TINU syndrome associated with reduced complement levels.

Abstract:

:The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels. We profile a 48-year-old white female with persistently reduced C4 complement levels during the acute phase of the pathology and with an unaltered immunologic profile. Renal biopsy evidenced a significant lymphocytic interstitial infiltration. Immunohistochemical studies of the interstitium infiltrates was positive for the presence of the T (CD3) markers (CD4 > CD8). Steroid therapy yielded a complete regression of the symptomatology with normalization of the complement levels. We suggest that it is possible to hypothesize that the various immunologic alterations associated with TINU, including the transient reduction complement levels, may be secondary to multiple inflammatory mechanisms which express themselves throughout the pathology.

journal_name

Nephron

journal_title

Nephron

authors

Conz PA,Milan M,Bragantini L,La Greca G,Bevilacqua PA

doi

10.1159/000046096

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

340-1

issue

3

eissn

1660-8151

issn

2235-3186

pii

46096

journal_volume

89

pub_type

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