Urinary angiotensin II: a marker of renal tissue activity?

Abstract:

:The methodology for the collection, extraction, separation and measurement of urinary angiotensin II [the octapeptide, ANG(1-8)] is described. To determine the origin of urinary ANG(1-8), mean arterial pressure, renal hemodynamics and the arterial, renal venous and urinary concentrations of ANG(1-8) were examined prior to and following the constant intra-arterial infusion of tritiated angiotensin II [3H-ANG(1-8)] in graded doses of 0.5, 2.0 and 2.5 ng/kg/min in 5 uninephrectomized, anesthetized female dogs. The infusion of 3H-ANG-(1-8) had no significant effect on mean arterial pressure, glomerular filtration rate, renal blood flow or urine flow rate. The mean concentration of ANG(1-8) in the urine was 3.7 fmol/ml. None or only trace amounts of 3H-ANG(1-8) were detected in the urine in spite of marked increases in renal arterial 3H-ANG(1-8) concentrations. These observations suggest that urinary ANG(1-8) was derived de novo from the intrarenal generation of angiotensin II. In addition, plasma and urinary concentrations of ANG(1-8) were assessed in patients with essential hypertension undergoing treatment with either a diuretic (n = 14) or an angiotensin-converting enzyme inhibitor (n = 14). Although the concentrations of plasma ANG(1-8) responded appropriately to the respective therapies, the urinary excretion of ANG(1-8) was not different following either therapy. These data suggest that ANG(1-8) collected from the urinary bladder may not occur in adequate concentrations to accurately assess the activity of the intrarenal renin-angiotensin system.

journal_name

Nephron

journal_title

Nephron

authors

Reams G,Villarreal D,Wu Z,Bauer JH

doi

10.1159/000188215

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

450-8

issue

4

eissn

1660-8151

issn

2235-3186

journal_volume

67

pub_type

临床试验,杂志文章,随机对照试验

相关文献

NEPHRON文献大全
  • Blood rheology after renal transplantation.

    abstract::Cardiovascular complications seriously affect posttransplant survival in patients after successful renal transplantation. Abnormalities in blood rheology may contribute to these complications. Therefore, we studied the blood rheology before and during a 1-year observation period after grafting in 9 patients by serial ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189330

    authors: Koppensteiner R,Derfler K,Ehringer H

    更新日期:1996-01-01 00:00:00

  • IgA nephropathy in blacks and Indians of Natal.

    abstract::IgA nephropathy besides exhibiting a characteristic geographical distribution has been noted to have a low incidence in the blacks of the USA. There is a paucity of data on IgA nephropathy in the blacks of Africa. We report our findings among the blacks and compare these with Indians. An analysis of the primary glomer...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185144

    authors: Seedat YK,Nathoo BC,Parag KB,Naiker IP,Ramsaroop R

    更新日期:1988-01-01 00:00:00

  • Time course of serum prolactin and sex hormones following successful renal transplantation.

    abstract:BACKGROUND:Chronic renal failure is commonly associated with disturbances in hypothalamic-pituitary-gonadal function. METHODS:The gonadotrophins, prolactin and estradiol or testosterone levels were measured immediately before renal transplantation, at discharge from the transplantation unit (19 +/- 8 days after Tx) an...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064079

    authors: Saha MT,Saha HH,Niskanen LK,Salmela KT,Pasternack AI

    更新日期:2002-01-01 00:00:00

  • Antilymphocyte antibodies against CD4+CD45R+ subsets in patients with IgA nephropathy.

    abstract::The authors analysed CD4+ subset populations and particularly subset killing in order to evaluate the presence of antilymphocyte antibody against CD4+ subsets in patients with IgA nephropathy (IgA N). This study was performed in 45 patients with IgA N, 30 patients with other forms of glomerulonephritis and 30 healthy ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186798

    authors: Sato M,Kino K,Nabeshima K,Koshikawa S

    更新日期:1992-01-01 00:00:00

  • Influence of splenectomy on human acute tubular necrosis.

    abstract::The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the inc...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183150

    authors: Pru CE,Fryd DS,Kjellstrand CM

    更新日期:1984-01-01 00:00:00

  • Reversible nephrotic range proteinuria with renal artery stenosis: a clinical example of renin-associated proteinuria.

    abstract::Nephrotic range proteinuria occurred in a 60-year-old woman with renal artery stenosis and marked hyperreninemia. Treatment by nephrectomy produced resolution of both proteinuria and hypertension. The gradual resolution of the proteinuria postoperatively suggested the proteinuria, at least in part, came from the contr...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182521

    authors: Eiser AR,Katz SM,Swartz C

    更新日期:1982-01-01 00:00:00

  • Nephrotoxicity of radiocontrast media in ischemic renal failure in rabbits.

    abstract::Ischemic renal failure was produced in rabbits by occluding the renal arteries for 90 min. Group 1 (n = 8) received radiocontrast media at the time of occlusion, group 2 (n = 8) 24 h after occlusion, and group 3 (n = 8) 3 days after occlusion. Group 4 (n = 12) was subjected to ischemic injury alone, group 5 (n = 4) se...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182829

    authors: Schultz SG,Lavelle KJ,Swain R

    更新日期:1982-01-01 00:00:00

  • Vocational rehabilitation in dialyzed patients. A cross-sectional study.

    abstract::The physicians in charge of 15 German hemodialysis units furnished data on 713 dialysis patients. Data relating to the vocational status were examined for 612 patients aged 60 years or below. It was found that the current working status varies with psychological and social factors. The data show that the vocational st...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181968

    authors: Tews HP,Schreiber WK,Huber W,Zelt J,Ritz E

    更新日期:1980-01-01 00:00:00

  • Elevated serum levels of 3-deoxyglucosone, a potent protein-cross-linking intermediate of the Maillard reaction, in uremic patients.

    abstract::3-Deoxyglucosone (3-DG) has been identified as an intermediate of the Maillard reaction in vitro. We measured serum 3-DG levels using gas chromatography/mass spectrometry and found a marked elevation in serum 3-DG levels in uremic patients compared with healthy subjects. The uremic patients with diabetes showed signif...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000188516

    authors: Niwa T,Takeda N,Miyazaki T,Yoshizumi H,Tatematsu A,Maeda K,Ohara M,Tomiyama S,Niimura K

    更新日期:1995-01-01 00:00:00

  • Analysis of urinary albumin excretion in gentamicin-treated rats.

    abstract::Gentamicin doses of 40 mg/kg body weight/day were administered intravenously to 62 Wistar rats. Nineteen animals were also treated orally with an NaHCO3 solution in place of water. The gentamicin-treated animals showed increased albuminuria immediately after the 3rd day of treatment. The fact that this increase was ma...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185043

    authors: Coimbra TM,Lachat JJ

    更新日期:1988-01-01 00:00:00

  • Impact of baseline health-related quality of life scores on survival of incident patients on peritoneal dialysis: a cohort study.

    abstract:INTRODUCTION:In an attempt to decrease mortality in patients with end-stage renal disease, an increase in the lifetime of these patients without much focus on health-related quality of life (HRQOL) was pursued for a long period of time. However, lately, an improvement in the quality of this extended lifetime has focuse...

    journal_title:Nephron

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000369139

    authors: Grincenkov FR,Fernandes N,Pereira Bdos S,Bastos K,Lopes AA,Finkelstein FO,Pecoits-Filho R,Qureshi AR,Divino-Filho JC,Bastos MG

    更新日期:2015-01-01 00:00:00

  • A rare cause of pulmonary-renal syndrome.

    abstract::Diseases affecting both the lung and the kidney have grave prognosis and serious diagnostic and therapeutic consequences. Here, 3 cases of pulmonary-renal syndrome caused by antiphospholipid syndrome are reported. The patients presented with dyspnea, renal insufficiency, pulmonary infiltrates on chest X-ray and areas ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064300

    authors: Henning BF,Gröne HJ,Tepel M,Büchner N,Kirchner J,Zidek W

    更新日期:2002-07-01 00:00:00

  • Failure of verapamil to protect from ischaemic renal damage.

    abstract::To reassess the reported protective effects of verapamil in renal ischaemia, we perfused the left kidney of uninephrectomized female Wistar rats with verapamil (0.1 and 1.0 mg/kg) immediately prior to clamping the renal artery for 60 min. When compared to controls, both doses of verapamil failed to afford protection w...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186279

    authors: Bock HA,Brunner FP,Torhorst J,Thiel G

    更新日期:1991-01-01 00:00:00

  • Acute Kidney Injury following Cardiac Surgery: A Clinical Model.

    abstract:BACKGROUND:Scientists use preclinical models of acute kidney injury (AKI) to decipher mechanisms and develop therapy, but translation of therapies to patients remains poor. Models that better resemble patients, including those within clinical care, should be considered. SUMMARY:Mice provide many advantages to the stud...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000501559

    authors: Billings FT 4th

    更新日期:2019-01-01 00:00:00

  • Prevalence of hyperoxaluria in idiopathic calcium oxalate kidney stone disease.

    abstract::Urinary excretion of oxalate, calcium and urate has been investigated in 88 patients affected by idiopathic calcium oxalate stone disease and in 20 normal subjects. Of these ions, only oxalate was found significantly higher in stone formers. Defining hyperoxaluria as urinary oxalate excretion greater than 2 SD above n...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183037

    authors: Baggio B,Gambaro G,Favaro S,Borsatti A

    更新日期:1983-01-01 00:00:00

  • Hemodialysis Patients Display a Declined Proportion of Th2 and Regulatory T Cells in Parallel with a High Interferon-γ Profile.

    abstract:BACKGROUND:A high prevalence of cardiovascular diseases (CVDs) and infections in patients with chronic kidney disease (CKD) arises partly due to a high inflammatory state and aberrations in immune cells function. Following in vitro stimulation of leukocytes with different T-cell mitogens, we observed a lower level of i...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000471814

    authors: Mansouri L,Nopp A,Jacobson SH,Hylander B,Lundahl J

    更新日期:2017-01-01 00:00:00

  • Chronic caffeine ingestion exacerbates 2-kidney, 1-clip hypertension and ameliorates deoxycorticosterone acetate-salt hypertension in rats.

    abstract::The present study was aimed to determine the effect of caffeine on the development of renal hypertension. Two-kidney, 1-clip (2K1C) hypertension and deoxycorticosterone acetate (DOCA, 200 mg/kg, subcutaneous implantation)-salt (0.9% NaCl drinking) hypertension were instituted in Sprague-Dawley rats. They were then gro...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187574

    authors: Choi KC,Lee J,Moon KH,Park KK,Kim SW,Kim NH

    更新日期:1993-01-01 00:00:00

  • Cardiac arrhythmias in chronic renal failure? Holter monitoring during dialysis and everyday activity at home.

    abstract::25 patients undergoing regular haemodialysis for chronic renal failure underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the intermediate period of everyday activity at home. A low dialysate potassium concentration (1.7 mEq/l) was used. Clinically significant arrhythmias (greater th...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183273

    authors: Kyriakidis M,Voudiclaris S,Kremastinos D,Robinson-Kyriakidis C,Vyssoulis G,Zervakis D,Toutouzas P,Komninos Z,Avgoustakis D

    更新日期:1984-01-01 00:00:00

  • Urinary Kidney Injury Molecule-1 but Not Urinary Neutrophil Gelatinase Associated Lipocalin Is Increased after Short Maximal Exercise.

    abstract:BACKGROUND AND AIMS:Urinary neutrophil gelatinase associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are markers of acute kidney injury. The albuminuria is a well-known abnormality after physical exercise. The aim of this study was to investigate changes in uNGAL and uKIM-1 after intensive exerc...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000481179

    authors: Wołyniec W,Ratkowski W,Urbański R,Bartoszewicz M,Siluk D,Wołyniec Z,Kasprowicz K,Zorena K,Renke M

    更新日期:2018-01-01 00:00:00

  • Membranous glomerulonephritis associated with enterococcal endocarditis.

    abstract::An autopsy case of membranous glomerulonephritis associated with enterococcal endocarditis was reported. Although enterococcal antigen was not identified in glomerular deposits, the eluate from the patient's renal tissue was shown to specifically recombine with cells of the enterococcus isolated from his own ante mort...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183435

    authors: Iida H,Mizumura Y,Uraoka T,Takata M,Sugimoto T,Miwa A,Yamagishi T

    更新日期:1985-01-01 00:00:00

  • Effect of vitamin C supplementation on renal oxalate deposits in five-sixths nephrectomized rats.

    abstract::We have previously reported that hyperoxalemia can be aggravated by vitamin C supplementation in regular hemodialysis patients. The present study was undertaken to examine the validity of this observation in an experimental setting. Fifty five-sixths nephrectomized rats were divided into two groups: 30 rats were allow...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185389

    authors: Ono K,Ono H,Ono T,Kikawa K,Oh Y

    更新日期:1989-01-01 00:00:00

  • A Multicenter Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR).

    abstract:BACKGROUND:Idiopathic membranous nephropathy remains the leading cause of nephrotic syndrome in Caucasian adults. Immunosuppressive therapy with cyclosporine (CSA) is often successful in reducing proteinuria, but its use is associated with a high relapse rate. Rituximab, a monoclonal antibody that specifically targets ...

    journal_title:Nephron

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000430849

    authors: Fervenza FC,Canetta PA,Barbour SJ,Lafayette RA,Rovin BH,Aslam N,Hladunewich MA,Irazabal MV,Sethi S,Gipson DS,Reich HN,Brenchley P,Kretzler M,Radhakrishnan J,Hebert LA,Gipson PE,Thomas LF,McCarthy ET,Appel GB,Jeffers

    更新日期:2015-01-01 00:00:00

  • Comparison of Immunohistochemical Staining for Large T Antigen and Capsid Protein VP1 in BK Polyomavirus-Associated Nephropathy.

    abstract:AIM:Most transplant centres use SV40 large T antigen (TAg) staining for the diagnosis and assessment of BK polyomavirus-associated nephropathy (BKPyVAN). This study was performed to evaluate the significance of capsid protein VP1 expression in BKPyVAN. METHODS:We performed immunohistochemical staining using anti-SV40 ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000510967

    authors: Masutani K,Matsukuma Y,Tsuchimoto A,Okabe Y,Doi A,Kaku K,Nakamura M,Nakano T,Tsuruya K,Kitazono T

    更新日期:2020-01-01 00:00:00

  • TINU syndrome associated with reduced complement levels.

    abstract::The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000046096

    authors: Conz PA,Milan M,Bragantini L,La Greca G,Bevilacqua PA

    更新日期:2001-11-01 00:00:00

  • Urinary kallikrein in normal pregnancy, pregnancy with hypertension, and toxemia.

    abstract::The 24-hour urinary excretion of kallikrein (K) and prostaglandin E2 (PGE2), which reflects their intrarenal synthesis, was measured in 7 normal women (NW), 10 women with essential hypertension (EH), 26 normal pregnant women (NP), 12 women with hypertension in pregnancy (HP), and 4 women with toxemia. All pregnant wom...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183426

    authors: Kovatz S,Arber I,Korzets Z,Rathaus M,Ben Aderet N,Bernheim J

    更新日期:1985-01-01 00:00:00

  • Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition.

    abstract::End-stage renal disease (ESRD) is common, costly, and it results from progressive chronic kidney disease (CKD). ESRD claims many lives every year. It is increasingly recognized that episodes of acute kidney injury (AKI) predispose to the future development of CKD and ESRD. While our understanding of the pathophysiolog...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000474960

    authors: Ó hAinmhire E,Humphreys BD

    更新日期:2017-01-01 00:00:00

  • Effects of chitosan-coated dialdehyde cellulose, a newly developed oral adsorbent, on glomerulonephritis induced by anti-Thy-1 antibody in rats.

    abstract::The effects of chitosan-coated dialdehyde cellulose (chitosan DAC), a newly developed oral adsorbent for urea and ammonia, were examined in a glomerulonephritis model in rats. Mesangial proliferative glomerulonephritis accompanied with proteinuria was induced by an intravenous injection of anti-rat Thy-1.1 monoclonal ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044973

    authors: Yagi M,Kato S,Nishitoba T,Sato H,Kobayashi N,Iinuma N,Nagano N

    更新日期:1998-01-01 00:00:00

  • Desferrioxamine enhances the haemopoietic response to erythropoietin, but adverse events are common.

    abstract::To determine whether the chelation of aluminium enhances the haemopoietic response to recombinant human erythropoietin (r-HuEPO), desferrioxamine (DFO) at a dose of 20-30 mg/kg was given to 7 of 17 transfusion-dependent haemodialysis patients treated with r-HuEPO (40 units/kg/dialysis i.v.). The two randomly allocated...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000186374

    authors: Roger SD,Stewart JH,Harris DC

    更新日期:1991-01-01 00:00:00

  • Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

    abstract::Chronic kidney disease (CKD) is a worldwide public health problem associated with a high prevalence of cardiovascular disease (CVD) and impaired quality of life. Previous research for preventing loss of glomerular filtration rate (GFR) has focused on reducing blood pressure (BP) and proteinuria. Angiotensin converting...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000447068

    authors: Ahmed A,Jorna T,Bhandari S

    更新日期:2016-01-01 00:00:00

  • Use of immunomodulators (thymopentine) in hepatitis B vaccine in elderly patients undergoing chronic hemodialysis.

    abstract::Thymopentine is a synthetic immunomodulator that positively affects T-lymphocyte maturation, reproduction and differentiation. In elderly uremic patients nonresponders to hepatitis B vaccine, the administration of this drug has been shown to improve the response to the new vaccination. ...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章

    doi:10.1159/000186942

    authors: Melappioni M,Baldassari M,Baldini S,Radicioni R,Panichi N

    更新日期:1992-01-01 00:00:00