Abstract:
:Continuous therapy with an angiotensin-converting enzyme (ACE) inhibitor has been shown to have a glomerular vasodepressor effect in the newly diabetic rat and to largely prevent subsequent development of severe sclerosing glomerular injury. Preliminary studies in humans with established diabetic glomerular injury reveal that ACE inhibitor therapy has an antiproteinuric effect and may also slow the decline in glomerular filtration rate that usually attends this disorder. Although promising, the human studies are inconclusive because of short duration and other limitations in experimental technique and study design. Additional trials are required to confirm more positively this amelioration of human diabetic glomerular injury by ACE inhibitor therapy.
journal_name
Nephronjournal_title
Nephronauthors
Myers BD,Meyer TWdoi
10.1159/000186031subject
Has Abstractpub_date
1990-01-01 00:00:00pages
27-9eissn
1660-8151issn
2235-3186journal_volume
55 Suppl 1pub_type
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