Abstract:
:Interleukin-6 (IL-6) was determined in serum and peritoneal dialysis effluent (PDE) of patients on chronic ambulatory peritoneal dialysis (CAPD) by a biological assay measuring the proliferation of the IL-6-dependent 7TD1 cell line. Six patients free of peritonitis displayed low but significant levels of IL-6 (mean +/- 42 pg/ml) in PDE, while IL-6 was undetectable in serum. In 6 patients with staphylococcal peritonitis, a tremendous increase in PDE levels of IL-6 was noted (range: 5,832-37,491 pg/ml), while serum IL-6 remained either undetectable or on a low level except in one case. After 5 days of antibiotic treatment, IL-6 levels in PDE returned to basal values. We conclude that CAPD results in an intraperitoneal secretion of IL-6 which is markedly but transiently increased during peritonitis episodes.
journal_name
Nephronjournal_title
Nephronauthors
Goldman M,Vandenabeele P,Moulart J,Amraoui Z,Abramowicz D,Nortier J,Vanherweghem JL,Fiers Wdoi
10.1159/000186154subject
Has Abstractpub_date
1990-01-01 00:00:00pages
277-80issue
3eissn
1660-8151issn
2235-3186journal_volume
56pub_type
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