Analysis of urinary albumin excretion in gentamicin-treated rats.

abstract：BACKGROUND:Previous studies showed that ceftriaxone can cause acute kidney injury (AKI) in the pediatric population. This study proposed a cellular model of crystalline nephropathy in ceftriaxone-associated AKI and explored the related pathophysiology by using a proteomic approach. METHODS:Ceftriaxone was crystallized...

journal_title：Nephron

authors： Chatchen S,Pongsakul N,Srisomsap C,Chiangjong W,Hongeng S,Svasti J,Chutipongtanate S

更新日期：2018-01-01 00:00:00

abstract：:Idiopathic hypercalciuria, though a common cause of nephrolithiasis, has not been recognized to cause hypocalcemia and severe bone disease. We describe an adolescent with idiopathic hypercalciuria who presented initially with severe hypocalcemia and osteoporosis and this was later complicated by recurrent renal calcul...

journal_title：Nephron

authors： Wong CK,Pun KK,Tam SC,Tsui EY,Kung AW,Lam KS,Wang CC

更新日期：1992-01-01 00:00:00

abstract：:Three unusual cases are described which demonstrated hypomagnesemia and symptoms resembling magnesium deficiency syndrome. The hypomagnesemia was most likely secondary to urinary losses from diuresis following release of post-renal obstruction and renal homotransplantation. Heretofore, this association has not been de...

journal_title：Nephron

authors： Davis BB,Preuss HG,Murdaugh HV Jr

更新日期：1975-01-01 00:00:00

abstract：:Interleukin-6 (IL-6) was determined in serum and peritoneal dialysis effluent (PDE) of patients on chronic ambulatory peritoneal dialysis (CAPD) by a biological assay measuring the proliferation of the IL-6-dependent 7TD1 cell line. Six patients free of peritonitis displayed low but significant levels of IL-6 (mean +/...

journal_title：Nephron

authors： Goldman M,Vandenabeele P,Moulart J,Amraoui Z,Abramowicz D,Nortier J,Vanherweghem JL,Fiers W

更新日期：1990-01-01 00:00:00

abstract：AIM:To determine the prevalence of kidney disease in a cohort of individuals with silicosis. METHODS:Review of medical records and questionnaires from patients reported to a state surveillance system for silicosis. Reporting of individuals with silicosis is required by state law. All individuals with silicosis reporte...

journal_title：Nephron

authors： Rosenman KD,Moore-Fuller M,Reilly MJ

更新日期：2000-05-01 00:00:00

abstract：:The effects of each of several tannins purified from Rhei Rhizoma on serum constituents were investigated in rats with adenine-induced renal failure. Blood levels of urea nitrogen, methylguanidine (MG), and guanidinosuccinic acid (GSA) were significantly decreased in rats given (-)-epicatechin 3-O-gallate at a dose of...

journal_title：Nephron

authors： Yokozawa T,Fujioka K,Oura H,Nonaka G,Nishioka I

更新日期：1991-01-01 00:00:00

abstract：:Increasing urinary net acid (titratable acid + NH4 - HCO-3) excretion is accompanied by an increased urinary Ca excretion because of reduced renal tubular reabsorption of filtered Ca. The relationships between urinary Ca excretion rates and urinary net acid excretion rates are reviewed for data: (1) among healthy adul...

journal_title：Nephron

authors： Lemann J Jr

更新日期：1999-01-01 00:00:00

abstract：:In an effort to elucidate immunopathogenic of membranous nephropathy (MN), freshly collected sera from patients with biopsy proven MN were assayed of circulating immune complexes (ICs) by the Raji cell method and for anti-renal tubular epithelial (RTE) antibodies by a newly established radioimmunoassay (RIA) and by in...

journal_title：Nephron

authors： Zager RA,Couser WG,Andrews BS,Bolton WK,Pohl MA

更新日期：1979-01-01 00:00:00

abstract：:This study was undertaken to test the hypothesis that ischemia prior to transplantation causes tubular damage without clinical evidence of graft dysfunction. The urinary excretion of fructose-1,6-bisphosphatase (EC 3.1.3.11, FBPase), a cytosolic enzyme located exclusively in the proximal tubules, and the lysosomal enz...

journal_title：Nephron

authors： Kotanko P,Margreiter R,Pfaller W

更新日期：1997-01-01 00:00:00

abstract：:Following successful kidney transplantation, renal anemia is gradually corrected during the first 3-4 months. Serum erythropoietin (EPO) levels are increased after the first postoperative day following grafting. In this study, the serum EPO levels in the early posttransplant phase were investigated in 8 living-donor a...

journal_title：Nephron

authors： Goch J,Birgegård G,Wikström B,Tufveson G,Danielson BG

更新日期：1992-01-01 00:00:00

abstract：:Acute interstitial nephritis (AIN) has been reported in association with therapy with a number of drugs. We report a patient who developed drug-related AIN while receiving intravenous amoxicillin therapy. The patient developed rash, secondary temperature elevation, and eosinophilia in association with nonoliguric rena...

journal_title：Nephron

authors： Appel GB,Garvey G,Silva F,Francke E,Neu HC,Weissman J

更新日期：1981-01-01 00:00:00

abstract：:Glomerulonephritis as well as kidney injury secondary to fulminant intravascular hemolysis are rare extrapulmonary manifestations of Mycoplasma pneumoniae infection. We describe a 50-year-old female diagnosed with M. pneumoniae infection-associated hemolytic anemia, characterized by negative cold agglutinin tests but ...

journal_title：Nephron

authors： Carrara C,Abbate M,Sabadini E,Remuzzi G

更新日期：2017-01-01 00:00:00

abstract：:Diabetic nephropathy is the leading cause of kidney failure. Treatments with drugs that block the renin-angiotensin system have proven beneficial in slowing kidney disease progression among those with diabetes; their benefit is limited and they do not stop disease progression. Despite multiple clinical trials of vario...

journal_title：Nephron

authors： Toto RD

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Renal function deteriorates with age, but a few studies have addressed this longitudinally in elderly women. Our objective was, using 5 estimated glomerular filtration rates (eGFR)-equations, to evaluate changes in renal function and association with adverse outcomes for a decade in 75-year-old women. ...

journal_title：Nephron

authors： Malmgren L,McGuigan FE,Berglundh S,Westman K,Christensson A,Åkesson K

更新日期：2015-01-01 00:00:00

abstract：:A total of 1,026 patients undergoing haemodialysis as the only chronic treatment were studied in all the dialysis units of the Veneto region, Italy. Aluminium was determined in water, dialysis fluids, and patients' serum. Aluminium mean concentration was 9.1 micrograms/l in tap water and 13.3 and 15.7 micrograms/l in ...

journal_title：Nephron

authors： Piccoli A,Andriani M,Mattiello G,Nordio M,Modena F,Dalla Rosa C

更新日期：1989-01-01 00:00:00

abstract：:Previous work has shown that cigarette-smoking affects platelets and endothelium in men and women without renal failure. The present study compared 10 male habitual smokers receiving maintenance hemodialysis for chronic renal failure with 11 healthy male habitual smokers before and after controlled cigarette-smoking a...

journal_title：Nephron

authors： Davis JW,Arnold J,Wiegmann T

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) is a crucial event in the development of renal interstitial fibrosis (RIF). A growing body of evidence indicates that β-catenin plays an important role in various types of fibrosis. Although members of the microRNA (miRNA)-200 family have been suggested to suppress...

journal_title：Nephron

authors： Gong Y,Qin Z,Zhou B,Chen H,Shi Z,Zhang J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Acid-base disturbances are frequent in critically ill patients. Arterial blood gas (ABG) is the gold standard in the diagnosis of these disturbances, but it is invasive with potential hazards. For patients with a central venous catheter, venous blood gas (VBG) sampling may be an alternative, less-invasive di...

journal_title：Nephron

authors： Schrauben SJ,Negoianu D,Costa C,Cohen RM,Goldfarb S,Fuchs BD,Berns JS

更新日期：2018-01-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been shown to be associated with cardiovascular disease in healthy subjects as well as in patients with end-stage renal disease (ESRD). In this study, we examined the allelic frequency and genotype distribution of the MTHFR gene in 151 Chinese ESRD ...

journal_title：Nephron

authors： Lim PS,Hung WR,Wei YH

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue might lie with pattern recognition receptors (PRRs), which are triggers of ischemic i...

journal_title：Nephron

authors： DeWolf SE,Shigeoka AA,Scheinok A,Kasimsetty SG,Welch AK,McKay DB

更新日期：2017-01-01 00:00:00

abstract：:Epidermal nevus syndrome is an unusual neurocutaneous disorder in which epidermal nevi are associated with abnormalities of the skeleton and central nervous system, including the eyes and somtimes the cardiovascular system. We treated a patient in whom the latter included renal artery stenosis. An 18-year-old man with...

journal_title：Nephron

authors： Aizawa K,Nakamura T,Ohyama Y,Saito Y,Hoshino J,Kanda T,Sumino H,Nagai R

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Urinary neutrophil gelatinase associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are markers of acute kidney injury. The albuminuria is a well-known abnormality after physical exercise. The aim of this study was to investigate changes in uNGAL and uKIM-1 after intensive exerc...

journal_title：Nephron

authors： Wołyniec W,Ratkowski W,Urbański R,Bartoszewicz M,Siluk D,Wołyniec Z,Kasprowicz K,Zorena K,Renke M

更新日期：2018-01-01 00:00:00

abstract：:We examined the types of guanine nucleotide-binding regulatory (G) protein subunits in isolated glomeruli, cortices excluding glomeruli and medullas of rat kidneys using bacterial toxin-catalyzed adenosine 5'-diphosphate (ADP) ribosylation and specific immunoblots. ADP ribosylation catalyzed by cholera or pertussis to...

journal_title：Nephron

authors： Yanagisawa H,Kurihara N,Klahr S,Morrissey J,Wada O

更新日期：1994-01-01 00:00:00

abstract：:The nature of uremic nephrocalcinosis was studied by means of X-ray microanalysis in 5/6 nephrectomized rats. The data show that calcified deposits in the renal parenchyma of uremic rats contained substantial amounts of calcium, magnesium, aluminum and silicon. Since calcificates did not reveal a uniform composition t...

journal_title：Nephron

authors： Goligorsky MS,Chaimovitz C,Rapoport J,Zevin L,Kiryati A,Lach S

更新日期：1983-01-01 00:00:00

abstract：:Cytomegalovirus is the most important viral infection in kidney transplants, but rarely affects the allograft after the sixth month posttransplantation. We present a patient who developed renal failure eighteen months posttransplant; a kidney biopsy showed cytomegalovirus inclusions, acute tubular necrosis and mild in...

journal_title：Nephron

authors： Trimarchi H,Jordan R,Iotti A,Forrester M,Iotti R,Freixas E,Martínez J,Schropp J,Pereyra H,Efrón E

更新日期：2002-10-01 00:00:00

abstract：:Two patients with AIDS-related complex who presented with renal failure and microscopic hematuria were found to have mesangial deposits of IgA at renal biopsy. Though such glomerular deposits have not yet been reported in patients with HIV infection, their occurrence is most likely not coincidental. Indeed, there are ...

journal_title：Nephron

authors： Kenouch S,Delahousse M,Méry JP,Nochy D

更新日期：1990-01-01 00:00:00

abstract：:Differences have been postulated for the mechanism of natriuresis due to atrial natriuretic peptide (ANP), salt loading with high salt diet (HS) and acute volume expansion (AcVE), in particular between AcVE and ANP based on the observed synergism between the two. Therefore the effects of and the interaction between th...

journal_title：Nephron

authors： Reddy S,Salipan-Moore N,Mildenberger S,Willis N,Györy AZ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:Glomerular basement membrane (GBM) thickening and mesangial matrix expansion are characteristic features of diabetic nephropathy. The present study investigates the role of endothelins (ETs) in the pathogenesis of such changes in diabetic nephropathy. METHODS:Diabetic (streptozotocin-induced, 65 mg/kg)...

journal_title：Nephron

authors： Chen S,Evans T,Deng D,Cukiernik M,Chakrabarti S

更新日期：2002-01-01 00:00:00

abstract：:Plasma immunoreactive atrial natriuretic factor (ANF) levels, their chromatographic profiles (high-performance liquid chromatography; HPLC) and changes during sequential ultrafiltration (UF; 1 litre/h) and biochemical correction without fluid removal (BC; 3 h) were studied in 8 end-stage chronic renal failure patients...

journal_title：Nephron

authors： Tonolo G,McMillan M,Richards AM,Montorsi P,Polonia J,Soro A,Troffa C,Glorioso N

更新日期：1990-01-01 00:00:00

abstract：:Continuous therapy with an angiotensin-converting enzyme (ACE) inhibitor has been shown to have a glomerular vasodepressor effect in the newly diabetic rat and to largely prevent subsequent development of severe sclerosing glomerular injury. Preliminary studies in humans with established diabetic glomerular injury rev...

journal_title：Nephron

authors： Myers BD,Meyer TW

更新日期：1990-01-01 00:00:00