Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis.

Abstract:

:Interleukin-6 (IL-6) was determined in serum and peritoneal dialysis effluent (PDE) of patients on chronic ambulatory peritoneal dialysis (CAPD) by a biological assay measuring the proliferation of the IL-6-dependent 7TD1 cell line. Six patients free of peritonitis displayed low but significant levels of IL-6 (mean +/- 42 pg/ml) in PDE, while IL-6 was undetectable in serum. In 6 patients with staphylococcal peritonitis, a tremendous increase in PDE levels of IL-6 was noted (range: 5,832-37,491 pg/ml), while serum IL-6 remained either undetectable or on a low level except in one case. After 5 days of antibiotic treatment, IL-6 levels in PDE returned to basal values. We conclude that CAPD results in an intraperitoneal secretion of IL-6 which is markedly but transiently increased during peritonitis episodes.

journal_name

Nephron

journal_title

Nephron

authors

Goldman M,Vandenabeele P,Moulart J,Amraoui Z,Abramowicz D,Nortier J,Vanherweghem JL,Fiers W

doi

10.1159/000186154

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

277-80

issue

3

eissn

1660-8151

issn

2235-3186

journal_volume

56

pub_type

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