Blood rheology after renal transplantation.

Abstract:

:Cardiovascular complications seriously affect posttransplant survival in patients after successful renal transplantation. Abnormalities in blood rheology may contribute to these complications. Therefore, we studied the blood rheology before and during a 1-year observation period after grafting in 9 patients by serial measurements of fibrinogen, red cell aggregation, hematocrit, spontaneous platelet aggregation, and plasma viscosity. Prior to grafting, fibrinogen and red cell aggregation were found to be increased in patients on regular hemodialysis as compared with healthy controls, whereas hematocrit and platelet aggregation were markedly reduced. After successful transplantation, the platelet aggregation progressively rose together with the hematocrit, while fibrinogen and red cell aggregation remained abnormally high. Our findings suggest that abnormal blood rheology in patients with chronic renal failure does not improve in response to successful renal transplantation: fibrinogen and red cell aggregation remain abnormally high; further, the overall blood flow properties are supposed to deteriorate due to the postoperative increase in hematocrit and spontaneous platelet aggregation. Adverse rheological conditions thus resulting may contribute to the increased frequency of vascular events observed in transplanted patients.

journal_name

Nephron

journal_title

Nephron

authors

Koppensteiner R,Derfler K,Ehringer H

doi

10.1159/000189330

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

328-32

issue

2

eissn

1660-8151

issn

2235-3186

journal_volume

74

pub_type

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