Impact of baseline health-related quality of life scores on survival of incident patients on peritoneal dialysis: a cohort study.

Abstract:

INTRODUCTION:In an attempt to decrease mortality in patients with end-stage renal disease, an increase in the lifetime of these patients without much focus on health-related quality of life (HRQOL) was pursued for a long period of time. However, lately, an improvement in the quality of this extended lifetime has focused on both the physical as well as the social and emotional aspects, as these parameters may be associated with clinical outcomes in end-stage renal disease patients. AIM:To evaluate the impact of self-determined HRQOL at admission on survival of incident peritoneal dialysis (PD) patients. PATIENTS AND METHODS:A total of 1,624 incident Brazilian PD patients participating in a multicenter prospective cohort study (BRAZPD) were evaluated. HRQOL was assessed using the SF-36, divided into mental and physical components. Cox proportional regression analysis was used to determine the influence of HRQOL (mental and physical components) on mortality. Multivariate Cox proportional hazards analyses were used to adjust gradually for more potential explanatory variables: first for demographic variables, followed by additional adjustment for socioeconomic, clinical and laboratory variables. The significance level in all analyses was set at p < 0.05. All analyses were carried out with SPSS 17.0. RESULTS:Incident PD patients presented with low HRQOL scores on admission to therapy. Even after correction for sociodemographic variables, comorbidities, PD modality and laboratory parameters, HRQOL (both the mental and the physical components) remained a predictor [HR: 0.97 (CI: 0.95-0.98); HR: 0.97 (CI: 0.96-0.99), respectively] of survival. CONCLUSION:On admission to therapy, patients presenting with low HRQOL scores for both the mental and the physical components were associated with a higher mortality. These results suggest that early and timely intervention measures to improve the QOL of these patients are important.

journal_name

Nephron

journal_title

Nephron

authors

Grincenkov FR,Fernandes N,Pereira Bdos S,Bastos K,Lopes AA,Finkelstein FO,Pecoits-Filho R,Qureshi AR,Divino-Filho JC,Bastos MG

doi

10.1159/000369139

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

97-103

issue

2

eissn

1660-8151

issn

2235-3186

pii

000369139

journal_volume

129

pub_type

杂志文章,多中心研究

相关文献

NEPHRON文献大全
  • Evaluation of the proteolytic activity of factor D accumulated as an active serine protease in patients with chronic renal failure.

    abstract::Complement factor D, a complement system serine protease, circulating in vivo as its active form, accumulates in patients with chronic renal failure. The pathophysiological role of this active protease in these patients was examined by studies on activities of excess factor D on 10 synthetic peptide substrates for som...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187824

    authors: Inagi R,Miyata T,Oda O,Maeda K,Inoue K

    更新日期:1994-01-01 00:00:00

  • Sustained-release bezafibrate corrects lipid abnormalities in patients on continuous ambulatory peritoneal dialysis.

    abstract::A study was undertaken in 24 Chinese patients on maintenance continuous ambulatory peritoneal dialysis, using bezafibrate in its sustained-release form to correct lipid abnormalities. Six patients who received 400 mg/day developed severe muscle weakness with grossly elevated creatine phosphokinase activities within 3 ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186101

    authors: Chan MK

    更新日期:1990-01-01 00:00:00

  • Polycythemia of end-stage renal failure: no inhibition of erythropoiesis by uremic serum and markedly increased serum erythropoietin level.

    abstract::This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184292

    authors: Muto S,Asano Y,Hosoda S,Shionoya S,Miura Y,Urabe A,Takaku F

    更新日期:1987-01-01 00:00:00

  • Activation of epidermal growth factor receptor in the early phase after renal ischemia-reperfusion in rat.

    abstract::In order to estimate a regenerative response in the early phase after renal ischemia-reperfusion in rat, we examined the time course of the activation of epidermal growth factor receptor (EGFR) as a response of signal transduction pathway after 45 min ischemia in kidney. The activation of EGFR was observed 5-30 min af...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045281

    authors: Yano T,Yazima S,Hagiwara K,Ozasa H,Ishizuka S,Horikawa S

    更新日期:1999-02-01 00:00:00

  • Colchicine-induced myopathy with normal creatine phosphokinase level in a renal transplant patient.

    abstract::A case of a renal transplant recipient with colchicine-induced myopathy is presented. He was on colchicine therapy for 10 months. He was hospitalized for investigation of fatigue, severe myalgia in the lower extremities and elevated serum aminotransferase levels. His viral markers and other factors that may cause myal...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000065439

    authors: Caglar K,Safali M,Yavuz I,Odabaşi Z,Yenicesu M,Vural A

    更新日期:2002-12-01 00:00:00

  • Acquired type II protein C deficiency in a long-term hemodialysis patient.

    abstract::We present a 57-year-old man with end-stage renal failure due to chronic glomerulonephritis, who had been on hemodialysis for 13.5 years and had suffered from recurrent painful swelling of the left leg for 4.7 years. A diagnosis of deep venous thrombosis was made by the phlebography. Coagulation studies showed decreas...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187835

    authors: Maruyama H,Gejyo F,Hanano M,Arakawa M

    更新日期:1994-01-01 00:00:00

  • Recovery of decreased ability of peripheral-blood mononuclear cells from chronic renal failure to produce interleukin-1 alpha and beta after renal transplantation.

    abstract::The ability of cultured peripheral-blood mononuclear cells (PBMC) to release interleukin-1 alpha and beta (IL-1 alpha, IL-1 beta) in response to concanavalin A (con A) was investigated in patients with chronic renal failure (CRF) and in renal transplant recipients. Mean IL-1 alpha level released by PBMC of healthy sub...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186478

    authors: Kang XX,Hirano T,Oka K,Tamaki T,Sakurai E,Kaji N,Yoshida M,Kozaki M

    更新日期:1991-01-01 00:00:00

  • The effect of dilazep on urinary protein excretion in spontaneous diabetic Chinese hamster.

    abstract::The effect of dilazep, an adenosine potentiator and platelet aggregation inhibitor, on experimental diabetic nephropathy was investigated in spontaneous diabetic Chinese hamster. Prediabetic animals, 8 weeks of age, were divided into two groups. In one group, 5 mg/kg dilazep was injected i.p. once a day. In the other ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187453

    authors: Morikawa A,Eto M,Makino I

    更新日期:1993-01-01 00:00:00

  • COVID-19 in Renal Transplant Recipients: Case Series and a Brief Review of Current Evidence.

    abstract::By April 26, 2020, infections related to coronavirus disease 2019 (COVID-19) affected people from 210 countries and caused 203,818 reported deaths worldwide. A few studies discussed the outcome of COVID-19 in kidney transplant recipients. This short series demonstrates our experience in managing COVID-19 disease in re...

    journal_title:Nephron

    pub_type:

    doi:10.1159/000512329

    authors: Elhadedy MA,Marie Y,Halawa A

    更新日期:2020-12-08 00:00:00

  • Randomized trial of methylcobalamin and folate effects on homocysteine in hemodialysis patients.

    abstract:BACKGROUND:There are no data available on the effects of intravenous (i.v.) methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fast...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000057605

    authors: Trimarchi H,Schiel A,Freixas E,Díaz M

    更新日期:2002-05-01 00:00:00

  • Effect of cisplatin on proximal straight tubule transport of divalent cations in the rabbit.

    abstract::Clearance and in vitro microperfusion studies were performed in rabbits to determine the effect of cisplatin on proximal straight tubule transport of calcium and magnesium. Rabbits were injected with cisplatin (2.5 mg/kg i.p. once weekly) for 3 weeks, whereas control rabbits received normal saline solution which serve...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184988

    authors: Wong NL,Sutton RA,Dirks JH

    更新日期:1988-01-01 00:00:00

  • Effect of ischemia on renal blood flow in the rat.

    abstract::The effect of ischemia on renal blood flow (RBF) in the rat has been an unsettled question. This study used a totally extractable indicator, radioactive microspheres, with a reference arterial sample, to study RBF quantitatively 10 and 60 min after 1 h of unilateral renal artery clamping in anesthetized, heparinized r...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181378

    authors: Riley AL

    更新日期:1978-01-01 00:00:00

  • Studies on abnormal lipid metabolism in experimental nephrotic syndrome.

    abstract::The specific lipid alterations in plasma and four different tissues, as well as the activities of plasma lecithin-cholesterol acyltransferase (LCAT) and tissue lipolytic enzymes were determined in experimental nephrotic and control rats. In nephrotic rats, the cholesterol level in the heart was significantly increased...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187323

    authors: Agbedana ED,Yamamoto T,Moriwaki Y,Suda M,Takahashi S,Higashino K

    更新日期:1993-01-01 00:00:00

  • An index of plasma refilling in hemodialysis patients.

    abstract::During hemodialysis therapy, a large amount of water is removed from the patient's blood in a short time; however, blood pressure remains stable in most patients. As water is removed, the circulating serum proteins become more concentrated, resulting in a marked increase in the driving force which pulls water from the...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189320

    authors: Tabei K,Nagashima H,Imura O,Sakurai T,Asano Y

    更新日期:1996-01-01 00:00:00

  • Failure of sodium restriction to abolish exaggerated natriuresis in poststreptococcal glomerulonephritis.

    abstract::Exaggerated natriuresis in response to hypertonic saline infusion occurs with great regularity in patients with documented previous attacks of poststreptococcal glomerulonephritis. Five patients were studied before and after 1 week of dietary sodium restriction in order to examine the possibility that increased extrac...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000180852

    authors: Schacht RG,Steele JM Jr,Lowenstein J,Baldwin DS

    更新日期:1977-01-01 00:00:00

  • Septicemia due to Yersinia enterocolitica in a long-term hemodialysis patient after a single desferrioxamine administration.

    abstract::A long-term hemodialysis male patient was known to have systemic iron overload due to regular blood transfusions. As he was suspected to have aluminum overload, he received a single intravenous administration of desferrioxamine (that supported the hypothesis). Four days later, he became highly febrile with no focus of...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185208

    authors: Hoen B,Renoult E,Jonon B,Kessler M

    更新日期:1988-01-01 00:00:00

  • Comparison of histomorphometry and computerized tomography of the spine in quantitating trabecular bone in renal osteodystrophy.

    abstract::Computerized tomography (CT) has the advantage of allowing the isolation of trabecular bone of the axial skeleton, which is the more sensitive to metabolic changes. By means of single-energy X-ray CT we have devised a method for assessing trabecular bone mass (TBM) at L-4 vertebral body, which has an acceptable reprod...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000184007

    authors: Torres A,Lorenzo V,Gonzalez-Posada JM

    更新日期:1986-01-01 00:00:00

  • Cytotoxicity of commercial peritoneal dialysis solutions towards peritoneal cells of chronically uremic mice.

    abstract::A gradual loss of cell viability was observed during in vitro incubation of peritoneal cells from chronically uremic mice in commercial peritoneal dialysis solutions. The magnitude of this cytotoxicity toward peritoneal cells harvested from uremic mice and controls was comparable. Resident peritoneal cells were always...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183855

    authors: Gallimore B,Gagnon RF,Stevenson MM

    更新日期:1986-01-01 00:00:00

  • Home hemodialysis. Revival of a superior dialysis treatment.

    abstract:BACKGROUND:Home hemodialysis is usually considered a superior therapy, whose decline is related to demographic, social, psychological and financial factors as well as to competition with renal transplantation and PD. METHODS:A home hemodialysis program was started in November 1998 in the University of Torino, Italy (2...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000063319

    authors: Piccoli GB,Bermond F,Mezza E,Quaglia M,Pacitti A,Jeantet A,Segoloni GP

    更新日期:2002-10-01 00:00:00

  • Prevalence of hypocitraturia and hypopyrophosphaturia in recurrent calcium stone formers: as isolated defects or associated with other metabolic abnormalities.

    abstract::Several underlying metabolic abnormalities may be present in patients with recurrent calcium calculus disease (RCCD). The aim of this study was to determine the prevalence of deficiencies of 2 well-known potent inhibitors of crystal formation and growth, citrate and pyrophosphate, in the various metabolic subgroups an...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000186179

    authors: Laminski NA,Meyers AM,Sonnekus MI,Smyth AE

    更新日期:1990-01-01 00:00:00

  • Renal calcium and magnesium handling in water immersion in nephrotic patients.

    abstract::The effect of water immersion to the neck on renal calcium and magnesium handling was studied in 11 nephrotic patients. There was an increase in the urinary excretion of both calcium and magnesium on immersion, and a return towards preimmersion control values in the hour following immersion. Clearances of calcium and ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182897

    authors: Brown C,Sutton JV,Adler A,Feinroth MV,Feinroth M,Friedman EA,Berlyne GM

    更新日期:1983-01-01 00:00:00

  • Effect of simvastatin on qualitative and quantitative changes of lipoprotein metabolism in CAPD patients.

    abstract::The efficacy of simvastatin, a competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, was investigated in 12 patients treated with continuous ambulatory peritoneal dialysis (CAPD), displaying hypercholesterolemia and moderate hypertriglyceridemia. After a 4-week placebo period, simvastatin was admi...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186993

    authors: Wanner C,Lubrich-Birkner I,Summ O,Wieland H,Schollmeyer P

    更新日期:1992-01-01 00:00:00

  • Trajectory of Estimated Glomerular Filtration Rate Predicts Renal Injury in Children with Multicystic Dysplastic Kidney.

    abstract:BACKGROUND/AIMS:Children with a solitary functioning kidney have a risk of renal injury caused by hyperfiltration. Timely intervention with renin-angiotensin inhibitors may be beneficial. We examined whether trajectory of estimated glomerular filtration rate (eGFR) would predict renal injury, defined as microalbuminuri...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000490200

    authors: Matsumura K,Sugii K,Awazu M

    更新日期:2018-01-01 00:00:00

  • Stomach phytobezoars in two uremic anorexic patients.

    abstract::Conglomerates of food and mucus or phytobezoars composed of vegetable matter are sometimes found in the stomach in the general population. Reports of phytobezoars in uremic patients are, however, scarce. Here we describe 2 uremic patients in which esophagogastroduodenoscopy was performed due to dyspepsia associated wi...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000049075

    authors: Catalano C,Leone L,Fabbian F,Conz PA

    更新日期:2002-03-01 00:00:00

  • Enhanced renal sympathetic tone in liver cirrhosis: evaluation by intrarenal administration of dihydroergocristine.

    abstract::Mean renal blood flow (MRBF), cortical blood flow (CBF), glomerular filtration rate (GFR), heart rate, arterial blood pressure, Na+ and K+ excretion were determined before and 10 min after intrarenal administration of dihydroergocristine (0.017 mg/kg b.w.) in 13 patients suffering from liver cirrhosis. Cardiac output ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182519

    authors: Gatta A,Merkel C,Grassetto M,Milani L,Zuin R,Ruol A

    更新日期:1982-01-01 00:00:00

  • Soluble P-selectin is released from activated platelets in vivo during hemodialysis.

    abstract::During hemodialysis, platelets are activated across a dialyzer. Soluble P-selectin (sP-selectin) is a form of P-selectin which is a glycoprotein relocated from secretory granules to the surfaces of platelets and endothelial cells after these cells have been physiologically activated. To investigate whether sP-selectin...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044903

    authors: Kawabata K,Nagake Y,Shikata K,Fukuda S,Nakazono H,Takahashi M,Ichikawa H,Makino H

    更新日期:1998-01-01 00:00:00

  • The determination of plasma transferrin receptor as good index of erythropoietic activity in renal anemia and after renal transplantation.

    abstract::Both the plasma determinations of erythropoietic (EPO) and transferrin receptor (TfR) would provide a good characterization of anemia especially when mixed erythron disorders underlie, such as in renal failure. Immunologic assays of EPO and TfR, as well as standard hematologic determinations (hematocrit, reticulocyte ...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000188938

    authors: de Paoli Vitali E,Ricci G,Perini L,Malacarne F,Vedovato M,Guerra G,Dapporto M,Gilli P

    更新日期:1996-01-01 00:00:00

  • Transforming growth factor-beta1 may be involved in shunt obstruction in patients on chronic hemodialysis.

    abstract::Obstructed shunt vessels were studied immunohistochemically to clarify the mechanism of shunt obstruction in hemodialysis patients. The subjects were 12 hemodialysis patients with shunt obstruction, and 8 patients newly started on hemodialysis were used as the controls. Cryosections of shunt tissue were prepared and s...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000045256

    authors: Taniguchi Y,Yorioka N,Yamashita K,Masaki T,Yamakido M

    更新日期:1999-01-01 00:00:00

  • Non-A, non-B hepatitis: clinical laboratory course in patients on hemodialysis and its correlation with the presence of anti-hepatitis C virus antibodies.

    abstract::136 patients on hemodialysis, 89 males and 47 females, were studied; we evaluated the index of hepatic function (SGOT and SGPT) and antibodies against HCV. We observed 42 cases of increased transaminases classified as non-A, non-B (NANB) hepatitis. Antibodies against HCV were present in 40 patients. Among 42 patients ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186903

    authors: La Russa A,Bufano G,Cauzzi L,Pecchini P

    更新日期:1992-01-01 00:00:00

  • Percutaneous renal biopsy in children: a 27-year experience.

    abstract:BACKGROUND:The introduction of automated biopsy devices and the localization of the kidney by ultrasound were aimed at optimizing efficacy and safety of the percutaneous renal biopsy procedure. We evaluated these technological advances in our renal biopsies performed in children. METHODS:We sequentially used the Silve...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000045090

    authors: Feneberg R,Schaefer F,Zieger B,Waldherr R,Mehls O,Schärer K

    更新日期:1998-08-01 00:00:00