Serial studies of the renin system in rats with glycerol-induced renal failure.

Abstract:

:Serial changes in plasma of renin concentration (PRC), renin-substrate concentration (PSC) and renin activity (PRA) were followed in rats during glycerol-induced acute renal failure. There was an early but transient increase in PRC and a more delayed and prolonged rise in PSC. PRA began to rise a few hours after glycerol administration at the expense of increases in renin, but by 24 h the high activity was maintained largely by increases in renin-substrate. No correlations between PSC, PRC, or PRA changes and severity of renal failure could be demonstrated. These results suggest that these changes are not causally related to the development of kidney failure.

journal_name

Nephron

journal_title

Nephron

authors

Carvalho JS,Page LB

doi

10.1159/000181196

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

47-53

issue

1

eissn

1660-8151

issn

2235-3186

journal_volume

20

pub_type

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