIMS AND METHODS:This study was carried out to clarify whether the urinary excretion of type IV collagen (u-IV collagen) detected by specific radioimmunoassay, can be used as an indicator for the progression of diabetic nephropathy. RESULTS:u-IV collagen was higher in diabetic subjects with microalbuminuria and overt ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045709
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND/AIMS:Enamel-renal syndrome is characterized by nephrocalcinosis, enamel defects, gingival hyperplasia and eruption failures. It has been recently identified that recessive mutations in the FAM20A gene result in amelogenesis imperfecta (AI)-gingival fibromatosis. The aim of this research to determine whether ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000486607
更新日期:2018-01-01 00:00:00
abstract::We studied the effects of oral furosemide, 80 mg/day for 7 days, on the response of urinary excretion of phosphate and cyclic AMP to exogenous parathyroid extract (PTE) in 6 normal subjects. All 6 subjects had marked increases in urinary calcium and a significant increase in urinary cyclic AMP from the control to the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183610
更新日期:1985-01-01 00:00:00
abstract::To clarify the in vivo involvement of cellular adhesion molecules and cytokines in human glomerulonephritis, we have investigated the glomerular and interstitial expression of intercellular adhesion molecule 1 (ICAM-1) in 69 kidney biopsy specimens by immunohistochemical methods and its correlation with serum bioactiv...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000190225
更新日期:1997-01-01 00:00:00
abstract::Plasma levels of granulocyte lactoferrin, granulocyte myeloperoxidase and granulocyte elastase in complex with alpha 1-proteinase inhibitor were investigated during hemodialysis in oliguric patients following cadaveric renal transplantation (CRT). The results were compared with those of patients undergoing regular hem...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184333
更新日期:1987-01-01 00:00:00
abstract::The daily loss of apolipoproteins into the dialysate from 5 patients on continuous ambulatory peritoneal dialysis (CAPD) was measured. The mean excretion of apolipoprotein (apo) AI and apo AII, major proteins of high-density lipoproteins (HDL), were 84 and 17 mg/day, respectively, while that of apo B, a major protein ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185289
更新日期:1989-01-01 00:00:00
abstract::To investigate autonomic mechanisms underlying persistent hypotension in long-term hemodialysis patients, high-frequency (HF, > 0.15 Hz) and low-frequency (LF, 0.04-0.15 Hz) components of heart rate variability and plasma noradrenaline were analyzed in 10 persistently hypotensive hemodialysis patients (group H), 11 no...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188906
更新日期:1996-01-01 00:00:00
abstract::A 57-year-old man with renal cell carcinoma associated with membranous glomerulonephropathy (MGN) developed a transient amelioration of the nephrotic syndrome after excision of the tumor. We tried to identify a nephritogenic tumor antigen using the immunoblotting technique in this patient with MGN, since previous stud...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000049047
更新日期:2002-02-01 00:00:00
abstract::Medullary sponge kidney was found in association with congenital absence of teeth (anodontia) in 3 siblings of a single family. Anodontia occurs in the rare familial syndrome of ectodermal dysplasia, but its association with a renal (mesodermal) anomaly is not known. The present report lends further support to a possi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184918
更新日期:1988-01-01 00:00:00
abstract::Pruritus is a common symptom among patients undergoing long-term hemodialysis. However, its etiology remains unclear. In an attempt to clarify its cause we tried to correlate pruritus and its intensity with several serological variables in 94 hemodialysis patients. Our results show that higher serum aluminum concentra...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189499
更新日期:1997-01-01 00:00:00
abstract::Postnephrectomy serum has been proved to enhance proliferation of mesangial cells in culture. Studies in offspring to uninephrectomized (UNx) mothers indicate that it remains active for a long period following UNx. On the other hand, postnephrectomy renal compensatory growth in vivo is known to be completed within a s...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044913
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION/AIMS:The Acute Kidney Injury Network classification is based on small increases in serum creatinine (sCr) for stage 1. This study investigated whether changes in the urinary concentration of neutrophil gelatinase-associated lipocalin (uNGAL) could predict small increases in sCr in patients undergoing coron...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000368413
更新日期:2015-01-01 00:00:00
abstract::A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart d...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181660
更新日期:1979-01-01 00:00:00
abstract::The purpose of this study was to characterize renal cell carcinoma tissue by the measurement of microacoustic properties. A scanning acoustic microscope system operating in the frequency range of 100-200 MHz was employed and the attenuation constant and sound speed were measured on the two-dimensional distribution. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189291
更新日期:1996-01-01 00:00:00
abstract::A 62-year-old woman gave clinical manifestation of liver cirrhosis. Urinary protein was false positive, no uremia was found and renal changes were entirely overlooked. Deposition of abundant lipids (globoside and ceramide trihexoside) was found in the kidneys; essentially degenerative changes of the tubular epithelia ...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180480
更新日期:1975-01-01 00:00:00
abstract::The variations of ionized and total calcium concentrations were studied during haemodialysis with high flux membrane using dialysate calcium concentrations of 1.63 and 1.76 mmol/l. The changes in ionized and total calcium were related to the predialytic calcium concentration difference between plasma and dialysate. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184951
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of treatment for renal anemia in patients with chronic kidney disease (CKD). This meta-analysis was designed to evaluate their efficacy and safety. METHOD:Eight databases were searched for randomized controlled trials (RCTs). ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000508812
更新日期:2020-01-01 00:00:00
abstract::The serum levels of 25-hydroxycholecalciferol, 24,25-dihydroxycholecalciferol, and 1,25-dihydroxycholecalciferol were measured simultaneously in three groups of adults with different renal function: normal (n = 24), glomerular filtration rate (GFR) greater than 70 ml/min; moderately decreased (n = 15), GFR 5-35 ml/min...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183383
更新日期:1985-01-01 00:00:00
abstract:INTRODUCTION:Alterations to the procurement biopsy are one of the main reasons that kidneys are not suitable for transplant and are discarded. The literature on procurement and reperfusion biopsy is inconsistent and heterogeneous. The objective of this study is to describe the correlation of the different histological ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000513120
更新日期:2021-01-28 00:00:00
abstract::Malignant hypertension and high plasma renin activity was found in a 39-year-old woman with an aldosterone-producing adenoma. Only 3 similar cases have been previously reported, and all patients died before or after identification of the adenoma. The present paper documents the first reported case of a successfully ma...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185866
更新日期:1990-01-01 00:00:00
abstract::After successful renal transplantation there is continuing malabsorption of calcium and phosphorus. This is due in part to impaired glomerular filtration rate, and in part to the action of steroid on calcium and phosphorus absorption. The effect of steroids is most marked over the first 18 months after transplantation...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181989
更新日期:1980-01-01 00:00:00