Acute volume expansion and salt-loading studies in rats. The role of atrial natriuretic peptide and catecholamines.


:Differences have been postulated for the mechanism of natriuresis due to atrial natriuretic peptide (ANP), salt loading with high salt diet (HS) and acute volume expansion (AcVE), in particular between AcVE and ANP based on the observed synergism between the two. Therefore the effects of and the interaction between the three were investigated in rats. ANP and AcVE produced the same natriuresis in HS as in normal salt (NS) rats and, in both, the actions of ANP and AcVe were significantly additive showing similarity in mechanisms. Synergism [(AcVE + ANP) - AcVE] was, however, present only in the NS rats. Proximal tubular sodium transport was the same with AcVE and ANP+AcVE suggesting that synergism is a property of more distal nephron segments. In conscious HS rats, plasma ANP was significantly less but natriuresis was higher than in NS rats. ANP therefore probably has some causative role in the natriuresis of AcVE but none in that of HS loading. Urinary dopamine was significantly increased by HS and further increased by AcVE in both NS and HS rats, the relationship between dopamine and natriuresis being significantly positive (r2 = 0.328) reaching equivalent levels in both NS and HS rats. Systemic benserazide prevented the increase in urinary dopamine but only attenuated the natriuresis of AcVE. We conclude that HS does not potentiate the natriuresis of AcVE or ANP, synergism between AcVE and ANP is not a proximal tubule event and dopamine accounts for significant natriuresis of VE in addition to other natriuretic factors.






Reddy S,Salipan-Moore N,Mildenberger S,Willis N,Györy AZ




Has Abstract


1998-01-01 00:00:00
















  • Circulating immune complexes after cadaver kidney transplantation.

    abstract::351 sera from 27 human recipients of renal allografts and 21 healthy blood donors were assayed for circulating immune complexes by the Clq solid-phase radioimmune assay. Increased Clq-binding activity (Clq-BA) was detected in pretransplant sera from 5 patients with chronic pyelonephritis (PN) and 3 patients with chron...


    pub_type: 杂志文章


    authors: Kaden J,Falck P,Groth J,Mebel M

    更新日期:1981-01-01 00:00:00

  • Urine and serum levels of the carboxyterminal domain (NCl) of collagen IV in membranous glomerulonephritis and diabetic nephropathy.

    abstract::Serum and urinary concentrations of NCl, the non collagenous globular domain of collagen IV, were used as markers for turnover of basement membranes. NCl levels were studied in membranous glomerulonephritis and diabetic nephropathy. Thirteen patients with membranous glomerulonephritis and 8 insulin-dependent diabetic ...


    pub_type: 杂志文章


    authors: Torffvit O,Agardh CD,Alm P,Wieslander J

    更新日期:1991-01-01 00:00:00

  • Renal transplantation in diabetes mellitus. Influence of preexisting vascular disease on outcome.

    abstract::We reviewed the recommendations and outcomes for all patients with diabetes mellitus and end-stage renal disease referred to the Medical Center Hospital of Vermont from 1971 through December 1983. During this period, we recommended transplantation in 53 of 73 patients evaluated. Thirty-two transplants were performed i...


    pub_type: 杂志文章


    authors: Rimmer JM,Sussman M,Foster R,Gennari FJ

    更新日期:1986-01-01 00:00:00

  • Reduced collagenolytic activity of rat kidneys with steptozotocin diabetes.

    abstract::Collagenolytic activity of rat kidneys with streptozotocin diabetes was estimated by means of a biological collagenase assay and compared to healthy controls. Collagenolytic activity was found significantly decreased in rat kidneys with diabetes correlating with blood glucose levels (r = -0.82, p less than 0.001). Ele...


    pub_type: 杂志文章


    authors: Lubec G,Leban J,Peyroux J,Sternberg M,Pollak A,Latzka U,Coradello H

    更新日期:1982-01-01 00:00:00

  • Acute interstitial nephritis due to amoxicillin therapy.

    abstract::Acute interstitial nephritis (AIN) has been reported in association with therapy with a number of drugs. We report a patient who developed drug-related AIN while receiving intravenous amoxicillin therapy. The patient developed rash, secondary temperature elevation, and eosinophilia in association with nonoliguric rena...


    pub_type: 杂志文章


    authors: Appel GB,Garvey G,Silva F,Francke E,Neu HC,Weissman J

    更新日期:1981-01-01 00:00:00

  • Cytoprotective effect of ulinastatin on LLC-PK1 cells treated with antimycin A, gentamicin, and cisplatin.

    abstract::The cytoprotective effect of ulinastatin was studied in LLC-PK1 cells treated with antimycin A, gentamicin, or cisplatin. All of the three agents induced a concentration-dependent increase in the release of lactate dehydrogenase and a decrease in the amount of remaining protein. In the cell injury models treated with ...


    pub_type: 杂志文章


    authors: Ishibashi M,Yamasaki F,Nakakuki M,Shinkawa T,Mizota M

    更新日期:1997-01-01 00:00:00

  • Decreased renal clearance of xanthine and hypoxanthine in a patient with renal hypouricemia: a new defect in renal handling of purines.

    abstract::Renal handling of urate, xanthine and hypoxanthine was studied in a hypouricemic patient who had increased plasma concentrations of xanthine and hypoxanthine. The patient, a 50-year-old man, had been suffering from Parkinson's disease, while neither systemic disorders nor particular renal diseases known to affect plas...


    pub_type: 杂志文章


    authors: Kawachi M,Kono N,Kiyokawa H,Mineo I,Nakajima H,Shimizu T,Yorifuji S,Kuwajima M,Tarui S

    更新日期:1992-01-01 00:00:00

  • Potassium depletion potentiates amphotericin-B-induced toxicity to renal tubules.

    abstract::Hypokalemia and potassium depletion are frequent complications of amphotericin B therapy. Both ischemic and gentamicin-induced renal failure is potentiated by potassium depletion; it is, therefore, possible that amphotericin B nephrotoxicity is similarly influenced. This study evaluated whether the acute nephrotoxic r...


    pub_type: 杂志文章


    authors: Bernardo JF,Murakami S,Branch RA,Sabra R

    更新日期:1995-01-01 00:00:00

  • Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.

    abstract::The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been shown to be associated with cardiovascular disease in healthy subjects as well as in patients with end-stage renal disease (ESRD). In this study, we examined the allelic frequency and genotype distribution of the MTHFR gene in 151 Chinese ESRD ...


    pub_type: 杂志文章


    authors: Lim PS,Hung WR,Wei YH

    更新日期:2001-03-01 00:00:00

  • Effects of imidazole-2-hydroxibenzoate on glycosaminoglycan and albumin urinary excretion in type 1 diabetic patients.

    abstract::The effect of imidazole-2-hydroxibenzoate on urinary excretion rates of glycosaminoglycans and albumin in 22 insulin-dependent diabetics with albumin excretion rates under 300 mg/day was evaluated in a 165-day double blind crossover study. Unlike placebo, the drug reduced glycosaminoglycan and albumin excretion rates ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Baggio B,Briani G,Cicerello E,Gambaro G,Giorato C,Iori E,Lavagnini T,Crepaldi G

    更新日期:1988-01-01 00:00:00

  • UK Renal Registry 17th Annual Report: Chapter 6 Adequacy of Haemodialysis in UK Adult Patients in 2013: National and Centre-specific Analyses.

    abstract:BACKGROUND:Outcomes in patients treated with haemodialysis(HD) are potentially influenced by the delivered dose of dialysis. The UK Renal Association publishes clinical practice guidelines recommendations for dialysis dose. The urea reduction ratio (URR) is a widely used measure of dialysis dose and has been historical...


    pub_type: 杂志文章


    authors: Shaw C,Steenkamp R,Davenport A

    更新日期:2015-01-01 00:00:00

  • Screening uremic 'toxins' using bromsulfophthalein clearance by the isolated perfused rat liver.

    abstract::The kinetics of bromosulfophthalein clearance from plasma, secretion into bile, and, by difference, storage in hepatic cells, were determined, using normal livers and blood from normal rats in the isolated perfused rat liver system. Two suspected uremic 'toxins', urea and guanidinosuccinic acid, were then administered...


    pub_type: 杂志文章


    authors: Liang MY,Toporek M,Schepartz B

    更新日期:1978-01-01 00:00:00

  • The effect of sodium intake on cystinuria with and without tiopronin treatment.

    abstract::As with many other amino acids the transport of cystine across the tubular epithelium is coupled to a parallel transport of sodium. We have studied the effect of a sodium-restricted diet on the urinary excretion of cystine in 13 patients with cystinuria, 7 of whom were treated with the SH compound tiopronin (2-mercapt...


    pub_type: 临床试验,杂志文章


    authors: Lindell A,Denneberg T,Edholm E,Jeppsson JO

    更新日期:1995-01-01 00:00:00

  • Development of calcium oxalate crystals on urothelium: effect of free radicals.

    abstract::The effects of free radicals on the development of crystals attached to the living epithelium have been studied using an experimental model that enables close simulation of the conditions prevailing in the kidney. The results obtained clearly demonstrate that free radical-damaged cells produce a favorable environment ...


    pub_type: 杂志文章


    authors: Grases F,García-Ferragut L,Costa-Bauzá A

    更新日期:1998-01-01 00:00:00

  • Mitochondrial granulation in the proximal renal tubule in uremia.

    abstract::Mitochondria contain electron-dense particles, partly composed of an amorphous form of calcium phosphate. We have used electron microscopy from percutaneous renal biopsy material to analyze mitochondrial granulation in the proximal renal tubule of nonuremic and uremic children. Based on a technique of cutting mitochon...


    pub_type: 杂志文章


    authors: Whitney JO,Goodman JR,Piel CF

    更新日期:1979-01-01 00:00:00

  • Trajectory of Estimated Glomerular Filtration Rate Predicts Renal Injury in Children with Multicystic Dysplastic Kidney.

    abstract:BACKGROUND/AIMS:Children with a solitary functioning kidney have a risk of renal injury caused by hyperfiltration. Timely intervention with renin-angiotensin inhibitors may be beneficial. We examined whether trajectory of estimated glomerular filtration rate (eGFR) would predict renal injury, defined as microalbuminuri...


    pub_type: 杂志文章


    authors: Matsumura K,Sugii K,Awazu M

    更新日期:2018-01-01 00:00:00

  • Cell characteristics of cultured glomeruli from different animal species.

    abstract::A modified sieving technique has been developed to isolate pure glomeruli from monkey, sheep, dog, rabbit and rat kidney. Glomeruli from all these species have been grown in tissue culture and the glomerular cell outgrowth studied by light microscopy and time-lapse cinemicroscopy. The pattern of growth was the same fo...


    pub_type: 杂志文章


    authors: Holdsworth SR,Glasgow EF,Atkins RC,Thomson NM

    更新日期:1978-01-01 00:00:00

  • Inpatient Kidney Function Recovery among Septic Shock Patients Who Initiated Kidney Replacement Therapy in the Hospital.

    abstract:BACKGROUND:Sepsis and septic shock are life-threatening causes of acute kidney injury (AKI) frequently seen and managed in intensive care units (ICUs). Sepsis-associated AKI (SA-AKI) independently contributes to the mortality of sepsis. Understanding the potential factors involved in kidney function recovery may furthe...


    pub_type: 杂志文章


    authors: Chen JCY,Hu B,Frank RD,Kashani KB

    更新日期:2020-01-01 00:00:00

  • Biochemistry and pathophysiology of vanadium.

    abstract::The biochemistry and function of vanadate and its possible role in health as well as in disease remains one of the most fascinating stories in biology. This review has surveyed the pertinent literature regarding its effect in the normal kidney and other tissues. While inhibition of the Na(+)-K+ ATPase enzyme was the f...


    pub_type: 社论,评审


    authors: Dafnis E,Sabatini S

    更新日期:1994-01-01 00:00:00

  • Colchicine-induced myopathy with normal creatine phosphokinase level in a renal transplant patient.

    abstract::A case of a renal transplant recipient with colchicine-induced myopathy is presented. He was on colchicine therapy for 10 months. He was hospitalized for investigation of fatigue, severe myalgia in the lower extremities and elevated serum aminotransferase levels. His viral markers and other factors that may cause myal...


    pub_type: 杂志文章


    authors: Caglar K,Safali M,Yavuz I,Odabaşi Z,Yenicesu M,Vural A

    更新日期:2002-12-01 00:00:00

  • Proliferative glomerulonephritis in monoclonal gammopathy.

    abstract::A 62-year-old white male suffering from plasmacytosis with monoclonal gammopathy developed gastrointestinal bleeding, microscopic hematuria, proteinuria and progressive azotemia. A renal biopsy demonstrated capillary wall thickening, mesangial hyperplasia, crescent formation and subepithelial humps. Serum immunoglobul...


    pub_type: 杂志文章


    authors: Dhar SK,Smith EC,Fresco R

    更新日期:1977-01-01 00:00:00

  • Severe acute renal failure: a comparison of acute continuous hemodiafiltration and conventional dialytic therapy.

    abstract::It is unknown whether continuous renal replacement techniques result in diminished morbidity and mortality when compared to conventional dialytic techniques. To investigate this issue a previously described, retrospectively studied group of critically ill patients with severe acute renal failure treated by conventiona...


    pub_type: 杂志文章


    authors: Bellomo R,Farmer M,Parkin G,Wright C,Boyce N

    更新日期:1995-01-01 00:00:00

  • Effect of neutral pH and low-glucose degradation product-containing peritoneal dialysis solution on residual renal function in peritoneal dialysis patients: a meta-analysis.

    abstract:BACKGROUND:Glucose degradation products (GDPs) in peritoneal dialysis (PD) solution (PDS) have been shown to inflict damage to the kidney, which is the major organ for advanced glycosylation end product elimination. Hence, this study investigated whether new PDSs with neutral pH and low-GDPs have a beneficial effect on...


    pub_type: 杂志文章,meta分析,评审


    authors: Wang J,Zhu N,Yuan W

    更新日期:2015-01-01 00:00:00

  • Transcapillary oncotic pressure in the edema of congestive heart failure.

    abstract::Tissue fluid and plasma oncotic pressure levels were measured in an unselected group of 13 patients presenting with congestive heart failure. Patients had a mean serum albumin of 3.6 g/dl +/- (SD) 0.35; serum oncotic pressure was 22.23 +/- 1.8 mm Hg; tissue fluid (lower leg) oncotic pressure was 0.985 +/- 0.34 mm Hg. ...


    pub_type: 杂志文章


    authors: Kwan T,Pintea M,Garcia Morino F,Preston RR,Li J,Caruso C,Berlyne SD,Berlyne GM

    更新日期:1990-01-01 00:00:00

  • Smoking is associated with alterations of blood thiol-group related antioxidants in patients on hemodialysis.

    abstract::Cardiovascular disease is the major complication and cause of mortality in the dialysis population, accounting for about 40% of deaths. Oxidative stress has been strongly implicated in the pathogenesis of these events. As patients in end-stage renal disease (ESRD) are in a state of elevated free radical activity, the ...


    pub_type: 杂志文章


    authors: Wang NP,Lim PS,Chen TT,Thien LM,Wang TH,Hsu WM

    更新日期:2002-12-01 00:00:00

  • Ultrastructural immunoperoxidase investigations of human glomerular cells in tissue culture.

    abstract::In order to elucidate the cells produced from human glomerular cultures, a pre-embedding ultrastructural immunoperoxidase technique was developed to investigate the precise localisation of a panel of monoclonal antibodies specific to human glomerular antigens in situ and used to identify the same antigens in vitro. Th...


    pub_type: 杂志文章


    authors: Jackson AE,Atkins RC,Glasgow EF

    更新日期:1989-01-01 00:00:00

  • Autoradiographic localization and age-related changes in vasopressin receptors in spontaneously hypertensive rats.

    abstract::To understand the regulation of vasopressin receptors in an animal model of hypertension, localization and age-related changes in renal arginine vasopressin (AVP) receptors in spontaneously hypertensive rats (SHR) were investigated using in vitro (macro) autoradiography and a radiolabeled receptor assay. Autoradiograp...


    pub_type: 杂志文章


    authors: Hosoya M,Ogura T,Watanabe H,Ota Z,Kageyama Z

    更新日期:1996-01-01 00:00:00

  • Total Calcium and Albumin Are Decreased in the Deeper Epidermis of Patients with Chronic Kidney Disease-Associated Pruritus.

    abstract:BACKGROUND/AIMS:In our earlier studies, we reported high concentrations of intra- and extracellular calcium ions (Ca2+) in the deeper epidermis of patients with chronic kidney disease (CKD) and associated pruritus. To determine the cause of this phenomenon, we measured total calcium (TCa) concentrations in the deeper e...


    pub_type: 杂志文章


    authors: Momose A,Shiraiwa Y,Narita S,Kusumi T,Goto S,Sera K

    更新日期:2017-01-01 00:00:00

  • Usefulness of a highly sensitive urinary and serum IL-6 assay in patients with diabetic nephropathy.

    abstract:BACKGROUND/AIM:Interleukin-6 (IL-6) promotes the growth of renal mesangial cells. IL-6 may play a major role in such mesangial proliferation, but there has been little research on IL-6 in relation to diabetic nephropathy because of the difficulty in measuring urinary and serum IL-6 levels. Using a newly developed, high...


    pub_type: 杂志文章


    authors: Shikano M,Sobajima H,Yoshikawa H,Toba T,Kushimoto H,Katsumata H,Tomita M,Kawashima S

    更新日期:2000-05-01 00:00:00

  • Combined chemotherapy and radiotherapy for esophageal carcinoma in a hemodialyzed patient. Long-term survival.

    abstract::The use of antimitotic chemotherapy in hemodialysis patients is not yet well codified, and each individual decision remains difficult. We report the case of a 68-year-old hemodialyzed man who developed a squamous cell carcinoma of the upper third of the esophagus. Necessarily disabling surgery was rejected, and three ...


    pub_type: 杂志文章


    authors: Rebibou JM,Chauffert B,Dumas M,Mousson C,Bone MC,Tanter Y,Rifle G

    更新日期:1996-01-01 00:00:00