Abstract:
:Plasma renin reactivity (PRR) is the in vitro rate of angiotensin generation after addition of exogenous renin to plasma. The purpose of the present study is to compare measurements of PRR in venous effluent from the involved and uninvolved kidneys in both experimental and clinical renovascular hypertension. A two-kidney model of experimental hypertension was created by placing an ameroid resin constrictor around one renal artery in each of seven dogs. Plasma renin activity (PRA) in venous plasma from the involved kidney increased (p less than 0.001); comparing PRA in venous effluent from the stenotic and nonstenotic kidneys, the PRA ratio also increased ( p less than 0.005). Renal venous PRR did not change on either side after occlusion of the renal artery (p greater than 0.1), and the renal venous PRR ratio did not differ from the mean control ratio of 1.0 +/- 1 SE (p greater than 0.1). Similarly, in 9 patients with renovascular hypertension, mean PRR in venous plasma from the two kidneys did not differ (p greater than 0.8). These results suggest that measurement of renal venous PRR is not helpful in confirming a diagnosis of renovascular hypertension.
journal_name
Nephronjournal_title
Nephronauthors
Kotchen TA,Welch WJ,Daugherty M,Ernst CBdoi
10.1159/000180893subject
Has Abstractpub_date
1977-01-01 00:00:00pages
228-35issue
4eissn
1660-8151issn
2235-3186journal_volume
19pub_type
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