Abstract:
:In an attempt to clarify the renal involvement induced by human parvovirus B19 (HPB19) infection, we investigated 6 adult patients with transient urinary abnormalities followed by erythema infectiosum. All patients had HPB19-specific IgM antibody and showed mild proteinuria of 0.2-1.2 g/day with or without microscopic hematuria. In 5 patients a decrease of complement was present, and in 2 the circulating immune complex levels were elevated. All patients showed mild or moderate endocapillary proliferation with leukocytic infiltrates in glomeruli and leukocytic infiltrates with edema around interlobular arteries and arterioles. Immunofluorescence microscopy revealed C3c deposits with immunoglobulins along the glomerular capillary walls and in the walls of small arteries and arterioles. Electron microscopic studies showed swelling of the endothelial cells and small electron-dense deposits in mesangium (in all 6 patients) and subendothelium (in 5 of 6 patients). However, HPB19 VP1 and VP2 capsid antigens were not demonstrated in the glomerulus or the vascular wall in any patient. These findings suggest that the renal lesions caused by an immune complex mediated phenomenon would be closely correlated with the HPB19 infection, although the precise mechanism is not entirely clear, and that in adults HPB19 should be thought of as a possible cause of acute postinfectious glomerulonephritis.
journal_name
Nephronjournal_title
Nephronauthors
Takeda S,Takaeda C,Takazakura E,Haratake Jdoi
10.1159/000046086subject
Has Abstractpub_date
2001-11-01 00:00:00pages
280-5issue
3eissn
1660-8151issn
2235-3186pii
46086journal_volume
89pub_type
杂志文章相关文献
NEPHRON文献大全abstract::We measured levels of platelet-derived microparticles (PMP), which have coagulative activity and are produced by platelet activation or physical stimulation, and CD62P/CD63-positive platelets in patients with diabetes mellitus to determine their clinical significance and effects on complications of diabetes including ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045292
更新日期:1999-01-01 00:00:00
abstract::8 patients with thrombotic microangiopathy were treated with a new antithrombotic agent, defibrotide. This drug displays considerable fibrinolytic and antithrombotic activity, and induces generation and release of a prostacyclin-like substance from vascular tissue. At admission all patients presented severe renal invo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000190340
更新日期:1985-01-01 00:00:00
abstract::We determined the clinical and immunopathological effects of dilazep hydrochloride (dilazep) on IgA nephropathy of ddY mice. Group I (early-treatment group, n = 10) was orally treated with 300 mg/kg body weight of this drug from 12 weeks of age until 60 weeks of age, and group II (late-treatment group, n = 10) was als...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045788
更新日期:2000-11-01 00:00:00
abstract::Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a new autosomal form of hypophosphatemic rickets, recently described. This disease is characterized, and differs from other forms of hereditary hypophosphatemic rickets and/or osteomalacia by increased serum levels of 1,25-dihydroxyvitamin D, hypercalci...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187029
更新日期:1992-01-01 00:00:00
abstract::Mixed IgM-IgG cryoglobulins were present in the serum of a patient with the nephrotic syndrome, recurrent purpura, chronic active hepatitis and ascites. A renal biopsy demonstrated deposition of IgM, IgG, and complement components C3 and C4 in intracapillary 'coagula' and glomerular capillary walls. No glomerular depo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180591
更新日期:1976-01-01 00:00:00
abstract::The effect of imidazole-2-hydroxibenzoate on urinary excretion rates of glycosaminoglycans and albumin in 22 insulin-dependent diabetics with albumin excretion rates under 300 mg/day was evaluated in a 165-day double blind crossover study. Unlike placebo, the drug reduced glycosaminoglycan and albumin excretion rates ...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000185115
更新日期:1988-01-01 00:00:00
abstract::We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046114
更新日期:2001-12-01 00:00:00
abstract::Exaggerated natriuresis in response to hypertonic saline infusion occurs with great regularity in patients with documented previous attacks of poststreptococcal glomerulonephritis. Five patients were studied before and after 1 week of dietary sodium restriction in order to examine the possibility that increased extrac...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180852
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Glomerular hyperfiltration (GH) is a hallmark of renal dysfunction in diabetes and obesity. Recent clinical trials demonstrated that SGLT2 inhibitors are renoprotective, possibly by abating hyperfiltration. The present review considers the current evidence for a cause-to-effect relationship between hyperfilt...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000499486
更新日期:2019-01-01 00:00:00
abstract::The three-dimensional ultrastructure of glomerular basement membrane (GBM) in surgically resected human kidneys was observed by the quick-freezing and deep-etching method. In three layers of human GBM, the middle layer exhibited polygonal meshwork structures, which were composed of fine fibrils. In addition, the outer...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188547
更新日期:1995-01-01 00:00:00
abstract::In an effort to elucidate immunopathogenic of membranous nephropathy (MN), freshly collected sera from patients with biopsy proven MN were assayed of circulating immune complexes (ICs) by the Raji cell method and for anti-renal tubular epithelial (RTE) antibodies by a newly established radioimmunoassay (RIA) and by in...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181675
更新日期:1979-01-01 00:00:00
abstract::Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187411
更新日期:1993-01-01 00:00:00
abstract::Decreased serum levels of high-density lipoprotein cholesterol (HDL-C) are a well-known risk factor for coronary heart disease (CHD) in the general population and have been suggested as one of the best predictor of CHD after renal transplantation. However, very heterogeneous HDL-C levels have been reported in renal tr...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045608
更新日期:2000-04-01 00:00:00
abstract::Joseph Andreas Jacobus Plenck was born in 1735 in Vienna where he studied surgery with Johan Christian Retter. At age 35 he was appointed Professor of Surgery and Obstetrics by Maria Theresia. Subsequently he became professor and life long secretary of the Medical Military Academy know as the Josephinum where he worke...
journal_title:Nephron
pub_type: 传,历史文章,杂志文章
doi:10.1159/000064450
更新日期:2002-09-01 00:00:00
abstract::The effect of intravenous 1 alpha(OH)D3 on circulating intact parathyroid hormone (PTH) and COOH-terminal immunoreactive PTH was examined in 21 patients on chronic hemodialysis. The patients were treated for 3 months with increasing doses of 1 alpha(OH)D3 under careful control of serum Ca2+. 1 alpha(OH)D3 was given in...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185744
更新日期:1989-01-01 00:00:00
abstract::The aim of this study was to assess the psychosocial effects of exercise training on hemodialysis (HD) patients. Thirty-one uremic patients, aged 50.6+/-11.6 years, on maintenance HD were studied. Twenty patients were selected at random for a 6-month exercise renal rehabilitation program (ERRP) consisting of 3 weekly ...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000190266
更新日期:1997-01-01 00:00:00
abstract::The function of renal allografts in patients who had received pretransplant immunoadsorption in order to remove cytotoxic anti-HLA antibodies was studied. We reviewed 6 patients who received a graft which functioned beyond 3 months; the mean follow-up period was 76 (range 62-89) months. Two grafts have been lost from ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000189281
更新日期:1996-01-01 00:00:00
abstract::Nephrotoxic agents such as puromycin aminonucleoside (PAN) and sodium maleate (MAL) have been used to induce experimental glomerular proteinuria and tubular disease, respectively. Current studies show that PAN caused a massive loss of albumin in the urine while not affecting the excretion of the smaller, sex-dependent...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182134
更新日期:1981-01-01 00:00:00
abstract::A simple three-pump-based system for the performance of continuous venovenous haemodialysis is described. The method employs access to the circulation via a double-lumen catheter, and by means of a standard extracorporeal peristaltic pump the blood is circulated through a haemofiltration filter. Standard solutions for...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188835
更新日期:1996-01-01 00:00:00
abstract:CONTEXT:Soluble urokinase-type plasminogen activator -(suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational modifications. Recently, [Hayek, et al: Nat Med 2017; 23: 945-953] it has been found that there is a link between suPAR and renal disease in several gui...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000490118
更新日期:2018-01-01 00:00:00
abstract::We investigated the best time of administration of desferrioxamine (DFO) with respect to the dialysis session, using the approach of the stochastic dynamic system, integrated with the classical pharmacokinetic models. In the 6 patients studied, the mean arrival times of DFO, aluminoxamine (AlO) and ferrioxamine (FO) w...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188845
更新日期:1996-01-01 00:00:00
abstract::This prospective study was designed to evaluate the eventual correction of anemia and iron status in 39 iron-deficient uremics starting hemodialysis. Nine patients (control group) had no iron supplementation, 10 had oral ferrous iron, and 20 were treated with intravenous iron gluconate. Follow-up periods were 12 month...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000045053
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Sclerostin is an osteocyte hormone that decreases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chronic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high. AIM:To assess the correlation of serum sclerostin levels ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000443845
更新日期:2016-01-01 00:00:00
abstract::Abnormalities in plasma composition of essential fatty acids (EFAs) may be associated with the etiology of pruritus and other skin problems in patients undergoing hemodialysis. To study whether an oral supplementation with omega-6 (n-6) EFAs would restore deranged plasma EFAs and ameliorate skin symptoms, 9 and 7 dial...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000045271
更新日期:1999-02-01 00:00:00
abstract::During the 12 weeks following 5/6 nephrectomy in rats with moderate uremia (creatinine 0.7-1.2 mg/100 ml, BUN 53-89 mg/100 ml), no significant increases in total soft tissue calcification were observed. The calcium concentration of skeletal muscle remained unchanged at 4, 8, and 12 weeks after surgery. A slight but no...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180786
更新日期:1977-01-01 00:00:00
abstract::Glycoprotein: galactosyl and glycoprotein: sialic acid transferase activities were measured in the serum of patients with minimal lesion nephrotic syndrome, acute renal failure, and chronic renal insufficiency of varying severity. The activity of galactosyl transferase was elevated in all patients but one. Sialic acid...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000180711
更新日期:1976-01-01 00:00:00
abstract::Serum leptin concentrations in normal humans have been reported to correlate with the body mass index (BMI) as well as with the body fat mass. In this study, we measured serum leptin concentrations in 107 patients on hemodialysis, 30 of whom had diabetes mellitus as the cause, and examined the clinical significance. F...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045122
更新日期:1998-09-01 00:00:00
abstract::The concentration changes, during hemodialysis treatment, of 18 characteristic uremia compounds, analyzed by high-pressure liquid chromatography in sera of renal patients were studied. Pre- to postdialysis concentration ratios (dialysis ratio, D) varied from 0.83 to 3.04 for the different solutes. A division into thre...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185746
更新日期:1989-01-01 00:00:00
abstract::The feasibility of room temperature incubation of Microstix-3 specimens to detect urinary tract infection was studied. This procedure, if successful, would allow home monitoring of patients and eliminate the need for an incubator. Four Microstix-3 strips were dipped into each of 1,241 urine specimens and incubated at ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182640
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:At present, the determination of dry weight in patients on hemodialysis is largely made empirically by trial and error. Extracellular volume (ECV) assessment by bioimpedance analysis (BIA) is a preferable technique for determining dry weight, and it also provides useful data on body composition. METHODS:We ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064471
更新日期:2002-09-01 00:00:00