Abstract:
AIMS:There is a trend toward deferring the initiation of chronic dialysis until absolutely indicated. This strategy, however, might lead to increased uncertainties in the timing of dialysis access creation prior to dialysis onset for patients approaching end-stage renal disease (ESRD), and the impact of which on hard end points remains largely unclear. We hereby investigated the effect of varied patterns of dialysis initiation on outcomes of new-onset hemodialysis (HD) patients. METHODS:Four hundred sixty-two prospectively recruited patients were stratified into planned elective (n = 117, 25%), planned urgent (n = 65, 14%) or unplanned urgent (n = 280, 61%) starters based on the timing of access creation with respect to dialysis initiation. The outcome measures were all-cause mortality, hospitalization and access reconstruction over 2 years. RESULTS:The mean estimated glomerular filtration rate (eGFR) was higher in the planned elective than in the planned urgent or unplanned urgent starters at access creation (5.3 vs. 4.4 or 4.3 ml/min/1.73 m2), but not at dialysis initiation (4.2 vs. 3.9 or 4.3 ml/min/1.73 m2). During the follow-up, the planned elective population exhibited the lowest rates of overall mortality and hospitalization, but not access reconstruction. Multivariate Cox's regression analysis showed that the planned urgent and the unplanned urgent groups, comparing to the planned elective population, displayed a greater risk of early death (hazards ratio [HR] 3.324, 95% CI 1.409-7.840; HR 2.510, 95% CI 1.177-5.355, respectively) and early hospitalization (sub-hazards ratio [SubHR] 2.238, 95% CI 1.530-3.274; SubHR 1.529, 95% CI 1.096-2.133, respectively). CONCLUSION:Incident ESRD patients undergoing planned elective start of HD, compared to their planned or unplanned urgent counterparts, showed reduced risk of overall mortality and hospitalization in the first 2 years after commencing long-term dialysis at a mean eGFR <5 ml/min/1.73 m2.
journal_name
Nephronjournal_title
Nephronauthors
Chen YM,Wang YC,Hwang SJ,Lin SH,Wu KDdoi
10.1159/000442168subject
Has Abstractpub_date
2016-01-01 00:00:00pages
33-42issue
1eissn
1660-8151issn
2235-3186pii
000442168journal_volume
132pub_type
杂志文章相关文献
NEPHRON文献大全abstract:BACKGROUND:Episodes of acute kidney injury (AKI) have been associated with the development of chronic kidney disease (CKD). However, follow-up pathways for patients who have survived AKI complicating critical illness are not well established. We hypothesised that patients who had AKI requiring renal replacement therapy...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000371448
更新日期:2015-01-01 00:00:00
abstract::The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046096
更新日期:2001-11-01 00:00:00
abstract::Chyloperitoneum is a rare condition in patients undergoing peritoneal dialysis. We report here a patient who developed chylous ascites during the course of tuberculous peritonitis. The diagnosis was confirmed by cultures of dialysate and peritoneal biopsy, and laparoscopy revealed severe hyperemia and intestine adhesi...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188969
更新日期:1996-01-01 00:00:00
abstract::Using immunofluorescence, we studied 19 patients with IgA nephropathy to determine whether the expression of intercellular adhesion molecule (ICAM)-1 in glomeruli might reflect the disease activity. The relationship between the expression of ICAM-1 and the infiltration of lymphocytes, monocytes and polymorphonuclear l...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187984
更新日期:1994-01-01 00:00:00
abstract::Several underlying metabolic abnormalities may be present in patients with recurrent calcium calculus disease (RCCD). The aim of this study was to determine the prevalence of deficiencies of 2 well-known potent inhibitors of crystal formation and growth, citrate and pyrophosphate, in the various metabolic subgroups an...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000186179
更新日期:1990-01-01 00:00:00
abstract::Chronic cyclosporine nephrotoxicity is characterized morphologically by cortical interstitial fibrosis. The most important collagens involved in renal fibrosis are collagen types I and III. In order to estimate the synthesis of type III and type I collagens, we analyzed serum levels of the amino-terminal propeptide of...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187929
更新日期:1994-01-01 00:00:00
abstract::Serial changes in plasma of renin concentration (PRC), renin-substrate concentration (PSC) and renin activity (PRA) were followed in rats during glycerol-induced acute renal failure. There was an early but transient increase in PRC and a more delayed and prolonged rise in PSC. PRA began to rise a few hours after glyce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181196
更新日期:1978-01-01 00:00:00
abstract::Tissue fluid and plasma oncotic pressure levels were measured in an unselected group of 13 patients presenting with congestive heart failure. Patients had a mean serum albumin of 3.6 g/dl +/- (SD) 0.35; serum oncotic pressure was 22.23 +/- 1.8 mm Hg; tissue fluid (lower leg) oncotic pressure was 0.985 +/- 0.34 mm Hg. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185804
更新日期:1990-01-01 00:00:00
abstract::Primary hyperoxaluria type 1 (PH1) is caused by deficiency of peroxisomal alanine-glyoxylate aminotransferase which is in humans exclusively expressed in liver cells. The disease is inherited as an autosomal recessive trait, and initial symptoms usually occur in early childhood. Up to the age of 25 years, 90% of the p...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045888
更新日期:2001-01-01 00:00:00
abstract::Human peritoneal mesothelial cells lie on a basement membrane-like material consisting of fibronectin (FN), type I collagen (CI), type III collagen (CIII) and laminin (LA). To understand how these extracellular matrix (ECM) proteins affect mesothelial cell behavior, we investigated their effect on the adhesion and pro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189530
更新日期:1997-01-01 00:00:00
abstract::Permanent loss of the ultrafiltration (UF) capacity of the peritoneum has been observed with an increasing frequency among our patients treated by long-term intermittent (IPD) and/or continuous ambulatory peritoneal dialysis (CAPD). The analysis of various characteristics of our PD population (patients age, dialysis t...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182927
更新日期:1983-01-01 00:00:00
abstract::Recent studies have shown that the mass transfer coefficients (MTC) for low- and middle-molecular-weight substances are maintained at medium terms in patients under continuous ambulatory peritoneal dialysis (CAPD) therapy. We have studied the MTC for parathormone (MW 5,500-6,000) in 29 patients under CAPD. 11 patients...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183201
更新日期:1984-01-01 00:00:00
abstract::We describe two preparations for chronic peritoneal dialysis in the dog. In one group uremia was induced by nephrectomy and in the other by ureteral ligation. Peritoneal access was obtained using the Ash disc column catheter. Survival of the animals ranged from 27 to 83 days. Using a dialysis schedule similar in conce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183093
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND/AIM:Interleukin (IL)-17 is a newly discovered cytokine that is secreted by activated memory CD4+ T cells and modulated the early stage of immune response. To elucidate the pathophysiology of minimal-change nephrotic syndrome (MCNS), we focused on IL-17, which is one of the key factors in regulating an inflam...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000058399
更新日期:2002-06-01 00:00:00
abstract::The concentration of ionic calcium (Ca2+ in the smooth muscular cells of the resistance vessels is a determining factor of their contraction. It depends on the influx of Ca2+ to the interior of the cells through the calcium channels in the sarcolemma. The effect of a specific Ca2+-channel blocking agent - nifedipine -...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183607
更新日期:1985-01-01 00:00:00
abstract::The use of antimitotic chemotherapy in hemodialysis patients is not yet well codified, and each individual decision remains difficult. We report the case of a 68-year-old hemodialyzed man who developed a squamous cell carcinoma of the upper third of the esophagus. Necessarily disabling surgery was rejected, and three ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189461
更新日期:1996-01-01 00:00:00
abstract::Previous work has shown that cigarette-smoking affects platelets and endothelium in men and women without renal failure. The present study compared 10 male habitual smokers receiving maintenance hemodialysis for chronic renal failure with 11 healthy male habitual smokers before and after controlled cigarette-smoking a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187354
更新日期:1993-01-01 00:00:00
abstract::Oral phosphatidylcholine at 900 mg/day was given to 4 patients with high lymph absorption for 8 weeks. Fluid and solute transfer before and after treatment were compared to 4 similar controls given placebo. None of the patients had overt ultrafiltration problems. After treatment, overnight peritoneal effluent phosphol...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000186527
更新日期:1991-01-01 00:00:00
abstract::An autopsy case of membranous glomerulonephritis associated with enterococcal endocarditis was reported. Although enterococcal antigen was not identified in glomerular deposits, the eluate from the patient's renal tissue was shown to specifically recombine with cells of the enterococcus isolated from his own ante mort...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183435
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Complete remission (CR) and partial remission (PR) are beneficial to the long-term outcome of patients with idiopathic membranous nephropathy (iMN). However, we are lacking in studies that evaluate the clinical predictors of response to treatment with prednisone plus cyclophosphamide (CP). The objectives of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000448291
更新日期:2017-01-01 00:00:00
abstract::Pyomyositis, an endemic disease of tropical origin, is increasingly reported in temperate zones, especially in patients with diabetes mellitus and in the immunocompromised. A 28-year-old renal transplant recipient presented with perforating skin lesions (Kyrle's disease), thigh pain, and swelling associated with fever...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189159
更新日期:1996-01-01 00:00:00
abstract::Hemodynamic and hormonal actions of acute (50 mg) and chronic (150 mg/day) captopril were tested in 10 patients with essential hypertension. Under short-term conditions blood pressure was reduced, heart rate and plasma adrenaline did not change, plasma angiotensin II and plasma aldosterone decreased. Plasma renin acti...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183910
更新日期:1986-01-01 00:00:00
abstract::We present a 57-year-old man with end-stage renal failure due to chronic glomerulonephritis, who had been on hemodialysis for 13.5 years and had suffered from recurrent painful swelling of the left leg for 4.7 years. A diagnosis of deep venous thrombosis was made by the phlebography. Coagulation studies showed decreas...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187835
更新日期:1994-01-01 00:00:00
abstract::We have evaluated the effect of the antihyperlipidemic agent probucol on hyperlipidemia in patients with nephrotic syndrome. Twelve patients with long-standing nephrotic syndrome received 500 mg of probucol daily for 12 weeks. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol were significantl...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184524
更新日期:1987-01-01 00:00:00
abstract::The effects of a high-protein (HP) and low-protein (LP) meal on glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and renal vascular resistance (RVR) were examined in conscious dogs. Ingestion of the HP and LP meal produced a temporary increase in systemic hemodynamic parameters due in part to a 'c...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188228
更新日期:1994-01-01 00:00:00
abstract::Increased free-radical production leading to oxidative stress may contribute to the development of cardiovascular complications in haemodialysis patients. The ferroxidase activity of caeruloplasmin forms an important component of antioxidant defences in body fluids. The aim of this study was to assess ferroxidase acti...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045579
更新日期:2000-03-01 00:00:00
abstract::To understand the regulation of vasopressin receptors in an animal model of hypertension, localization and age-related changes in renal arginine vasopressin (AVP) receptors in spontaneously hypertensive rats (SHR) were investigated using in vitro (macro) autoradiography and a radiolabeled receptor assay. Autoradiograp...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188855
更新日期:1996-01-01 00:00:00
abstract::The methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been shown to be associated with cardiovascular disease in healthy subjects as well as in patients with end-stage renal disease (ESRD). In this study, we examined the allelic frequency and genotype distribution of the MTHFR gene in 151 Chinese ESRD ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045922
更新日期:2001-03-01 00:00:00
abstract::Chronic kidney disease (CKD) is a worldwide public health problem associated with a high prevalence of cardiovascular disease (CVD) and impaired quality of life. Previous research for preventing loss of glomerular filtration rate (GFR) has focused on reducing blood pressure (BP) and proteinuria. Angiotensin converting...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000447068
更新日期:2016-01-01 00:00:00
abstract::The effect of intravenous 1 alpha(OH)D3 on circulating intact parathyroid hormone (PTH) and COOH-terminal immunoreactive PTH was examined in 21 patients on chronic hemodialysis. The patients were treated for 3 months with increasing doses of 1 alpha(OH)D3 under careful control of serum Ca2+. 1 alpha(OH)D3 was given in...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185744
更新日期:1989-01-01 00:00:00