Abstract:
:To reassess the reported protective effects of verapamil in renal ischaemia, we perfused the left kidney of uninephrectomized female Wistar rats with verapamil (0.1 and 1.0 mg/kg) immediately prior to clamping the renal artery for 60 min. When compared to controls, both doses of verapamil failed to afford protection with respect to urine flow, plasma creatinine, creatinine clearance or histology 24 and 48 h after ischaemia, whereas the purine nucleotide inosine (200 mg/kg) was partially protective: mean plasma creatinine 48 h after ischaemia (+/- SEM) was 547 +/- 54 mumol/l in controls, 686 +/- 38 mumol/l with 0.1 mg/kg verapamil, 491 +/- 68 mumol/l with 1.0 mg/kg verapamil and 374 +/- 45 mumol/l with inosine (p less than 0.05 vs. controls). Using the same model, the effect of verapamil 1.0 mg/kg on renal blood flow, creatinine clearance, urine flow and arterial pressure was studied in the first 2 h after ischaemia. Although significant amounts of verapamil were present in the kidney during ischaemia as evidenced by decreases in systemic blood pressure and in renal vascular resistance after unclamping the renal artery, the early course of renal failure was not altered when compared to controls. In conclusion, we have been unable to confirm earlier reports of a protective effect of verapamil in this rat model of ischaemic renal failure. If there is such an effect, its demonstration appears to depend on very specific experimental circumstances. Based on the results of this and other studies, verapamil is unlikely to afford an impressive overall benefit in the clinical setting of ischaemic renal failure.
journal_name
Nephronjournal_title
Nephronauthors
Bock HA,Brunner FP,Torhorst J,Thiel Gdoi
10.1159/000186279subject
Has Abstractpub_date
1991-01-01 00:00:00pages
299-305issue
3eissn
1660-8151issn
2235-3186journal_volume
57pub_type
杂志文章相关文献
NEPHRON文献大全abstract::Prolongation of repolarization dispersion (QT interval dispersion) measured from the 12-lead surface ECG has been associated with sudden cardiac death and ventricular tachyarrhythmias in a variety of cardiac disorders. The aim of our study was to assess the effects of hemodialysis (HD) and continuous ambulatory perito...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000065038
更新日期:2002-08-01 00:00:00
abstract::We have previously reported that hyperoxalemia can be aggravated by vitamin C supplementation in regular hemodialysis patients. The present study was undertaken to examine the validity of this observation in an experimental setting. Fifty five-sixths nephrectomized rats were divided into two groups: 30 rats were allow...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185389
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of treatment for renal anemia in patients with chronic kidney disease (CKD). This meta-analysis was designed to evaluate their efficacy and safety. METHOD:Eight databases were searched for randomized controlled trials (RCTs). ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000508812
更新日期:2020-01-01 00:00:00
abstract::Classic renal tubular acidosis is characterized by a primary defect in establishment of a large hydrogen ion gradient across the distal renal tubule. Thus the development of hyperchlorenic metabolic acidosis follows. In addition, hypokalemia results from renal potassium wasting secondary hyperaldosteronism from sodium...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181626
更新日期:1979-01-01 00:00:00
abstract::Losses in thyroxine-binding globulin (TBG) in peritoneal dialysate and thyroid function were evaluated in patients undergoing continuous ambulatory peritoneal dialysis (CAPD), in comparison to patients on hemodialysis (HD) without TBG loss in the dialysate. The TBG concentration in the peritoneal dialysate was 0.26 +/...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183634
更新日期:1986-01-01 00:00:00
abstract::The purpose of this study was to characterize renal cell carcinoma tissue by the measurement of microacoustic properties. A scanning acoustic microscope system operating in the frequency range of 100-200 MHz was employed and the attenuation constant and sound speed were measured on the two-dimensional distribution. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189291
更新日期:1996-01-01 00:00:00
abstract::DNA-anti-DNA cold precipitable complexes (CPC) isolated from 21 patients with systemic lupus erythematosus were tested for their ability to stimulate polymorphonuclear leukocyte (PMN) chemotaxis and to activate complement in vitro. The complexes activated complement in 20 out of 21 cases and stimulated PMN chemotaxis ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182509
更新日期:1982-01-01 00:00:00
abstract::During chronic chlorthalidone treatment of patients with essential hypertension, distal tubular sodium reabsorption is continuously inhibited. At the same time, sodium balance is maintained by an increase of the proximal tubular sodium reabsorption. In the present study, we investigated whether this increase is caused...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184485
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue might lie with pattern recognition receptors (PRRs), which are triggers of ischemic i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000456016
更新日期:2017-01-01 00:00:00
abstract::In an effort to elucidate immunopathogenic of membranous nephropathy (MN), freshly collected sera from patients with biopsy proven MN were assayed of circulating immune complexes (ICs) by the Raji cell method and for anti-renal tubular epithelial (RTE) antibodies by a newly established radioimmunoassay (RIA) and by in...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181675
更新日期:1979-01-01 00:00:00
abstract::A 5-year-old Japanese boy showed nephritis similar to, but distinct from, that in Alport syndrome. Nephrotic syndrome without hematuria was noticed at age 2, although renal biopsy at age 4 revealed widespread irregular thickening of the glomerular basement membrane with splitting of the lamina densa on electron micros...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186136
更新日期:1990-01-01 00:00:00
abstract::Using a 2-hour 47Ca absorption test, significant depression of active calcium absorption was demonstrated in 48 vitamin D untreated haemodialysis patients. This malabsorption of calcium could be corrected by the daily oral administration of 1--2 microgram of 1alphaOHD3 and 1--1.5 microgram of 1,25(OH)2D3. 5 microgram ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181223
更新日期:1978-01-01 00:00:00
abstract::A low-protein, low-phosphorus diet supplemented with essential amino acids and keto analogues was given to 12 rats, starting from the 90th day after subtotal nephrectomy. The purpose was to assess its effect on the residual renal function and on the nutritional status in rats with already established severe renal fail...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185055
更新日期:1988-01-01 00:00:00
abstract::We report a case of visceral leishmaniasis in a 38-year-old renal transplant recipient living in an endemic country. Antimonial derivatives induced a rapid remission. A review of the literature disclosed 8 cases of this association with a fatal fulminant outcome in 5 cases. We suggest that the specific immunosuppressi...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000186779
更新日期:1992-01-01 00:00:00
abstract::We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046114
更新日期:2001-12-01 00:00:00
abstract::Mitochondria contain electron-dense particles, partly composed of an amorphous form of calcium phosphate. We have used electron microscopy from percutaneous renal biopsy material to analyze mitochondrial granulation in the proximal renal tubule of nonuremic and uremic children. Based on a technique of cutting mitochon...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181739
更新日期:1979-01-01 00:00:00
abstract::Cyclosporine (CsA) nephrotoxicity is partially mediated by renal vasoconstriction due to an imbalance between vasodilator and vasoconstrictor eicosanoids. LSL 90202 is a purified lysine salt of eicosapentaenoic acid which is a known inhibitor of renal eicosanoid synthesis. The aim of the present work was to determine ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187890
更新日期:1994-01-01 00:00:00
abstract::Increasing urinary net acid (titratable acid + NH4 - HCO-3) excretion is accompanied by an increased urinary Ca excretion because of reduced renal tubular reabsorption of filtered Ca. The relationships between urinary Ca excretion rates and urinary net acid excretion rates are reviewed for data: (1) among healthy adul...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000046294
更新日期:1999-01-01 00:00:00
abstract::We report a case of rapidly progressive glomerulonephritis due to antiglomerular basement membrane (anti-GBM) antibodies that progressed to end-stage renal disease in a 35-year-old man who used intranasal cocaine on an occasional basis. In contrast to many prior reports of acute renal failure occurring with cocaine-as...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045328
更新日期:1999-01-01 00:00:00
abstract::Focal segmental glomerulosclerosis (FSGS) is a histological pattern of podocyte and glomerulus injury. FSGS can be primary and secondary to other diseases or due to a genetic cause. Strikingly, genetic causes for adult-onset FSGS are often overlooked, likely because identifying patients with genetic forms of FSGS base...
journal_title:Nephron
pub_type:
doi:10.1159/000499937
更新日期:2019-01-01 00:00:00
abstract::We conducted a retrospective study with 750 peritoneal dialysis (PD) patients in a Spanish multicenter registry between 1993 and 1999 to analyze comorbidity and mortality in type 1 diabetes (T1D), type 2 diabetes (T2D) and nondiabetic (ND) patients. 163 patients (21.7%) were diabetic--96 T1D (58.8%) and 67 T2D (42.2%)...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000049065
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND/AIMS:The renal prognosis of post-renal acute kidney injury (PoR-AKI) has not been verified so far. The objective of this study was to assess the association of baseline anemia with long-term renal prognosis in patients with PoR-AKI. METHODS:We performed a multicenter retrospective cohort study. Consecutive ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000452810
更新日期:2017-01-01 00:00:00
abstract::We report a case of graft intolerance syndrome in which transplant nephrectomy was performed 11 years after kidney transplantation. A 46-year-old man was admitted to our hospital in February 2018 with a mild fever, left lower abdominal pain, and gross hematuria with enlargement of the transplanted kidney. Urinary trac...
journal_title:Nephron
pub_type:
doi:10.1159/000511558
更新日期:2020-01-01 00:00:00
abstract::Mixed IgM-IgG cryoglobulins were present in the serum of a patient with the nephrotic syndrome, recurrent purpura, chronic active hepatitis and ascites. A renal biopsy demonstrated deposition of IgM, IgG, and complement components C3 and C4 in intracapillary 'coagula' and glomerular capillary walls. No glomerular depo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180591
更新日期:1976-01-01 00:00:00
abstract::Parathyroidectomy was carried out in 26 patients over a 14-year period. Excellent results were obtained in patients with severe hyperparathyroidism. Vascular calcification, hypercalcaemia and pruritus did not justify surgery unless associated with unequivocal hyperparathyroidism. 13 patients required intravenous calci...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182921
更新日期:1983-01-01 00:00:00
abstract::In 2014 57.5% of HD patients and 62.7% of PD patients achieved the audit measure for phosphate. 29.0% of HD and 30.3% of PD patients had a serum phosphate above the audit standard range. 79.1% of HD and 79.7% of PD patients had adjusted calcium between 2.2–2.5 mmol/L. 57.4% of HD and 65.0% of PD patients had a serum P...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000444823
更新日期:2016-01-01 00:00:00
abstract::Diffuse crescentic glomerulonephritis was observed in a 40-year-old male patient who had a ventriculoatrial shunt implanted after a traffic accident 10 years previously. Immediately after treatment with immunosuppressants and plasma pheresis, signs of meningitis and septicemia developed. The responsible organism isola...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183441
更新日期:1985-01-01 00:00:00
abstract::The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been shown to be associated with cardiovascular disease in healthy subjects as well as in patients with end-stage renal disease (ESRD). In this study, we examined the allelic frequency and genotype distribution of the MTHFR gene in 151 Chinese ESRD ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045922
更新日期:2001-03-01 00:00:00
abstract::Cardiovascular disease remains the major cause of mortality in hemodialysis patients. Abnormal oxidative stress and impaired antioxidant defense may contribute to accelerated atherogenesis associated with uremia. As oxidative modification of lipids appears to be a prerequisite for the development of atherosclerotic le...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045830
更新日期:2000-12-01 00:00:00
abstract::Familial lecithin-cholesterol acyltransferase deficiency is a hereditary disorder of lipid metabolism. Lipid material is deposited in the kidneys, the glomerular capillary basement membrane is irregularly thickened, detachment and even loss of endothelial cells are seen in the glomeruli. Proteinuria was present in 8 o...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180835
更新日期:1977-01-01 00:00:00