Abstract:
:The TINU syndrome (tubulointerstitial nephritis and uveitis) was first described by Dobrin et al. in 1975. Since then, more than 50 cases have been documented each with diverse immunopathogenetic and genetic characteristics. The aim of this report is to describe a case of TINU associated with reduced complement levels. We profile a 48-year-old white female with persistently reduced C4 complement levels during the acute phase of the pathology and with an unaltered immunologic profile. Renal biopsy evidenced a significant lymphocytic interstitial infiltration. Immunohistochemical studies of the interstitium infiltrates was positive for the presence of the T (CD3) markers (CD4 > CD8). Steroid therapy yielded a complete regression of the symptomatology with normalization of the complement levels. We suggest that it is possible to hypothesize that the various immunologic alterations associated with TINU, including the transient reduction complement levels, may be secondary to multiple inflammatory mechanisms which express themselves throughout the pathology.
journal_name
Nephronjournal_title
Nephronauthors
Conz PA,Milan M,Bragantini L,La Greca G,Bevilacqua PAdoi
10.1159/000046096subject
Has Abstractpub_date
2001-11-01 00:00:00pages
340-1issue
3eissn
1660-8151issn
2235-3186pii
46096journal_volume
89pub_type
杂志文章相关文献
NEPHRON文献大全abstract::This study sought to determine if low doses of ciclosporin (CS) designed to give fasting serum levels of 50-100 ng/ml achieve effective immunosuppression when used from the early postoperative period after renal transplantation. Ninety-four primary renal transplant recipients were studied. Group 1 patients were treate...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000186007
更新日期:1990-01-01 00:00:00
abstract::Eighteen hemodialysis, 12 chronic ambulatory peritoneal dialysis (CAPD), and 20 renal transplant patients performed maximal treadmill exercise tests. Heart rates and blood pressures were determined every minute and maximal oxygen consumption was measured directly. Exercise capacity as measured by VO2 max is low in dia...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183632
更新日期:1986-01-01 00:00:00
abstract::An abnormal level of serum lipids may be one of the major risk factors for the development of atherosclerosis in patients with chronic renal failure (CRF). In the present study, the effect of polyunsaturated fatty acid-rich and low carbohydrate diet on serum lipids and HDL-cholesterol was studied in 6 nonnephrotic and...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182652
更新日期:1982-01-01 00:00:00
abstract::Pulmonary calcifications are known to occur in patients with chronic renal failure. Recently, scintigrams with bone-seeking radionuclides have been used to detect subclinical pulmonary calcium deposits. We studied 18 children on maintenance dialysis without evidence of pulmonary calcification on chest X-ray. Four chil...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183911
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Home hemodialysis is usually considered a superior therapy, whose decline is related to demographic, social, psychological and financial factors as well as to competition with renal transplantation and PD. METHODS:A home hemodialysis program was started in November 1998 in the University of Torino, Italy (2...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000063319
更新日期:2002-10-01 00:00:00
abstract::The capacity of peripheral blood mononuclear cells (PBMC) to undergo spontaneous and induced interleukin-1 (IL-1) production was examined in 10 healthy controls and in 10 patients undergoing intermittent hemodialysis (HD) using cuprophane membranes. Extracellular and cytoplasmic IL-1 activity was assayed by biologic a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185187
更新日期:1988-01-01 00:00:00
abstract::A 72-year-old non-diabetic uremic woman underwent right nephrectomy for urolithiasis at the age of 50. Because pyuria, fever, chilliness and left flank pain developed during preparing for arteriovenous fistula, she was admitted to National Cheng Kung University Hospital. Renal cell carcinoma (RCC) complicated with emp...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064452
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Little is known about the effect of posttransplant opioid use on adherence to immunosuppressant therapy (IST) among adult renal transplant recipients (RTRs). OBJECTIVE:The aim of this study was to examine the relationship between opioid use and IST adherence among adult RTRs during the first year posttran...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000507257
更新日期:2020-01-01 00:00:00
abstract::A study was undertaken in 24 Chinese patients on maintenance continuous ambulatory peritoneal dialysis, using bezafibrate in its sustained-release form to correct lipid abnormalities. Six patients who received 400 mg/day developed severe muscle weakness with grossly elevated creatine phosphokinase activities within 3 ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186101
更新日期:1990-01-01 00:00:00
abstract::The effect of ischemia on renal blood flow (RBF) in the rat has been an unsettled question. This study used a totally extractable indicator, radioactive microspheres, with a reference arterial sample, to study RBF quantitatively 10 and 60 min after 1 h of unilateral renal artery clamping in anesthetized, heparinized r...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000181378
更新日期:1978-01-01 00:00:00
abstract::Cadmium-induced renal effects were followed (1989) in 16 workers previously exposed to cadmium, who had been shown 5 years earlier to have had tubular damage; all but 1 worker had persistent tubular damage (beta 2-microglobulin > 60 micrograms/mmol creatinine). The mean glomerular filtration rate (GFR) decreased from ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187282
更新日期:1993-01-01 00:00:00
abstract::The serum levels of 25-hydroxycholecalciferol, 24,25-dihydroxycholecalciferol, and 1,25-dihydroxycholecalciferol were measured simultaneously in three groups of adults with different renal function: normal (n = 24), glomerular filtration rate (GFR) greater than 70 ml/min; moderately decreased (n = 15), GFR 5-35 ml/min...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183383
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Several studies have provided convincing evidence that in apparently healthy subjects elevated serum levels of plasma C-reactive protein (CRP) are associated with an increased risk of experiencing myocardial infarction and sudden cardiac death. It has been claimed that, in dialytic patients, the hepatic synt...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000065018
更新日期:2002-08-01 00:00:00
abstract::A 66-year-old white man presented with severe chronic renal failure. He had no past or present symptomatic glucose intolerance nor a family history of diabetes mellitus. Several fasting plasma glucose determinations, hemoglobin Alc and an oral glucose tolerance test were normal. Funduscopic ophthalmoscopy and retinal ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187061
更新日期:1992-01-01 00:00:00
abstract::We studied complexes composed of C1q and beta 2-microglobulin (C1q.beta 2M) or serum amyloid P-component (C1q.SAP) in the sera of 38 patients receiving hemodialysis (HD) and 20 healthy control subjects using an enzyme-linked immunoassay. We also compared complex levels in HD patients with and without symptoms of HD-as...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188506
更新日期:1995-01-01 00:00:00
abstract::Conjugated diene fatty acids (CDFA) were evaluated by second derivative spectrophotometry in the plasma and adipose tissue of 42 chronic renal failure (CFR) patients in conservative treatment, 40 patients treated by hemodialysis (HD) with cuprophane, cellulose acetate or hemophan, 29 treated by hemodiafiltration (HDF)...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187520
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The epithelial-mesenchymal transition (EMT) is a crucial event in the development of renal interstitial fibrosis (RIF). A growing body of evidence indicates that β-catenin plays an important role in various types of fibrosis. Although members of the microRNA (miRNA)-200 family have been suggested to suppress...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000479168
更新日期:2017-01-01 00:00:00
abstract::An animal model with experimental uremia is an important research tool for the study of the sequence of pathophysiological events taking place in the uremic syndrome. An appreciable number of animal models and methods for the induction of chronic uremia have been published. It is surprising that no such method has bee...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183491
更新日期:1985-01-01 00:00:00
abstract::Both the plasma determinations of erythropoietic (EPO) and transferrin receptor (TfR) would provide a good characterization of anemia especially when mixed erythron disorders underlie, such as in renal failure. Immunologic assays of EPO and TfR, as well as standard hematologic determinations (hematocrit, reticulocyte ...
journal_title:Nephron
pub_type: 临床试验,杂志文章
doi:10.1159/000188938
更新日期:1996-01-01 00:00:00
abstract::In 88 patients with the nephrotic syndrome (NS) we estimated plasma volume (PV) with 131I-albumin (RISA) and calculated blood volume (BV) from PV and whole body hematocrit (Ht). To assess whether this method gives erroneously high values in the NS, the transcapillary escape rate of albumin (TER) and large vessel Ht/wh...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183302
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Icodextrin, an effective osmotic substance that has been proposed as an alternative agent for peritoneal dialysis induces ultrafiltration over long dwells. This study examines the peritoneal transport after exposure to Icodextrin in rats. METHODS:Animals were divided in 4 groups and injected daily for 30 da...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000064481
更新日期:2002-09-01 00:00:00
abstract::To clarify the reliability of urinary trehalase activity as a marker of cellular proliferation and/or damage of renal proximal tubules, the activity was examined in healthy newborn infants or infants treated with tobramycin, a drug known as causing tubular cell damage. Eighty-one newborn infants (56 mature infants and...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188643
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Depression is the most common mental health disorder among those with end-stage renal disease (ESRD), with prevalence of 15-40%. However, the association between chronic kidney disease (CKD) and depression is more variable. We examined the associations of CKD with depression, perceived health status, and qua...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000455750
更新日期:2017-01-01 00:00:00
abstract::Plasma and urine beta-2-microglobulin (B2m) were measured in 37 renal transplant recipients and 34 healthy subjects. Serum B2m was found to be a more sensitive index of renal function than serum creatinine. Renal transplant recipients had significantly higher urine B2m when compared with normal controls. Normal subjec...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000183376
更新日期:1985-01-01 00:00:00
abstract::In order to assess the effects of sodium depletion on tubular Na and H2O transport in man, renal clearance studies were performed under control conditions and after sodium depletion in 7 normal subjects. The control diet contained 250 mEq of Na daily. Sodium depletion was induced by placing subjects on a 20-mEq/day na...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182635
更新日期:1982-01-01 00:00:00
abstract::Bone mineral content (BMC) was measured at the lumbar spine region by means of dual photon absorptiometry over a 3-year period in 20 patients on regular hemodialysis (RHD). Baseline mean BMC at the start of the monitoring was significantly decreased to 82.64% of predicted value (p less than 0.05). During a 3-year foll...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000185620
更新日期:1989-01-01 00:00:00
abstract::The effect of dilazep, an adenosine potentiator and platelet aggregation inhibitor, on experimental diabetic nephropathy was investigated in spontaneous diabetic Chinese hamster. Prediabetic animals, 8 weeks of age, were divided into two groups. In one group, 5 mg/kg dilazep was injected i.p. once a day. In the other ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187453
更新日期:1993-01-01 00:00:00
abstract:AIM:To determine the prevalence of kidney disease in a cohort of individuals with silicosis. METHODS:Review of medical records and questionnaires from patients reported to a state surveillance system for silicosis. Reporting of individuals with silicosis is required by state law. All individuals with silicosis reporte...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000045624
更新日期:2000-05-01 00:00:00
abstract::A 45-year-old male was admitted to the hospital because of polyuria and polydipsia. After admission, proteinuria and hematuria were found. The kidney function deteriorated and necessitated the initiation of chronic hemodialysis. Examination of the bone marrow revealed multiple myeloma and kappa light chains were found...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000182980
更新日期:1983-01-01 00:00:00
abstract::X-linked nephrogenic diabetes insipidus (NDI) is a rare disease caused by mutations in the vasopressin V2 receptor (AVPR2) gene. We analyzed the AVPR2 gene in 6 unrelated Korean families with X-linked NDI, and found 6 novel mutations. Two of them were missense point mutations, 2 were short deletions causing frameshift...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000189581
更新日期:1997-01-01 00:00:00