Abstract:
:Several underlying metabolic abnormalities may be present in patients with recurrent calcium calculus disease (RCCD). The aim of this study was to determine the prevalence of deficiencies of 2 well-known potent inhibitors of crystal formation and growth, citrate and pyrophosphate, in the various metabolic subgroups and as single defects. In 107 patients with RCCD, urinary citrate was significantly decreased in all metabolic subgroups with 49% of patients having hypocitraturia (2.53 +/- 1.19 mmol/24 h) versus controls (3.44 +/- 0.96 mmol/24 h; p less than 0.001). Reduced pyrophosphate:creatinine ratios were present in all the patient subgroups, and 48% of all patients had reduced ratios (1.68 +/- 1.68 vs. 3.10 +/- 2.66 in controls; p less than 0.01). There was no correlation between citrate and pyrophosphate concentration. Isolated hypocitraturia was found in 11.2%, reduced pyrophosphate:creatinine ratios as the single defect in 11.2% and a combination of both in 12.1% of patients. Thus inhibitor defects play an important role in patients with RCCD and frequently occur as isolated biochemical defects.
journal_name
Nephronjournal_title
Nephronauthors
Laminski NA,Meyers AM,Sonnekus MI,Smyth AEdoi
10.1159/000186179subject
Has Abstractpub_date
1990-01-01 00:00:00pages
379-86issue
4eissn
1660-8151issn
2235-3186journal_volume
56pub_type
临床试验,杂志文章相关文献
NEPHRON文献大全abstract::We describe two preparations for chronic peritoneal dialysis in the dog. In one group uremia was induced by nephrectomy and in the other by ureteral ligation. Peritoneal access was obtained using the Ash disc column catheter. Survival of the animals ranged from 27 to 83 days. Using a dialysis schedule similar in conce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183093
更新日期:1983-01-01 00:00:00
abstract::Obstructed shunt vessels were studied immunohistochemically to clarify the mechanism of shunt obstruction in hemodialysis patients. The subjects were 12 hemodialysis patients with shunt obstruction, and 8 patients newly started on hemodialysis were used as the controls. Cryosections of shunt tissue were prepared and s...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000045256
更新日期:1999-01-01 00:00:00
abstract::The serum levels of 25-hydroxycholecalciferol, 24,25-dihydroxycholecalciferol, and 1,25-dihydroxycholecalciferol were measured simultaneously in three groups of adults with different renal function: normal (n = 24), glomerular filtration rate (GFR) greater than 70 ml/min; moderately decreased (n = 15), GFR 5-35 ml/min...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183383
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Previous studies showed that ceftriaxone can cause acute kidney injury (AKI) in the pediatric population. This study proposed a cellular model of crystalline nephropathy in ceftriaxone-associated AKI and explored the related pathophysiology by using a proteomic approach. METHODS:Ceftriaxone was crystallized...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000486324
更新日期:2018-01-01 00:00:00
abstract::A retrospective analysis of renal vein renin results has been done in 96 patients with renal artery stenosis and hypertension studied in two Italian centers (Sassari and Pisa) with respect to the outcome of either surgery or percutaneous transluminal angioplasty (PTA). In all patients the renal vein renin ratio and th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184039
更新日期:1986-01-01 00:00:00
abstract::An autopsy case of membranous glomerulonephritis associated with enterococcal endocarditis was reported. Although enterococcal antigen was not identified in glomerular deposits, the eluate from the patient's renal tissue was shown to specifically recombine with cells of the enterococcus isolated from his own ante mort...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183435
更新日期:1985-01-01 00:00:00
abstract::The effects of chitosan-coated dialdehyde cellulose (chitosan DAC), a newly developed oral adsorbent for urea and ammonia, were examined in a glomerulonephritis model in rats. Mesangial proliferative glomerulonephritis accompanied with proteinuria was induced by an intravenous injection of anti-rat Thy-1.1 monoclonal ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000044973
更新日期:1998-01-01 00:00:00
abstract::This paper reviews the control of aldosterone secretion, including the role played by hepatic metabolic clearance, ACTH, and the renin-angiotensin system, and the interrelationships of aldosterone secretion with sodium and potassium metabolism. The physiological modulations of aldosterone secretion by the upright post...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181613
更新日期:1979-01-01 00:00:00
abstract::We present a rare case of IgA nephropathy in a patient who developed atypical hemolytic uremic syndrome (aHUS) associated with a complement factor H (CFH) gene mutation, and who was successfully treated with eculizmab. A 76-year-old man was admitted as the patients had thrombotic microangiopathies findings. The patien...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000485194
更新日期:2018-01-01 00:00:00
abstract::8 patients who developed proteinuria whilst receiving penicillamine for rheumatoid arthritis have been studied. Light microscopy of renal biopsy specimens showed evidence of an extramembranous nephropathy in 6 cases, with epimembranous spikes infrequently described previously in association with penicillamine. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181984
更新日期:1980-01-01 00:00:00
abstract::We recently showed in dogs that there is a close relationship between bicarbonate reabsorption and glomerular filtration rate (GFR). The present studies were designed to confirm these findings in five normal men. Bicarbonate titrations were done after ingesting a low protein diet for one week and were repeated followi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180453
更新日期:1975-01-01 00:00:00
abstract::The capacity of peripheral blood mononuclear cells (PBMC) to undergo spontaneous and induced interleukin-1 (IL-1) production was examined in 10 healthy controls and in 10 patients undergoing intermittent hemodialysis (HD) using cuprophane membranes. Extracellular and cytoplasmic IL-1 activity was assayed by biologic a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185187
更新日期:1988-01-01 00:00:00
abstract::Cardiovascular complications seriously affect posttransplant survival in patients after successful renal transplantation. Abnormalities in blood rheology may contribute to these complications. Therefore, we studied the blood rheology before and during a 1-year observation period after grafting in 9 patients by serial ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189330
更新日期:1996-01-01 00:00:00
abstract::The effect of changes in the dialysate calcium concentration on calcium fractions and parathyroid hormone species in plasma during hemodialysis has been examined. C-terminal immunoreactive parathyroid hormone was suppressed when plasma calcium increased by greater than 25% whereas N-terminal fragments demonstrated an ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000180870
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Sclerostin is an osteocyte hormone that decreases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chronic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high. AIM:To assess the correlation of serum sclerostin levels ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000443845
更新日期:2016-01-01 00:00:00
abstract::A 2-year prospective study was done in 45 patients to see whether the FENa test, done at first nephrology consultation visit for acute renal failure, was useful in prognosticating whether patients would recover renal function spontaneously or need dialysis. Of 26 patients who recovered renal function spontaneously, 8 ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183110
更新日期:1984-01-01 00:00:00
abstract::Hypertension secondary to renal transplantation was studied in our experimental model in the rat. In this model an intravenous injection of donor strain blood into recipients of allogeneic donor kidneys prior to transplantation was used to prolong the allograft survival. A reduced renal function associated with the hy...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183428
更新日期:1985-01-01 00:00:00
abstract::In order to elucidate the cells produced from human glomerular cultures, a pre-embedding ultrastructural immunoperoxidase technique was developed to investigate the precise localisation of a panel of monoclonal antibodies specific to human glomerular antigens in situ and used to identify the same antigens in vitro. Th...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185583
更新日期:1989-01-01 00:00:00
abstract::To explain the occurrence of tubular and glomerular proteinuria in patients with primarily tubular or glomerular dysfunction, it is usually assumed that the mechanisms responsible for the renal tubular transport of small and large proteins are different. The present in vivo study does not support this hypothesis since...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184090
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND/AIMS:The renal prognosis of post-renal acute kidney injury (PoR-AKI) has not been verified so far. The objective of this study was to assess the association of baseline anemia with long-term renal prognosis in patients with PoR-AKI. METHODS:We performed a multicenter retrospective cohort study. Consecutive ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000452810
更新日期:2017-01-01 00:00:00
abstract::Experiences with peritonitis in a continuous ambulatory peritoneal dialysis (CAPD) program at a single center over 8 years were reviewed. Home-acquired peritonitis rates have been less than 1 episode per patient year since 1982. Gram-positive organisms continue to account for most episodes in a similar proportion. Act...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183807
更新日期:1986-01-01 00:00:00
abstract::A previously described method for recovering a proximal renal tubular epitheal antigen (HRTE-1) from normal human kidney was modified by using ion-exchange and immunoaffinity chromatography in order to create easily reproducible conditions for antigen isolation. Radioiodinated HRTE-1 was then used to establish a 3-hou...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181942
更新日期:1980-01-01 00:00:00
abstract::X-linked nephrogenic diabetes insipidus (NDI) is a rare disease caused by mutations in the vasopressin V2 receptor (AVPR2) gene. We analyzed the AVPR2 gene in 6 unrelated Korean families with X-linked NDI, and found 6 novel mutations. Two of them were missense point mutations, 2 were short deletions causing frameshift...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189581
更新日期:1997-01-01 00:00:00
abstract::From July 1984 to December 1987, 9 patients with lupus nephritis did not respond to the administration of two courses of methylprednisolone pulse therapy and cyclophosphamide treatment for 56 days. Therefore, high-dose intravenous human gamma-globulin (IVIG) was administrated. Before IVIG therapy, renal biopsy showed ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185772
更新日期:1989-01-01 00:00:00
abstract::To investigate autonomic mechanisms underlying persistent hypotension in long-term hemodialysis patients, high-frequency (HF, > 0.15 Hz) and low-frequency (LF, 0.04-0.15 Hz) components of heart rate variability and plasma noradrenaline were analyzed in 10 persistently hypotensive hemodialysis patients (group H), 11 no...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188906
更新日期:1996-01-01 00:00:00
abstract::Cardiovascular disease is the major complication and cause of mortality in the dialysis population, accounting for about 40% of deaths. Oxidative stress has been strongly implicated in the pathogenesis of these events. As patients in end-stage renal disease (ESRD) are in a state of elevated free radical activity, the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000065438
更新日期:2002-12-01 00:00:00
abstract::A patient with collagenofibrotic glomerulopathy associated with hepatic persinusoidal fibrosis is described. Renal biopsy revealed that the glomerular tufts contained homogeneous material that was proved by electron microscopy to be collagen fibers. The material was reactive to anti-type III collagen monoclonal antibo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187180
更新日期:1993-01-01 00:00:00
abstract::Tubular necrosis elicits a process of renal tissue repair characterized by an increase of cell turnover in tubular epithelium. The present study was undertaken to examine the distribution of epidermal growth factor (EGF) and/or of its larger precursor proEGF in the kidney undergoing tubular regeneration. Sprague-Dawle...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186253
更新日期:1991-01-01 00:00:00
abstract::A simple three-pump-based system for the performance of continuous venovenous haemodialysis is described. The method employs access to the circulation via a double-lumen catheter, and by means of a standard extracorporeal peristaltic pump the blood is circulated through a haemofiltration filter. Standard solutions for...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188835
更新日期:1996-01-01 00:00:00
abstract::29 patients receiving haemodialysis treatment for chronic renal failure were divided into two groups on the basis of the presence or absence of bone disease as defined by radiology and bone alkaline phosphatase. The group of patient with bone disease showed a significantly greater increase in protein-bound calcium dur...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181632
更新日期:1979-01-01 00:00:00