Abstract:
:The concentration of ionic calcium (Ca2+ in the smooth muscular cells of the resistance vessels is a determining factor of their contraction. It depends on the influx of Ca2+ to the interior of the cells through the calcium channels in the sarcolemma. The effect of a specific Ca2+-channel blocking agent - nifedipine - on arterial hypertension in a group of 18 patients with chronic renal hypertension is reported in this study. The combination of nifedipine and propranolol in the control of hypertension in 6 of these patients in a long-term follow-up was also studied. It was concluded: (1) Ca2+ blockade had a rapid and powerful antihypertensive effect in all patients; (2) the antihypertensive effect was higher with high initial blood pressure levels; this fact was especially evident and appeared particularly useful in hypertensive emergencies; (3) in some patients, the action of nifedipine was dose-dependent; (4) nifedipine had a short-lived action; (5) the combination nifedipine-propranolol was efficient in the long-term control of hypertension.
journal_name
Nephronjournal_title
Nephronauthors
Moreira J,Barata JD,Olias Jdoi
10.1159/000183607subject
Has Abstractpub_date
1985-01-01 00:00:00pages
314-9issue
4eissn
1660-8151issn
2235-3186journal_volume
41pub_type
杂志文章相关文献
NEPHRON文献大全abstract::A very simple analytical procedure with dimethylmethylene blue as photometric reagent was applied for the evaluation of glycosaminoglycan (GAG) urinary excretions and concentrations in both sexes, calcium oxalate stone formers, and a control group. The GAG concentrations varied significantly in stone formers (males an...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188306
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of treatment for renal anemia in patients with chronic kidney disease (CKD). This meta-analysis was designed to evaluate their efficacy and safety. METHOD:Eight databases were searched for randomized controlled trials (RCTs). ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000508812
更新日期:2020-01-01 00:00:00
abstract::The purpose of the study was to investigate the effects of parathyroid hormone (PTH) infusion on antioxidant enzyme activity and lipid peroxidation of erythrocytes in five-sixths nephrectomized (Nx) rats. Five-sixths Nx rats had a higher osmotic fragility in red blood cells (RBC). Thyroparathyroidectomy (TPTX) effecti...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189046
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Cyst infection is one of the complications of autosomal dominant polycystic kidney disease and polycystic liver disease. The diagnosis is typically made on a mix of clinical, laboratory and imaging abnormalities but the importance of individual items is uncertain. We aimed to perform a Delphi survey amongst ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000446664
更新日期:2016-01-01 00:00:00
abstract::HLA antigens of Japanese patients with primary glomerulopathies were determined, and the frequency of each HLA antigen was compared with that of Japanese normal controls. IgA nephropathy with HLA-DR4, idiopathic membraneous glomerulopathy with DR2, lipoid nephrosis with DRw53 and poststreptococcal glomerulonephritis w...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184089
更新日期:1987-01-01 00:00:00
abstract::Complement factor D, a complement system serine protease, circulating in vivo as its active form, accumulates in patients with chronic renal failure. The pathophysiological role of this active protease in these patients was examined by studies on activities of excess factor D on 10 synthetic peptide substrates for som...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187824
更新日期:1994-01-01 00:00:00
abstract::Classic renal tubular acidosis is characterized by a primary defect in establishment of a large hydrogen ion gradient across the distal renal tubule. Thus the development of hyperchlorenic metabolic acidosis follows. In addition, hypokalemia results from renal potassium wasting secondary hyperaldosteronism from sodium...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181626
更新日期:1979-01-01 00:00:00
abstract::Like other biguanide agents, metformin is an anti-hyperglycemic agent with lower tendency towards hypoglycemia compared to other anti-diabetic drugs. Given its favorable effects on serum lipids, obese body habitus, cardiovascular disease, and mortality, metformin is recommended as the first-line pharmacologic agent fo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000450862
更新日期:2017-01-01 00:00:00
abstract::Continuous therapy with an angiotensin-converting enzyme (ACE) inhibitor has been shown to have a glomerular vasodepressor effect in the newly diabetic rat and to largely prevent subsequent development of severe sclerosing glomerular injury. Preliminary studies in humans with established diabetic glomerular injury rev...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186031
更新日期:1990-01-01 00:00:00
abstract::Chronic kidney disease (CKD) is a worldwide public health problem associated with a high prevalence of cardiovascular disease (CVD) and impaired quality of life. Previous research for preventing loss of glomerular filtration rate (GFR) has focused on reducing blood pressure (BP) and proteinuria. Angiotensin converting...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000447068
更新日期:2016-01-01 00:00:00
abstract::End-stage renal disease (ESRD) is common, costly, and it results from progressive chronic kidney disease (CKD). ESRD claims many lives every year. It is increasingly recognized that episodes of acute kidney injury (AKI) predispose to the future development of CKD and ESRD. While our understanding of the pathophysiolog...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000474960
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Sepsis and septic shock are life-threatening causes of acute kidney injury (AKI) frequently seen and managed in intensive care units (ICUs). Sepsis-associated AKI (SA-AKI) independently contributes to the mortality of sepsis. Understanding the potential factors involved in kidney function recovery may furthe...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000507999
更新日期:2020-01-01 00:00:00
abstract::During chronic chlorthalidone treatment of patients with essential hypertension, distal tubular sodium reabsorption is continuously inhibited. At the same time, sodium balance is maintained by an increase of the proximal tubular sodium reabsorption. In the present study, we investigated whether this increase is caused...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184485
更新日期:1987-01-01 00:00:00
abstract::This report describes the case of a 50-year-old male with end-stage renal failure accompanied with congenital heart disease and polycythemia. After he had received continuous ambulatory peritoneal dialysis for 1 year, he still remained polycythemic and his serum erythropoietin titer, assayed using fetal mouse liver ce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000184292
更新日期:1987-01-01 00:00:00
abstract::A new case of acute renal failure after rifampicin is presented, together with a review of the 36 similar cases published up to date in the literature. Evidence is provided that irregularities in drug intake, either as true intermittent treatment or as discontinuation of continuous therapy, play an important role in t...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180596
更新日期:1976-01-01 00:00:00
abstract::We examined the ultrastructure of the bovine glomerular basement membrane (GBM) and tubular basement membrane (TBM) using ultra-high-resolution scanning electron microscopy after conductive staining without metal coating. Purified basement membranes (BMs) were obtained by sonication and acellular BMs by detergent trea...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187800
更新日期:1994-01-01 00:00:00
abstract::Two observers, unaware of each other's findings and of the diagnosis, examined red cells in the urine of 109 patients by phase-contrast microscopy. All specimens were examined uncentrifuged by inverted microscopy, and 48 of the 109 were also examined under a light microscope after centrifugation. We were unable to con...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000184011
更新日期:1986-01-01 00:00:00
abstract::Propranolol-induced hypoglycemia in hemodialysis patients has been increasingly recognized. We studied the effects of a nonselective beta-blocker (propranolol) and a beta 1-selective-blocker (metoprolol) on glucose metabolism during pharmacologic hyperglucagonemia in these patients. cAMP and insulin responses to gluca...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183367
更新日期:1985-01-01 00:00:00
abstract::Both the plasma determinations of erythropoietic (EPO) and transferrin receptor (TfR) would provide a good characterization of anemia especially when mixed erythron disorders underlie, such as in renal failure. Immunologic assays of EPO and TfR, as well as standard hematologic determinations (hematocrit, reticulocyte ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000188938
更新日期:1996-01-01 00:00:00
abstract::We found a strain of nonobese, nondiabetic (NON) mice which has spontaneous lipid deposition in glomerular capillary lumina. This strain was developed together with a diabetic strain of nonobese diabetic (NOD) mice for the generation of mouse models of diabetes mellitus. In the NON strain, contrary to the name, impair...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186417
更新日期:1991-01-01 00:00:00
abstract::The effect of dilazep, an adenosine potentiator and platelet aggregation inhibitor, on experimental diabetic nephropathy was investigated in spontaneous diabetic Chinese hamster. Prediabetic animals, 8 weeks of age, were divided into two groups. In one group, 5 mg/kg dilazep was injected i.p. once a day. In the other ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187453
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Control of hyperphosphatemia in patients on dialysis remains a major challenge. OBJECTIVE:This study evaluated predictors of serum phosphorus (sP) control among dialysis patients treated with noncalcium, oral phosphate binder therapy in a phase 3 clinical trial. METHODS:Post hoc analyses were performed u...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000507258
更新日期:2020-01-01 00:00:00
abstract::Patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency very often show progressive glomerulosclerosis with evolution to end-stage disease. High levels of an abnormal lipoprotein (lipoprotein X) cause glomerular capillary endothelial damage. The ultrastructural study of renal biopsy specimens sho...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046001
更新日期:2001-07-01 00:00:00
abstract::Hyperparathyroidism is a common problem for patients on renal replacement therapy programs. Many long-term dialysis patients require parathyroidectomy while on dialysis. Some patients, however, despite severe renal osteodystrophy, are transplanted, and in these a large proportion show a slow resolution of bony problem...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000046051
更新日期:2001-09-01 00:00:00
abstract::We describe two preparations for chronic peritoneal dialysis in the dog. In one group uremia was induced by nephrectomy and in the other by ureteral ligation. Peritoneal access was obtained using the Ash disc column catheter. Survival of the animals ranged from 27 to 83 days. Using a dialysis schedule similar in conce...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183093
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cardiac surgery-associated severe acute kidney injury (SAKI) is associated with high mortality and poor quality of life. A prognostic score for SAKI may enable prevention of complications. METHODS:This observational study of 2,552 patients undergoing cardiac surgery from January 2006 to December 2011 i...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000499345
更新日期:2019-01-01 00:00:00
abstract::We attempted to treat 5 patients on CAPD with fungal peritonitis without removing the catheter. In 1 case, amphotericin B caused a severe chemical peritonitis. The other 4 patients received amphotericin B intravenously and miconazole or flucytosine intraperitoneally. Recovery was obtained in 3 cases without removing t...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183582
更新日期:1985-01-01 00:00:00
abstract:AIM:To clarify the role of leukocyte subsets in the development of glomerulosclerosis (GS) and interstitial lesions which may contribute to the prognosis of membranous nephropathy (MN), we investigated infiltrating cells in both glomeruli and interstitium in biopsy specimens. METHODS:Forty-one cases of MN were divided...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045213
更新日期:1998-12-01 00:00:00
abstract::Calcitonin, whatever its origin, produces a decrease in the renal tubular reabsorption of sodium, phosphate and calcium in man and in the rat. Renal receptors for calcitonin have been demonstrated in the membranes of rat tubular cells using 125I salmon calcitonin as a tracer. Hormone-receptor interaction initiates the...
journal_title:Nephron
pub_type: 杂志文章,评审
doi:10.1159/000180515
更新日期:1975-01-01 00:00:00
abstract::The authors describe an unusual case of radial artery pseudoaneurysm in a patient with a Brescia-Cimino fistula. Evaluation of a pulsatile mass on the patient's forearm which occurred after hemodialysis led to a nondiagnostic fistulogram. Color flow ultrasound was helpful in identifying the nature of the abnormality, ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188958
更新日期:1996-01-01 00:00:00