Abstract:
:A low-protein, low-phosphorus diet supplemented with essential amino acids and keto analogues was given to 12 rats, starting from the 90th day after subtotal nephrectomy. The purpose was to assess its effect on the residual renal function and on the nutritional status in rats with already established severe renal failure. Ten control rats in the same conditions, following a standard diet supplying normal amounts of protein and phosphorus were also studied. The supplemented diet exerted a well-evident protection of residual renal function and structure: lower rate of decline of creatinine clearance, lower mortality, significant decrease of proteinuria and almost total absence of histological signs of activity. The nutritional status was also well protected by the dietary therapy: increase of body weight, normal values of total serum protein, and low-constant values of urea appearance. In the control rats body weight decreased, total serum protein was lower than normal and the values of urea appearance were increasing simultaneously with a decreasing food intake and body weight.
journal_name
Nephronjournal_title
Nephronauthors
Barsotti G,Moriconi L,Cupisti A,Dani L,Ciardella F,Lupetti S,Giovannetti Sdoi
10.1159/000185055subject
Has Abstractpub_date
1988-01-01 00:00:00pages
197-202issue
3eissn
1660-8151issn
2235-3186journal_volume
49pub_type
杂志文章相关文献
NEPHRON文献大全abstract::A case of a renal transplant recipient with colchicine-induced myopathy is presented. He was on colchicine therapy for 10 months. He was hospitalized for investigation of fatigue, severe myalgia in the lower extremities and elevated serum aminotransferase levels. His viral markers and other factors that may cause myal...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000065439
更新日期:2002-12-01 00:00:00
abstract:AIM:To determine the prevalence of kidney disease in a cohort of individuals with silicosis. METHODS:Review of medical records and questionnaires from patients reported to a state surveillance system for silicosis. Reporting of individuals with silicosis is required by state law. All individuals with silicosis reporte...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045624
更新日期:2000-05-01 00:00:00
abstract::Recurrent intradialytic hypotension is probably the most severely disabling feature in dialysis patients and the etiology is multifactorial. We assessed the efficacy and safety of midodrine, a selective alpha1-adrenergic pressor agent in 12 patients with recurrent intradialytic hypotension. Symptomatic intradialytic h...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000190288
更新日期:1997-01-01 00:00:00
abstract::We have evaluated the effect of the antihyperlipidemic agent probucol on hyperlipidemia in patients with nephrotic syndrome. Twelve patients with long-standing nephrotic syndrome received 500 mg of probucol daily for 12 weeks. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol were significantl...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184524
更新日期:1987-01-01 00:00:00
abstract::The effect of intravenous 1 alpha(OH)D3 on circulating intact parathyroid hormone (PTH) and COOH-terminal immunoreactive PTH was examined in 21 patients on chronic hemodialysis. The patients were treated for 3 months with increasing doses of 1 alpha(OH)D3 under careful control of serum Ca2+. 1 alpha(OH)D3 was given in...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185744
更新日期:1989-01-01 00:00:00
abstract::Plasma renin reactivity (PRR) is the in vitro rate of angiotensin generation after addition of exogenous renin to plasma. The purpose of the present study is to compare measurements of PRR in venous effluent from the involved and uninvolved kidneys in both experimental and clinical renovascular hypertension. A two-kid...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180893
更新日期:1977-01-01 00:00:00
abstract::A 41-year-old woman was admitted to the hospital because of renal failure requiring hemodialysis treatment. Renal biopsy revealed active chronic interstitial nephritis. Renal function nearly normalized after removal of a copper-containing intrauterine device (IUCD). We conclude that copper-IUCDs may lead to renal fail...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186847
更新日期:1992-01-01 00:00:00
abstract::The effects of contrast media on renal function and the cortical retention of contrast media after abdominal angiography were investigated. Sixteen nondiabetic patients with predialytic chronic renal failure received either the nonionic dimeric contrast medium iodixanol or the monomeric contrast medium iohexol in a do...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000189139
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Depression is the most common mental health disorder among those with end-stage renal disease (ESRD), with prevalence of 15-40%. However, the association between chronic kidney disease (CKD) and depression is more variable. We examined the associations of CKD with depression, perceived health status, and qua...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000455750
更新日期:2017-01-01 00:00:00
abstract::Tissue fluid and plasma oncotic pressure levels were measured in an unselected group of 13 patients presenting with congestive heart failure. Patients had a mean serum albumin of 3.6 g/dl +/- (SD) 0.35; serum oncotic pressure was 22.23 +/- 1.8 mm Hg; tissue fluid (lower leg) oncotic pressure was 0.985 +/- 0.34 mm Hg. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185804
更新日期:1990-01-01 00:00:00
abstract::The variations of ionized and total calcium concentrations were studied during haemodialysis with high flux membrane using dialysate calcium concentrations of 1.63 and 1.76 mmol/l. The changes in ionized and total calcium were related to the predialytic calcium concentration difference between plasma and dialysate. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184951
更新日期:1988-01-01 00:00:00
abstract::Normal and streptozotocin diabetic rats were subjected to ischemic injury by unilateral renal artery occlusion for 60 min. The cortical and the medullary oxygen consumption (QO2) in the postischemic and the control, contralateral nonischemic, kidneys were measured 1 h, 1 day, and 1, 2 and 4 weeks for normal rats and 1...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187367
更新日期:1993-01-01 00:00:00
abstract::Fibrinogen fragments (X, Y, D and E) and fibrin fragments (D-dimer and E) were examined in the urine of 52 patients with various types of renal diseases. One or more of the fibrinogen fragments were detectable in all the urine specimens. D-Dimer together with fibrinogen fragments was found in 38 of the 52 patients. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182833
更新日期:1982-01-01 00:00:00
abstract::To reassess the reported protective effects of verapamil in renal ischaemia, we perfused the left kidney of uninephrectomized female Wistar rats with verapamil (0.1 and 1.0 mg/kg) immediately prior to clamping the renal artery for 60 min. When compared to controls, both doses of verapamil failed to afford protection w...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186279
更新日期:1991-01-01 00:00:00
abstract::The daily loss of apolipoproteins into the dialysate from 5 patients on continuous ambulatory peritoneal dialysis (CAPD) was measured. The mean excretion of apolipoprotein (apo) AI and apo AII, major proteins of high-density lipoproteins (HDL), were 84 and 17 mg/day, respectively, while that of apo B, a major protein ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185289
更新日期:1989-01-01 00:00:00
abstract::The accumulation in blood plasma and efficiency of hemodialysis of pyrimidine compounds (orotic acid, orotidine, pseudouridine, uridine, thymine) as well as uric acid and creatinine in 23 patients with chronic renal failure (CRF) was investigated. As a reference, the analysis of the above metabolites in the plasma of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187313
更新日期:1993-01-01 00:00:00
abstract::A 16-year-old female with acro-renal-ocular syndrome complicated by ventricular septal defect is described. Renal biopsy was performed for the first time in this syndrome, and the results suggested that proteinuria and renal dysfunction were caused by chronic pyelonephritis secondary to malrotation of the kidney and a...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000185264
更新日期:1989-01-01 00:00:00
abstract::Continuous therapy with an angiotensin-converting enzyme (ACE) inhibitor has been shown to have a glomerular vasodepressor effect in the newly diabetic rat and to largely prevent subsequent development of severe sclerosing glomerular injury. Preliminary studies in humans with established diabetic glomerular injury rev...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186031
更新日期:1990-01-01 00:00:00
abstract::While the bulk of renal hypertrophy induced by contralateral nephrectomy or a high-protein diet consists of tubular cell growth, there is some evidence suggesting that mesangial cells play a role in this phenomenon. Previous data suggest that this role of mesangial cells is associated with their proliferation. We, the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045668
更新日期:2000-07-01 00:00:00
abstract::Diabetic nephropathy (DN), a distinct manifestation of diabetic kidney disease, affects approximately 30% of patients with diabetes. While most attention has been focused on glomerular changes related to DN, there is growing evidence that tubulopathy is a key feature in the pathogenesis of this disease. The renal prox...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000494512
更新日期:2019-01-01 00:00:00
abstract::We reviewed the recommendations and outcomes for all patients with diabetes mellitus and end-stage renal disease referred to the Medical Center Hospital of Vermont from 1971 through December 1983. During this period, we recommended transplantation in 53 of 73 patients evaluated. Thirty-two transplants were performed i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183693
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:In an attempt to decrease mortality in patients with end-stage renal disease, an increase in the lifetime of these patients without much focus on health-related quality of life (HRQOL) was pursued for a long period of time. However, lately, an improvement in the quality of this extended lifetime has focuse...
journal_title:Nephron
pub_type: 杂志文章,多中心研究
doi:10.1159/000369139
更新日期:2015-01-01 00:00:00
abstract::Mizoribine has been shown to possess an immunosuppressive action that inhibits the proliferation of lymphocytes selectively by interfering with inosine monophosphate dehydrogenase. Recent studies have demonstrated that mizoribine improves renal tubulointerstitial fibrosis in the rat model of unilateral ureteral obstru...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046065
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND/AIM:Interleukin (IL)-17 is a newly discovered cytokine that is secreted by activated memory CD4+ T cells and modulated the early stage of immune response. To elucidate the pathophysiology of minimal-change nephrotic syndrome (MCNS), we focused on IL-17, which is one of the key factors in regulating an inflam...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000058399
更新日期:2002-06-01 00:00:00
abstract::Most hypertensive subjects are overweight, and as a consequence have an increased prevalence of hypercholesterolaemia, impaired glucose tolerance, and left ventricular hypertrophy. Reduction of the blood pressure by antihypertensive drugs without control of the obesity leaves these additional risk factors for cardiova...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184543
更新日期:1987-01-01 00:00:00
abstract::In Wistar rats V-U reflux with distilled water and sterile saline of varying osmolar strength produces scars in the perihilar region of the kidneys in 80% of animals. Using Indian ink as a marker, rupture of the forniceal epithelium regularly followed V-U reflux. Intrapelvic pressure rose to 120 mm Hg during the reflu...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180706
更新日期:1976-01-01 00:00:00
abstract::Primary hyperoxaluria type 1 (PH1) is caused by deficiency of peroxisomal alanine-glyoxylate aminotransferase which is in humans exclusively expressed in liver cells. The disease is inherited as an autosomal recessive trait, and initial symptoms usually occur in early childhood. Up to the age of 25 years, 90% of the p...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045888
更新日期:2001-01-01 00:00:00
abstract::Because of the great problem of viral hepatitis in hemodialysis patients, the Italian Society of Nephrology decided to perform a national epidemiologic survey. We contacted 467 nephrological centers by a questionnaire which let us have information on 25,746 uremic patients: 18,338 on HD, 2,250 on PD and 5,176 with kid...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186905
更新日期:1992-01-01 00:00:00
abstract::Ischemic acute kidney injury (AKI) is predominantly mediated by the innate inflammatory response to damage-associated molecular patterns released during the reperfusion phase of the ischemic event. In this study, we show that pre-emptive IgM infusions to increase binding of natural IgM (nIgM) anti-leucocyte autoantibo...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000501639
更新日期:2019-01-01 00:00:00
abstract::A study was undertaken in 24 Chinese patients on maintenance continuous ambulatory peritoneal dialysis, using bezafibrate in its sustained-release form to correct lipid abnormalities. Six patients who received 400 mg/day developed severe muscle weakness with grossly elevated creatine phosphokinase activities within 3 ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186101
更新日期:1990-01-01 00:00:00