Assessment of renal function in the early stages of nephrotoxicity induced by iodinated contrast media.

Abstract:

:To determine whether there are early renal function parameters (RFP) which can be monitored to rapidly detect nephrotoxicity induced by contrast media (CM), we observed RFP in 16 patients with normal renal function before and after administration of CM. Forty-eight hours after diatrizoate meglumine administration, blood urea nitrogen (BUN) and serum creatinine (SCr) increased (p < 0.05). In all patients, acute tubular damage was revealed by early urinary RFP. Increases in levels of serum angiotensin-I-converting enzyme (ACE), beta(2)-microglobulin (beta(2)M) and urinary albumin (Alb) were associated with alterations in glomerular function. The changes in early RFP occurred earlier than those of BUN and SCr. The present study demonstrates that serum ACE, beta(2)M, urinary Alb, gamma-glutamyl-transpeptidase and N-acetyl-beta-D-glucosidase are sensitive parameters for the early assessment of subclinical nephrotoxicity induced by CM.

journal_name

Nephron

journal_title

Nephron

authors

Duan SB,Wu HW,Luo JA,Liu FY

doi

10.1159/000045488

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

122-5

issue

2

eissn

1660-8151

issn

2235-3186

pii

45488

journal_volume

83

pub_type

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