Effect of intravenous 1-alpha-hydroxyvitamin D3 on secondary hyperparathyroidism in chronic uremic patients on maintenance hemodialysis.

Abstract:

:The effect of intravenous 1 alpha(OH)D3 on circulating intact parathyroid hormone (PTH) and COOH-terminal immunoreactive PTH was examined in 21 patients on chronic hemodialysis. The patients were treated for 3 months with increasing doses of 1 alpha(OH)D3 under careful control of serum Ca2+. 1 alpha(OH)D3 was given intravenously at doses of up to 4 micrograms three times a week, and blood samples were obtained every week, including 1 week before treatment (basal control). No patients were treated with oral vitamin D metabolites. At the end of the study intact PTH levels were reduced by an average of 67 +/- 6%, and COOH-terminal immunoreactive PTH levels were reduced by 35 +/- 6%. Serum Ca2+ was kept within normal levels, but showed a slight increase from 1.17 to 1.30 mmol/l. An effect of calcium on PTH secretion could not be excluded, but an effect of 1 alpha(OH)D3, independent of serum Ca2+ was also found. This effect may be mediated by 1,25(OH)2D3, assuming a large capacity of the 25-hydroxylase in the liver to convert 1 alpha(OH)D3 to 1,25(OH)2D3. Also, the parathyroid glands may possess receptors for 1 alpha(OH)D3 with an effect similar to that established for the 1,25(OH)2D3 receptors. Thus, although the exact mechanisms of the action of 1 alpha(OH)D3 have not yet been completely clarified, it is concluded that intravenous administration of 1 alpha(OH)D3 may be of benefit in the treatment of secondary hyperparathyroidism of uremia.

journal_name

Nephron

journal_title

Nephron

authors

Brandi L,Daugaard H,Tvedegaard E,Storm T,Olgaard K

doi

10.1159/000185744

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

194-200

issue

3

eissn

1660-8151

issn

2235-3186

journal_volume

53

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • International Multi-Specialty Delphi Survey: Identification of Diagnostic Criteria for Hepatic and Renal Cyst Infection.

    abstract:BACKGROUND:Cyst infection is one of the complications of autosomal dominant polycystic kidney disease and polycystic liver disease. The diagnosis is typically made on a mix of clinical, laboratory and imaging abnormalities but the importance of individual items is uncertain. We aimed to perform a Delphi survey amongst ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000446664

    authors: Lantinga MA,Darding AJ,de Sévaux RG,Alam A,Bleeker-Rovers CP,Bobot M,Cornec-Le Gall E,Gevers TJ,Hassoun Z,Meijer E,Mrug M,Nevens F,Onuchic LF,Pei Y,Piccoli GB,Pirson Y,Rangan GK,Torra R,Visser FW,Jouret F,Kanaan N

    更新日期:2016-01-01 00:00:00

  • Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.

    abstract::The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been shown to be associated with cardiovascular disease in healthy subjects as well as in patients with end-stage renal disease (ESRD). In this study, we examined the allelic frequency and genotype distribution of the MTHFR gene in 151 Chinese ESRD ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045922

    authors: Lim PS,Hung WR,Wei YH

    更新日期:2001-03-01 00:00:00

  • Factors influencing the intestinal absorption of calcium and phosphorus following renal transplantation.

    abstract::After successful renal transplantation there is continuing malabsorption of calcium and phosphorus. This is due in part to impaired glomerular filtration rate, and in part to the action of steroid on calcium and phosphorus absorption. The effect of steroids is most marked over the first 18 months after transplantation...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181989

    authors: Walker GS,Peacock M,Marshall DH,Giles GR,Davison AM

    更新日期:1980-01-01 00:00:00

  • Exercise and Prediabetes after Renal Transplantation (EXPRED): Protocol Description.

    abstract:BACKGROUND:Post-transplant diabetes mellitus (PTDM) is a frequent and severe complication after renal transplantation. In fact, PTDM is a risk factor for both infection and cardiovascular diseases. The prevalence and incidence of PTDM have a bimodal evolution: early (up to 3 months) and late PTDM (beyond 12 months). Th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000511320

    authors: Morales Febles R,Negrín Mena N,Rodríguez-Rodríguez AE,Díaz Martín L,González Rinne F,Marrero Miranda D,González Rinne A,Álvarez González A,Pérez Tamajón L,Acosta Sørensen C,Rodríguez Hernández A,Domínguez-Rodríguez A,García Baute

    更新日期:2021-01-01 00:00:00

  • The herbal medicine Sairei-to inhibits proliferation of rat mesangial cells.

    abstract:BACKGROUND:The herbal medicine Sairei-to is efficacious in renal diseases where mesangial proliferation is a key event. We examined whether Sairei-to inhibits proliferation of cultured rat mesangial cells and investigated its mechanism of action. METHODS:The effect of Sairei-to on [(3)H]-thymidine incorporation stimul...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064112

    authors: Awazu M,Fujita H,Omori S,Hida M

    更新日期:2002-01-01 00:00:00

  • Soluble P-selectin is released from activated platelets in vivo during hemodialysis.

    abstract::During hemodialysis, platelets are activated across a dialyzer. Soluble P-selectin (sP-selectin) is a form of P-selectin which is a glycoprotein relocated from secretory granules to the surfaces of platelets and endothelial cells after these cells have been physiologically activated. To investigate whether sP-selectin...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044903

    authors: Kawabata K,Nagake Y,Shikata K,Fukuda S,Nakazono H,Takahashi M,Ichikawa H,Makino H

    更新日期:1998-01-01 00:00:00

  • Effect of hemodialysis on plasma levels of vasoactive peptides: endothelin, calcitonin gene-related peptide and human atrial natriuretic peptide.

    abstract::To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP) in the regulation of blood pressure in uremic patients, and to determine the effect of various types of dialyzer membranes on hemodialysis (HD)-induced changes in pla...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187399

    authors: Niwa T,Fujishiro T,Uema K,Tsuzuki T,Tominaga Y,Emoto Y,Miyazaki T,Maeda K

    更新日期:1993-01-01 00:00:00

  • Effect of dialysate calcium concentration on plasma parathyroid hormone during hemodialysis.

    abstract::The effect of changes in the dialysate calcium concentration on calcium fractions and parathyroid hormone species in plasma during hemodialysis has been examined. C-terminal immunoreactive parathyroid hormone was suppressed when plasma calcium increased by greater than 25% whereas N-terminal fragments demonstrated an ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180870

    authors: McIntosh CH,Fuchs C,Dorn D,Quellhorst E,Henning HV,Hesch RD,Scheler F

    更新日期:1977-01-01 00:00:00

  • Stomach phytobezoars in two uremic anorexic patients.

    abstract::Conglomerates of food and mucus or phytobezoars composed of vegetable matter are sometimes found in the stomach in the general population. Reports of phytobezoars in uremic patients are, however, scarce. Here we describe 2 uremic patients in which esophagogastroduodenoscopy was performed due to dyspepsia associated wi...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000049075

    authors: Catalano C,Leone L,Fabbian F,Conz PA

    更新日期:2002-03-01 00:00:00

  • Elevated serum uric acid. A cardiovascular risk factor?

    abstract::A critical survey of the literature suggests that elevated serum uric acid is definitely associated with hypertension and may function as an independent risk factor in the development of this disease. The possible role of an elevated serum uric acid as an independent risk factor for the development of ischemic heart d...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181660

    authors: Tweeddale MG,Fodor JG

    更新日期:1979-01-01 00:00:00

  • Meshwork structures in bovine glomerular and tubular basement membrane as revealed by ultra-high-resolution scanning electron microscopy.

    abstract::We examined the ultrastructure of the bovine glomerular basement membrane (GBM) and tubular basement membrane (TBM) using ultra-high-resolution scanning electron microscopy after conductive staining without metal coating. Purified basement membranes (BMs) were obtained by sonication and acellular BMs by detergent trea...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187800

    authors: Yamasaki Y,Makino H,Ota Z

    更新日期:1994-01-01 00:00:00

  • Desferrioxamine enhances the haemopoietic response to erythropoietin, but adverse events are common.

    abstract::To determine whether the chelation of aluminium enhances the haemopoietic response to recombinant human erythropoietin (r-HuEPO), desferrioxamine (DFO) at a dose of 20-30 mg/kg was given to 7 of 17 transfusion-dependent haemodialysis patients treated with r-HuEPO (40 units/kg/dialysis i.v.). The two randomly allocated...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000186374

    authors: Roger SD,Stewart JH,Harris DC

    更新日期:1991-01-01 00:00:00

  • Conjugated diene fatty acids in patients with chronic renal failure: evidence of increased lipid peroxidation?

    abstract::Conjugated diene fatty acids (CDFA) were evaluated by second derivative spectrophotometry in the plasma and adipose tissue of 42 chronic renal failure (CFR) patients in conservative treatment, 40 patients treated by hemodialysis (HD) with cuprophane, cellulose acetate or hemophan, 29 treated by hemodiafiltration (HDF)...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187520

    authors: Lucchi L,Banni S,Botti B,Cappelli G,Medici G,Melis MP,Tomasi A,Vannini V,Lusvarghi E

    更新日期:1993-01-01 00:00:00

  • Morphine modulates mesangial immunoglobulin G uptake in rats with antithymocyte serum-induced mesangial cell injury.

    abstract::The glomerular mesangium is an important site of activity in patients with heroin addiction. We studied the effect of morphine, a metabolite of heroin, on the mesangial immunoglobulin G aggregate uptake in a model of specific mesangial cell injury. Isolated specific mesangial cell injury was developed in Lewis rats by...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189301

    authors: Singhal PC,Pan CQ,Sagar S,Valderrama E,Stahl RA

    更新日期:1996-01-01 00:00:00

  • Nephrotoxicity of radiocontrast media in ischemic renal failure in rabbits.

    abstract::Ischemic renal failure was produced in rabbits by occluding the renal arteries for 90 min. Group 1 (n = 8) received radiocontrast media at the time of occlusion, group 2 (n = 8) 24 h after occlusion, and group 3 (n = 8) 3 days after occlusion. Group 4 (n = 12) was subjected to ischemic injury alone, group 5 (n = 4) se...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182829

    authors: Schultz SG,Lavelle KJ,Swain R

    更新日期:1982-01-01 00:00:00

  • Glucose-induced insulin secretion in uremia: relation with acid-base balance and effects of bicarbonate administration.

    abstract::In order to evaluate effects of metabolic acidosis on glucose metabolism in uremia, we studied, by an intravenous glucose tolerance test (IVGTT), 46 patients with severe chronic renal failure divided into three groups according to their blood bicarbonate (BB) values: group A formed by 15 patients without or with light...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187141

    authors: Allegra V,Mengozzi G,Martimbianco L,Vasile A

    更新日期:1993-01-01 00:00:00

  • Cytoprotective effect of ulinastatin on LLC-PK1 cells treated with antimycin A, gentamicin, and cisplatin.

    abstract::The cytoprotective effect of ulinastatin was studied in LLC-PK1 cells treated with antimycin A, gentamicin, or cisplatin. All of the three agents induced a concentration-dependent increase in the release of lactate dehydrogenase and a decrease in the amount of remaining protein. In the cell injury models treated with ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000190195

    authors: Ishibashi M,Yamasaki F,Nakakuki M,Shinkawa T,Mizota M

    更新日期:1997-01-01 00:00:00

  • Effect of neutral pH and low-glucose degradation product-containing peritoneal dialysis solution on residual renal function in peritoneal dialysis patients: a meta-analysis.

    abstract:BACKGROUND:Glucose degradation products (GDPs) in peritoneal dialysis (PD) solution (PDS) have been shown to inflict damage to the kidney, which is the major organ for advanced glycosylation end product elimination. Hence, this study investigated whether new PDSs with neutral pH and low-GDPs have a beneficial effect on...

    journal_title:Nephron

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000368235

    authors: Wang J,Zhu N,Yuan W

    更新日期:2015-01-01 00:00:00

  • Chronic hemodialysis in the anephric goat.

    abstract::The Spanish brush goat (Capra hiricus) was studied as an animal model for the anephric state. This rugged animal has a hardy appetite and offers ready blood access for dialysis and sampling. BUN, plasma creatinine and potassium could be brought to normal values by daily hemodialysis. Continual weight loss, severe anem...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181750

    authors: Bower JD,Holbert RD,Pearson JE,Jones Q,Bengis R,Berndt WO

    更新日期:1980-01-01 00:00:00

  • Acute volume expansion and salt-loading studies in rats. The role of atrial natriuretic peptide and catecholamines.

    abstract::Differences have been postulated for the mechanism of natriuresis due to atrial natriuretic peptide (ANP), salt loading with high salt diet (HS) and acute volume expansion (AcVE), in particular between AcVE and ANP based on the observed synergism between the two. Therefore the effects of and the interaction between th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045024

    authors: Reddy S,Salipan-Moore N,Mildenberger S,Willis N,Györy AZ

    更新日期:1998-01-01 00:00:00

  • Failure of verapamil to protect from ischaemic renal damage.

    abstract::To reassess the reported protective effects of verapamil in renal ischaemia, we perfused the left kidney of uninephrectomized female Wistar rats with verapamil (0.1 and 1.0 mg/kg) immediately prior to clamping the renal artery for 60 min. When compared to controls, both doses of verapamil failed to afford protection w...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186279

    authors: Bock HA,Brunner FP,Torhorst J,Thiel G

    更新日期:1991-01-01 00:00:00

  • Proteoglycan expression in the normal rat kidney.

    abstract::Proteoglycans constitute a heterogenous group of complex macromolecules, consisting of a backbone core protein and a variable number of sulfated polysaccharide side chains covalently linked to the core. A dual function for these polyanionic glycosaminoglycans in kidney physiology has been proposed: to maintain a fixed...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000190325

    authors: Pyke C,Kristensen P,Ostergaard PB,Oturai PS,Rømer J

    更新日期:1997-01-01 00:00:00

  • Comparison of toxic effects of methylguanidine, guanidinosuccinic acid and creatinine in rats with adenine-induced chronic renal failure.

    abstract::Methylguanidine (MG), guanidinosuccinic acid (GSA) and creatinine (Cr), which accumulate in the body in parallel with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine was given to rats for 24 days to induce renal fai...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185328

    authors: Yokozawa T,Mo ZL,Oura H

    更新日期:1989-01-01 00:00:00

  • Glomerular Hyperfiltration: An Early Marker of Nephropathy in Fabry Disease.

    abstract:BACKGROUND AND OBJECTIVES:Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several stu...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000493469

    authors: Riccio E,Sabbatini M,Bruzzese D,Annicchiarico Petruzzelli L,Pellegrino A,Spinelli L,Esposito R,Imbriaco M,Feriozzi S,Pisani A,on behalf of AFFIINITY Group.

    更新日期:2019-01-01 00:00:00

  • Onset, time course, and persistence of increased haemodialysis-induced breath isoprene emission.

    abstract::Recent findings of increased isoprene emission in the exhaled breath of patients undergoing haemodialysis and experimental evidence of the potential toxic and cancerogenic effects of isoprene hydrocarbon led us to assess how long haemodialysis patients are exposed to how much isoprene after a single haemodialysis sess...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045958

    authors: Trovarelli G,Brunori F,De Medio GE,Timio M,Lippi G,Pelli MA,Capodicasa E

    更新日期:2001-05-01 00:00:00

  • Ionized and total calcium variations induced by haemodialysis.

    abstract::The variations of ionized and total calcium concentrations were studied during haemodialysis with high flux membrane using dialysate calcium concentrations of 1.63 and 1.76 mmol/l. The changes in ionized and total calcium were related to the predialytic calcium concentration difference between plasma and dialysate. Th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184951

    authors: Kancir CB,Wanscher M,Petersen PH

    更新日期:1988-01-01 00:00:00

  • Total Red Blood Cell Transfusions for Chronic Hemodialysis Patients in a Single Center, 2009-2013.

    abstract:BACKGROUND:Anemia management in chronic hemodialysis (HD) has been affected by the implementation of the prospective payment system (PPS) and changes in clinical guidelines. These factors could impact red blood cell (RBC) transfusion in HD patients. Our distinctive care system contains complete records for all RBC tran...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000445447

    authors: Albright RC Jr,Dillon JJ,Hocum CL,Stubbs JR,Johnson PM,Hickson LJ,Williams AW,Dingli D,McCarthy JT

    更新日期:2016-01-01 00:00:00

  • Clinical features of aluminum-associated bone disease in long-term hemodialysis patients.

    abstract::We encountered 11 patients with aluminum-associated bone disease (AABD), and treated them with deferoxamine (DFO). In 3 patients, a second bone biopsy was done during DFO treatment. Clinical features of AABD were compared with surgically proven secondary hyperparathyroidism (2 degrees HPT) with osteitis fibrosa on X-r...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183668

    authors: Iwamoto N,Ono T,Yamazaki S,Fukuda T,Kondo M,Yamamoto N,Hiratake Y,Masugi Y,Kubo Y,Hino M

    更新日期:1986-01-01 00:00:00

  • Importance of Genetic Diagnostics in Adult-Onset Focal Segmental Glomerulosclerosis.

    abstract::Focal segmental glomerulosclerosis (FSGS) is a histological pattern of podocyte and glomerulus injury. FSGS can be primary and secondary to other diseases or due to a genetic cause. Strikingly, genetic causes for adult-onset FSGS are often overlooked, likely because identifying patients with genetic forms of FSGS base...

    journal_title:Nephron

    pub_type:

    doi:10.1159/000499937

    authors: Snoek R,Nguyen TQ,van der Zwaag B,van Zuilen AD,Kruis HME,van Gils-Verrij LA,Goldschmeding R,Knoers NVAM,Rookmaaker MB,van Eerde AM

    更新日期:2019-01-01 00:00:00

  • High-renin malignant hypertension secondary to an aldosterone-producing adenoma.

    abstract::Malignant hypertension and high plasma renin activity was found in a 39-year-old woman with an aldosterone-producing adenoma. Only 3 similar cases have been previously reported, and all patients died before or after identification of the adenoma. The present paper documents the first reported case of a successfully ma...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185866

    authors: Ideishi M,Kishikawa K,Kinoshita A,Sasaguri M,Ikeda M,Takebayashi S,Arakawa K

    更新日期:1990-01-01 00:00:00