Peritoneal transport after long-term exposure to Icodextrin in rats.

Abstract:

BACKGROUND:Icodextrin, an effective osmotic substance that has been proposed as an alternative agent for peritoneal dialysis induces ultrafiltration over long dwells. This study examines the peritoneal transport after exposure to Icodextrin in rats. METHODS:Animals were divided in 4 groups and injected daily for 30 days with Icodextrin 7.5 % (n = 14), Glucose 4.25 % (n = 19) or glucose 4.25% plus Icodextrin 7.5 % (n = 13). Rats of the control group (n = 15) were not exposed. A 4-hour permeability study was performed using glucose at days 1, 30 and 60. At days 2, 31 and 61 the same animals were injected with Icodextrin. RESULTS:Slopes of effluent sodium at day 30 were significantly higher (p < 0.001) in the glucose (0.006 +/- 0.016), Icodextrin (0.013 +/- 0.014) and mixed groups (0.012 +/- 0.017) than in the control group (-0.041 +/- 0.021). Urea D/P ratio was not significantly different in the 4 groups. After 30 days, glucose effluent levels were significantly lower (p < 0.001) in the glucose (701 +/- 278 mg/dl), Icodextrin (552 +/- 209 mg/dl) and mixed groups (587 +/- 344 mg/dl) than in control rats (1519 +/- 413 mg/dl). Effluent protein (mg/l) in the mixed group (1,555 +/- 357) was significantly higher (p < 0.001) than control (376 +/- 33), glucose (1,015 +/- 232) and Icodextrin (765 +/- 75) groups at day 30. CONCLUSION:The long-term use of Icodextrin does not affect small molecule transport, but induces changes in the peritoneal protein excretion, especially when Icodextrin and glucose are injected together.

journal_name

Nephron

journal_title

Nephron

authors

Frajewicki V,Kushnir D,Wajsbrot V,Kohan R,Shostak A,Gotloib L

doi

10.1159/000064481

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

174-82

issue

1

eissn

1660-8151

issn

2235-3186

pii

nef92174

journal_volume

92

pub_type

杂志文章

相关文献

NEPHRON文献大全
  • Hypercalciuria and nephrocalcinosis, a feature of Wilson's disease.

    abstract::Hypercalciuria and nephrocalcinosis are not uncommon in patients with Wilson's disease but have only once been reported as the presenting sign. We diagnosed Wilson's disease in a 17-year-old male patient 6 years after his first episode of gross hematuria and 2 years after detection of hypercalciuria and nephrocalcinos...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187530

    authors: Hoppe B,Neuhaus T,Superti-Furga A,Forster I,Leumann E

    更新日期:1993-01-01 00:00:00

  • Soluble P-selectin is released from activated platelets in vivo during hemodialysis.

    abstract::During hemodialysis, platelets are activated across a dialyzer. Soluble P-selectin (sP-selectin) is a form of P-selectin which is a glycoprotein relocated from secretory granules to the surfaces of platelets and endothelial cells after these cells have been physiologically activated. To investigate whether sP-selectin...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044903

    authors: Kawabata K,Nagake Y,Shikata K,Fukuda S,Nakazono H,Takahashi M,Ichikawa H,Makino H

    更新日期:1998-01-01 00:00:00

  • Proenkephalin: A New Biomarker for Glomerular Filtration Rate and Acute Kidney Injury.

    abstract::Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not exclusively filtered by the kidney and rises relatively late after the onset of acute kidney injury (AKI). This leads to delays in recog...

    journal_title:Nephron

    pub_type: 杂志文章,评审

    doi:10.1159/000509352

    authors: Khorashadi M,Beunders R,Pickkers P,Legrand M

    更新日期:2020-01-01 00:00:00

  • The role of alpha-glutathione S-transferase in the monitoring of hemodialysis patients with hepatitis C virus infection undergoing high-dose interferon-alpha-2b therapy.

    abstract::The study aimed to evaluate the behavior of alpha-glutathione S-transferase (alpha-GST) in the serum of hemodialysis patients with hepatitis C virus (HCV) infection following treatment with high-dose IFN-alpha-2b. Ten patients with detected anti-HCV antibodies and HCV RNA by RT-PCR were selected and treated with high-...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045363

    authors: Boran M,Cetin S

    更新日期:1999-01-01 00:00:00

  • Safety of Percutaneous Ultrasound-Guided Kidney Biopsy in Patients with AA Amyloidosis.

    abstract:BACKGROUND:Bleeding is the most frequent complication of kidney biopsy. Although bleeding risk in patients with AA amyloidosis after kidney biopsy has not been studied in a large population, AA amyloidosis has long been perceived as a risk factor for bleeding. The aim of the present study was to evaluate post-biopsy bl...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000437443

    authors: Altindal M,Yildirim T,Turkmen E,Unal M,Boga I,Yilmaz R,Arici M,Altun B,Erdem Y

    更新日期:2015-01-01 00:00:00

  • Influence of splenectomy on human acute tubular necrosis.

    abstract::The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the inc...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183150

    authors: Pru CE,Fryd DS,Kjellstrand CM

    更新日期:1984-01-01 00:00:00

  • Effects of imidazole-2-hydroxibenzoate on glycosaminoglycan and albumin urinary excretion in type 1 diabetic patients.

    abstract::The effect of imidazole-2-hydroxibenzoate on urinary excretion rates of glycosaminoglycans and albumin in 22 insulin-dependent diabetics with albumin excretion rates under 300 mg/day was evaluated in a 165-day double blind crossover study. Unlike placebo, the drug reduced glycosaminoglycan and albumin excretion rates ...

    journal_title:Nephron

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000185115

    authors: Baggio B,Briani G,Cicerello E,Gambaro G,Giorato C,Iori E,Lavagnini T,Crepaldi G

    更新日期:1988-01-01 00:00:00

  • Agreement between the classical urea kinetic model and direct dialysis quantification: importance of urea rebound.

    abstract::From a review of the literature regarding kinetic models used for assessing the adequacy of hemodialysis, no definite conclusions can be drawn as to whether the classical urea kinetic model (UKM) or modified direct dialysis quantification (mDDQ) is more reliable. We compared mDDQ with classical UKM and with a modified...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189473

    authors: Bosticardo GM,Alloatti S

    更新日期:1996-01-01 00:00:00

  • Effects of chitosan-coated dialdehyde cellulose, a newly developed oral adsorbent, on glomerulonephritis induced by anti-Thy-1 antibody in rats.

    abstract::The effects of chitosan-coated dialdehyde cellulose (chitosan DAC), a newly developed oral adsorbent for urea and ammonia, were examined in a glomerulonephritis model in rats. Mesangial proliferative glomerulonephritis accompanied with proteinuria was induced by an intravenous injection of anti-rat Thy-1.1 monoclonal ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000044973

    authors: Yagi M,Kato S,Nishitoba T,Sato H,Kobayashi N,Iinuma N,Nagano N

    更新日期:1998-01-01 00:00:00

  • Extracellular matrix proteins modulate human peritoneal mesothelial cell behavior.

    abstract::Human peritoneal mesothelial cells lie on a basement membrane-like material consisting of fibronectin (FN), type I collagen (CI), type III collagen (CIII) and laminin (LA). To understand how these extracellular matrix (ECM) proteins affect mesothelial cell behavior, we investigated their effect on the adhesion and pro...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189530

    authors: Yen CJ,Fang CC,Chen YM,Lin RH,Wu KD,Lee PH,Tsai TJ

    更新日期:1997-01-01 00:00:00

  • Efficiency of hemodialysis of pyrimidine compounds in patients with chronic renal failure.

    abstract::The accumulation in blood plasma and efficiency of hemodialysis of pyrimidine compounds (orotic acid, orotidine, pseudouridine, uridine, thymine) as well as uric acid and creatinine in 23 patients with chronic renal failure (CRF) was investigated. As a reference, the analysis of the above metabolites in the plasma of ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187313

    authors: Daniewska-Michalska D,Motyl T,Gellert R,Kukulska W,Podgurniak M,Opechowska-Pacocha E,Ostrowski K

    更新日期:1993-01-01 00:00:00

  • An index of plasma refilling in hemodialysis patients.

    abstract::During hemodialysis therapy, a large amount of water is removed from the patient's blood in a short time; however, blood pressure remains stable in most patients. As water is removed, the circulating serum proteins become more concentrated, resulting in a marked increase in the driving force which pulls water from the...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000189320

    authors: Tabei K,Nagashima H,Imura O,Sakurai T,Asano Y

    更新日期:1996-01-01 00:00:00

  • Mesangial glomerulopathy and IgM rheumatoid factor in rheumatoid arthritis.

    abstract::Hematuria and proteinuria in rheumatoid arthritis (RA) are commonly associated with drug therapy but occur independently of drugs, amyloid or urologic disorders. The latter occurrences suggest a primary renal lesion associated with RA. Review of reported renal biopsies identifies mesangial glomerulopathy as a common f...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000185262

    authors: Pollet S,Depner T,Moore P,Olander H,Robbins D

    更新日期:1989-01-01 00:00:00

  • Epidemiology of viral hepatitis in dialysis centers: a national survey.

    abstract::Because of the great problem of viral hepatitis in hemodialysis patients, the Italian Society of Nephrology decided to perform a national epidemiologic survey. We contacted 467 nephrological centers by a questionnaire which let us have information on 25,746 uremic patients: 18,338 on HD, 2,250 on PD and 5,176 with kid...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000186905

    authors: Mioli VA,Balestra E,Bibiano L,Carletti P,Della Bella S,Fanciulli E,Gaffi G,Marinelli R,Perilli R,Ricciatti AM

    更新日期:1992-01-01 00:00:00

  • The herbal medicine Sairei-to inhibits proliferation of rat mesangial cells.

    abstract:BACKGROUND:The herbal medicine Sairei-to is efficacious in renal diseases where mesangial proliferation is a key event. We examined whether Sairei-to inhibits proliferation of cultured rat mesangial cells and investigated its mechanism of action. METHODS:The effect of Sairei-to on [(3)H]-thymidine incorporation stimul...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000064112

    authors: Awazu M,Fujita H,Omori S,Hida M

    更新日期:2002-01-01 00:00:00

  • Prostaglandin and thromboxane formation in glomeruli from rats with reduced renal mass.

    abstract::In vitro formation of prostaglandins (PG) E2, F2 alpha, 6-keto-F1 alpha, and thromboxane B2 (TxB2) by glomeruli from rats with reduced renal mass (RRM) were evaluated by radioimmunoassay. Four weeks following ablation of renal mass, PGE2, PGF2 alpha, and TxB2 production by glomeruli from RRM rats was significantly gre...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183676

    authors: Stahl RA,Kudelka S,Paravicini M,Schollmeyer P

    更新日期:1986-01-01 00:00:00

  • Age-related appearance of amyloid P component in human renal glomeruli.

    abstract::Amyloid P component (AP) is a matrix glycoprotein of adult renal glomeruli. To establish whether the deposition of AP in glomeruli is an age-related phenomenon, this study used indirect immunofluorescence (IF) to investigate 34 renal biopsy specimens and 11 renal autopsy specimens. The biopsy specimens were taken from...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000190315

    authors: Rantala IS,Helin HJ,Mustonen JT,Reunala T

    更新日期:1997-01-01 00:00:00

  • Vocational rehabilitation in dialyzed patients. A cross-sectional study.

    abstract::The physicians in charge of 15 German hemodialysis units furnished data on 713 dialysis patients. Data relating to the vocational status were examined for 612 patients aged 60 years or below. It was found that the current working status varies with psychological and social factors. The data show that the vocational st...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000181968

    authors: Tews HP,Schreiber WK,Huber W,Zelt J,Ritz E

    更新日期:1980-01-01 00:00:00

  • Reduced collagenolytic activity of rat kidneys with steptozotocin diabetes.

    abstract::Collagenolytic activity of rat kidneys with streptozotocin diabetes was estimated by means of a biological collagenase assay and compared to healthy controls. Collagenolytic activity was found significantly decreased in rat kidneys with diabetes correlating with blood glucose levels (r = -0.82, p less than 0.001). Ele...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000182517

    authors: Lubec G,Leban J,Peyroux J,Sternberg M,Pollak A,Latzka U,Coradello H

    更新日期:1982-01-01 00:00:00

  • Glomerular Hyperfiltration: An Early Marker of Nephropathy in Fabry Disease.

    abstract:BACKGROUND AND OBJECTIVES:Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several stu...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000493469

    authors: Riccio E,Sabbatini M,Bruzzese D,Annicchiarico Petruzzelli L,Pellegrino A,Spinelli L,Esposito R,Imbriaco M,Feriozzi S,Pisani A,on behalf of AFFIINITY Group.

    更新日期:2019-01-01 00:00:00

  • HDL cholesterol and TaqIB cholesteryl ester transfer protein gene polymorphism in renal transplant recipients.

    abstract::Decreased serum levels of high-density lipoprotein cholesterol (HDL-C) are a well-known risk factor for coronary heart disease (CHD) in the general population and have been suggested as one of the best predictor of CHD after renal transplantation. However, very heterogeneous HDL-C levels have been reported in renal tr...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045608

    authors: Radeau T,Vohl MC,Houde I,Lachance JG,Noël R,Després JP,Douville P,Bergeron J

    更新日期:2000-04-01 00:00:00

  • Hyperosmolality, High Blood Pressure, and Decreased Estimated Glomerular Filtration Rate in US Adolescents, National Health and Nutrition Examination Survey 1999-2012.

    abstract:BACKGROUND:Experimental evidence suggests that hyperosmolality may be a causative factor in the development of both salt-sensitive hypertension and chronic kidney disease (CKD). There are no population-wide studies in young persons to assess the relationships among these factors. OBJECTIVE:To determine the association...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000497780

    authors: Chmielewski J,Khalsa DD,Carmody JB

    更新日期:2019-01-01 00:00:00

  • Exercise capacity in hemodialysis, CAPD, and renal transplant patients.

    abstract::Eighteen hemodialysis, 12 chronic ambulatory peritoneal dialysis (CAPD), and 20 renal transplant patients performed maximal treadmill exercise tests. Heart rates and blood pressures were determined every minute and maximal oxygen consumption was measured directly. Exercise capacity as measured by VO2 max is low in dia...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183632

    authors: Painter P,Messer-Rehak D,Hanson P,Zimmerman SW,Glass NR

    更新日期:1986-01-01 00:00:00

  • The FENa test is of no prognostic value in acute renal failure.

    abstract::A 2-year prospective study was done in 45 patients to see whether the FENa test, done at first nephrology consultation visit for acute renal failure, was useful in prognosticating whether patients would recover renal function spontaneously or need dialysis. Of 26 patients who recovered renal function spontaneously, 8 ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000183110

    authors: Pru C,Kjellstrand CM

    更新日期:1984-01-01 00:00:00

  • The pathogenic role of immunoglobulin A polymers in immunoglobulin A nephropathy.

    abstract::Circumstantial evidence that pIgA has a key role in glomerular injury of IgAN is now strong. Although the answers to the questions posed in this review are necessarily incomplete, they do indicate that (1) pIgA is a major component of mesangial IgA. (2) circulating pIgA is increased and this pIgA is particularly enhan...

    journal_title:Nephron

    pub_type: 社论

    doi:10.1159/000187509

    authors: Harper SJ,Feehally J

    更新日期:1993-01-01 00:00:00

  • Characteristics of Patients Who Achieve Serum Phosphorus Control on Sucroferric Oxyhydroxide or Sevelamer Carbonate: A post hoc Analysis of a Phase 3 Study.

    abstract:INTRODUCTION:Control of hyperphosphatemia in patients on dialysis remains a major challenge. OBJECTIVE:This study evaluated predictors of serum phosphorus (sP) control among dialysis patients treated with noncalcium, oral phosphate binder therapy in a phase 3 clinical trial. METHODS:Post hoc analyses were performed u...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000507258

    authors: Covic AC,Sprague SM,Rastogi A,Ketteler M,Walpen S,Perrin A,Floege J

    更新日期:2020-01-01 00:00:00

  • Role of fibronectin in immune glomerulonephritis.

    abstract::There is already a considerable amount of evidence suggesting that fibronectin (Fn) plays an important role in the pathogenic process in some forms of glomerulonephritis (GN). It has been postulated that Fn may participate in the progression or regression of glomerular diseases. The Fn is presented in the kidney as a ...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187249

    authors: Altunkova I,Minkova V,Belovezhdov N

    更新日期:1993-01-01 00:00:00

  • Serum propeptides of type I and III procollagens in renal transplant recipients. A comparison of cyclosporine and azathioprine treatment.

    abstract::Chronic cyclosporine nephrotoxicity is characterized morphologically by cortical interstitial fibrosis. The most important collagens involved in renal fibrosis are collagen types I and III. In order to estimate the synthesis of type III and type I collagens, we analyzed serum levels of the amino-terminal propeptide of...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000187929

    authors: Heickendorff L,Frost L,Madsen JK,Pedersen EB

    更新日期:1994-01-01 00:00:00

  • Guidelines for Classification of Acute Kidney Diseases and Disorders.

    abstract::Recent efforts have standardized definitions and classification systems for acute kidney injury (AKI) and chronic kidney disease (CKD). These efforts have enhanced communication, recognition, and awareness of acute and CKDs and stimulated research on both disorders. However, abnormalities of kidney function and struct...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000441425

    authors: Barry R,James MT

    更新日期:2015-01-01 00:00:00

  • L-lysine reduces nonenzymatic glycation of glomerular basement membrane collagen and albuminuria in diabetic rats.

    abstract::In this study, we examined the hypothesis whether exogenous administration of L-lysine in drinking water would reduce nonenzymatic glycation of glomerular basement membrane (GBM) collagen and thus albuminuria in streptozotocin-diabetic rats. The rationale is that the administered lysine would combine with the circulat...

    journal_title:Nephron

    pub_type: 杂志文章

    doi:10.1159/000045904

    authors: Jyothirmayi GN,Modak R,Reddi AS

    更新日期:2001-02-01 00:00:00