Renal transplantation in diabetes mellitus. Influence of preexisting vascular disease on outcome.

Abstract:

:We reviewed the recommendations and outcomes for all patients with diabetes mellitus and end-stage renal disease referred to the Medical Center Hospital of Vermont from 1971 through December 1983. During this period, we recommended transplantation in 53 of 73 patients evaluated. Thirty-two transplants were performed in 30 patients. Of the 30 patients, 10 had clinical vascular disease prior to transplantation, i.e., claudication, amputation, active angina, myocardial infarction, or stroke. Seven of the 10 had only claudication or amputation. These 10 patients showed a clear excess in graft failure and mortality. One- and 2-year graft survival was 37 and 13%; patient survival was 48 and 24%. By comparison, the 20 patients without evident vascular disease had 1- and 2-year graft survival rates of 83 and 75% and patient survival rates of 85% at both 1 and 2 years. The incidence of cardiovascular death in the group with vascular disease was 45% at 1 year and 63% at 2 years, as compared with none in the group without vascular disease. The high graft loss and mortality in this group after transplantation should be a major consideration when therapeutic alternatives are considered in diabetics with end-stage renal disease.

journal_name

Nephron

journal_title

Nephron

authors

Rimmer JM,Sussman M,Foster R,Gennari FJ

doi

10.1159/000183693

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

304-10

issue

4

eissn

1660-8151

issn

2235-3186

journal_volume

42

pub_type

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