Abstract:
:Postnephrectomy serum has been proved to enhance proliferation of mesangial cells in culture. Studies in offspring to uninephrectomized (UNx) mothers indicate that it remains active for a long period following UNx. On the other hand, postnephrectomy renal compensatory growth in vivo is known to be completed within a short period. In this study we assessed the proliferative responses of mesangial cells from single kidneys of rats which were cultured 48 h or 4 months following contralateral nephrectomy. The proliferative stimulus was provided by different postnephrectomy sera. Proliferation of both experimental cell populations was significantly greater than that of controls. Moreover, the proliferation rate of early postcontralateral nephrectomy mesangial cells was greater than those harvested 4 months after nephrectomy. We, therefore, propose that the early in vivo completion of single kidney compensatory hypertrophy, at least in part, is due to progressive blunting of renal cell responsiveness to the mitotic stimulus of the animal's serum.
journal_name
Nephronjournal_title
Nephronauthors
Weissgarten J,Modai D,Cohn M,Berman S,Averbukh Zdoi
10.1159/000044913subject
Has Abstractpub_date
1998-01-01 00:00:00pages
212-4issue
2eissn
1660-8151issn
2235-3186pii
nef78212journal_volume
78pub_type
杂志文章相关文献
NEPHRON文献大全abstract:BACKGROUND/AIMS:Albuminuria is a risk factor for coronary artery calcification (CAC) and cardiovascular disease (CVD). Although the urine dipstick test is widely used to screen albuminuria, little is known about the association between low-grade urine dipstick albumin and CAC. The aim of this study is to investigate th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000490954
更新日期:2018-01-01 00:00:00
abstract::A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064452
更新日期:2002-09-01 00:00:00
abstract::A case of a renal transplant recipient with colchicine-induced myopathy is presented. He was on colchicine therapy for 10 months. He was hospitalized for investigation of fatigue, severe myalgia in the lower extremities and elevated serum aminotransferase levels. His viral markers and other factors that may cause myal...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000065439
更新日期:2002-12-01 00:00:00
abstract::The present prospective study was conducted in order to establish the relationship between complement activation and stimulation of phagocyte oxidative metabolism observed in long-term hemodialysis (HD) patients during the early phase of dialysis with cellulosic membranes. Two groups of 10 randomized (HD) patients tre...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000186565
更新日期:1991-01-01 00:00:00
abstract::As the nephron population diminishes and azotemia develops, each remaining nephron adapts and increases its function by as much as 80%. To determine whether this adaption is permanent or transient, a rat model utilizing one remnant kidney and one normal control kidney was used. In stage one, immediately after ligation...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182879
更新日期:1982-01-01 00:00:00
abstract::We followed renal function through the natriuretic phase of 6 occasions of drug-induced recovery from minimal lesions nephrotic syndrome (MLNS). Protein excretion started to fall 1-3 days prior to the start of the natriuresis. The natriuresis was accompanied by a rise in glomerular filtration rate (GFR, inulin clearan...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184486
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Alterations to the procurement biopsy are one of the main reasons that kidneys are not suitable for transplant and are discarded. The literature on procurement and reperfusion biopsy is inconsistent and heterogeneous. The objective of this study is to describe the correlation of the different histological ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000513120
更新日期:2021-01-28 00:00:00
abstract::The relationship between glycosaminoglycans and beta 2-microglobulin, glycosaminoglycans and N-acetyl-beta-D-glucosaminidase as well as the relationship between the chondroitin sulfate/heparan sulfate ratio and SDS electrophoresis in the urine of subjects from the endemic area of Balkan nephropathy was studied in orde...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187564
更新日期:1993-01-01 00:00:00
abstract::Pruritus is a common symptom among patients undergoing long-term hemodialysis. However, its etiology remains unclear. In an attempt to clarify its cause we tried to correlate pruritus and its intensity with several serological variables in 94 hemodialysis patients. Our results show that higher serum aluminum concentra...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189499
更新日期:1997-01-01 00:00:00
abstract::X-linked nephrogenic diabetes insipidus (NDI) is a rare disease caused by mutations in the vasopressin V2 receptor (AVPR2) gene. We analyzed the AVPR2 gene in 6 unrelated Korean families with X-linked NDI, and found 6 novel mutations. Two of them were missense point mutations, 2 were short deletions causing frameshift...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189581
更新日期:1997-01-01 00:00:00
abstract::Radial arterial spasm in uremic patients undergoing construction of internal arteriovenous (AV) dialysis fistulas was investigated transcutaneously using ultrasonic Doppler flowmetry. In 5 of 15 patients, radial arterial blood flow was significantly decreased 5 min after anastomosing the radial cephalic vein with the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187390
更新日期:1993-01-01 00:00:00
abstract::In an attempt to clarify the renal involvement induced by human parvovirus B19 (HPB19) infection, we investigated 6 adult patients with transient urinary abnormalities followed by erythema infectiosum. All patients had HPB19-specific IgM antibody and showed mild proteinuria of 0.2-1.2 g/day with or without microscopic...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046086
更新日期:2001-11-01 00:00:00
abstract::Cytomegalovirus is the most important viral infection in kidney transplants, but rarely affects the allograft after the sixth month posttransplantation. We present a patient who developed renal failure eighteen months posttransplant; a kidney biopsy showed cytomegalovirus inclusions, acute tubular necrosis and mild in...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000063316
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Complete remission (CR) and partial remission (PR) are beneficial to the long-term outcome of patients with idiopathic membranous nephropathy (iMN). However, we are lacking in studies that evaluate the clinical predictors of response to treatment with prednisone plus cyclophosphamide (CP). The objectives of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000448291
更新日期:2017-01-01 00:00:00
abstract::Previous work has shown that cigarette-smoking affects platelets and endothelium in men and women without renal failure. The present study compared 10 male habitual smokers receiving maintenance hemodialysis for chronic renal failure with 11 healthy male habitual smokers before and after controlled cigarette-smoking a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187354
更新日期:1993-01-01 00:00:00
abstract::The decreases in serum osmolality as well as the rate of ultrafiltration during hemodialysis and the influence of each upon the side effects of this treatment were studied in 13 chronic stable dialysis patients. Mannitol (9 mosm/kg water) was infused in two out of four dialyses, in a double blind fashion. A solution o...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000182039
更新日期:1981-01-01 00:00:00
abstract::Two patients with AIDS-related complex who presented with renal failure and microscopic hematuria were found to have mesangial deposits of IgA at renal biopsy. Though such glomerular deposits have not yet been reported in patients with HIV infection, their occurrence is most likely not coincidental. Indeed, there are ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185891
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Anemia management in chronic hemodialysis (HD) has been affected by the implementation of the prospective payment system (PPS) and changes in clinical guidelines. These factors could impact red blood cell (RBC) transfusion in HD patients. Our distinctive care system contains complete records for all RBC tran...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000445447
更新日期:2016-01-01 00:00:00
abstract::An autopsy case of membranous glomerulonephritis associated with enterococcal endocarditis was reported. Although enterococcal antigen was not identified in glomerular deposits, the eluate from the patient's renal tissue was shown to specifically recombine with cells of the enterococcus isolated from his own ante mort...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183435
更新日期:1985-01-01 00:00:00
abstract::Thrombospondin (TSP) is a multifunctional glycoprotein that is synthesized by a variety of cells including mesangial cells (MCs). To clarify the effect of TSP on the pathogenesis of diabetic nephropathy, we studied the effect of glucose concentrations on TSP synthesis in cultured human MCs. Thereafter, the effects of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044989
更新日期:1998-01-01 00:00:00
abstract:AIMS:There is a trend toward deferring the initiation of chronic dialysis until absolutely indicated. This strategy, however, might lead to increased uncertainties in the timing of dialysis access creation prior to dialysis onset for patients approaching end-stage renal disease (ESRD), and the impact of which on hard e...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000442168
更新日期:2016-01-01 00:00:00
abstract::We present a rare case of IgA nephropathy in a patient who developed atypical hemolytic uremic syndrome (aHUS) associated with a complement factor H (CFH) gene mutation, and who was successfully treated with eculizmab. A 76-year-old man was admitted as the patients had thrombotic microangiopathies findings. The patien...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000485194
更新日期:2018-01-01 00:00:00
abstract::Dopexamine hydrochloride is a synthetic dopamine analogue recently developed to improve myocardial and renal performance in patients suffering from low cardiac output states. The present study was designed to assess the pharmacological profile and the anatomical localization of [3H]-dopexamine binding sites within the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187518
更新日期:1993-01-01 00:00:00
abstract::Renal handling of urate, xanthine and hypoxanthine was studied in a hypouricemic patient who had increased plasma concentrations of xanthine and hypoxanthine. The patient, a 50-year-old man, had been suffering from Parkinson's disease, while neither systemic disorders nor particular renal diseases known to affect plas...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186961
更新日期:1992-01-01 00:00:00
abstract::Platelet-activating factor (PAF) belongs to a new class of lipid chemical inflammatory mediators described as acetyl glyceryl ether phosphorylcholine. Although PAF has been implicated in kidney injury, its role in renal immune injury has not been clearly defined yet. We studied the levels of PAF in the plasma and urin...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000188948
更新日期:1996-01-01 00:00:00
abstract::A 2-year prospective study was done in 45 patients to see whether the FENa test, done at first nephrology consultation visit for acute renal failure, was useful in prognosticating whether patients would recover renal function spontaneously or need dialysis. Of 26 patients who recovered renal function spontaneously, 8 ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183110
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Several studies have provided convincing evidence that in apparently healthy subjects elevated serum levels of plasma C-reactive protein (CRP) are associated with an increased risk of experiencing myocardial infarction and sudden cardiac death. It has been claimed that, in dialytic patients, the hepatic synt...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000065018
更新日期:2002-08-01 00:00:00
abstract::The main regulatory hormone for the control of erythropoiesis is erythropoietin (EPO). This glycoprotein has a molecular weight of 34,000 daltons, about 40% of which is represented by carbohydrates. EPO leads to an enhanced mitosis and differentiation of erythroid precursors (colony-forming unit erythroid) in the bone...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185562
更新日期:1989-01-01 00:00:00
abstract::Lipoproteins might be involved in the pathogenesis of glomerular damage. Uptake of low-density lipoprotein (LDL) by cultured human glomerular cells has been studied using LDL, labelled with the fluorescent probe 1,1'-dioctadecyl-3,3,3'3'-tetramethyl-indocarbocyanine perchlorate (diI). Cells have been characterised usi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185978
更新日期:1990-01-01 00:00:00
abstract::Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187411
更新日期:1993-01-01 00:00:00