Acute effect of passive Heymann nephritis on renal blood flow and glomerular filtration rate in the rat: role of the anaphylatoxin C5a and the alpha-adrenergic nervous system.

abstract：:Mizoribine has been shown to possess an immunosuppressive action that inhibits the proliferation of lymphocytes selectively by interfering with inosine monophosphate dehydrogenase. Recent studies have demonstrated that mizoribine improves renal tubulointerstitial fibrosis in the rat model of unilateral ureteral obstru...

journal_title：Nephron

authors： Sato N,Shiraiwa K,Kai K,Watanabe A,Ogawa S,Kobayashi Y,Yamagishi-Imai H,Utsunomiya Y,Mitarai T

更新日期：2001-10-01 00:00:00

abstract：:Patients with familial lecithin-cholesterol acyltransferase (LCAT) deficiency very often show progressive glomerulosclerosis with evolution to end-stage disease. High levels of an abnormal lipoprotein (lipoprotein X) cause glomerular capillary endothelial damage. The ultrastructural study of renal biopsy specimens sho...

journal_title：Nephron

authors： Sessa A,Battini G,Meroni M,Daidone G,Carnera I,Brambilla PL,Viganò G,Giordano F,Pallotti F,Torri Tarelli L,Calabresi L,Rolleri M,Bertolini S

更新日期：2001-07-01 00:00:00

abstract：:HLA antigens of Japanese patients with primary glomerulopathies were determined, and the frequency of each HLA antigen was compared with that of Japanese normal controls. IgA nephropathy with HLA-DR4, idiopathic membraneous glomerulopathy with DR2, lipoid nephrosis with DRw53 and poststreptococcal glomerulonephritis w...

journal_title：Nephron

authors： Naito S,Kohara M,Arakawa K

更新日期：1987-01-01 00:00:00

abstract：CONTEXT:Soluble urokinase-type plasminogen activator -(suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational modifications. Recently, [Hayek, et al: Nat Med 2017; 23: 945-953] it has been found that there is a link between suPAR and renal disease in several gui...

journal_title：Nephron

authors： Saleem MA

更新日期：2018-01-01 00:00:00

abstract：:1 day after bilateral ureteral occlusion (BUO), the extracellular fluid (ECF) volume of rats was increased by 2.8 ml/100 g body weight above those values observed after either a sham operation or after 1 day of unilateral ureteral occlusion (UUO). The plasma urea concentration of BUO rats averaged about five times the...

journal_title：Nephron

authors： Sophasan S,Sorrasuchart S

更新日期：1984-01-01 00:00:00

abstract：:Obstructed shunt vessels were studied immunohistochemically to clarify the mechanism of shunt obstruction in hemodialysis patients. The subjects were 12 hemodialysis patients with shunt obstruction, and 8 patients newly started on hemodialysis were used as the controls. Cryosections of shunt tissue were prepared and s...

journal_title：Nephron

authors： Taniguchi Y,Yorioka N,Yamashita K,Masaki T,Yamakido M

更新日期：1999-01-01 00:00:00

abstract：:The high blood flow rate/gram of kidney tissue supplies mainly the renal cortex. The net effect of the interaction of the renin-angiotensin system, the kallikrein-kinin system and prostaglandins is to autoregulate renal blood flow within a narrow range. Drugs and neurogenic factors also influence renal hemodynamics. T...

journal_title：Nephron

authors： Maher JF

更新日期：1981-01-01 00:00:00

abstract：:The effects of chronic ethanol ingestion on the rat kidney were studied. Rats were fed a liquid diet containing ethanol for 5 weeks to induce chronic alcoholism. Renal ischemia was introduced by clamping the renal artery and vein either for 10 or 20 min. The glomerular filtration rate (GFR) and the renal blood flow (R...

journal_title：Nephron

authors： Ishigami M,Ohnishi ST,Chan R,Shimada Y,Yabuki S

更新日期：1989-01-01 00:00:00

abstract：:A 51-year-old man with diabetes mellitus and the nephrotic syndrome on renal biopsy was found to have diabetic glomerulosclerosis, amyloidosis and membranous glomerulopathy. The presence of three distinct glomerular diseases in the same patient is unique. Possible factors involved in their pathogenesis are discussed a...

journal_title：Nephron

authors： Bertani T,Olesnicky L,Abu-Regiaba S,Glasberg S,Pirani CL

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:At present, the determination of dry weight in patients on hemodialysis is largely made empirically by trial and error. Extracellular volume (ECV) assessment by bioimpedance analysis (BIA) is a preferable technique for determining dry weight, and it also provides useful data on body composition. METHODS:We ...

journal_title：Nephron

authors： Chen YC,Chen HH,Yeh JC,Chen SY

更新日期：2002-09-01 00:00:00

abstract：:In order to elucidate the mechanism of peritoneal dialysis fluid inhibition of cell functions, laboratory-prepared fluids were used to investigate the specific influences of low pH and high lactate concentration on neutrophil viability, phagocytosis, respiratory burst activation and leukotriene B4 (LTB4) generation. I...

journal_title：Nephron

authors： Liberek T,Topley N,Jörres A,Petersen MM,Coles GA,Gahl GM,Williams JD

更新日期：1993-01-01 00:00:00

abstract：:CBA/CaH-kdkd mice develop hereditary tubulointerstitial disease with mononuclear cell infiltration and cyst formation, possibly representing a model of human nephronophthisis. The purpose of the present investigation was to examine the components of the fibrotic changes which typically develop in the kidneys of these ...

journal_title：Nephron

authors： Sibalic V,Sun L,Sibalic A,Oertli B,Ritthaler T,Wüthrich RP

更新日期：1998-11-01 00:00:00

abstract：:Cardiovascular disease is the major complication and cause of mortality in the dialysis population, accounting for about 40% of deaths. Oxidative stress has been strongly implicated in the pathogenesis of these events. As patients in end-stage renal disease (ESRD) are in a state of elevated free radical activity, the ...

journal_title：Nephron

authors： Wang NP,Lim PS,Chen TT,Thien LM,Wang TH,Hsu WM

更新日期：2002-12-01 00:00:00

abstract：:After successful renal transplantation there is continuing malabsorption of calcium and phosphorus. This is due in part to impaired glomerular filtration rate, and in part to the action of steroid on calcium and phosphorus absorption. The effect of steroids is most marked over the first 18 months after transplantation...

journal_title：Nephron

authors： Walker GS,Peacock M,Marshall DH,Giles GR,Davison AM

更新日期：1980-01-01 00:00:00

abstract：:Platelet-activating factor (PAF) belongs to a new class of lipid chemical inflammatory mediators described as acetyl glyceryl ether phosphorylcholine. Although PAF has been implicated in kidney injury, its role in renal immune injury has not been clearly defined yet. We studied the levels of PAF in the plasma and urin...

journal_title：Nephron

authors： Iatrou C,Moustakas G,Antonopoulou S,Demopoulos CA,Ziroyiannis P

更新日期：1996-01-01 00:00:00

abstract：:Renal nerves were stimulated either directly (loop electrodes) or indirectly (bilateral carotid occlusion with maintenance of control blood pressure) in anesthetized dogs to determine the effects on renal blood flow (RBF), glomerular filtration rate (GFR), sodium excretion (UNaV), and intrarenal distribution of blood ...

journal_title：Nephron

authors： Katz MA,Shear L

更新日期：1975-01-01 00:00:00

abstract：:A patient with collagenofibrotic glomerulopathy associated with hepatic persinusoidal fibrosis is described. Renal biopsy revealed that the glomerular tufts contained homogeneous material that was proved by electron microscopy to be collagen fibers. The material was reactive to anti-type III collagen monoclonal antibo...

journal_title：Nephron

authors： Mizuiri S,Hasegawa A,Kikuchi A,Amagasaki Y,Nakamura N,Sakaguchi H

更新日期：1993-01-01 00:00:00

abstract：:We investigated the incidence of painless (silent) myocardial ischemia, manifested as S-T segment deviation, by Holter ECG monitoring in patients with chronic renal failure undergoing regular hemodialysis. Forty-five patients underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the int...

journal_title：Nephron

authors： Kremastinos D,Paraskevaidis I,Voudiklari S,Apostolou T,Kyriakides Z,Zirogiannis P,Toutouzas P

更新日期：1992-01-01 00:00:00

abstract：:The efficacy of simvastatin, a competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, was investigated in 12 patients treated with continuous ambulatory peritoneal dialysis (CAPD), displaying hypercholesterolemia and moderate hypertriglyceridemia. After a 4-week placebo period, simvastatin was admi...

journal_title：Nephron

authors： Wanner C,Lubrich-Birkner I,Summ O,Wieland H,Schollmeyer P

更新日期：1992-01-01 00:00:00

abstract：:A prospective study evaluated the complications in 154 patients in whom a permanent peritoneal dialysis catheter was inserted percutaneously from April 1982 to June 1986. Obstruction to flow and fluid leakage occurred in 9.2 and 2.6% of the catheters, respectively. Catheter survival was 64.6 and 48.6% at 1- and 2-year...

journal_title：Nephron

authors： Allon M,Soucie JM,Macon EJ

更新日期：1988-01-01 00:00:00

abstract：:In pharmacologic doses E series prostaglandins attenuate the development of immune complex nephritis. We studied the effect of the dietary prostaglandin precursor linoleic acid on murine apoferritin-induced immune complex glomerulonephritis. High, normal, or low linoleic acid diets were fed to mice for 4 weeks prior t...

journal_title：Nephron

authors： Kher V,Barcelli U,Weiss M,Pollak VE

更新日期：1985-01-01 00:00:00

abstract：:We recently showed in dogs that there is a close relationship between bicarbonate reabsorption and glomerular filtration rate (GFR). The present studies were designed to confirm these findings in five normal men. Bicarbonate titrations were done after ingesting a low protein diet for one week and were repeated followi...

journal_title：Nephron

authors： Bennett CM,Falkinburg NR,Springberg PD

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND/AIMS:Glomerular basement membrane (GBM) thickening and mesangial matrix expansion are characteristic features of diabetic nephropathy. The present study investigates the role of endothelins (ETs) in the pathogenesis of such changes in diabetic nephropathy. METHODS:Diabetic (streptozotocin-induced, 65 mg/kg)...

journal_title：Nephron

authors： Chen S,Evans T,Deng D,Cukiernik M,Chakrabarti S

更新日期：2002-01-01 00:00:00

abstract：:Kidney biopsy remains the gold standard for uncovering the pathogenesis of acute and chronic kidney diseases. However, the ability to perform high resolution, quantitative, molecular and cellular interrogation of this precious tissue is still at a developing stage compared to other fields such as oncology. Here, we di...

journal_title：Nephron

authors： Winfree S,Dagher PC,Dunn KW,Eadon MT,Ferkowicz M,Barwinska D,Kelly KJ,Sutton TA,El-Achkar TM

更新日期：2018-01-01 00:00:00

abstract：:4 patients on regular dialysis were studied by the echocardiographic method during ultrafiltration and dialysis performed sequentially according to two different protocols. Blood pressure, heart rate, cardiac output, stroke volume, systolic and diastolic dimension of the left ventricle, systolic and diastolic volumes ...

journal_title：Nephron

authors： Cini G,Camici M,Pentimone F,Palla R

更新日期：1982-01-01 00:00:00

abstract：:The effects of dietary protein both before and after uranyl-nitrate-induced acute renal failure were investigated. Male Sprague-Dawley rats were maintained on high-protein (60%), normal-protein (20%), low-protein (5%) and no-protein diets for 8 days prior to intravenous administration of uranyl nitrate (10 mg/kg). Imm...

journal_title：Nephron

authors： Andrews PM,Bates SB

更新日期：1987-01-01 00:00:00

abstract：:This study sought to determine if low doses of ciclosporin (CS) designed to give fasting serum levels of 50-100 ng/ml achieve effective immunosuppression when used from the early postoperative period after renal transplantation. Ninety-four primary renal transplant recipients were studied. Group 1 patients were treate...

journal_title：Nephron

authors： Brady HR,Kamel KS,Harding ME,Cook GT,deVeber GA,Cardella CJ

更新日期：1990-01-01 00:00:00

abstract：:A 5-year-old Japanese boy showed nephritis similar to, but distinct from, that in Alport syndrome. Nephrotic syndrome without hematuria was noticed at age 2, although renal biopsy at age 4 revealed widespread irregular thickening of the glomerular basement membrane with splitting of the lamina densa on electron micros...

journal_title：Nephron

authors： Kawakami H,Murakami T,Murano I,Ushijima T,Taguchi T,Hattori S,Kajii T

更新日期：1990-01-01 00:00:00

abstract：:The effect of water immersion to the neck on renal calcium and magnesium handling was studied in 11 nephrotic patients. There was an increase in the urinary excretion of both calcium and magnesium on immersion, and a return towards preimmersion control values in the hour following immersion. Clearances of calcium and ...

journal_title：Nephron

authors： Brown C,Sutton JV,Adler A,Feinroth MV,Feinroth M,Friedman EA,Berlyne GM

更新日期：1983-01-01 00:00:00

abstract：:The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels...

journal_title：Nephron

authors： Conz PA,Milan M,Bragantini L,La Greca G,Bevilacqua PA

更新日期：2001-11-01 00:00:00