Sodium-valproate-induced interstitial nephritis.

Abstract:

:A 5-year-old Chinese girl had had absence seizures and received sodium valproate (VPA) treatment which provided good control. Six months later, she developed interstitial nephritis with proteinuria and microhematuria. Renal biopsy revealed interstitial nephritis with granular deposition of immunoglobulin G (IgG) and C3 in the renal tubular basement membrane (TBM). Ultrastructurally, dilated smooth endoreticular cisternae with mitochondrial degeneration in the tubular cells and scattered electron-dense deposits within the TBM were also noted. Serum circulating immune complexes were detectable, ACH50 and properdin factor B increased. Mononuclear cells (MNC) from the patient after in vitro incubation with VPA (100 micrograms/ml) induced interleukin-2 (IL-2) production and lymphoproliferative response. However, there was no response in controls. The serum VPA level ranged from 84 to 92 micrograms/ml. After VPA was stopped, the microhematuria and proteinuria disappeared. These observations indicate that VPA-induced interstitial nephritis represents a sequence of interrelationships among multiple immunologic factors.

journal_name

Nephron

journal_title

Nephron

authors

Lin CY,Chiang H

doi

10.1159/000184867

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

43-6

issue

1

eissn

1660-8151

issn

2235-3186

journal_volume

48

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Safety of Percutaneous Ultrasound-Guided Kidney Biopsy in Patients with AA Amyloidosis.

    abstract:BACKGROUND:Bleeding is the most frequent complication of kidney biopsy. Although bleeding risk in patients with AA amyloidosis after kidney biopsy has not been studied in a large population, AA amyloidosis has long been perceived as a risk factor for bleeding. The aim of the present study was to evaluate post-biopsy bl...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000437443

    authors: Altindal M,Yildirim T,Turkmen E,Unal M,Boga I,Yilmaz R,Arici M,Altun B,Erdem Y

    更新日期:2015-01-01 00:00:00

  • Exercise capacity in hemodialysis, CAPD, and renal transplant patients.

    abstract::Eighteen hemodialysis, 12 chronic ambulatory peritoneal dialysis (CAPD), and 20 renal transplant patients performed maximal treadmill exercise tests. Heart rates and blood pressures were determined every minute and maximal oxygen consumption was measured directly. Exercise capacity as measured by VO2 max is low in dia...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183632

    authors: Painter P,Messer-Rehak D,Hanson P,Zimmerman SW,Glass NR

    更新日期:1986-01-01 00:00:00

  • Recovery of decreased ability of peripheral-blood mononuclear cells from chronic renal failure to produce interleukin-1 alpha and beta after renal transplantation.

    abstract::The ability of cultured peripheral-blood mononuclear cells (PBMC) to release interleukin-1 alpha and beta (IL-1 alpha, IL-1 beta) in response to concanavalin A (con A) was investigated in patients with chronic renal failure (CRF) and in renal transplant recipients. Mean IL-1 alpha level released by PBMC of healthy sub...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186478

    authors: Kang XX,Hirano T,Oka K,Tamaki T,Sakurai E,Kaji N,Yoshida M,Kozaki M

    更新日期:1991-01-01 00:00:00

  • Urinary excretion of oxalate in renal failure.

    abstract::The daily urinary excretion of oxalate has been found to be lower than normal in patients with renal failure and the decrease to be directly proportional to the impairment of renal function. It has also been found that the gut flora from uremic patients destroys oxalate 'in vitro' more efficiently than the gut flora f...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182486

    authors: Camici M,Balestri PL,Lupetti S,Colizzi V,Falcone G

    更新日期:1982-01-01 00:00:00

  • SGLT-2 Inhibition: A Potential New Treatment for Diabetic Kidney Disease?

    abstract::Diabetic nephropathy is the leading cause of kidney failure. Treatments with drugs that block the renin-angiotensin system have proven beneficial in slowing kidney disease progression among those with diabetes; their benefit is limited and they do not stop disease progression. Despite multiple clinical trials of vario...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000450895

    authors: Toto RD

    更新日期:2017-01-01 00:00:00

  • High proximal excretion of sodium during activation of beta 2-adrenoreceptors in humans.

    abstract::The effects of acute beta 2-type adrenoreceptor activation with intravenous albuterol on plasma and urinary sodium, potassium, calcium, magnesium, phosphate and lithium were investigated in 9 volunteers during acute hydration. When compared with the control infusion with inactive vehicle, beta 2-type adrenoreceptor ac...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187403

    authors: Duss G,Bianchetti MG,Cattaneo FA,Mullis PE,Krämer R,Peheim E,Oetliker OH

    更新日期:1993-01-01 00:00:00

  • Differential changes of cell cycle regulators and activities in kidneys during pre- and postnatal development.

    abstract::The present study was designed to determine the changes of the cyclin/CDK (cyclin dependent kinase)/CKI (CDK inhibitors) system in kidneys during pre- and postnatal development. All protein levels of cyclins (cyclins D1, D3, E, A, B) and protein levels and activities of CDKs (CDK4, CDK2, cdc2) were high in kidneys dur...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045302

    authors: Park SK,Kim W,Lee H,Lee DY,Koh GY

    更新日期:1999-01-01 00:00:00

  • Effect of vitamin C supplementation on renal oxalate deposits in five-sixths nephrectomized rats.

    abstract::We have previously reported that hyperoxalemia can be aggravated by vitamin C supplementation in regular hemodialysis patients. The present study was undertaken to examine the validity of this observation in an experimental setting. Fifty five-sixths nephrectomized rats were divided into two groups: 30 rats were allow...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185389

    authors: Ono K,Ono H,Ono T,Kikawa K,Oh Y

    更新日期:1989-01-01 00:00:00

  • Effect of simvastatin on qualitative and quantitative changes of lipoprotein metabolism in CAPD patients.

    abstract::The efficacy of simvastatin, a competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, was investigated in 12 patients treated with continuous ambulatory peritoneal dialysis (CAPD), displaying hypercholesterolemia and moderate hypertriglyceridemia. After a 4-week placebo period, simvastatin was admi...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186993

    authors: Wanner C,Lubrich-Birkner I,Summ O,Wieland H,Schollmeyer P

    更新日期:1992-01-01 00:00:00

  • Glomerular Hyperfiltration: An Early Marker of Nephropathy in Fabry Disease.

    abstract:BACKGROUND AND OBJECTIVES:Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several stu...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000493469

    authors: Riccio E,Sabbatini M,Bruzzese D,Annicchiarico Petruzzelli L,Pellegrino A,Spinelli L,Esposito R,Imbriaco M,Feriozzi S,Pisani A,on behalf of AFFIINITY Group.

    更新日期:2019-01-01 00:00:00

  • Changes in active and inactive renin with haemodialysis.

    abstract::Active (A) and inactive (I) plasma renin concentrations (PRC) were examined during haemodialysis in relation to blood pressure and body weight changes. Patients had either one (n = 15) or two (n = 51) remnant kidneys in situ, or were anephric (n = 4). 6 of the two remnant kidney patients had non-functioning renal allo...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182848

    authors: Thatcher R,Whitworth JA,Skinner SL

    更新日期:1982-01-01 00:00:00

  • Importance of Genetic Diagnostics in Adult-Onset Focal Segmental Glomerulosclerosis.

    abstract::Focal segmental glomerulosclerosis (FSGS) is a histological pattern of podocyte and glomerulus injury. FSGS can be primary and secondary to other diseases or due to a genetic cause. Strikingly, genetic causes for adult-onset FSGS are often overlooked, likely because identifying patients with genetic forms of FSGS base...

    journal_title:Nephron

    pub_type:

    doi:10.1159/000499937

    authors: Snoek R,Nguyen TQ,van der Zwaag B,van Zuilen AD,Kruis HME,van Gils-Verrij LA,Goldschmeding R,Knoers NVAM,Rookmaaker MB,van Eerde AM

    更新日期:2019-01-01 00:00:00

  • HCV infections in dialysis patients.

    abstract::HCV is seen as an emergent problem in Dialysis Units; in fact, the patients of these centers are at high risk for blood-transmitted infections, through coming microepidemies. For this reason and using the same method, we have studied the prevalence of anti-HCV and virus-derived hepatitis in a dialytic population of 10...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186922

    authors: Scotto G,Savastano AM,Forcella M,Tantimonaco G,Amato G,Salatino G,Pappani A,Stella I

    更新日期:1992-01-01 00:00:00

  • Declining Estimated Glomerular Filtration Rate and Its Association with Mortality and Comorbidity Over 10 Years in Elderly Women.

    abstract:BACKGROUND/AIMS:Renal function deteriorates with age, but a few studies have addressed this longitudinally in elderly women. Our objective was, using 5 estimated glomerular filtration rates (eGFR)-equations, to evaluate changes in renal function and association with adverse outcomes for a decade in 75-year-old women. ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000435790

    authors: Malmgren L,McGuigan FE,Berglundh S,Westman K,Christensson A,Åkesson K

    更新日期:2015-01-01 00:00:00

  • UK Renal Registry 18th Annual Report: Chapter 9 Biochemical Variables amongst UK Adult Dialysis Patients in 2014: National and Centre-specific Analyses.

    abstract::In 2014 57.5% of HD patients and 62.7% of PD patients achieved the audit measure for phosphate. 29.0% of HD and 30.3% of PD patients had a serum phosphate above the audit standard range. 79.1% of HD and 79.7% of PD patients had adjusted calcium between 2.2–2.5 mmol/L. 57.4% of HD and 65.0% of PD patients had a serum P...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000444823

    authors: Nicholas J,Evans R,Shaw C,Dawnay A

    更新日期:2016-01-01 00:00:00

  • Dialysis granulocytopenia is preceded by an increased surface expression of the adhesion-promoting glucoprotein Mac-1.

    abstract::We studied the expression of Mac-1 on granulocytes (flow cytometry) from 9 patients (27 examinations) during hemodialysis with cuprophane membranes (CuM). Samples were drawn before dialysis and from the arterial and venous lines at 5, 15 and 180 min. Granulocytopenia was most pronounced after 15 min of treatment. Mac-...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186865

    authors: Lundahl J,Hed J,Jacobson SH

    更新日期:1992-01-01 00:00:00

  • The acute effect of passive Heymann nephritis on renal blood flow and glomerular filtration rate in rats.

    abstract::The acute renal hemodynamic changes during induction of passive Heymann nephritis (PHN) may be of importance for the understanding of the pathogenesis of this model. We studied the renal blood flow (RBF) and glomerular filtration rate (GFR) during and after infusion of anti-FxlA into the left renal artery of rats for ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185783

    authors: Sekse I,Iversen BM,Matre R,Ofstad J

    更新日期:1989-01-01 00:00:00

  • Calcium and phosphate plasma levels in dialysis patients after dietary Ca-P overload. Role of gastric acid secretion.

    abstract::In normal subjects, the gastric ionisation of calcium and phosphate seems to be a prerequisite for their intestinal absorption. We investigated the behavior of the plasma calcium and phosphate profile in 30 patients on regular dialysis treatment in the 6 h following a meal containing 1 g of calcium and 2 g of phosphat...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064290

    authors: Graziani G,Badalamenti S,Como G,Gallieni M,Finazzi S,Angelini C,Brancaccio D,Ponticelli C

    更新日期:2002-07-01 00:00:00

  • Elevated serum uric acid. A cardiovascular risk factor?

    abstract::A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart d...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181660

    authors: Tweeddale MG,Fodor JG

    更新日期:1979-01-01 00:00:00

  • Relationship between serum phosphate concentration and proximal tubular bicarbonate transport.

    abstract::Micropuncture studies were performed in intact and thyroparathyroidectomized (TPTX) dogs to evaluate the relationship between the absolute level of serum ultrafilterable phosphate concentration (SUFP) and proximal bicarbonate reabsorption. In both groups of animals, a reverse linear relationship was noted between the ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180864

    authors: Puschett JB,Fernandez PC

    更新日期:1977-01-01 00:00:00

  • Prostaglandin and thromboxane formation in glomeruli from rats with reduced renal mass.

    abstract::In vitro formation of prostaglandins (PG) E2, F2 alpha, 6-keto-F1 alpha, and thromboxane B2 (TxB2) by glomeruli from rats with reduced renal mass (RRM) were evaluated by radioimmunoassay. Four weeks following ablation of renal mass, PGE2, PGF2 alpha, and TxB2 production by glomeruli from RRM rats was significantly gre...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183676

    authors: Stahl RA,Kudelka S,Paravicini M,Schollmeyer P

    更新日期:1986-01-01 00:00:00

  • Sialyl Lewis X and anti-P-selectin antibody attenuate lipopolysaccharide-induced acute renal failure in rabbits.

    abstract:BACKGROUND/AIM:Acute renal failure (ARF) is one of the common problems associated with sepsis or multiple organ dysfunction syndrome (MODS). We have investigated the effects of inhibiting selectin-mediated cell adhesion on lipopolysaccharide-induced ARF in rabbits, using sialyl Lewis X oligosaccharide and PB1.3, an ant...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045942

    authors: Hayashi H,Imanishi N,Ohnishi M,Tojo SJ

    更新日期:2001-04-01 00:00:00

  • Domestic cases of hemorrhagic fever with renal syndrome in the United States.

    abstract::Although serologic studies have identified hantaviral infection in the United States, acute disease has not been recognized. This study describes 3 cases of domestically acquired hemorrhagic fever with renal syndrome (HFRS) in the United States. Infection was due to a local strain of Seoul virus (Baltimore rat virus)....

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188086

    authors: Glass GE,Watson AJ,LeDuc JW,Childs JE

    更新日期:1994-01-01 00:00:00

  • Effect of chronic renal failure with and without secondary hyperparathyroidism on the activities of synaptosomal tyrosine hydroxylase and monoamine oxidase.

    abstract::Norepinephrine (NE) content, release and uptake by brain synaptosomes are reduced in chronic renal failure (CRF), and this has been attributed to the state of secondary hyperparathyroidism. The decrease in NE content in CRF could not be explained by changes in NE uptake or release since in normal circumstances, NE con...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186831

    authors: Islam A,Smorgorzewski M,Zayed MA,Massry SG

    更新日期:1992-01-01 00:00:00

  • Urate deposits in the renal medulla. Prevalence and associations.

    abstract::Urate deposits within microtophi were found in 8% of unselected autopsies in Brisbane, Australia. Significant association were demonstrated with (a) a history of gouty arthritis and (b) the existence of nitrogen retention and renal disease of apparently primary, but not gouty, origin. However, in 26% of the patients, ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182373

    authors: Linnane JW,Burry AF,Emmerson BT

    更新日期:1981-01-01 00:00:00

  • Guidelines for Classification of Acute Kidney Diseases and Disorders.

    abstract::Recent efforts have standardized definitions and classification systems for acute kidney injury (AKI) and chronic kidney disease (CKD). These efforts have enhanced communication, recognition, and awareness of acute and CKDs and stimulated research on both disorders. However, abnormalities of kidney function and struct...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000441425

    authors: Barry R,James MT

    更新日期:2015-01-01 00:00:00

  • Post-obstruction diuresis: influence of renal prostaglandins.

    abstract::The possible role of altered renal prostaglandin metabolism in the generation of post-obstruction diuresis (POD) was examined in 16 adult male Sprague-Dawley rats. Inhibition of cyclooxygenase by the administration of a combination of two nonsteroidal anti-inflammatory drugs (NSAID), meclofenamate and indomethacin in ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186766

    authors: Kauker ML,Zawada ET

    更新日期:1992-01-01 00:00:00

  • Redistribution of epidermal growth factor immunoreactivity in renal tissue after nephrotoxin-induced tubular injury.

    abstract::Tubular necrosis elicits a process of renal tissue repair characterized by an increase of cell turnover in tubular epithelium. The present study was undertaken to examine the distribution of epidermal growth factor (EGF) and/or of its larger precursor proEGF in the kidney undergoing tubular regeneration. Sprague-Dawle...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186253

    authors: Nonclercq D,Toubeau G,Lambricht P,Heuson-Stiennon JA,Laurent G

    更新日期:1991-01-01 00:00:00

  • Effect of chronic fluoride exposure in uremic rats.

    abstract::This study was conducted to test the hypothesis that the margin of safe fluoride exposure is narrowed in rats that are physiologically compromised by renal dysfunction. The study objective was to determine whether increases in fluoride retention and tissue fluoride levels in rats with surgically induced renal insuffic...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044888

    authors: Dunipace A,Brizendine E,Wilson M,Zhang W,Wilson C,Katz B,Kafrawy A,Stookey G

    更新日期:1998-01-01 00:00:00

  • Subtotal nephrectomy stimulates cyclooxygenase 2 expression and prostacyclin synthesis in the rat remnant kidney.

    abstract:BACKGROUND:Recently, two isoforms of cyclooxygenase (COX) have been identified, a constitutive form (COX-1) and a mitogen-inducible form (COX-2). Several studies have suggested that COX is activated in renal insufficiency, but little is known about the relationship between progression of renal insufficiency and the COX...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000057615

    authors: Horiba N,Kumano E,Watanabe T,Shinkura H,Sugimoto T,Inoue M

    更新日期:2002-05-01 00:00:00