Development of calcium oxalate crystals on urothelium: effect of free radicals.

Abstract:

:The effects of free radicals on the development of crystals attached to the living epithelium have been studied using an experimental model that enables close simulation of the conditions prevailing in the kidney. The results obtained clearly demonstrate that free radical-damaged cells produce a favorable environment for crystal development. At low free radical concentrations, crystals develop on calcium-enriched zones, whereas at higher concentrations, crystals develop on areas with a destroyed monolayer of superficial cells. Evaluation of the action of some products with antioxidant action and/or crystallization-inhibitory capacity is also included. Antioxidants, such as ascorbic acid and mannitol, exerted the most remarkable effects in avoiding calcium oxalate crystal development, whereas crystal inhibitors, such as citric acid, did not produce any remarkable reduction in calcium oxalate crystallization. Phytic acid notably decreased calcium oxalate crystal development. The ability of phytic acid to diminish calcium oxalate crystallization must be attributed to the combination of its inhibitory capacity of calcium oxalate crystallization and its preventive antioxidant action.

journal_name

Nephron

journal_title

Nephron

authors

Grases F,García-Ferragut L,Costa-Bauzá A

doi

10.1159/000044939

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

296-301

issue

3

eissn

1660-8151

issn

2235-3186

pii

nef78296

journal_volume

78

pub_type

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